Details of the Target

General Information of Target

Target ID LDTP08398
Target Name Low-density lipoprotein receptor class A domain-containing protein 3 (LDLRAD3)
Gene Name LDLRAD3
Gene ID 143458
Synonyms
LRAD3; Low-density lipoprotein receptor class A domain-containing protein 3; LDLR class A domain-containing protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MWLLGPLCLLLSSAAESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSD
EKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHC
KNGLCIDKSFICDGQNNCQDNSDEESCESSQEPGSGQVFVTSENQLVYYPSITYAIIGSS
VIFVLVVALLALVLHHQRKRNNLMTLPVHRLQHPVLLSRLVVLDHPHHCNVTYNVNNGIQ
YVASQAEQNASEVGSPPSYSEALLDQRPAWYDLPPPPYSSDTESLNQADLPPYRSRSGSA
NSASSQAASSLLSVEDTSHSPGQPGPQEGTAEPRDSEPSQGTEEV
Target Bioclass
Other
Family
LDLR family
Subcellular location
Cell membrane
Function
May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production. May regulate ITCH and NEDD4 E3 ligase activity and degradation.; (Microbial infection) Acts as a receptor for Venezuelan equine encephalitis virus.
Uniprot ID
Q86YD5
Ensemble ID
ENST00000315571.6
HGNC ID
HGNC:27046

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.D140N .
HSC3 SNV: p.D281N .
IPC298 SNV: p.P274S .
MEWO SNV: p.Q212E .
RPMI8226 SNV: p.S80I .
TKKK SNV: p.E16V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C49(1.06)  LDD1492  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C49(0.96)  LDD1509  [1]
 LDCM0259  AC14 HEK-293T C49(0.62)  LDD1512  [1]
 LDCM0278  AC19 HEK-293T C49(1.35)  LDD1517  [1]
 LDCM0282  AC22 HEK-293T C49(0.62)  LDD1521  [1]
 LDCM0284  AC24 HEK-293T C49(0.84)  LDD1523  [1]
 LDCM0287  AC27 HEK-293T C49(1.27)  LDD1526  [1]
 LDCM0290  AC3 HEK-293T C49(1.51)  LDD1529  [1]
 LDCM0291  AC30 HEK-293T C49(0.61)  LDD1530  [1]
 LDCM0293  AC32 HEK-293T C49(1.41)  LDD1532  [1]
 LDCM0296  AC35 HEK-293T C49(1.27)  LDD1535  [1]
 LDCM0299  AC38 HEK-293T C49(0.65)  LDD1538  [1]
 LDCM0302  AC40 HEK-293T C49(0.99)  LDD1541  [1]
 LDCM0305  AC43 HEK-293T C49(1.00)  LDD1544  [1]
 LDCM0308  AC46 HEK-293T C49(0.62)  LDD1547  [1]
 LDCM0310  AC48 HEK-293T C49(0.93)  LDD1549  [1]
 LDCM0314  AC51 HEK-293T C49(1.07)  LDD1553  [1]
 LDCM0317  AC54 HEK-293T C49(0.66)  LDD1556  [1]
 LDCM0319  AC56 HEK-293T C49(0.99)  LDD1558  [1]
 LDCM0322  AC59 HEK-293T C49(1.09)  LDD1561  [1]
 LDCM0323  AC6 HEK-293T C49(1.07)  LDD1562  [1]
 LDCM0326  AC62 HEK-293T C49(0.94)  LDD1565  [1]
 LDCM0328  AC64 HEK-293T C49(1.24)  LDD1567  [1]
 LDCM0345  AC8 HEK-293T C49(0.78)  LDD1569  [1]
 LDCM0275  AKOS034007705 HEK-293T C49(0.88)  LDD1514  [1]
 LDCM0368  CL10 HEK-293T C49(0.64)  LDD1572  [1]
 LDCM0371  CL102 HEK-293T C49(1.01)  LDD1575  [1]
 LDCM0372  CL103 HEK-293T C49(1.11)  LDD1576  [1]
 LDCM0375  CL106 HEK-293T C49(1.37)  LDD1579  [1]
 LDCM0376  CL107 HEK-293T C49(0.88)  LDD1580  [1]
 LDCM0380  CL110 HEK-293T C49(1.08)  LDD1584  [1]
 LDCM0381  CL111 HEK-293T C49(0.95)  LDD1585  [1]
 LDCM0384  CL114 HEK-293T C49(1.07)  LDD1588  [1]
 LDCM0385  CL115 HEK-293T C49(1.26)  LDD1589  [1]
 LDCM0388  CL118 HEK-293T C49(1.08)  LDD1592  [1]
 LDCM0389  CL119 HEK-293T C49(1.40)  LDD1593  [1]
 LDCM0390  CL12 HEK-293T C49(0.80)  LDD1594  [1]
 LDCM0393  CL122 HEK-293T C49(1.00)  LDD1597  [1]
 LDCM0394  CL123 HEK-293T C49(0.99)  LDD1598  [1]
 LDCM0397  CL126 HEK-293T C49(1.02)  LDD1601  [1]
 LDCM0398  CL127 HEK-293T C49(0.92)  LDD1602  [1]
 LDCM0401  CL14 HEK-293T C49(1.25)  LDD1605  [1]
 LDCM0402  CL15 HEK-293T C49(2.97)  LDD1606  [1]
 LDCM0406  CL19 HEK-293T C49(1.35)  LDD1610  [1]
 LDCM0407  CL2 HEK-293T C49(0.89)  LDD1611  [1]
 LDCM0410  CL22 HEK-293T C49(0.62)  LDD1614  [1]
 LDCM0412  CL24 HEK-293T C49(1.29)  LDD1616  [1]
 LDCM0414  CL26 HEK-293T C49(1.02)  LDD1618  [1]
 LDCM0415  CL27 HEK-293T C49(0.98)  LDD1619  [1]
 LDCM0418  CL3 HEK-293T C49(1.15)  LDD1622  [1]
 LDCM0420  CL31 HEK-293T C49(0.95)  LDD1624  [1]
 LDCM0423  CL34 HEK-293T C49(0.53)  LDD1627  [1]
 LDCM0425  CL36 HEK-293T C49(1.67)  LDD1629  [1]
 LDCM0428  CL39 HEK-293T C49(1.11)  LDD1632  [1]
 LDCM0433  CL43 HEK-293T C49(1.18)  LDD1637  [1]
 LDCM0436  CL46 HEK-293T C49(0.49)  LDD1640  [1]
 LDCM0438  CL48 HEK-293T C49(1.20)  LDD1642  [1]
 LDCM0441  CL50 HEK-293T C49(1.46)  LDD1645  [1]
 LDCM0446  CL55 HEK-293T C49(1.55)  LDD1649  [1]
 LDCM0449  CL58 HEK-293T C49(0.75)  LDD1652  [1]
 LDCM0452  CL60 HEK-293T C49(1.20)  LDD1655  [1]
 LDCM0454  CL62 HEK-293T C49(1.26)  LDD1657  [1]
 LDCM0455  CL63 HEK-293T C49(0.84)  LDD1658  [1]
 LDCM0459  CL67 HEK-293T C49(1.26)  LDD1662  [1]
 LDCM0462  CL7 HEK-293T C49(1.45)  LDD1665  [1]
 LDCM0463  CL70 HEK-293T C49(0.66)  LDD1666  [1]
 LDCM0465  CL72 HEK-293T C49(1.04)  LDD1668  [1]
 LDCM0467  CL74 HEK-293T C49(1.01)  LDD1670  [1]
 LDCM0472  CL79 HEK-293T C49(0.84)  LDD1675  [1]
 LDCM0476  CL82 HEK-293T C49(0.56)  LDD1679  [1]
 LDCM0478  CL84 HEK-293T C49(0.84)  LDD1681  [1]
 LDCM0480  CL86 HEK-293T C49(1.07)  LDD1683  [1]
 LDCM0481  CL87 HEK-293T C49(1.30)  LDD1684  [1]
 LDCM0486  CL91 HEK-293T C49(0.97)  LDD1689  [1]
 LDCM0489  CL94 HEK-293T C49(0.73)  LDD1692  [1]
 LDCM0491  CL96 HEK-293T C49(1.01)  LDD1694  [1]
 LDCM0493  CL98 HEK-293T C49(0.83)  LDD1696  [1]
 LDCM0494  CL99 HEK-293T C49(1.09)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C49(1.16)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C49(0.86)  LDD1671  [1]
 LDCM0427  Fragment51 HEK-293T C49(0.81)  LDD1631  [1]
 LDCM0022  KB02 HEK-293T C49(1.06)  LDD1492  [1]
 LDCM0023  KB03 HEK-293T C49(0.94)  LDD1497  [1]
 LDCM0024  KB05 HEK-293T C49(0.87)  LDD1502  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcriptional coactivator YAP1 (YAP1) YAP1 family P46937

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402