Details of the Target
General Information of Target
Target ID | LDTP08610 | |||||
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Target Name | Protein mono-ADP-ribosyltransferase PARP9 (PARP9) | |||||
Gene Name | PARP9 | |||||
Gene ID | 83666 | |||||
Synonyms |
BAL; BAL1; Protein mono-ADP-ribosyltransferase PARP9; EC 2.4.2.-; ADP-ribosyltransferase diphtheria toxin-like 9; ARTD9; B aggressive lymphoma protein; Poly [ADP-ribose] polymerase 9; PARP-9 |
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3D Structure | ||||||
Sequence |
MDFSMVAGAAAYNEKSGRITSLSLLFQKVFAQIFPQWRKGNTEECLPYKCSETGALGENY
SWQIPINHNDFKILKNNERQLCEVLQNKFGCISTLVSPVQEGNSKSLQVFRKMLTPRIEL SVWKDDLTTHAVDAVVNAANEDLLHGGGLALALVKAGGFEIQEESKQFVARYGKVSAGEI AVTGAGRLPCKQIIHAVGPRWMEWDKQGCTGKLQRAIVSILNYVIYKNTHIKTVAIPALS SGIFQFPLNLCTKTIVETIRVSLQGKPMMSNLKEIHLVSNEDPTVAAFKAASEFILGKSE LGQETTPSFNAMVVNNLTLQIVQGHIEWQTADVIVNSVNPHDITVGPVAKSILQQAGVEM KSEFLATKAKQFQRSQLVLVTKGFNLFCKYIYHVLWHSEFPKPQILKHAMKECLEKCIEQ NITSISFPALGTGNMEIKKETAAEILFDEVLTFAKDHVKHQLTVKFVIFPTDLEIYKAFS SEMAKRSKMLSLNNYSVPQSTREEKRENGLEARSPAINLMGFNVEEMYEAHAWIQRILSL QNHHIIENNHILYLGRKEHDILSQLQKTSSVSITEIISPGRTELEIEGARADLIEVVMNI EDMLCKVQEEMARKKERGLWRSLGQWTIQQQKTQDEMKENIIFLKCPVPPTQELLDQKKQ FEKCGLQVLKVEKIDNEVLMAAFQRKKKMMEEKLHRQPVSHRLFQQVPYQFCNVVCRVGF QRMYSTPCDPKYGAGIYFTKNLKNLAEKAKKISAADKLIYVFEAEVLTGFFCQGHPLNIV PPPLSPGAIDGHDSVVDNVSSPETFVIFSGMQAIPQYLWTCTQEYVQSQDYSSGPMRPFA QHPWRGFASGSPVD |
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Target Bioclass |
Enzyme
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Family |
ARTD/PARP family
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Subcellular location |
Cytoplasm, cytosol
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Function |
ADP-ribosyltransferase which, in association with E3 ligase DTX3L, plays a role in DNA damage repair and in immune responses including interferon-mediated antiviral defenses. Within the complex, enhances DTX3L E3 ligase activity which is further enhanced by PARP9 binding to poly(ADP-ribose). In association with DTX3L and in presence of E1 and E2 enzymes, mediates NAD(+)-dependent mono-ADP-ribosylation of ubiquitin which prevents ubiquitin conjugation to substrates such as histones. During DNA repair, PARP1 recruits PARP9/BAL1-DTX3L complex to DNA damage sites via PARP9 binding to ribosylated PARP1. Subsequent PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. In response to DNA damage, PARP9-DTX3L complex is required for efficient non-homologous end joining (NHEJ); the complex function is negatively modulated by PARP9 activity. Dispensable for B-cell receptor (BCR) assembly through V(D)J recombination and class switch recombination (CSR). In macrophages, positively regulates pro-inflammatory cytokines production in response to IFNG stimulation by suppressing PARP14-mediated STAT1 ADP-ribosylation and thus promoting STAT1 phosphorylation. Also suppresses PARP14-mediated STAT6 ADP-ribosylation.
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Uniprot ID | ||||||
Ensemble ID | ||||||
HGNC ID | ||||||
ChEMBL ID |
Probe(s) Labeling This Target
ABPP Probe
Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
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DBIA Probe Info |
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C388(8.23) | LDD0204 | [1] | |
4-Iodoacetamidophenylacetylene Probe Info |
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C664(0.00); C91(0.00) | LDD0038 | [2] | |
IA-alkyne Probe Info |
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C664(0.00); C728(0.00); C91(0.00); C82(0.00) | LDD0036 | [2] | |
Lodoacetamide azide Probe Info |
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C664(0.00); C82(0.00); C251(0.00); C728(0.00) | LDD0037 | [2] | |
NAIA_5 Probe Info |
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N.A. | LDD2223 | [3] |
Competitor(s) Related to This Target
Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
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LDCM0296 | AC35 | PaTu 8988t | C728(1.04) | LDD1175 | [4] |
LDCM0297 | AC36 | PaTu 8988t | C728(1.28) | LDD1176 | [4] |
LDCM0298 | AC37 | PaTu 8988t | C728(1.36) | LDD1177 | [4] |
LDCM0299 | AC38 | PaTu 8988t | C728(1.29) | LDD1178 | [4] |
LDCM0300 | AC39 | PaTu 8988t | C728(1.27) | LDD1179 | [4] |
LDCM0302 | AC40 | PaTu 8988t | C728(1.41) | LDD1181 | [4] |
LDCM0303 | AC41 | PaTu 8988t | C728(1.21) | LDD1182 | [4] |
LDCM0304 | AC42 | PaTu 8988t | C728(1.31) | LDD1183 | [4] |
LDCM0305 | AC43 | PaTu 8988t | C728(1.19) | LDD1184 | [4] |
LDCM0306 | AC44 | PaTu 8988t | C728(1.60) | LDD1185 | [4] |
LDCM0307 | AC45 | PaTu 8988t | C728(1.43) | LDD1186 | [4] |
LDCM0102 | BDHI 8 | Jurkat | C388(8.23) | LDD0204 | [1] |
LDCM0387 | CL117 | PaTu 8988t | C728(1.15) | LDD1266 | [4] |
LDCM0388 | CL118 | PaTu 8988t | C728(1.29) | LDD1267 | [4] |
LDCM0389 | CL119 | PaTu 8988t | C728(1.23) | LDD1268 | [4] |
LDCM0391 | CL120 | PaTu 8988t | C728(1.11) | LDD1270 | [4] |
LDCM0420 | CL31 | PaTu 8988t | C728(1.11) | LDD1299 | [4] |
LDCM0421 | CL32 | PaTu 8988t | C728(1.14) | LDD1300 | [4] |
LDCM0422 | CL33 | PaTu 8988t | C728(1.11) | LDD1301 | [4] |
LDCM0423 | CL34 | PaTu 8988t | C728(1.30) | LDD1302 | [4] |
LDCM0424 | CL35 | PaTu 8988t | C728(1.33) | LDD1303 | [4] |
LDCM0425 | CL36 | PaTu 8988t | C728(1.08) | LDD1304 | [4] |
LDCM0426 | CL37 | PaTu 8988t | C728(1.27) | LDD1305 | [4] |
LDCM0428 | CL39 | PaTu 8988t | C728(1.25) | LDD1307 | [4] |
LDCM0430 | CL40 | PaTu 8988t | C728(1.02) | LDD1309 | [4] |
LDCM0431 | CL41 | PaTu 8988t | C728(1.28) | LDD1310 | [4] |
LDCM0432 | CL42 | PaTu 8988t | C728(1.23) | LDD1311 | [4] |
LDCM0433 | CL43 | PaTu 8988t | C728(1.23) | LDD1312 | [4] |
LDCM0434 | CL44 | PaTu 8988t | C728(1.34) | LDD1313 | [4] |
LDCM0435 | CL45 | PaTu 8988t | C728(1.35) | LDD1314 | [4] |
LDCM0453 | CL61 | PaTu 8988t | C728(1.00) | LDD1332 | [4] |
LDCM0454 | CL62 | PaTu 8988t | C728(1.52) | LDD1333 | [4] |
LDCM0455 | CL63 | PaTu 8988t | C728(1.72) | LDD1334 | [4] |
LDCM0456 | CL64 | PaTu 8988t | C728(1.57) | LDD1335 | [4] |
LDCM0457 | CL65 | PaTu 8988t | C728(1.33) | LDD1336 | [4] |
LDCM0458 | CL66 | PaTu 8988t | C728(1.37) | LDD1337 | [4] |
LDCM0459 | CL67 | PaTu 8988t | C728(1.94) | LDD1338 | [4] |
LDCM0460 | CL68 | PaTu 8988t | C728(1.66) | LDD1339 | [4] |
LDCM0461 | CL69 | PaTu 8988t | C728(2.07) | LDD1340 | [4] |
LDCM0463 | CL70 | PaTu 8988t | C728(1.09) | LDD1342 | [4] |
LDCM0464 | CL71 | PaTu 8988t | C728(1.93) | LDD1343 | [4] |
LDCM0465 | CL72 | PaTu 8988t | C728(1.28) | LDD1344 | [4] |
LDCM0466 | CL73 | PaTu 8988t | C728(1.53) | LDD1345 | [4] |
LDCM0467 | CL74 | PaTu 8988t | C728(1.29) | LDD1346 | [4] |
LDCM0469 | CL76 | PaTu 8988t | C728(1.11) | LDD1348 | [4] |
LDCM0470 | CL77 | PaTu 8988t | C728(1.19) | LDD1349 | [4] |
LDCM0471 | CL78 | PaTu 8988t | C728(1.35) | LDD1350 | [4] |
LDCM0472 | CL79 | PaTu 8988t | C728(1.52) | LDD1351 | [4] |
LDCM0474 | CL80 | PaTu 8988t | C728(1.37) | LDD1353 | [4] |
LDCM0475 | CL81 | PaTu 8988t | C728(1.32) | LDD1354 | [4] |
LDCM0476 | CL82 | PaTu 8988t | C728(1.53) | LDD1355 | [4] |
LDCM0477 | CL83 | PaTu 8988t | C728(1.68) | LDD1356 | [4] |
LDCM0478 | CL84 | PaTu 8988t | C728(1.15) | LDD1357 | [4] |
LDCM0479 | CL85 | PaTu 8988t | C728(1.13) | LDD1358 | [4] |
LDCM0480 | CL86 | PaTu 8988t | C728(1.28) | LDD1359 | [4] |
LDCM0481 | CL87 | PaTu 8988t | C728(1.36) | LDD1360 | [4] |
LDCM0482 | CL88 | PaTu 8988t | C728(1.57) | LDD1361 | [4] |
LDCM0483 | CL89 | PaTu 8988t | C728(1.10) | LDD1362 | [4] |
LDCM0485 | CL90 | PaTu 8988t | C728(1.41) | LDD1364 | [4] |
LDCM0468 | Fragment33 | PaTu 8988t | C728(1.60) | LDD1347 | [4] |
LDCM0427 | Fragment51 | PaTu 8988t | C728(1.39) | LDD1306 | [4] |
LDCM0022 | KB02 | 22RV1 | C82(1.74); C251(1.59) | LDD2243 | [5] |
LDCM0023 | KB03 | Jurkat | C728(4.31) | LDD0209 | [1] |
LDCM0024 | KB05 | COLO792 | C728(2.24); C251(1.73) | LDD3310 | [5] |
References