Details of the Target

General Information of Target

Target ID LDTP08348
Target Name Lipolysis-stimulated lipoprotein receptor (LSR)
Gene Name LSR
Gene ID 51599
Synonyms
ILDR3; LISCH; Lipolysis-stimulated lipoprotein receptor; Angulin-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQQDGLGVGTRNGSGKGRSVHPSWPWCAPRPLRYFGRDARARRAQTAAMALLAGGLSRGL
GSHPAAAGRDAVVFVWLLLSTWCTAPARAIQVTVSNPYHVVILFQPVTLPCTYQMTSTPT
QPIVIWKYKSFCRDRIADAFSPASVDNQLNAQLAAGNPGYNPYVECQDSVRTVRVVATKQ
GNAVTLGDYYQGRRITITGNADLTFDQTAWGDSGVYYCSVVSAQDLQGNNEAYAELIVLG
RTSGVAELLPGFQAGPIEDWLFVVVVCLAAFLIFLLLGICWCQCCPHTCCCYVRCPCCPD
KCCCPEALYAAGKAATSGVPSIYAPSTYAHLSPAKTPPPPAMIPMGPAYNGYPGGYPGDV
DRSSSAGGQGSYVPLLRDTDSSVASEVRSGYRIQASQQDDSMRVLYYMEKELANFDPSRP
GPPSGRVERAMSEVTSLHEDDWRSRPSRGPALTPIRDEEWGGHSPRSPRGWDQEPAREQA
GGGWRARRPRARSVDALDDLTPPSTAESGSRSPTSNGGRSRAYMPPRSRSRDDLYDQDDS
RDFPRSRDPHYDDFRSRERPPADPRSHHHRTRDPRDNGSRSGDLPYDGRLLEEAVRKKGS
EERRRPHKEEEEEAYYPPAPPPYSETDSQASRERRLKKNLALSRESLVV
Target Bioclass
Immunoglobulin
Family
Immunoglobulin superfamily, LISCH7 family
Subcellular location
Cell membrane
Function
Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells. Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions.
Uniprot ID
Q86X29
Ensemble ID
ENST00000347609.8
HGNC ID
HGNC:29572

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K335(4.87)  LDD0277  [1]
Probe 1
 Probe Info  		Y535(10.52); Y586(27.92); Y623(11,752.00)  LDD3495  [2]
DBIA
 Probe Info  		C302(1.07); C303(1.07); C304(1.07)  LDD0078  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HCT 116 C166(1.05)  LDD0532  [3]
 LDCM0226  AC11 HCT 116 C166(1.10)  LDD0543  [3]
 LDCM0237  AC12 HCT 116 C166(0.71)  LDD0554  [3]
 LDCM0259  AC14 HCT 116 C166(0.82)  LDD0576  [3]
 LDCM0270  AC15 HCT 116 C166(0.87)  LDD0587  [3]
 LDCM0276  AC17 HCT 116 C166(0.98)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C166(1.24)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C166(1.19)  LDD0595  [3]
 LDCM0280  AC20 HCT 116 C166(0.90)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C166(0.97)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C166(0.93)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C166(0.97)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C166(1.08)  LDD0601  [3]
 LDCM0323  AC6 HCT 116 C166(0.83)  LDD0640  [3]
 LDCM0334  AC7 HCT 116 C166(0.76)  LDD0651  [3]
 LDCM0345  AC8 HCT 116 C166(1.09)  LDD0662  [3]
 LDCM0248  AKOS034007472 HCT 116 C166(0.93)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C166(0.87)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C166(1.16)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C302(1.07); C303(1.07); C304(1.07)  LDD0078  [3]
 LDCM0367  CL1 HCT 116 C166(1.07)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C166(0.90)  LDD0685  [3]
 LDCM0370  CL101 HCT 116 C166(1.14)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C166(0.87)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C166(1.09)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C166(0.86)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C166(1.02)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C166(1.02)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C166(1.03)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C166(1.16)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C166(1.14)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C166(0.78)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C166(0.97)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C166(1.01)  LDD0698  [3]
 LDCM0390  CL12 HCT 116 C166(0.97)  LDD0707  [3]
 LDCM0400  CL13 HCT 116 C166(1.28)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C166(1.11)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C166(1.10)  LDD0719  [3]
 LDCM0407  CL2 HCT 116 C166(1.01)  LDD0724  [3]
 LDCM0418  CL3 HCT 116 C166(0.96)  LDD0735  [3]
 LDCM0429  CL4 HCT 116 C166(0.90)  LDD0746  [3]
 LDCM0436  CL46 HCT 116 C166(2.10)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C166(0.76)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C166(0.86)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C166(0.68)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C166(0.97)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C166(0.72)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C166(1.00)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C166(0.79)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C166(0.73)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C166(0.94)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C166(0.89)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C166(0.70)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C166(0.72)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C166(1.06)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C166(1.14)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C166(1.04)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C166(0.64)  LDD0769  [3]
 LDCM0462  CL7 HCT 116 C166(1.10)  LDD0779  [3]
 LDCM0473  CL8 HCT 116 C166(1.05)  LDD0790  [3]
 LDCM0484  CL9 HCT 116 C166(1.07)  LDD0801  [3]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.