Details of the Target

General Information of Target

Target ID LDTP08824
Target Name Protein O-mannosyl-transferase TMTC2 (TMTC2)
Gene Name TMTC2
Gene ID 160335
Synonyms
Protein O-mannosyl-transferase TMTC2; EC 2.4.1.109; Transmembrane O-mannosyltransferase targeting cadherins 2; Transmembrane and tetratricopeptide repeat-containing 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MIAELVSSALGLALYLNTLSADFCYDDSRAIKTNQDLLPETPWTHIFYNDFWGTLLTHSG
SHKSYRPLCTLSFRLNHAIGGLNPWSYHLVNVLLHAAVTGLFTSFSKILLGDGYWTFMAG
LMFASHPIHTEAVAGIVGRADVGASLFFLLSLLCYIKHCSTRGYSARTWGWFLGSGLCAG
CSMLWKEQGVTVLAVSAVYDVFVFHRLKIKQILPTIYKRKNLSLFLSISLLIFWGSSLLG
ARLYWMGNKPPSFSNSDNPAADSDSLLTRTLTFFYLPTKNLWLLLCPDTLSFDWSMDAVP
LLKTVCDWRNLHTVAFYTGLLLLAYYGLKSPSVDRECNGKTVTNGKQNANGHSCLSDVEY
QNSETKSSFASKVENGIKNDVSQRTQLPSTENIVVLSLSLLIIPFVPATNLFFYVGFVIA
ERVLYIPSMGFCLLITVGARALYVKVQKRFLKSLIFYATATLIVFYGLKTAIRNGDWQNE
EMLYRSGIKVNPAKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQEN
SRFAEALHYYKLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHA
HKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLP
EAEHWYMESLRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQF
LLEEARLIEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPA
ALMNLGAILHLNGRLQKAEANYLRALQLKPDDVITQSNLRKLWNIMEKQGLKTSKT
Target Bioclass
Enzyme
Family
TMTC family
Subcellular location
Membrane
Function
Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3.
Uniprot ID
Q8N394
Ensemble ID
ENST00000321196.8
HGNC ID
HGNC:25440

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C713(1.15)  LDD3312  [1]
AHL-Pu-1
 Probe Info  		C354(3.38)  LDD0171  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C354(3.38)  LDD0171  [2]
 LDCM0215  AC10 HEK-293T C713(0.88)  LDD1508  [3]
 LDCM0259  AC14 HEK-293T C587(1.04)  LDD1512  [3]
 LDCM0277  AC18 HEK-293T C713(0.68)  LDD1516  [3]
 LDCM0279  AC2 HEK-293T C713(0.75)  LDD1518  [3]
 LDCM0282  AC22 HEK-293T C587(1.05)  LDD1521  [3]
 LDCM0286  AC26 HEK-293T C713(1.08)  LDD1525  [3]
 LDCM0291  AC30 HEK-293T C587(1.00)  LDD1530  [3]
 LDCM0295  AC34 HEK-293T C713(1.10)  LDD1534  [3]
 LDCM0299  AC38 HEK-293T C587(1.14)  LDD1538  [3]
 LDCM0304  AC42 HEK-293T C713(0.90)  LDD1543  [3]
 LDCM0308  AC46 HEK-293T C587(1.08)  LDD1547  [3]
 LDCM0313  AC50 HEK-293T C713(1.12)  LDD1552  [3]
 LDCM0317  AC54 HEK-293T C587(1.23)  LDD1556  [3]
 LDCM0321  AC58 HEK-293T C713(0.77)  LDD1560  [3]
 LDCM0323  AC6 HEK-293T C587(0.96)  LDD1562  [3]
 LDCM0326  AC62 HEK-293T C587(1.01)  LDD1565  [3]
 LDCM0368  CL10 HEK-293T C587(0.84)  LDD1572  [3]
 LDCM0369  CL100 HEK-293T C713(0.92)  LDD1573  [3]
 LDCM0373  CL104 HEK-293T C713(1.11)  LDD1577  [3]
 LDCM0377  CL108 HEK-293T C713(0.91)  LDD1581  [3]
 LDCM0382  CL112 HEK-293T C713(0.88)  LDD1586  [3]
 LDCM0386  CL116 HEK-293T C713(1.29)  LDD1590  [3]
 LDCM0391  CL120 HEK-293T C713(1.15)  LDD1595  [3]
 LDCM0395  CL124 HEK-293T C713(0.82)  LDD1599  [3]
 LDCM0399  CL128 HEK-293T C713(1.15)  LDD1603  [3]
 LDCM0403  CL16 HEK-293T C713(1.09)  LDD1607  [3]
 LDCM0405  CL18 HEK-293T C713(1.22)  LDD1609  [3]
 LDCM0410  CL22 HEK-293T C587(0.98)  LDD1614  [3]
 LDCM0416  CL28 HEK-293T C713(1.02)  LDD1620  [3]
 LDCM0419  CL30 HEK-293T C713(0.88)  LDD1623  [3]
 LDCM0423  CL34 HEK-293T C587(0.89)  LDD1627  [3]
 LDCM0429  CL4 HEK-293T C713(0.90)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C713(0.94)  LDD1634  [3]
 LDCM0432  CL42 HEK-293T C713(0.90)  LDD1636  [3]
 LDCM0436  CL46 HEK-293T C587(0.81)  LDD1640  [3]
 LDCM0443  CL52 HEK-293T C713(0.88)  LDD1646  [3]
 LDCM0445  CL54 HEK-293T C713(1.17)  LDD1648  [3]
 LDCM0449  CL58 HEK-293T C587(1.00)  LDD1652  [3]
 LDCM0451  CL6 HEK-293T C713(0.84)  LDD1654  [3]
 LDCM0456  CL64 HEK-293T C713(1.07)  LDD1659  [3]
 LDCM0458  CL66 HEK-293T C713(0.99)  LDD1661  [3]
 LDCM0463  CL70 HEK-293T C587(0.89)  LDD1666  [3]
 LDCM0469  CL76 HEK-293T C713(0.91)  LDD1672  [3]
 LDCM0471  CL78 HEK-293T C713(1.18)  LDD1674  [3]
 LDCM0476  CL82 HEK-293T C587(0.98)  LDD1679  [3]
 LDCM0482  CL88 HEK-293T C713(1.25)  LDD1685  [3]
 LDCM0485  CL90 HEK-293T C713(0.94)  LDD1688  [3]
 LDCM0489  CL94 HEK-293T C587(0.91)  LDD1692  [3]
 LDCM0022  KB02 HEK-293T C713(1.22)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C713(0.97)  LDD1497  [3]
 LDCM0024  KB05 HMCB C713(1.15)  LDD3312  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402