Details of the Target

General Information of Target

Target ID LDTP08105
Target Name RNA 5'-monophosphate methyltransferase (BCDIN3D)
Gene Name BCDIN3D
Gene ID 144233
Synonyms
RNA 5'-monophosphate methyltransferase; EC 2.1.1.-; BCDIN3 domain-containing protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAVPTELDGGSVKETAAEEESRVLAPGAAPFGNFPHYSRFHPPEQRLRLLPPELLRQLFP
ESPENGPILGLDVGCNSGDLSVALYKHFLSLPDGETCSDASREFRLLCCDIDPVLVKRAE
KECPFPDALTFITLDFMNQRTRKVLLSSFLSQFGRSVFDIGFCMSITMWIHLNHGDHGLW
EFLAHLSSLCHYLLVEPQPWKCYRAAARRLRKLGLHDFDHFHSLAIRGDMPNQIVQILTQ
DHGMELICCFGNTSWDRSLLLFRAKQTIETHPIPESLIEKGKEKNRLSFQKQ
Target Bioclass
Enzyme
Family
Methyltransferase superfamily
Subcellular location
Cytoplasm
Function
O-methyltransferase that specifically monomethylates 5'-monophosphate of cytoplasmic histidyl tRNA (tRNA(His)), acting as a capping enzyme by protecting tRNA(His) from cleavage by DICER1. Also able, with less efficiently, to methylate the 5' monophosphate of a subset of pre-miRNAs, acting as a negative regulator of miRNA processing. The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Was also reported to mediate dimethylation of pre-miR-145; however dimethylation cannot be reproduced by another group which observes a monomethylation of pre-miR-145.
Uniprot ID
Q7Z5W3
Ensemble ID
ENST00000333924.6
HGNC ID
HGNC:27050
ChEMBL ID
CHEMBL3588740

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C97(1.03)  LDD1492  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C97(0.98)  LDD1508  [1]
 LDCM0237  AC12 HEK-293T C97(1.25)  LDD1510  [1]
 LDCM0277  AC18 HEK-293T C97(1.00)  LDD1516  [1]
 LDCM0279  AC2 HEK-293T C97(1.31)  LDD1518  [1]
 LDCM0280  AC20 HEK-293T C97(1.32)  LDD1519  [1]
 LDCM0281  AC21 HEK-293T C97(1.11)  LDD1520  [1]
 LDCM0284  AC24 HEK-293T C97(0.81)  LDD1523  [1]
 LDCM0286  AC26 HEK-293T C97(1.01)  LDD1525  [1]
 LDCM0288  AC28 HEK-293T C97(1.01)  LDD1527  [1]
 LDCM0289  AC29 HEK-293T C97(0.97)  LDD1528  [1]
 LDCM0293  AC32 HEK-293T C97(0.80)  LDD1532  [1]
 LDCM0295  AC34 HEK-293T C97(0.88)  LDD1534  [1]
 LDCM0297  AC36 HEK-293T C97(1.14)  LDD1536  [1]
 LDCM0298  AC37 HEK-293T C97(0.89)  LDD1537  [1]
 LDCM0301  AC4 HEK-293T C97(0.97)  LDD1540  [1]
 LDCM0302  AC40 HEK-293T C97(0.79)  LDD1541  [1]
 LDCM0304  AC42 HEK-293T C97(0.99)  LDD1543  [1]
 LDCM0306  AC44 HEK-293T C97(1.07)  LDD1545  [1]
 LDCM0307  AC45 HEK-293T C97(0.87)  LDD1546  [1]
 LDCM0310  AC48 HEK-293T C97(0.80)  LDD1549  [1]
 LDCM0312  AC5 HEK-293T C97(0.97)  LDD1551  [1]
 LDCM0313  AC50 HEK-293T C97(1.04)  LDD1552  [1]
 LDCM0315  AC52 HEK-293T C97(1.18)  LDD1554  [1]
 LDCM0316  AC53 HEK-293T C97(1.02)  LDD1555  [1]
 LDCM0319  AC56 HEK-293T C97(1.01)  LDD1558  [1]
 LDCM0321  AC58 HEK-293T C97(1.01)  LDD1560  [1]
 LDCM0324  AC60 HEK-293T C97(0.99)  LDD1563  [1]
 LDCM0325  AC61 HEK-293T C97(0.97)  LDD1564  [1]
 LDCM0328  AC64 HEK-293T C97(0.80)  LDD1567  [1]
 LDCM0345  AC8 HEK-293T C97(0.92)  LDD1569  [1]
 LDCM0248  AKOS034007472 HEK-293T C97(0.83)  LDD1511  [1]
 LDCM0275  AKOS034007705 HEK-293T C97(0.83)  LDD1514  [1]
 LDCM0372  CL103 HEK-293T C97(0.97)  LDD1576  [1]
 LDCM0376  CL107 HEK-293T C97(1.05)  LDD1580  [1]
 LDCM0381  CL111 HEK-293T C97(0.95)  LDD1585  [1]
 LDCM0385  CL115 HEK-293T C97(0.96)  LDD1589  [1]
 LDCM0389  CL119 HEK-293T C97(0.95)  LDD1593  [1]
 LDCM0390  CL12 HEK-293T C97(1.00)  LDD1594  [1]
 LDCM0394  CL123 HEK-293T C97(0.98)  LDD1598  [1]
 LDCM0398  CL127 HEK-293T C97(1.15)  LDD1602  [1]
 LDCM0402  CL15 HEK-293T C97(0.89)  LDD1606  [1]
 LDCM0405  CL18 HEK-293T C97(1.05)  LDD1609  [1]
 LDCM0408  CL20 HEK-293T C97(1.07)  LDD1612  [1]
 LDCM0409  CL21 HEK-293T C97(1.01)  LDD1613  [1]
 LDCM0412  CL24 HEK-293T C97(1.02)  LDD1616  [1]
 LDCM0415  CL27 HEK-293T C97(1.07)  LDD1619  [1]
 LDCM0418  CL3 HEK-293T C97(0.98)  LDD1622  [1]
 LDCM0419  CL30 HEK-293T C97(1.01)  LDD1623  [1]
 LDCM0421  CL32 HEK-293T C97(1.29)  LDD1625  [1]
 LDCM0422  CL33 HEK-293T C97(0.87)  LDD1626  [1]
 LDCM0425  CL36 HEK-293T C97(0.94)  LDD1629  [1]
 LDCM0428  CL39 HEK-293T C97(0.89)  LDD1632  [1]
 LDCM0432  CL42 HEK-293T C97(1.05)  LDD1636  [1]
 LDCM0434  CL44 HEK-293T C97(1.18)  LDD1638  [1]
 LDCM0435  CL45 HEK-293T C97(0.80)  LDD1639  [1]
 LDCM0438  CL48 HEK-293T C97(0.87)  LDD1642  [1]
 LDCM0445  CL54 HEK-293T C97(1.13)  LDD1648  [1]
 LDCM0447  CL56 HEK-293T C97(1.43)  LDD1650  [1]
 LDCM0448  CL57 HEK-293T C97(0.99)  LDD1651  [1]
 LDCM0451  CL6 HEK-293T C97(0.98)  LDD1654  [1]
 LDCM0452  CL60 HEK-293T C97(0.88)  LDD1655  [1]
 LDCM0455  CL63 HEK-293T C97(1.05)  LDD1658  [1]
 LDCM0458  CL66 HEK-293T C97(1.13)  LDD1661  [1]
 LDCM0460  CL68 HEK-293T C97(1.11)  LDD1663  [1]
 LDCM0461  CL69 HEK-293T C97(1.11)  LDD1664  [1]
 LDCM0465  CL72 HEK-293T C97(1.04)  LDD1668  [1]
 LDCM0471  CL78 HEK-293T C97(1.16)  LDD1674  [1]
 LDCM0473  CL8 HEK-293T C97(1.21)  LDD1676  [1]
 LDCM0474  CL80 HEK-293T C97(1.10)  LDD1677  [1]
 LDCM0475  CL81 HEK-293T C97(0.90)  LDD1678  [1]
 LDCM0478  CL84 HEK-293T C97(0.92)  LDD1681  [1]
 LDCM0481  CL87 HEK-293T C97(1.00)  LDD1684  [1]
 LDCM0484  CL9 HEK-293T C97(1.05)  LDD1687  [1]
 LDCM0485  CL90 HEK-293T C97(0.95)  LDD1688  [1]
 LDCM0487  CL92 HEK-293T C97(0.98)  LDD1690  [1]
 LDCM0488  CL93 HEK-293T C97(1.07)  LDD1691  [1]
 LDCM0491  CL96 HEK-293T C97(0.86)  LDD1694  [1]
 LDCM0494  CL99 HEK-293T C97(0.95)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C97(1.09)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C97(1.08)  LDD1671  [1]
 LDCM0022  KB02 HEK-293T C97(1.03)  LDD1492  [1]
 LDCM0023  KB03 HEK-293T C97(1.09)  LDD1497  [1]
 LDCM0024  KB05 HEK-293T C97(0.87)  LDD1502  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402