Details of the Target

General Information of Target

Target ID LDTP07953
Target Name Mitoguardin 2 (MIGA2)
Gene Name MIGA2
Gene ID 84895
Synonyms
C9orf54; FAM73B; Mitoguardin 2; Protein FAM73B
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAFRRAEGTSMIQALAMTVAEIPVFLYTTFGQSAFSQLRLTPGLRKVLFATALGTVALAL
AAHQLKRRRRRKKQVGPEMGGEQLGTVPLPILLARKVPSVKKGYSSRRVQSPSSKSNDTL
SGISSIEPSKHSGSSHSVASMMAVNSSSPTAACSGLWDARGMEESLTTSDGNAESLYMQG
MELFEEALQKWEQALSVGQRGDSGSTPMPRDGLRNPETASEPLSEPESQRKEFAEKLESL
LHRAYHLQEEFGSTFPADSMLLDLERTLMLPLTEGSLRLRADDEDSLTSEDSFFSATELF
ESLQTGDYPIPLSRPAAAYEEALQLVKEGRVPCRTLRTELLGCYSDQDFLAKLHCVRQAF
EGLLEDKSNQLFFGKVGRQMVTGLMTKAEKSPKGFLESYEEMLSYALRPETWATTRLELE
GRGVVCMSFFDIVLDFILMDAFEDLENPPASVLAVLRNRWLSDSFKETALATACWSVLKA
KRRLLMVPDGFISHFYSVSEHVSPVLAFGFLGPKPQLAEVCAFFKHQIVQYLRDMFDLDN
VRYTSLPALADDILQLSRRRSEILLGYLGVPAASSAGVNGALPRENGPLGELQ
Target Bioclass
Transporter and channel
Family
Mitoguardin family
Subcellular location
Mitochondrion outer membrane
Function
Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD.
Uniprot ID
Q7L4E1
Ensemble ID
ENST00000358369.8
HGNC ID
HGNC:23621

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
IGROV1 SNV: p.E410K .
JURKAT SNV: p.T338M .
NCIH2172 Insertion: p.Q199PfsTer27 .
NUGC3 SNV: p.S137N .
OVK18 SNV: p.E467Ter .
TF1 SNV: p.A61V .
ZR751 SNV: p.Q179E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C343(1.02)  LDD1511  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0259  AC14 HEK-293T C343(0.99)  LDD1512  [1]
 LDCM0281  AC21 HEK-293T C343(0.92)  LDD1520  [1]
 LDCM0282  AC22 HEK-293T C343(1.05)  LDD1521  [1]
 LDCM0284  AC24 HEK-293T C343(1.04)  LDD1523  [1]
 LDCM0289  AC29 HEK-293T C343(0.96)  LDD1528  [1]
 LDCM0291  AC30 HEK-293T C343(0.93)  LDD1530  [1]
 LDCM0293  AC32 HEK-293T C343(1.00)  LDD1532  [1]
 LDCM0298  AC37 HEK-293T C343(1.06)  LDD1537  [1]
 LDCM0299  AC38 HEK-293T C343(0.93)  LDD1538  [1]
 LDCM0302  AC40 HEK-293T C343(0.99)  LDD1541  [1]
 LDCM0307  AC45 HEK-293T C343(1.05)  LDD1546  [1]
 LDCM0308  AC46 HEK-293T C343(1.13)  LDD1547  [1]
 LDCM0310  AC48 HEK-293T C343(1.06)  LDD1549  [1]
 LDCM0312  AC5 HEK-293T C343(1.06)  LDD1551  [1]
 LDCM0316  AC53 HEK-293T C343(1.06)  LDD1555  [1]
 LDCM0317  AC54 HEK-293T C343(1.08)  LDD1556  [1]
 LDCM0319  AC56 HEK-293T C343(1.12)  LDD1558  [1]
 LDCM0323  AC6 HEK-293T C343(0.96)  LDD1562  [1]
 LDCM0325  AC61 HEK-293T C343(1.04)  LDD1564  [1]
 LDCM0326  AC62 HEK-293T C343(1.00)  LDD1565  [1]
 LDCM0328  AC64 HEK-293T C343(0.99)  LDD1567  [1]
 LDCM0345  AC8 HEK-293T C343(1.04)  LDD1569  [1]
 LDCM0248  AKOS034007472 HEK-293T C343(1.02)  LDD1511  [1]
 LDCM0275  AKOS034007705 HEK-293T C343(1.10)  LDD1514  [1]
 LDCM0367  CL1 HEK-293T C343(0.86)  LDD1571  [1]
 LDCM0368  CL10 HEK-293T C343(0.95)  LDD1572  [1]
 LDCM0370  CL101 HEK-293T C343(0.98)  LDD1574  [1]
 LDCM0372  CL103 HEK-293T C343(0.87)  LDD1576  [1]
 LDCM0374  CL105 HEK-293T C343(1.05)  LDD1578  [1]
 LDCM0376  CL107 HEK-293T C343(0.99)  LDD1580  [1]
 LDCM0378  CL109 HEK-293T C343(0.97)  LDD1582  [1]
 LDCM0381  CL111 HEK-293T C343(1.04)  LDD1585  [1]
 LDCM0383  CL113 HEK-293T C343(0.90)  LDD1587  [1]
 LDCM0385  CL115 HEK-293T C343(1.00)  LDD1589  [1]
 LDCM0387  CL117 HEK-293T C343(0.97)  LDD1591  [1]
 LDCM0389  CL119 HEK-293T C343(1.05)  LDD1593  [1]
 LDCM0390  CL12 HEK-293T C343(1.03)  LDD1594  [1]
 LDCM0392  CL121 HEK-293T C343(0.90)  LDD1596  [1]
 LDCM0394  CL123 HEK-293T C343(0.95)  LDD1598  [1]
 LDCM0396  CL125 HEK-293T C343(1.04)  LDD1600  [1]
 LDCM0398  CL127 HEK-293T C343(0.97)  LDD1602  [1]
 LDCM0400  CL13 HEK-293T C343(0.89)  LDD1604  [1]
 LDCM0402  CL15 HEK-293T C343(0.86)  LDD1606  [1]
 LDCM0409  CL21 HEK-293T C343(1.00)  LDD1613  [1]
 LDCM0410  CL22 HEK-293T C343(0.89)  LDD1614  [1]
 LDCM0412  CL24 HEK-293T C343(0.92)  LDD1616  [1]
 LDCM0413  CL25 HEK-293T C343(0.91)  LDD1617  [1]
 LDCM0415  CL27 HEK-293T C343(1.06)  LDD1619  [1]
 LDCM0418  CL3 HEK-293T C343(1.05)  LDD1622  [1]
 LDCM0422  CL33 HEK-293T C343(1.10)  LDD1626  [1]
 LDCM0423  CL34 HEK-293T C343(0.97)  LDD1627  [1]
 LDCM0425  CL36 HEK-293T C343(0.95)  LDD1629  [1]
 LDCM0426  CL37 HEK-293T C343(0.88)  LDD1630  [1]
 LDCM0428  CL39 HEK-293T C343(1.02)  LDD1632  [1]
 LDCM0435  CL45 HEK-293T C343(0.88)  LDD1639  [1]
 LDCM0436  CL46 HEK-293T C343(1.00)  LDD1640  [1]
 LDCM0438  CL48 HEK-293T C343(1.03)  LDD1642  [1]
 LDCM0439  CL49 HEK-293T C343(0.86)  LDD1643  [1]
 LDCM0448  CL57 HEK-293T C343(0.94)  LDD1651  [1]
 LDCM0449  CL58 HEK-293T C343(0.96)  LDD1652  [1]
 LDCM0452  CL60 HEK-293T C343(1.01)  LDD1655  [1]
 LDCM0453  CL61 HEK-293T C343(0.92)  LDD1656  [1]
 LDCM0455  CL63 HEK-293T C343(0.95)  LDD1658  [1]
 LDCM0461  CL69 HEK-293T C343(0.94)  LDD1664  [1]
 LDCM0463  CL70 HEK-293T C343(1.00)  LDD1666  [1]
 LDCM0465  CL72 HEK-293T C343(1.03)  LDD1668  [1]
 LDCM0466  CL73 HEK-293T C343(0.86)  LDD1669  [1]
 LDCM0475  CL81 HEK-293T C343(0.98)  LDD1678  [1]
 LDCM0476  CL82 HEK-293T C343(0.92)  LDD1679  [1]
 LDCM0478  CL84 HEK-293T C343(1.16)  LDD1681  [1]
 LDCM0479  CL85 HEK-293T C343(1.00)  LDD1682  [1]
 LDCM0481  CL87 HEK-293T C343(0.95)  LDD1684  [1]
 LDCM0484  CL9 HEK-293T C343(0.87)  LDD1687  [1]
 LDCM0488  CL93 HEK-293T C343(1.04)  LDD1691  [1]
 LDCM0489  CL94 HEK-293T C343(0.95)  LDD1692  [1]
 LDCM0491  CL96 HEK-293T C343(0.98)  LDD1694  [1]
 LDCM0492  CL97 HEK-293T C343(0.97)  LDD1695  [1]
 LDCM0494  CL99 HEK-293T C343(0.92)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C343(0.99)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C343(1.01)  LDD1671  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402