Details of the Target

General Information of Target

Target ID LDTP08581
Target Name CD302 antigen (CD302)
Gene Name CD302
Gene ID 9936
Synonyms
CLEC13A; DCL1; KIAA0022; CD302 antigen; C-type lectin BIMLEC; C-type lectin domain family 13 member A; DEC205-associated C-type lectin 1; Type I transmembrane C-type lectin receptor DCL-1; CD antigen CD302
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLRAALPALLLPLLGLAAAAVADCPSSTWIQFQDSCYIFLQEAIKVESIEDVRNQCTDHG
ADMISIHNEEENAFILDTLKKQWKGPDDILLGMFYDTDDASFKWFDNSNMTFDKWTDQDD
DEDLVDTCAFLHIKTGEWKKGNCEVSSVEGTLCKTAIPYKRKYLSDNHILISALVIASTV
ILTVLGAIIWFLYKKHSDSRFTTVFSTAPQSPYNEDCVLVVGEENEYPVQFD
Target Bioclass
Other
Subcellular location
Membrane
Function Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration.
Uniprot ID
Q8IX05
Ensemble ID
ENST00000259053.6
HGNC ID
HGNC:30843

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
Ishikawa (Heraklio) 02 ER Insertion: p.T155NfsTer13; p.N225KfsTer2 .
LNCaP clone FGC SNV: p.K114R .
MINO SNV: p.A8V .
NUGC3 SNV: p.D58N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C217(0.88)  LDD1513  [1]
AOyne
 Probe Info  		15.00  LDD0443  [2]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C310
 Probe Info  		67.18  LDD1977  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0270  AC15 HEK-293T C217(0.88)  LDD1513  [1]
 LDCM0283  AC23 HEK-293T C217(1.01)  LDD1522  [1]
 LDCM0292  AC31 HEK-293T C217(1.03)  LDD1531  [1]
 LDCM0300  AC39 HEK-293T C217(0.99)  LDD1539  [1]
 LDCM0309  AC47 HEK-293T C217(0.81)  LDD1548  [1]
 LDCM0318  AC55 HEK-293T C217(0.85)  LDD1557  [1]
 LDCM0327  AC63 HEK-293T C217(0.94)  LDD1566  [1]
 LDCM0334  AC7 HEK-293T C217(0.90)  LDD1568  [1]
 LDCM0379  CL11 HEK-293T C217(0.98)  LDD1583  [1]
 LDCM0411  CL23 HEK-293T C217(0.95)  LDD1615  [1]
 LDCM0424  CL35 HEK-293T C217(1.39)  LDD1628  [1]
 LDCM0437  CL47 HEK-293T C217(1.12)  LDD1641  [1]
 LDCM0450  CL59 HEK-293T C217(1.08)  LDD1653  [1]
 LDCM0464  CL71 HEK-293T C217(0.98)  LDD1667  [1]
 LDCM0477  CL83 HEK-293T C217(1.09)  LDD1680  [1]
 LDCM0490  CL95 HEK-293T C217(0.84)  LDD1693  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable glutathione peroxidase 8 (GPX8) Glutathione peroxidase family Q8TED1
ADP-ribosylation factor-like protein 13B (ARL13B) Arf family Q3SXY8
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Leukocyte surface antigen CD53 (CD53) Tetraspanin (TM4SF) family P19397
Guided entry of tail-anchored proteins factor 1 (GET1) WRB/GET1 family O00258
Cytokine and receptor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interleukin-7 receptor subunit alpha (IL7R) Type I cytokine receptor family P16871
Interferon gamma receptor 2 (IFNGR2) Type II cytokine receptor family P38484
Interleukin-10 receptor subunit alpha (IL10RA) Type II cytokine receptor family Q13651
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Fibronectin type III domain-containing protein 9 (FNDC9) . Q8TBE3

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
3 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587