Details of the Target

General Information of Target

Target ID LDTP07544
Target Name Zinc transporter ZIP4 (SLC39A4)
Gene Name SLC39A4
Gene ID 55630
Synonyms
ZIP4; Zinc transporter ZIP4; Solute carrier family 39 member 4; Zrt- and Irt-like protein 4; ZIP-4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASLVSLELGLLLAVLVVTATASPPAGLLSLLTSGQGALDQEALGGLLNTLADRVHCANG
PCGKCLSVEDALGLGEPEGSGLPPGPVLEARYVARLSAAAVLYLSNPEGTCEDARAGLWA
SHADHLLALLESPKALTPGLSWLLQRMQARAAGQTPKMACVDIPQLLEEAVGAGAPGSAG
GVLAALLDHVRSGSCFHALPSPQYFVDFVFQQHSSEVPMTLAELSALMQRLGVGREAHSD
HSHRHRGASSRDPVPLISSSNSSSVWDTVCLSARDVMAAYGLSEQAGVTPEAWAQLSPAL
LQQQLSGACTSQSRPPVQDQLSQSERYLYGSLATLLICLCAVFGLLLLTCTGCRGVTHYI
LQTFLSLAVGAVTGDAVLHLTPKVLGLHTHSEEGLSPQPTWRLLAMLAGLYAFFLFENLF
NLLLPRDPEDLEDGPCGHSSHSHGGHSHGVSLQLAPSELRQPKPPHEGSRADLVAEESPE
LLNPEPRRLSPELRLLPYMITLGDAVHNFADGLAVGAAFASSWKTGLATSLAVFCHELPH
ELGDFAALLHAGLSVRQALLLNLASALTAFAGLYVALAVGVSEESEAWILAVATGLFLYV
ALCDMLPAMLKVRDPRPWLLFLLHNVGLLGGWTVLLLLSLYEDDITF
Target Bioclass
Transporter and channel
Family
ZIP transporter (TC 2.A.5) family
Subcellular location
Cell membrane
Function
Selective transporter that mediates the uptake of Zn(2+). Plays an essential role for dietary zinc uptake from small intestine. The Zn(2+) uniporter activity is regulated by zinc availability. Exhibits also polyspecific binding and transport of Cu(2+), Cd(2+) and possibly Ni(2+) but at higher concentrations.
Uniprot ID
Q6P5W5
Ensemble ID
ENST00000276833.9
HGNC ID
HGNC:17129

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A375 SNV: p.P86S .
DEL SNV: p.Y641Ter .
HCT116 Deletion: p.V356SfsTer10 .
HT Deletion: p.V317SfsTer32 .
HUPT4 SNV: p.S639F .
MELJUSO SNV: p.G85S .
NCIH1155 SNV: p.E467Q .
RCC10RGB SNV: p.D430Y .
SKMM2 SNV: p.A564V .
SNGM Insertion: p.H466PfsTer20
SNV: p.S105N		 .
TCCSUP SNV: p.Q453H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
DBIA
 Probe Info  		C57(0.82); C62(0.82)  LDD0531  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C57(0.82); C62(0.82)  LDD0531  [2]
 LDCM0279  AC2 HCT 116 C57(0.79); C62(0.79)  LDD0596  [2]
 LDCM0290  AC3 HCT 116 C57(0.82); C62(0.82)  LDD0607  [2]
 LDCM0301  AC4 HCT 116 C57(0.88); C62(0.88)  LDD0618  [2]
 LDCM0312  AC5 HCT 116 C57(0.84); C62(0.84)  LDD0629  [2]
 LDCM0320  AC57 HCT 116 C57(1.13); C62(1.13)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C57(0.78); C62(0.78)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C57(0.86); C62(0.86)  LDD0639  [2]
 LDCM0324  AC60 HCT 116 C57(0.92); C62(0.92)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C57(0.92); C62(0.92)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C57(1.49); C62(1.49)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C57(1.28); C62(1.28)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C57(1.13); C62(1.13)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C57(1.08); C62(1.08)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C57(0.78); C62(0.78)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C57(1.21); C62(1.21)  LDD0648  [2]
 LDCM0020  ARS-1620 HCC44 C57(0.96); C62(0.96)  LDD2171  [2]
 LDCM0369  CL100 HCT 116 C57(0.80); C62(0.80)  LDD0686  [2]
 LDCM0396  CL125 HCT 116 C57(1.26); C62(1.26)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C57(0.94); C62(0.94)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C57(1.10); C62(1.10)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C57(1.07); C62(1.07)  LDD0716  [2]
 LDCM0436  CL46 HCT 116 C57(1.32); C62(1.32)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C57(1.30); C62(1.30)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C57(1.05); C62(1.05)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C57(0.95); C62(0.95)  LDD0756  [2]
 LDCM0441  CL50 HCT 116 C57(1.01); C62(1.01)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C57(1.08); C62(1.08)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C57(1.05); C62(1.05)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C57(1.04); C62(1.04)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C57(0.90); C62(0.90)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C57(1.30); C62(1.30)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C57(1.08); C62(1.08)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C57(1.08); C62(1.08)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C57(1.02); C62(1.02)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C57(1.14); C62(1.14)  LDD0767  [2]
 LDCM0452  CL60 HCT 116 C57(1.13); C62(1.13)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C57(1.00); C62(1.00)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C57(0.95); C62(0.95)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C57(0.93); C62(0.93)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C57(1.19); C62(1.19)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C57(1.04); C62(1.04)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C57(0.95); C62(0.95)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C57(1.08); C62(1.08)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C57(1.14); C62(1.14)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C57(0.94); C62(0.94)  LDD0778  [2]
 LDCM0463  CL70 HCT 116 C57(1.01); C62(1.01)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C57(1.05); C62(1.05)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C57(0.95); C62(0.95)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C57(1.16); C62(1.16)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C57(0.89); C62(0.89)  LDD0784  [2]
 LDCM0486  CL91 HCT 116 C57(0.86); C62(0.86)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C57(0.88); C62(0.88)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C57(0.83); C62(0.83)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C57(0.92); C62(0.92)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C57(0.86); C62(0.86)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C57(1.00); C62(1.00)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C57(1.01); C62(1.01)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C57(0.99); C62(0.99)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C57(0.88); C62(0.88)  LDD0811  [2]
 LDCM0468  Fragment33 HCT 116 C57(1.15); C62(1.15)  LDD0785  [2]
 LDCM0021  THZ1 HCT 116 C57(0.96); C62(0.96)  LDD2173  [2]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Zinc Chloride . DB14533
Zinc Sulfate Unspecified Form . DB14548

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.