Details of the Target

General Information of Target

Target ID LDTP07952
Target Name Protein Bop (RTL10)
Gene Name RTL10
Gene ID 79680
Synonyms
BOP; C22orf29; Protein Bop; BH3-only protein; Retrotransposon Gag-like protein 10
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPRGRCRQQGPRIPIWAAANYANAHPWQQMDKASPGVAYTPLVDPWIERPCCGDTVCVRT
TMEQKSTASGTCGGKPAERGPLAGHMPSSRPHRVDFCWVPGSDPGTFDGSPWLLDRFLAQ
LGDYMSFHFEHYQDNISRVCEILRRLTGRAQAWAAPYLDGDLPLPDDYELFCQDLKEVVQ
DPNSFAEYHAVVTCPLPLASSQLPVAPQLPVVRQYLARFLEGLALDMGTAPRSLPAAMAT
PAVSGSNSVSRSALFEQQLTKESTPGPKEPPVLPSSTCSSKPGPVEPASSQPEEAAPTPV
PRLSESANPPAQRPDPAHPGGPKPQKTEEEVLETEGDQEVSLGTPQEVVEAPETPGEPPL
SPGF
Target Bioclass
Other
Subcellular location
Mitochondrion
Function Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation RTL10/BOP intrinsic apoptotic signaling activity.
Uniprot ID
Q7L3V2
Ensemble ID
ENST00000328554.9
HGNC ID
HGNC:26112

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C72(3.16)  LDD3397  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0167  [2]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C72(0.84)  LDD0813  [4]
 LDCM0216  AC100 HEK-293T C72(0.86)  LDD0814  [4]
 LDCM0217  AC101 HEK-293T C72(0.99)  LDD0815  [4]
 LDCM0218  AC102 HEK-293T C72(0.85)  LDD0816  [4]
 LDCM0219  AC103 HEK-293T C72(0.88)  LDD0817  [4]
 LDCM0220  AC104 HEK-293T C72(0.76)  LDD0818  [4]
 LDCM0221  AC105 HEK-293T C72(1.02)  LDD0819  [4]
 LDCM0222  AC106 HEK-293T C72(1.28)  LDD0820  [4]
 LDCM0223  AC107 HEK-293T C72(0.93)  LDD0821  [4]
 LDCM0224  AC108 HEK-293T C72(1.17)  LDD0822  [4]
 LDCM0225  AC109 HEK-293T C72(1.18)  LDD0823  [4]
 LDCM0226  AC11 HEK-293T C72(0.83)  LDD0824  [4]
 LDCM0227  AC110 HEK-293T C72(0.82)  LDD0825  [4]
 LDCM0228  AC111 HEK-293T C72(0.68)  LDD0826  [4]
 LDCM0229  AC112 HEK-293T C72(0.74)  LDD0827  [4]
 LDCM0230  AC113 HEK-293T C72(0.98)  LDD0828  [4]
 LDCM0231  AC114 HEK-293T C72(0.94)  LDD0829  [4]
 LDCM0232  AC115 HEK-293T C72(1.03)  LDD0830  [4]
 LDCM0233  AC116 HEK-293T C72(1.01)  LDD0831  [4]
 LDCM0234  AC117 HEK-293T C72(0.88)  LDD0832  [4]
 LDCM0235  AC118 HEK-293T C72(0.84)  LDD0833  [4]
 LDCM0236  AC119 HEK-293T C72(0.81)  LDD0834  [4]
 LDCM0237  AC12 HEK-293T C72(0.70)  LDD0835  [4]
 LDCM0238  AC120 HEK-293T C72(0.77)  LDD0836  [4]
 LDCM0239  AC121 HEK-293T C72(0.75)  LDD0837  [4]
 LDCM0240  AC122 HEK-293T C72(0.72)  LDD0838  [4]
 LDCM0241  AC123 HEK-293T C72(0.74)  LDD0839  [4]
 LDCM0242  AC124 HEK-293T C72(0.77)  LDD0840  [4]
 LDCM0243  AC125 HEK-293T C72(0.71)  LDD0841  [4]
 LDCM0244  AC126 HEK-293T C72(0.67)  LDD0842  [4]
 LDCM0245  AC127 HEK-293T C72(0.61)  LDD0843  [4]
 LDCM0259  AC14 HEK-293T C72(0.90)  LDD0857  [4]
 LDCM0270  AC15 HEK-293T C72(0.76)  LDD0868  [4]
 LDCM0278  AC19 HEK-293T C194(0.74)  LDD1517  [5]
 LDCM0281  AC21 HEK-293T C72(0.85)  LDD1520  [5]
 LDCM0285  AC25 HEK-293T C72(0.77)  LDD0883  [4]
 LDCM0286  AC26 HEK-293T C72(0.68)  LDD0884  [4]
 LDCM0287  AC27 HEK-293T C72(0.83)  LDD0885  [4]
 LDCM0288  AC28 HEK-293T C72(0.62)  LDD0886  [4]
 LDCM0289  AC29 HEK-293T C72(0.75)  LDD0887  [4]
 LDCM0290  AC3 HEK-293T C194(0.74)  LDD1529  [5]
 LDCM0291  AC30 HEK-293T C72(0.76)  LDD0889  [4]
 LDCM0292  AC31 HEK-293T C72(0.80)  LDD0890  [4]
 LDCM0293  AC32 HEK-293T C72(0.79)  LDD0891  [4]
 LDCM0294  AC33 HEK-293T C72(0.83)  LDD0892  [4]
 LDCM0295  AC34 HEK-293T C72(0.78)  LDD0893  [4]
 LDCM0296  AC35 HEK-293T C72(1.06)  LDD0894  [4]
 LDCM0297  AC36 HEK-293T C72(0.88)  LDD0895  [4]
 LDCM0298  AC37 HEK-293T C72(0.83)  LDD0896  [4]
 LDCM0299  AC38 HEK-293T C72(0.95)  LDD0897  [4]
 LDCM0300  AC39 HEK-293T C72(0.89)  LDD0898  [4]
 LDCM0302  AC40 HEK-293T C72(0.91)  LDD0900  [4]
 LDCM0303  AC41 HEK-293T C72(0.95)  LDD0901  [4]
 LDCM0304  AC42 HEK-293T C72(0.89)  LDD0902  [4]
 LDCM0305  AC43 HEK-293T C72(0.93)  LDD0903  [4]
 LDCM0306  AC44 HEK-293T C72(0.95)  LDD0904  [4]
 LDCM0307  AC45 HEK-293T C72(0.93)  LDD0905  [4]
 LDCM0308  AC46 HEK-293T C72(0.94)  LDD0906  [4]
 LDCM0309  AC47 HEK-293T C72(0.90)  LDD0907  [4]
 LDCM0310  AC48 HEK-293T C72(0.88)  LDD0908  [4]
 LDCM0311  AC49 HEK-293T C72(0.82)  LDD0909  [4]
 LDCM0312  AC5 HEK-293T C72(0.82)  LDD1551  [5]
 LDCM0313  AC50 HEK-293T C72(0.97)  LDD0911  [4]
 LDCM0314  AC51 HEK-293T C72(0.72)  LDD0912  [4]
 LDCM0315  AC52 HEK-293T C72(0.69)  LDD0913  [4]
 LDCM0316  AC53 HEK-293T C72(0.81)  LDD0914  [4]
 LDCM0317  AC54 HEK-293T C72(0.81)  LDD0915  [4]
 LDCM0318  AC55 HEK-293T C72(0.78)  LDD0916  [4]
 LDCM0319  AC56 HEK-293T C72(0.88)  LDD0917  [4]
 LDCM0322  AC59 HEK-293T C194(0.67)  LDD1561  [5]
 LDCM0323  AC6 HEK-293T C72(0.84)  LDD0921  [4]
 LDCM0325  AC61 HEK-293T C72(1.03)  LDD1564  [5]
 LDCM0334  AC7 HEK-293T C72(0.76)  LDD0932  [4]
 LDCM0345  AC8 HEK-293T C72(0.64)  LDD0943  [4]
 LDCM0365  AC98 HEK-293T C72(1.06)  LDD0963  [4]
 LDCM0366  AC99 HEK-293T C72(0.89)  LDD0964  [4]
 LDCM0248  AKOS034007472 HEK-293T C72(0.95)  LDD0846  [4]
 LDCM0356  AKOS034007680 HEK-293T C72(0.72)  LDD0954  [4]
 LDCM0275  AKOS034007705 HEK-293T C72(0.69)  LDD0873  [4]
 LDCM0367  CL1 HEK-293T C72(1.01)  LDD0965  [4]
 LDCM0368  CL10 HEK-293T C72(0.61)  LDD0966  [4]
 LDCM0370  CL101 HEK-293T C72(0.62)  LDD0968  [4]
 LDCM0371  CL102 HEK-293T C72(0.64)  LDD0969  [4]
 LDCM0372  CL103 HEK-293T C72(0.62)  LDD0970  [4]
 LDCM0373  CL104 HEK-293T C72(0.71)  LDD0971  [4]
 LDCM0379  CL11 HEK-293T C72(0.67)  LDD0977  [4]
 LDCM0382  CL112 HEK-293T C72(0.67)  LDD0980  [4]
 LDCM0383  CL113 HEK-293T C72(0.84)  LDD0981  [4]
 LDCM0384  CL114 HEK-293T C72(0.57)  LDD0982  [4]
 LDCM0385  CL115 HEK-293T C72(0.73)  LDD0983  [4]
 LDCM0386  CL116 HEK-293T C72(0.71)  LDD0984  [4]
 LDCM0387  CL117 HEK-293T C72(0.93)  LDD0985  [4]
 LDCM0388  CL118 HEK-293T C72(0.94)  LDD0986  [4]
 LDCM0389  CL119 HEK-293T C72(0.89)  LDD0987  [4]
 LDCM0390  CL12 HEK-293T C72(1.03)  LDD0988  [4]
 LDCM0391  CL120 HEK-293T C72(1.00)  LDD0989  [4]
 LDCM0392  CL121 HEK-293T C72(0.77)  LDD0990  [4]
 LDCM0393  CL122 HEK-293T C72(0.91)  LDD0991  [4]
 LDCM0394  CL123 HEK-293T C72(0.90)  LDD0992  [4]
 LDCM0395  CL124 HEK-293T C72(0.85)  LDD0993  [4]
 LDCM0400  CL13 HEK-293T C72(1.00)  LDD0998  [4]
 LDCM0401  CL14 HEK-293T C72(0.91)  LDD0999  [4]
 LDCM0402  CL15 HEK-293T C72(0.96)  LDD1000  [4]
 LDCM0406  CL19 HEK-293T C194(1.14)  LDD1610  [5]
 LDCM0407  CL2 HEK-293T C72(0.97)  LDD1005  [4]
 LDCM0409  CL21 HEK-293T C72(1.25)  LDD1613  [5]
 LDCM0418  CL3 HEK-293T C72(0.93)  LDD1016  [4]
 LDCM0420  CL31 HEK-293T C194(0.82)  LDD1624  [5]
 LDCM0422  CL33 HEK-293T C72(1.01)  LDD1626  [5]
 LDCM0429  CL4 HEK-293T C72(0.85)  LDD1027  [4]
 LDCM0433  CL43 HEK-293T C194(1.02)  LDD1637  [5]
 LDCM0435  CL45 HEK-293T C72(1.07)  LDD1639  [5]
 LDCM0440  CL5 HEK-293T C72(0.85)  LDD1038  [4]
 LDCM0446  CL55 HEK-293T C194(0.78)  LDD1649  [5]
 LDCM0448  CL57 HEK-293T C72(1.32)  LDD1651  [5]
 LDCM0451  CL6 HEK-293T C72(0.99)  LDD1049  [4]
 LDCM0453  CL61 HEK-293T C72(1.20)  LDD1051  [4]
 LDCM0454  CL62 HEK-293T C72(1.00)  LDD1052  [4]
 LDCM0455  CL63 HEK-293T C72(0.93)  LDD1053  [4]
 LDCM0456  CL64 HEK-293T C72(1.18)  LDD1054  [4]
 LDCM0457  CL65 HEK-293T C72(1.16)  LDD1055  [4]
 LDCM0458  CL66 HEK-293T C72(1.18)  LDD1056  [4]
 LDCM0459  CL67 HEK-293T C72(1.24)  LDD1057  [4]
 LDCM0460  CL68 HEK-293T C72(0.90)  LDD1058  [4]
 LDCM0461  CL69 HEK-293T C72(1.07)  LDD1059  [4]
 LDCM0462  CL7 HEK-293T C72(0.85)  LDD1060  [4]
 LDCM0463  CL70 HEK-293T C72(1.41)  LDD1061  [4]
 LDCM0464  CL71 HEK-293T C72(1.07)  LDD1062  [4]
 LDCM0465  CL72 HEK-293T C72(1.14)  LDD1063  [4]
 LDCM0466  CL73 HEK-293T C72(1.06)  LDD1064  [4]
 LDCM0467  CL74 HEK-293T C72(0.81)  LDD1065  [4]
 LDCM0472  CL79 HEK-293T C194(0.78)  LDD1675  [5]
 LDCM0473  CL8 HEK-293T C72(1.29)  LDD1071  [4]
 LDCM0475  CL81 HEK-293T C72(1.30)  LDD1678  [5]
 LDCM0484  CL9 HEK-293T C72(1.08)  LDD1082  [4]
 LDCM0486  CL91 HEK-293T C194(0.24)  LDD1689  [5]
 LDCM0488  CL93 HEK-293T C72(1.06)  LDD1691  [5]
 LDCM0468  Fragment33 HEK-293T C72(0.70)  LDD1066  [4]
 LDCM0022  KB02 ICC18 C72(1.57)  LDD2385  [1]
 LDCM0023  KB03 ICC3 C72(1.96)  LDD2808  [1]
 LDCM0024  KB05 PF-382 C72(3.16)  LDD3397  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apoptosis regulator BAX (BAX) Bcl-2 family Q07812
Bcl-2 homologous antagonist/killer (BAK1) Bcl-2 family Q16611
Bcl-2-like protein 2 (BCL2L2) Bcl-2 family Q92843
Voltage-dependent anion-selective channel protein 1 (VDAC1) Eukaryotic mitochondrial porin family P21796
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) Bcl-2 family Q07820

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402