Details of the Target

General Information of Target

Target ID LDTP08657
Target Name Procollagen galactosyltransferase 2 (COLGALT2)
Gene Name COLGALT2
Gene ID 23127
Synonyms
C1orf17; GLT25D2; KIAA0584; Procollagen galactosyltransferase 2; EC 2.4.1.50; Collagen beta(1-O)galactosyltransferase 2; ColGalT 2; Glycosyltransferase 25 family member 2; Hydroxylysine galactosyltransferase 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAARPAATLAWSLLLLSSALLREGCRARFVAERDSEDDGEEPVVFPESPLQSPTVLVAVL
ARNAAHTLPHFLGCLERLDYPKSRMAIWAATDHNVDNTTEIFREWLKNVQRLYHYVEWRP
MDEPESYPDEIGPKHWPTSRFAHVMKLRQAALRTAREKWSDYILFIDVDNFLTNPQTLNL
LIAENKTIVAPMLESRGLYSNFWCGITPKGFYKRTPDYVQIREWKRTGCFPVPMVHSTFL
IDLRKEASDKLTFYPPHQDYTWTFDDIIVFAFSSRQAGIQMYLCNREHYGYLPIPLKPHQ
TLQEDIENLIHVQIEAMIDRPPMEPSQYVSVVPKYPDKMGFDEIFMINLKRRKDRRDRML
RTLYEQEIEVKIVEAVDGKALNTSQLKALNIEMLPGYRDPYSSRPLTRGEIGCFLSHYSV
WKEVIDRELEKTLVIEDDVRFEHQFKKKLMKLMDNIDQAQLDWELIYIGRKRMQVKEPEK
AVPNVANLVEADYSYWTLGYVISLEGAQKLVGANPFGKMLPVDEFLPVMYNKHPVAEYKE
YYESRDLKAFSAEPLLIYPTHYTGQPGYLSDTETSTIWDNETVATDWDRTHAWKSRKQSR
IYSNAKNTEALPPPTSLDTVPSRDEL
Target Bioclass
Enzyme
Family
Glycosyltransferase 25 family
Subcellular location
Endoplasmic reticulum lumen
Function Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of collagen.
Uniprot ID
Q8IYK4
Ensemble ID
ENST00000361927.9
HGNC ID
HGNC:16790

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K146(4.36)  LDD0277  [1]
IPM
 Probe Info  		C204(0.00); C413(0.00)  LDD0241  [2]
DBIA
 Probe Info  		C204(2.40)  LDD3310  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0284  AC24 HEK-293T C204(0.90)  LDD1523  [5]
 LDCM0293  AC32 HEK-293T C204(0.87)  LDD1532  [5]
 LDCM0302  AC40 HEK-293T C204(0.79)  LDD1541  [5]
 LDCM0310  AC48 HEK-293T C204(0.74)  LDD1549  [5]
 LDCM0319  AC56 HEK-293T C204(0.81)  LDD1558  [5]
 LDCM0328  AC64 HEK-293T C204(0.74)  LDD1567  [5]
 LDCM0345  AC8 HEK-293T C204(1.05)  LDD1569  [5]
 LDCM0275  AKOS034007705 HEK-293T C204(0.78)  LDD1514  [5]
 LDCM0369  CL100 HEK-293T C204(1.07)  LDD1573  [5]
 LDCM0373  CL104 HEK-293T C204(1.10)  LDD1577  [5]
 LDCM0377  CL108 HEK-293T C204(0.96)  LDD1581  [5]
 LDCM0382  CL112 HEK-293T C204(0.88)  LDD1586  [5]
 LDCM0386  CL116 HEK-293T C204(1.04)  LDD1590  [5]
 LDCM0390  CL12 HEK-293T C204(0.91)  LDD1594  [5]
 LDCM0391  CL120 HEK-293T C204(1.02)  LDD1595  [5]
 LDCM0395  CL124 HEK-293T C204(1.03)  LDD1599  [5]
 LDCM0399  CL128 HEK-293T C204(1.04)  LDD1603  [5]
 LDCM0403  CL16 HEK-293T C204(1.04)  LDD1607  [5]
 LDCM0412  CL24 HEK-293T C204(0.90)  LDD1616  [5]
 LDCM0416  CL28 HEK-293T C204(1.07)  LDD1620  [5]
 LDCM0425  CL36 HEK-293T C204(0.81)  LDD1629  [5]
 LDCM0429  CL4 HEK-293T C204(1.10)  LDD1633  [5]
 LDCM0430  CL40 HEK-293T C204(1.06)  LDD1634  [5]
 LDCM0438  CL48 HEK-293T C204(0.89)  LDD1642  [5]
 LDCM0443  CL52 HEK-293T C204(1.06)  LDD1646  [5]
 LDCM0452  CL60 HEK-293T C204(0.91)  LDD1655  [5]
 LDCM0456  CL64 HEK-293T C204(1.09)  LDD1659  [5]
 LDCM0465  CL72 HEK-293T C204(0.89)  LDD1668  [5]
 LDCM0469  CL76 HEK-293T C204(1.01)  LDD1672  [5]
 LDCM0478  CL84 HEK-293T C204(0.79)  LDD1681  [5]
 LDCM0482  CL88 HEK-293T C204(1.01)  LDD1685  [5]
 LDCM0491  CL96 HEK-293T C204(0.78)  LDD1694  [5]
 LDCM0022  KB02 769-P C204(2.33)  LDD2246  [3]
 LDCM0023  KB03 769-P C204(2.59)  LDD2663  [3]
 LDCM0024  KB05 COLO792 C204(2.40)  LDD3310  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hippocalcin-like protein 1 (HPCAL1) Recoverin family P37235
Ubiquilin-2 (UBQLN2) . Q9UHD9

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402