Details of the Target

General Information of Target

Target ID LDTP07699
Target Name Probable palmitoyltransferase ZDHHC24 (ZDHHC24)
Gene Name ZDHHC24
Gene ID 254359
Synonyms
Probable palmitoyltransferase ZDHHC24; EC 2.3.1.225; Zinc finger DHHC domain-containing protein 24
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGQPWAAGSTDGAPAQLPLVLTALWAAAVGLELAYVLVLGPGPPPLGPLARALQLALAAF
QLLNLLGNVGLFLRSDPSIRGVMLAGRGLGQGWAYCYQCQSQVPPRSGHCSACRVCILRR
DHHCRLLGRCVGFGNYRPFLCLLLHAAGVLLHVSVLLGPALSALLRAHTPLHMAALLLLP
WLMLLTGRVSLAQFALAFVTDTCVAGALLCGAGLLFHGMLLLRGQTTWEWARGQHSYDLG
PCHNLQAALGPRWALVWLWPFLASPLPGDGITFQTTADVGHTAS
Target Bioclass
Enzyme
Family
DHHC palmitoyltransferase family
Subcellular location
Membrane
Function Probable palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates.
Uniprot ID
Q6UX98
Ensemble ID
ENST00000310442.5
HGNC ID
HGNC:27387

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C113(0.00); C110(0.00)  LDD0241  [1]
BTD
 Probe Info  		C110(0.42)  LDD2117  [2]
AHL-Pu-1
 Probe Info  		C242(3.09)  LDD0171  [3]
DBIA
 Probe Info  		C242(1.04); C113(0.92)  LDD1511  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C110(0.42)  LDD2117  [2]
 LDCM0026  4SU-RNA+native RNA DM93 C242(3.09)  LDD0171  [3]
 LDCM0270  AC15 HEK-293T C242(1.14)  LDD1513  [4]
 LDCM0281  AC21 HEK-293T C242(0.97); C113(0.93)  LDD1520  [4]
 LDCM0283  AC23 HEK-293T C242(1.08)  LDD1522  [4]
 LDCM0289  AC29 HEK-293T C242(1.06); C113(1.06)  LDD1528  [4]
 LDCM0292  AC31 HEK-293T C242(1.01)  LDD1531  [4]
 LDCM0298  AC37 HEK-293T C242(1.14); C113(1.00)  LDD1537  [4]
 LDCM0300  AC39 HEK-293T C242(1.11)  LDD1539  [4]
 LDCM0307  AC45 HEK-293T C242(0.99); C113(1.04)  LDD1546  [4]
 LDCM0309  AC47 HEK-293T C242(1.09)  LDD1548  [4]
 LDCM0312  AC5 HEK-293T C242(1.05); C113(0.87)  LDD1551  [4]
 LDCM0316  AC53 HEK-293T C242(1.06); C113(0.96)  LDD1555  [4]
 LDCM0318  AC55 HEK-293T C242(1.06)  LDD1557  [4]
 LDCM0325  AC61 HEK-293T C242(1.17); C113(1.07)  LDD1564  [4]
 LDCM0327  AC63 HEK-293T C242(1.12)  LDD1566  [4]
 LDCM0334  AC7 HEK-293T C242(1.13)  LDD1568  [4]
 LDCM0248  AKOS034007472 HEK-293T C242(1.04); C113(0.92)  LDD1511  [4]
 LDCM0367  CL1 HEK-293T C242(1.30); C113(0.90)  LDD1571  [4]
 LDCM0369  CL100 HEK-293T C242(1.20)  LDD1573  [4]
 LDCM0370  CL101 HEK-293T C242(1.14); C113(0.97)  LDD1574  [4]
 LDCM0371  CL102 HEK-293T C113(0.78)  LDD1575  [4]
 LDCM0372  CL103 HEK-293T C113(0.94)  LDD1576  [4]
 LDCM0373  CL104 HEK-293T C242(1.00)  LDD1577  [4]
 LDCM0374  CL105 HEK-293T C242(1.05); C113(1.07)  LDD1578  [4]
 LDCM0375  CL106 HEK-293T C113(0.88)  LDD1579  [4]
 LDCM0376  CL107 HEK-293T C113(1.03)  LDD1580  [4]
 LDCM0377  CL108 HEK-293T C242(1.08)  LDD1581  [4]
 LDCM0378  CL109 HEK-293T C242(1.09); C113(0.95)  LDD1582  [4]
 LDCM0379  CL11 HEK-293T C242(1.27)  LDD1583  [4]
 LDCM0380  CL110 HEK-293T C113(1.30)  LDD1584  [4]
 LDCM0381  CL111 HEK-293T C113(1.00)  LDD1585  [4]
 LDCM0382  CL112 HEK-293T C242(1.10)  LDD1586  [4]
 LDCM0383  CL113 HEK-293T C242(1.17); C113(0.94)  LDD1587  [4]
 LDCM0384  CL114 HEK-293T C113(0.99)  LDD1588  [4]
 LDCM0385  CL115 HEK-293T C113(1.09)  LDD1589  [4]
 LDCM0386  CL116 HEK-293T C242(1.07)  LDD1590  [4]
 LDCM0387  CL117 HEK-293T C242(1.12); C113(1.03)  LDD1591  [4]
 LDCM0388  CL118 HEK-293T C113(0.69)  LDD1592  [4]
 LDCM0389  CL119 HEK-293T C113(0.95)  LDD1593  [4]
 LDCM0391  CL120 HEK-293T C242(1.20)  LDD1595  [4]
 LDCM0392  CL121 HEK-293T C242(1.08); C113(0.93)  LDD1596  [4]
 LDCM0393  CL122 HEK-293T C113(0.69)  LDD1597  [4]
 LDCM0394  CL123 HEK-293T C113(1.03)  LDD1598  [4]
 LDCM0395  CL124 HEK-293T C242(1.17)  LDD1599  [4]
 LDCM0396  CL125 HEK-293T C242(1.08); C113(0.86)  LDD1600  [4]
 LDCM0397  CL126 HEK-293T C113(1.06)  LDD1601  [4]
 LDCM0398  CL127 HEK-293T C113(0.86)  LDD1602  [4]
 LDCM0399  CL128 HEK-293T C242(1.09)  LDD1603  [4]
 LDCM0400  CL13 HEK-293T C242(1.21); C113(0.88)  LDD1604  [4]
 LDCM0401  CL14 HEK-293T C113(0.97)  LDD1605  [4]
 LDCM0402  CL15 HEK-293T C113(1.04)  LDD1606  [4]
 LDCM0403  CL16 HEK-293T C242(0.94)  LDD1607  [4]
 LDCM0407  CL2 HEK-293T C113(1.05)  LDD1611  [4]
 LDCM0409  CL21 HEK-293T C242(1.29); C113(1.11)  LDD1613  [4]
 LDCM0411  CL23 HEK-293T C242(1.26)  LDD1615  [4]
 LDCM0413  CL25 HEK-293T C242(1.29); C113(0.85)  LDD1617  [4]
 LDCM0414  CL26 HEK-293T C113(0.97)  LDD1618  [4]
 LDCM0415  CL27 HEK-293T C113(0.94)  LDD1619  [4]
 LDCM0416  CL28 HEK-293T C242(1.01)  LDD1620  [4]
 LDCM0418  CL3 HEK-293T C113(1.07)  LDD1622  [4]
 LDCM0422  CL33 HEK-293T C242(1.03); C113(0.99)  LDD1626  [4]
 LDCM0424  CL35 HEK-293T C242(1.10)  LDD1628  [4]
 LDCM0426  CL37 HEK-293T C242(1.05); C113(0.86)  LDD1630  [4]
 LDCM0428  CL39 HEK-293T C113(1.04)  LDD1632  [4]
 LDCM0429  CL4 HEK-293T C242(1.31)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C242(1.01)  LDD1634  [4]
 LDCM0435  CL45 HEK-293T C242(1.20); C113(0.97)  LDD1639  [4]
 LDCM0437  CL47 HEK-293T C242(1.06)  LDD1641  [4]
 LDCM0439  CL49 HEK-293T C242(1.14); C113(1.01)  LDD1643  [4]
 LDCM0441  CL50 HEK-293T C113(1.04)  LDD1645  [4]
 LDCM0443  CL52 HEK-293T C242(1.21)  LDD1646  [4]
 LDCM0448  CL57 HEK-293T C242(1.07); C113(0.99)  LDD1651  [4]
 LDCM0450  CL59 HEK-293T C242(1.29)  LDD1653  [4]
 LDCM0453  CL61 HEK-293T C242(1.15); C113(0.87)  LDD1656  [4]
 LDCM0454  CL62 HEK-293T C113(0.84)  LDD1657  [4]
 LDCM0455  CL63 HEK-293T C113(1.02)  LDD1658  [4]
 LDCM0456  CL64 HEK-293T C242(1.54)  LDD1659  [4]
 LDCM0461  CL69 HEK-293T C242(1.28); C113(0.92)  LDD1664  [4]
 LDCM0464  CL71 HEK-293T C242(1.27)  LDD1667  [4]
 LDCM0466  CL73 HEK-293T C242(1.19); C113(0.85)  LDD1669  [4]
 LDCM0467  CL74 HEK-293T C113(0.87)  LDD1670  [4]
 LDCM0469  CL76 HEK-293T C242(0.99)  LDD1672  [4]
 LDCM0475  CL81 HEK-293T C242(1.15); C113(0.97)  LDD1678  [4]
 LDCM0477  CL83 HEK-293T C242(1.17)  LDD1680  [4]
 LDCM0479  CL85 HEK-293T C242(1.11); C113(0.76)  LDD1682  [4]
 LDCM0480  CL86 HEK-293T C113(0.79)  LDD1683  [4]
 LDCM0481  CL87 HEK-293T C113(1.02)  LDD1684  [4]
 LDCM0482  CL88 HEK-293T C242(1.07)  LDD1685  [4]
 LDCM0484  CL9 HEK-293T C242(1.21); C113(1.03)  LDD1687  [4]
 LDCM0488  CL93 HEK-293T C242(1.23); C113(1.07)  LDD1691  [4]
 LDCM0490  CL95 HEK-293T C242(1.08)  LDD1693  [4]
 LDCM0492  CL97 HEK-293T C242(1.21); C113(0.90)  LDD1695  [4]
 LDCM0493  CL98 HEK-293T C113(1.16)  LDD1696  [4]
 LDCM0494  CL99 HEK-293T C113(0.93)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C113(1.11)  LDD1698  [4]
 LDCM0468  Fragment33 HEK-293T C113(0.88)  LDD1671  [4]
 LDCM0427  Fragment51 HEK-293T C113(0.80)  LDD1631  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Anterior gradient protein 2 homolog (AGR2) AGR family O95994
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
E3 ubiquitin-protein ligase RNF5 (RNF5) RNF5 family Q99942
Estradiol 17-beta-dehydrogenase 11 (HSD17B11) Short-chain dehydrogenases/reductases (SDR) family Q8NBQ5
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Stomatin-like protein 3 (STOML3) Band 7/mec-2 family Q8TAV4
G protein-activated inward rectifier potassium channel 2 (KCNJ6) Inward rectifier-type potassium channel family P48051
Hippocampus abundant transcript-like protein 1 (MFSD14B) Major facilitator superfamily Q5SR56
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proto-oncogene c-Rel (REL) . Q04864
Transcription factor 4 (TCF4) . P15884
Cytokine and receptor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor necrosis factor ligand superfamily member 14 (TNFSF14) Tumor necrosis factor family O43557
Interferon gamma receptor 2 (IFNGR2) Type II cytokine receptor family P38484
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein INCA1 (INCA1) INCA family Q0VD86
Protein stum homolog (STUM) SPEC3 family Q69YW2
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4
Sperm-associated antigen 4 protein (SPAG4) . Q9NPE6

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402