Details of the Target

General Information of Target

Target ID LDTP08446
Target Name TIR domain-containing adapter molecule 1 (TICAM1)
Gene Name TICAM1
Gene ID 148022
Synonyms
PRVTIRB; TRIF; TIR domain-containing adapter molecule 1; TICAM-1; Proline-rich, vinculin and TIR domain-containing protein B; Putative NF-kappa-B-activating protein 502H; Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta; MyD88-3; TIR domain-containing adapter protein inducing IFN-beta
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MACTGPSLPSAFDILGAAGQDKLLYLKHKLKTPRPGCQGQDLLHAMVLLKLGQETEARIS
LEALKADAVARLVARQWAGVDSTEDPEEPPDVSWAVARLYHLLAEEKLCPASLRDVAYQE
AVRTLSSRDDHRLGELQDEARNRCGWDIAGDPGSIRTLQSNLGCLPPSSALPSGTRSLPR
PIDGVSDWSQGCSLRSTGSPASLASNLEISQSPTMPFLSLHRSPHGPSKLCDDPQASLVP
EPVPGGCQEPEEMSWPPSGEIASPPELPSSPPPGLPEVAPDATSTGLPDTPAAPETSTNY
PVECTEGSAGPQSLPLPILEPVKNPCSVKDQTPLQLSVEDTTSPNTKPCPPTPTTPETSP
PPPPPPPSSTPCSAHLTPSSLFPSSLESSSEQKFYNFVILHARADEHIALRVREKLEALG
VPDGATFCEDFQVPGRGELSCLQDAIDHSAFIILLLTSNFDCRLSLHQVNQAMMSNLTRQ
GSPDCVIPFLPLESSPAQLSSDTASLLSGLVRLDEHSQIFARKVANTFKPHRLQARKAMW
RKEQDTRALREQSQHLDGERMQAAALNAAYSAYLQSYLSYQAQMEQLQVAFGSHMSFGTG
APYGARMPFGGQVPLGAPPPFPTWPGCPQPPPLHAWQAGTPPPPSPQPAAFPQSLPFPQS
PAFPTASPAPPQSPGLQPLIIHHAQMVQLGLNNHMWNQRGSQAPEDKTQEAE
Target Type
Patented-recorded
Target Bioclass
Other
Subcellular location
Cytoplasmic vesicle, autophagosome
Function
Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines.
TTD ID
T44190
Uniprot ID
Q8IUC6
DrugMap ID
TT2GQT6
Ensemble ID
ENST00000248244.6
HGNC ID
HGNC:18348

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C192(1.50)  LDD0547  [1]
NAIA_4
 Probe Info  		N.A.  LDD2226  [2]
NAIA_5
 Probe Info  		N.A.  LDD2223  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0230  AC113 HCT 116 C192(1.50)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C192(1.24)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C192(0.87)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C192(1.12)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C192(1.28)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C192(1.19)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C192(1.05)  LDD0553  [1]
 LDCM0238  AC120 HCT 116 C192(1.25)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C192(0.88)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C192(1.03)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C192(1.22)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C192(1.26)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C192(1.04)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C192(0.99)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C192(1.44)  LDD0562  [1]
 LDCM0246  AC128 HCT 116 C192(0.60)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C192(0.63)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C192(0.72)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C192(0.71)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C192(0.71)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C192(0.64)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C192(0.71)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C192(0.69)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C192(0.66)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C192(0.69)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C192(0.62)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C192(0.65)  LDD0575  [1]
 LDCM0260  AC140 HCT 116 C192(0.75)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C192(0.71)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C192(0.75)  LDD0579  [1]
 LDCM0263  AC143 HCT 116 C192(0.97)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C192(1.15)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C192(1.10)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C192(1.18)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C192(1.28)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C192(1.01)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C192(0.85)  LDD0586  [1]
 LDCM0271  AC150 HCT 116 C192(0.94)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C192(1.14)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C192(1.10)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C192(1.22)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C192(1.01)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C192(1.18)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C192(1.17)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C192(1.32)  LDD2161  [1]
 LDCM0403  CL16 HCT 116 C192(1.37)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C192(1.16)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C192(1.40)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C192(1.37)  LDD0723  [1]
 LDCM0408  CL20 HCT 116 C192(1.46)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C192(1.46)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C192(1.59)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C192(1.16)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C192(1.67)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C192(1.67)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C192(1.76)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C192(1.68)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C192(1.56)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C192(1.62)  LDD0734  [1]
 LDCM0419  CL30 HCT 116 C192(1.54)  LDD0736  [1]
 LDCM0453  CL61 HCT 116 C192(1.79)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C192(1.12)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C192(1.23)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C192(1.61)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C192(1.02)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C192(1.19)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C192(1.28)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C192(0.96)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C192(1.77)  LDD0778  [1]
 LDCM0463  CL70 HCT 116 C192(0.99)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C192(1.04)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C192(1.54)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C192(1.12)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C192(1.10)  LDD0784  [1]
 LDCM0468  Fragment33 HCT 116 C192(1.24)  LDD0785  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264