Details of the Target

General Information of Target

Target ID LDTP07633
Target Name SHC-transforming protein 4 (SHC4)
Gene Name SHC4
Gene ID 399694
Synonyms
SHCD; SHC-transforming protein 4; Rai-like protein; RaLP; SHC-transforming protein D; hShcD; Src homology 2 domain-containing-transforming protein C4; SH2 domain protein C4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRERGQDSLAGLVLYVGLFGHPGMLHRAKYSRFRNESITSLDEGSSGGSVGNKGSPQPPH
PALAPHLPTEDATLPSQESPTPLCTLIPRMASMKLANPATLLSLKNFCLGTKEVPRLKLQ
ESRDPGSSGPSSPETSLSRSGTAPPPQQDLVGHRATALTPDSCPLPGPGEPTLRSRQDRH
FLQHLLGMGMNYCVRYMGCVEVLQSMRSLDFGMRTQVTREAISRLCEAVPGANGAIKKRK
PPVKFLSTVLGKSNLQFSGMNIKLTISTCSLTLMNLDNQQIIANHHMQSISFASGGDPDT
TDYVAYVAKDPVNQRACHILECHNGMAQDVISTIGQAFELRFKQYLKNPSLNTSCESEEV
HIDSHAEEREDHEYYNEIPGKQPPVGGVSDMRIKVQATEQMAYCPIQCEKLCYLPGNSKC
SSVYENCLEQSRAIGNVHPRGVQSQRDTSLLKHTCRVDLFDDPCYINTQALQSTPGSAGN
QRSAQPLGSPWHCGKAPETVQPGATAQPASSHSLPHIKQQLWSEECYHGKLSRKAAESLL
VKDGDFLVRESATSPGQYVLSGLQGGQAKHLLLVDPEGKVRTKDHVFDNVGHLIRYHMDN
SLPIISSGSEVSLKQPVRKDNNPALLHSNK
Target Bioclass
Other
Subcellular location
Postsynaptic cell membrane
Function Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.
Uniprot ID
Q6S5L8
Ensemble ID
ENST00000332408.9
HGNC ID
HGNC:16743

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.Y196C .
DU145 SNV: p.P164Q DBIA    Probe Info 
MCAS SNV: p.P242S DBIA    Probe Info 
MFE319 SNV: p.S127Y .
NCIH2172 SNV: p.A316V .
NUGC3 SNV: p.K619N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0222  [1]
DBIA
 Probe Info  		C199(1.23)  LDD0547  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0230  AC113 HCT 116 C199(1.23)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C199(0.92)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C199(1.00)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C199(0.85)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C199(1.04)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C199(0.82)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C199(0.96)  LDD0553  [2]
 LDCM0238  AC120 HCT 116 C199(0.78)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C199(1.17)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C199(1.18)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C199(1.05)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C199(0.82)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C199(0.93)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C199(0.99)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C199(0.72)  LDD0562  [2]
 LDCM0296  AC35 HCT 116 C199(0.83)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C199(0.84)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C199(0.76)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C199(0.84)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C199(1.08)  LDD0617  [2]
 LDCM0302  AC40 HCT 116 C199(0.83)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C199(0.83)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C199(0.94)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C199(0.88)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C199(0.84)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C199(0.76)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C199(1.06)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C199(1.07)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C199(1.24)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C199(1.03)  LDD0628  [2]
 LDCM0313  AC50 HCT 116 C199(0.95)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C199(1.12)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C199(1.21)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C199(1.21)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C199(1.18)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C199(1.16)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C199(1.49)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C199(1.05)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C199(1.10)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C199(1.14)  LDD0639  [2]
 LDCM0324  AC60 HCT 116 C199(0.96)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C199(0.96)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C199(0.96)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C199(0.97)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C199(1.21)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C199(0.92)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C199(1.07)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C199(1.27)  LDD0648  [2]
 LDCM0349  AC83 HCT 116 C199(0.78)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C199(0.69)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C199(0.73)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C199(0.68)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C199(0.88)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C199(0.82)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C199(0.85)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C199(0.78)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C199(0.80)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C199(0.78)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C199(0.84)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C199(0.71)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C199(0.93)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C199(0.67)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C199(0.77)  LDD0681  [2]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [1]
 LDCM0387  CL117 HCT 116 C199(1.17)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C199(0.90)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C199(0.84)  LDD0706  [2]
 LDCM0391  CL120 HCT 116 C199(0.74)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C199(1.07)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C199(1.17)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C199(1.09)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C199(1.07)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C199(0.96)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C199(0.87)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C199(0.83)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C199(1.39)  LDD0716  [2]
 LDCM0404  CL17 HCT 116 C199(0.86)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C199(1.00)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C199(1.01)  LDD0723  [2]
 LDCM0408  CL20 HCT 116 C199(0.99)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C199(0.91)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C199(0.90)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C199(1.09)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C199(0.94)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C199(1.07)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C199(0.95)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C199(1.06)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C199(1.07)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C199(0.89)  LDD0734  [2]
 LDCM0419  CL30 HCT 116 C199(1.09)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C199(1.00)  LDD0737  [2]
 LDCM0022  KB02 22RV1 C59(1.67)  LDD2243  [3]
 LDCM0023  KB03 22RV1 C59(2.50)  LDD2660  [3]
 LDCM0024  KB05 COLO792 C59(1.92)  LDD3310  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hepatocyte growth factor receptor (MET) Tyr protein kinase family P08581
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Androgen receptor (AR) Nuclear hormone receptor family P10275

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840