Details of the Target

General Information of Target

Target ID LDTP08665
Target Name Tomoregulin-1 (TMEFF1)
Gene Name TMEFF1
Gene ID 100526694
Synonyms
C9orf2; Tomoregulin-1; TR-1; H7365; Transmembrane protein with EGF-like and one follistatin-like domain
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGAAAAEAPLRLPAAPPLAFCCYTSVLLLFAFSLPGSRASNQPPGGGGGSGGDCPGGKGK
SINCSELNVRESDVRVCDESSCKYGGVCKEDGDGLKCACQFQCHTNYIPVCGSNGDTYQN
ECFLRRAACKHQKEITVIARGPCYSDNGSGSGEGEEEGSGAEVHRKHSKCGPCKYKAECD
EDAENVGCVCNIDCSGYSFNPVCASDGSSYNNPCFVREASCIKQEQIDIRHLGHCTDTDD
TSLLGKKDDGLQYRPDVKDASDQREDVYIGNHMPCPENLNGYCIHGKCEFIYSTQKASCR
CESGYTGQHCEKTDFSILYVVPSRQKLTHVLIAAIIGAVQIAIIVAIVMCITRKCPKNNR
GRRQKQNLGHFTSDTSSRMV
Target Bioclass
Transporter and channel
Family
Tomoregulin family
Subcellular location
Cell membrane
Function May inhibit NODAL and BMP signaling during neural patterning. May be a tumor suppressor in brain cancers.
Uniprot ID
Q8IYR6
Ensemble ID
ENST00000374879.5
HGNC ID
HGNC:11866

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL148 SNV: p.G337E .
CCK81 SNV: p.S208C; p.P356S .
HDMYZ SNV: p.V74I; p.G196V .
JURKAT SNV: p.A128T .
SBC5 SNV: p.I343F .
U937 SNV: p.I192V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C64(1.03)  LDD1510  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0237  AC12 HEK-293T C64(1.03)  LDD1510  [1]
 LDCM0259  AC14 HEK-293T C64(0.97)  LDD1512  [1]
 LDCM0270  AC15 HEK-293T C64(1.13)  LDD1513  [1]
 LDCM0280  AC20 HEK-293T C64(0.93)  LDD1519  [1]
 LDCM0281  AC21 HEK-293T C64(1.00)  LDD1520  [1]
 LDCM0282  AC22 HEK-293T C64(0.95)  LDD1521  [1]
 LDCM0283  AC23 HEK-293T C64(1.17)  LDD1522  [1]
 LDCM0288  AC28 HEK-293T C64(1.01)  LDD1527  [1]
 LDCM0289  AC29 HEK-293T C64(1.06)  LDD1528  [1]
 LDCM0291  AC30 HEK-293T C64(0.99)  LDD1530  [1]
 LDCM0292  AC31 HEK-293T C64(1.19)  LDD1531  [1]
 LDCM0297  AC36 HEK-293T C64(1.00)  LDD1536  [1]
 LDCM0298  AC37 HEK-293T C64(1.08)  LDD1537  [1]
 LDCM0299  AC38 HEK-293T C64(1.01)  LDD1538  [1]
 LDCM0300  AC39 HEK-293T C64(1.12)  LDD1539  [1]
 LDCM0301  AC4 HEK-293T C64(0.98)  LDD1540  [1]
 LDCM0306  AC44 HEK-293T C64(1.03)  LDD1545  [1]
 LDCM0307  AC45 HEK-293T C64(1.11)  LDD1546  [1]
 LDCM0308  AC46 HEK-293T C64(0.98)  LDD1547  [1]
 LDCM0309  AC47 HEK-293T C64(1.10)  LDD1548  [1]
 LDCM0312  AC5 HEK-293T C64(0.97)  LDD1551  [1]
 LDCM0315  AC52 HEK-293T C64(0.94)  LDD1554  [1]
 LDCM0316  AC53 HEK-293T C64(1.07)  LDD1555  [1]
 LDCM0317  AC54 HEK-293T C64(1.03)  LDD1556  [1]
 LDCM0318  AC55 HEK-293T C64(1.16)  LDD1557  [1]
 LDCM0323  AC6 HEK-293T C64(0.99)  LDD1562  [1]
 LDCM0324  AC60 HEK-293T C64(1.02)  LDD1563  [1]
 LDCM0325  AC61 HEK-293T C64(1.07)  LDD1564  [1]
 LDCM0326  AC62 HEK-293T C64(1.01)  LDD1565  [1]
 LDCM0327  AC63 HEK-293T C64(1.17)  LDD1566  [1]
 LDCM0334  AC7 HEK-293T C64(1.19)  LDD1568  [1]
 LDCM0248  AKOS034007472 HEK-293T C64(0.86)  LDD1511  [1]
 LDCM0368  CL10 HEK-293T C64(1.15)  LDD1572  [1]
 LDCM0379  CL11 HEK-293T C64(1.13)  LDD1583  [1]
 LDCM0408  CL20 HEK-293T C64(1.04)  LDD1612  [1]
 LDCM0409  CL21 HEK-293T C64(1.13)  LDD1613  [1]
 LDCM0410  CL22 HEK-293T C64(0.97)  LDD1614  [1]
 LDCM0411  CL23 HEK-293T C64(1.17)  LDD1615  [1]
 LDCM0421  CL32 HEK-293T C64(0.91)  LDD1625  [1]
 LDCM0422  CL33 HEK-293T C64(1.01)  LDD1626  [1]
 LDCM0423  CL34 HEK-293T C64(1.01)  LDD1627  [1]
 LDCM0424  CL35 HEK-293T C64(1.19)  LDD1628  [1]
 LDCM0434  CL44 HEK-293T C64(1.10)  LDD1638  [1]
 LDCM0435  CL45 HEK-293T C64(1.03)  LDD1639  [1]
 LDCM0436  CL46 HEK-293T C64(1.00)  LDD1640  [1]
 LDCM0437  CL47 HEK-293T C64(1.18)  LDD1641  [1]
 LDCM0447  CL56 HEK-293T C64(0.97)  LDD1650  [1]
 LDCM0448  CL57 HEK-293T C64(1.11)  LDD1651  [1]
 LDCM0449  CL58 HEK-293T C64(1.03)  LDD1652  [1]
 LDCM0450  CL59 HEK-293T C64(1.07)  LDD1653  [1]
 LDCM0460  CL68 HEK-293T C64(0.90)  LDD1663  [1]
 LDCM0461  CL69 HEK-293T C64(1.07)  LDD1664  [1]
 LDCM0463  CL70 HEK-293T C64(1.06)  LDD1666  [1]
 LDCM0464  CL71 HEK-293T C64(1.46)  LDD1667  [1]
 LDCM0473  CL8 HEK-293T C64(1.03)  LDD1676  [1]
 LDCM0474  CL80 HEK-293T C64(1.12)  LDD1677  [1]
 LDCM0475  CL81 HEK-293T C64(1.01)  LDD1678  [1]
 LDCM0476  CL82 HEK-293T C64(1.06)  LDD1679  [1]
 LDCM0477  CL83 HEK-293T C64(1.05)  LDD1680  [1]
 LDCM0484  CL9 HEK-293T C64(1.04)  LDD1687  [1]
 LDCM0487  CL92 HEK-293T C64(1.08)  LDD1690  [1]
 LDCM0488  CL93 HEK-293T C64(1.10)  LDD1691  [1]
 LDCM0489  CL94 HEK-293T C64(1.00)  LDD1692  [1]
 LDCM0490  CL95 HEK-293T C64(1.22)  LDD1693  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402