Details of the Target

General Information of Target

Target ID LDTP08815
Target Name Mesoderm induction early response protein 2 (MIER2)
Gene Name MIER2
Gene ID 54531
Synonyms
KIAA1193; Mesoderm induction early response protein 2; Mi-er2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEASSLGRQSPRVVSCLEHSLCPGEPGLQTTAVVSMGSGDHQFNLAEILSQNYSVRGEC
EEASRCPDKPKEELEKDFISQSNDMPFDELLALYGYEASDPISDRESEGGDVAPNLPDMT
LDKEQIAKDLLSGEEEEETQSSADDLTPSVTSHEASDLFPNRSGSRFLADEDREPGSSAS
SDTEEDSLPANKCKKEIMVGPQFQADLSNLHLNRHCEKIYENEDQLLWDPSVLPEREVEE
FLYRAVKRRWHEMAGPQLPEGEAVKDSEQALYELVKCNFNVEEALRRLRFNVKVIRDGLC
AWSEEECRNFEHGFRVHGKNFHLIQANKVRTRSVGECVEYYYLWKKSERYDYFAQQTRLG
RRKYVPSGTTDADQDLDGSDPDGPGRPRPEQDTLTGMRTDPLSVDGTAGGLDEPGVASDG
LPSSEPGPCSFQQLDESPAVPLSHRPPALADPASYQPAVTAPEPDASPRLAVDFALPKEL
PLISSHVDLSGDPEETVAPAQVALSVTEFGLIGIGDVNPFLAAHPTCPAPGLHSEPLSHC
NVMTC
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function Transcriptional repressor.
Uniprot ID
Q8N344
Ensemble ID
ENST00000264819.7
HGNC ID
HGNC:29210

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C300(1.17)  LDD0078  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C300(0.38); C307(0.38)  LDD1093  [1]
 LDCM0226  AC11 HEK-293T C300(0.71)  LDD1509  [2]
 LDCM0270  AC15 HEK-293T C300(0.91)  LDD1513  [2]
 LDCM0276  AC17 HCT 116 C277(0.83)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C277(0.90)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C277(1.00)  LDD0595  [1]
 LDCM0279  AC2 PaTu 8988t C300(0.34); C307(0.34)  LDD1158  [1]
 LDCM0280  AC20 HCT 116 C277(0.97)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C277(0.71)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C277(0.74)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C277(0.98)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C277(0.89)  LDD0601  [1]
 LDCM0287  AC27 HEK-293T C300(1.05)  LDD1526  [2]
 LDCM0289  AC29 HEK-293T C300(1.02)  LDD1528  [2]
 LDCM0290  AC3 PaTu 8988t C300(0.37); C307(0.37)  LDD1169  [1]
 LDCM0292  AC31 HEK-293T C300(0.85)  LDD1531  [2]
 LDCM0296  AC35 HCT 116 C277(0.97)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C277(0.89)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C277(1.33)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C277(1.43)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C277(1.28)  LDD0617  [1]
 LDCM0301  AC4 PaTu 8988t C300(0.39); C307(0.39)  LDD1180  [1]
 LDCM0302  AC40 HCT 116 C277(1.84)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C277(1.19)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C277(1.46)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C277(1.27)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C277(1.11)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C277(1.18)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C277(0.73)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C277(0.59)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C277(0.85)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C277(0.84)  LDD0628  [1]
 LDCM0312  AC5 PaTu 8988t C300(0.37); C307(0.37)  LDD1191  [1]
 LDCM0313  AC50 HCT 116 C277(0.67)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C277(0.77)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C277(0.99)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C277(1.01)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C277(0.53)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C277(1.11)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C277(1.14)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C277(0.95)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C277(1.05)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C277(0.94)  LDD0639  [1]
 LDCM0324  AC60 HCT 116 C277(1.07)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C277(1.07)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C277(1.26)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C277(1.14)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C277(1.19)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C277(1.68)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C277(1.56)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C277(1.09)  LDD0648  [1]
 LDCM0332  AC68 PaTu 8988t C300(0.97); C307(0.97)  LDD1211  [1]
 LDCM0333  AC69 PaTu 8988t C300(1.05); C307(1.05)  LDD1212  [1]
 LDCM0334  AC7 HEK-293T C300(1.07)  LDD1568  [2]
 LDCM0335  AC70 PaTu 8988t C300(1.07); C307(1.07)  LDD1214  [1]
 LDCM0336  AC71 PaTu 8988t C300(1.10); C307(1.10)  LDD1215  [1]
 LDCM0337  AC72 PaTu 8988t C300(1.33); C307(1.33)  LDD1216  [1]
 LDCM0338  AC73 PaTu 8988t C300(1.14); C307(1.14)  LDD1217  [1]
 LDCM0339  AC74 PaTu 8988t C300(1.08); C307(1.08)  LDD1218  [1]
 LDCM0340  AC75 PaTu 8988t C300(2.22); C307(2.22)  LDD1219  [1]
 LDCM0341  AC76 PaTu 8988t C300(1.10); C307(1.10)  LDD1220  [1]
 LDCM0342  AC77 PaTu 8988t C300(1.13); C307(1.13)  LDD1221  [1]
 LDCM0343  AC78 PaTu 8988t C300(0.89); C307(0.89)  LDD1222  [1]
 LDCM0344  AC79 PaTu 8988t C300(1.29); C307(1.29)  LDD1223  [1]
 LDCM0346  AC80 PaTu 8988t C300(1.15); C307(1.15)  LDD1225  [1]
 LDCM0347  AC81 PaTu 8988t C300(1.06); C307(1.06)  LDD1226  [1]
 LDCM0348  AC82 PaTu 8988t C300(1.11); C307(1.11)  LDD1227  [1]
 LDCM0248  AKOS034007472 HEK-293T C300(1.11)  LDD1511  [2]
 LDCM0020  ARS-1620 HCC44 C300(1.17)  LDD0078  [1]
 LDCM0369  CL100 PaTu 8988t C300(0.45); C307(0.45)  LDD1248  [1]
 LDCM0371  CL102 HEK-293T C60(0.93)  LDD1575  [2]
 LDCM0374  CL105 HCT 116 C277(0.74)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C277(0.87)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C277(0.98)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C277(0.93)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C277(0.69)  LDD0695  [1]
 LDCM0379  CL11 HEK-293T C300(1.17)  LDD1583  [2]
 LDCM0380  CL110 HCT 116 C277(0.97)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C277(0.63)  LDD0698  [1]
 LDCM0384  CL114 HEK-293T C60(0.97)  LDD1588  [2]
 LDCM0387  CL117 HCT 116 C277(1.24)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C277(1.41)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C277(1.23)  LDD0706  [1]
 LDCM0391  CL120 HCT 116 C277(1.46)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C277(0.79)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C277(0.77)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C277(0.56)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C277(0.62)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C277(0.79)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C277(0.98)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C277(0.98)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C277(1.20)  LDD0716  [1]
 LDCM0401  CL14 HEK-293T C60(0.83)  LDD1605  [2]
 LDCM0406  CL19 HEK-293T C300(1.25)  LDD1610  [2]
 LDCM0407  CL2 HEK-293T C60(1.01)  LDD1611  [2]
 LDCM0409  CL21 HEK-293T C300(1.20)  LDD1613  [2]
 LDCM0411  CL23 HEK-293T C300(1.14)  LDD1615  [2]
 LDCM0414  CL26 HEK-293T C60(0.78)  LDD1618  [2]
 LDCM0420  CL31 PaTu 8988t C300(1.11); C307(1.11)  LDD1299  [1]
 LDCM0421  CL32 PaTu 8988t C300(1.23); C307(1.23)  LDD1300  [1]
 LDCM0422  CL33 PaTu 8988t C300(1.43); C307(1.43)  LDD1301  [1]
 LDCM0423  CL34 PaTu 8988t C300(1.25); C307(1.25)  LDD1302  [1]
 LDCM0424  CL35 PaTu 8988t C300(1.12); C307(1.12)  LDD1303  [1]
 LDCM0425  CL36 PaTu 8988t C300(1.29); C307(1.29)  LDD1304  [1]
 LDCM0426  CL37 PaTu 8988t C300(1.40); C307(1.40)  LDD1305  [1]
 LDCM0428  CL39 PaTu 8988t C300(1.20); C307(1.20)  LDD1307  [1]
 LDCM0430  CL40 PaTu 8988t C300(1.20); C307(1.20)  LDD1309  [1]
 LDCM0431  CL41 PaTu 8988t C300(1.20); C307(1.20)  LDD1310  [1]
 LDCM0432  CL42 PaTu 8988t C300(1.38); C307(1.38)  LDD1311  [1]
 LDCM0433  CL43 PaTu 8988t C300(1.43); C307(1.43)  LDD1312  [1]
 LDCM0434  CL44 PaTu 8988t C300(1.33); C307(1.33)  LDD1313  [1]
 LDCM0435  CL45 PaTu 8988t C300(1.26); C307(1.26)  LDD1314  [1]
 LDCM0437  CL47 HEK-293T C300(1.67)  LDD1641  [2]
 LDCM0441  CL50 HEK-293T C60(0.91)  LDD1645  [2]
 LDCM0446  CL55 HEK-293T C300(1.12)  LDD1649  [2]
 LDCM0448  CL57 HEK-293T C300(1.47)  LDD1651  [2]
 LDCM0450  CL59 HEK-293T C300(1.16)  LDD1653  [2]
 LDCM0454  CL62 HEK-293T C60(0.80)  LDD1657  [2]
 LDCM0459  CL67 HEK-293T C300(0.87)  LDD1662  [2]
 LDCM0461  CL69 HEK-293T C300(1.02)  LDD1664  [2]
 LDCM0462  CL7 HEK-293T C300(0.94)  LDD1665  [2]
 LDCM0464  CL71 HEK-293T C300(1.19)  LDD1667  [2]
 LDCM0467  CL74 HEK-293T C60(1.04)  LDD1670  [2]
 LDCM0469  CL76 PaTu 8988t C300(1.27); C307(1.27)  LDD1348  [1]
 LDCM0470  CL77 PaTu 8988t C300(1.16); C307(1.16)  LDD1349  [1]
 LDCM0471  CL78 PaTu 8988t C300(1.43); C307(1.43)  LDD1350  [1]
 LDCM0472  CL79 PaTu 8988t C300(1.58); C307(1.58)  LDD1351  [1]
 LDCM0474  CL80 PaTu 8988t C300(1.61); C307(1.61)  LDD1353  [1]
 LDCM0475  CL81 PaTu 8988t C300(1.24); C307(1.24)  LDD1354  [1]
 LDCM0476  CL82 PaTu 8988t C300(1.34); C307(1.34)  LDD1355  [1]
 LDCM0477  CL83 PaTu 8988t C300(1.70); C307(1.70)  LDD1356  [1]
 LDCM0478  CL84 PaTu 8988t C300(1.82); C307(1.82)  LDD1357  [1]
 LDCM0479  CL85 PaTu 8988t C300(1.05); C307(1.05)  LDD1358  [1]
 LDCM0480  CL86 PaTu 8988t C300(1.98); C307(1.98)  LDD1359  [1]
 LDCM0481  CL87 PaTu 8988t C300(1.89); C307(1.89)  LDD1360  [1]
 LDCM0482  CL88 PaTu 8988t C300(1.92); C307(1.92)  LDD1361  [1]
 LDCM0483  CL89 PaTu 8988t C300(1.74); C307(1.74)  LDD1362  [1]
 LDCM0484  CL9 HEK-293T C300(1.15)  LDD1687  [2]
 LDCM0485  CL90 PaTu 8988t C300(1.47); C307(1.47)  LDD1364  [1]
 LDCM0486  CL91 PaTu 8988t C300(0.36); C307(0.36)  LDD1365  [1]
 LDCM0487  CL92 PaTu 8988t C300(0.25); C307(0.25)  LDD1366  [1]
 LDCM0488  CL93 PaTu 8988t C300(0.32); C307(0.32)  LDD1367  [1]
 LDCM0489  CL94 PaTu 8988t C300(0.40); C307(0.40)  LDD1368  [1]
 LDCM0490  CL95 PaTu 8988t C300(0.38); C307(0.38)  LDD1369  [1]
 LDCM0491  CL96 PaTu 8988t C300(0.31); C307(0.31)  LDD1370  [1]
 LDCM0492  CL97 PaTu 8988t C300(0.37); C307(0.37)  LDD1371  [1]
 LDCM0493  CL98 PaTu 8988t C300(0.38); C307(0.38)  LDD1372  [1]
 LDCM0494  CL99 PaTu 8988t C300(0.28); C307(0.28)  LDD1373  [1]
 LDCM0427  Fragment51 PaTu 8988t C300(1.31); C307(1.31)  LDD1306  [1]
 LDCM0022  KB02 EoL-1 C60(1.21)  LDD2324  [3]
 LDCM0023  KB03 EoL-1 C60(1.11)  LDD2741  [3]
 LDCM0024  KB05 EoL-1 C60(1.40)  LDD3158  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Microspherule protein 1 (MCRS1) . Q96EZ8

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840