Details of the Target

General Information of Target

Target ID LDTP07519
Target Name Zinc finger protein 1 homolog (ZFP1)
Gene Name ZFP1
Gene ID 162239
Synonyms
ZNF475; Zinc finger protein 1 homolog; Zfp-1; Zinc finger protein 475
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNKSQGSVSFTDVTVDFTQEEWEQLDPSQRILYMDVMLENYSNLLSVEVWKADDQMERDH
RNPDEQARQFLILKNQTPIEERGDLFGKALNLNTDFVSLRQVPYKYDLYEKTLKYNSDLL
NSNRSYAGKQTDECNEFGKALLYLKQEKTHSGVEYSEYNKSGKALSHKAAIFKHQKIKNL
VQPFICTYCDKAFSFKSLLISHKRIHTGEKPYECNVCKKTFSHKANLIKHQRIHTGEKPF
ECPECGKAFTHQSNLIVHQRAHMEKKPYECSECGKTFAQKFELTTHQRIHTGERPYECNE
CAKTFFKKSNLIIHQKIHTGEKRYECSECGKSFIQNSQLIIHMRTHTGEKPYECTECGKT
FSQRSTLRLHLRIHTGEKPYECSECGKAFSRKSRLSVHQRVHIGEKP
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q6P2D0
Ensemble ID
ENST00000393430.6
HGNC ID
HGNC:23328

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
JURKAT SNV: p.E282K .
NCIH1048 SNV: p.T149P .
SKMEL30 SNV: p.C242Y .
TE11 SNV: p.E21Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C134(6.81)  LDD1706  [1]
DBIA
 Probe Info  		C270(0.79); C273(0.79)  LDD0593  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C134(0.97)  LDD1508  [4]
 LDCM0226  AC11 HEK-293T C134(1.17)  LDD1509  [4]
 LDCM0259  AC14 HEK-293T C134(1.09)  LDD1512  [4]
 LDCM0276  AC17 HCT 116 C270(0.79); C273(0.79)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C270(0.73); C273(0.73)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C270(0.84); C273(0.84)  LDD0595  [2]
 LDCM0279  AC2 HEK-293T C134(1.27)  LDD1518  [4]
 LDCM0280  AC20 HCT 116 C270(0.93); C273(0.93)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C270(0.83); C273(0.83)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C270(1.10); C273(1.10)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C270(0.82); C273(0.82)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C270(0.93); C273(0.93)  LDD0601  [2]
 LDCM0286  AC26 HEK-293T C134(1.01)  LDD1525  [4]
 LDCM0287  AC27 HEK-293T C134(1.07)  LDD1526  [4]
 LDCM0289  AC29 HEK-293T C134(0.98)  LDD1528  [4]
 LDCM0290  AC3 HEK-293T C134(1.04)  LDD1529  [4]
 LDCM0291  AC30 HEK-293T C134(1.04)  LDD1530  [4]
 LDCM0295  AC34 HEK-293T C134(0.94)  LDD1534  [4]
 LDCM0296  AC35 HEK-293T C134(1.01)  LDD1535  [4]
 LDCM0298  AC37 HEK-293T C134(0.98)  LDD1537  [4]
 LDCM0299  AC38 HEK-293T C134(1.02)  LDD1538  [4]
 LDCM0304  AC42 HEK-293T C134(1.01)  LDD1543  [4]
 LDCM0305  AC43 HEK-293T C134(1.04)  LDD1544  [4]
 LDCM0307  AC45 HEK-293T C134(1.00)  LDD1546  [4]
 LDCM0308  AC46 HEK-293T C134(1.17)  LDD1547  [4]
 LDCM0312  AC5 HEK-293T C134(1.10)  LDD1551  [4]
 LDCM0313  AC50 HEK-293T C134(1.00)  LDD1552  [4]
 LDCM0314  AC51 HEK-293T C134(1.08)  LDD1553  [4]
 LDCM0316  AC53 HEK-293T C134(1.00)  LDD1555  [4]
 LDCM0317  AC54 HEK-293T C134(1.10)  LDD1556  [4]
 LDCM0320  AC57 HCT 116 C270(0.58); C273(0.58)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C270(0.58); C273(0.58)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C270(0.51); C273(0.51)  LDD0639  [2]
 LDCM0323  AC6 HEK-293T C134(1.04)  LDD1562  [4]
 LDCM0324  AC60 HCT 116 C270(0.68); C273(0.68)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C270(0.74); C273(0.74)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C270(0.58); C273(0.58)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C270(0.64); C273(0.64)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C270(0.55); C273(0.55)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C270(0.59); C273(0.59)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C270(0.58); C273(0.58)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C270(0.35); C273(0.35)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C270(0.77); C273(0.77)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C270(0.84); C273(0.84)  LDD0650  [2]
 LDCM0335  AC70 HCT 116 C270(0.54); C273(0.54)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C270(0.77); C273(0.77)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C270(0.59); C273(0.59)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C270(0.55); C273(0.55)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C270(0.47); C273(0.47)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C270(0.49); C273(0.49)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C270(0.79); C273(0.79)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C270(0.80); C273(0.80)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C270(0.91); C273(0.91)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C270(0.72); C273(0.72)  LDD0661  [2]
 LDCM0346  AC80 HCT 116 C270(0.54); C273(0.54)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C270(0.87); C273(0.87)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C270(0.43); C273(0.43)  LDD0665  [2]
 LDCM0248  AKOS034007472 HEK-293T C134(0.98)  LDD1511  [4]
 LDCM0368  CL10 HEK-293T C134(1.57)  LDD1572  [4]
 LDCM0369  CL100 HEK-293T C134(1.00)  LDD1573  [4]
 LDCM0371  CL102 HEK-293T C134(1.10)  LDD1575  [4]
 LDCM0373  CL104 HEK-293T C134(1.01)  LDD1577  [4]
 LDCM0374  CL105 HCT 116 C270(0.88); C273(0.88)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C270(0.84); C273(0.84)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C270(0.71); C273(0.71)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C270(0.58); C273(0.58)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C270(0.72); C273(0.72)  LDD0695  [2]
 LDCM0380  CL110 HCT 116 C270(0.74); C273(0.74)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C270(0.69); C273(0.69)  LDD0698  [2]
 LDCM0382  CL112 HEK-293T C134(1.03)  LDD1586  [4]
 LDCM0384  CL114 HEK-293T C134(0.97)  LDD1588  [4]
 LDCM0386  CL116 HEK-293T C134(1.11)  LDD1590  [4]
 LDCM0388  CL118 HEK-293T C134(0.86)  LDD1592  [4]
 LDCM0391  CL120 HEK-293T C134(1.05)  LDD1595  [4]
 LDCM0393  CL122 HEK-293T C134(1.22)  LDD1597  [4]
 LDCM0395  CL124 HEK-293T C134(1.07)  LDD1599  [4]
 LDCM0396  CL125 HCT 116 C270(0.85); C273(0.85)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C270(0.79); C273(0.79)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C270(0.72); C273(0.72)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C270(0.57); C273(0.57)  LDD0716  [2]
 LDCM0401  CL14 HEK-293T C134(1.09)  LDD1605  [4]
 LDCM0403  CL16 HCT 116 C270(0.90); C273(0.90)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C270(0.80); C273(0.80)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C270(0.76); C273(0.76)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C270(0.79); C273(0.79)  LDD0723  [2]
 LDCM0407  CL2 HEK-293T C134(1.11)  LDD1611  [4]
 LDCM0408  CL20 HCT 116 C270(0.55); C273(0.55)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C270(0.48); C273(0.48)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C270(0.59); C273(0.59)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C270(0.46); C273(0.46)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C270(0.46); C273(0.46)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C270(0.59); C273(0.59)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C270(0.67); C273(0.67)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C270(0.78); C273(0.78)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C270(0.67); C273(0.67)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C270(0.54); C273(0.54)  LDD0734  [2]
 LDCM0419  CL30 HCT 116 C270(0.68); C273(0.68)  LDD0736  [2]
 LDCM0420  CL31 HEK-293T C134(1.04)  LDD1624  [4]
 LDCM0422  CL33 HEK-293T C134(1.17)  LDD1626  [4]
 LDCM0423  CL34 HEK-293T C134(1.17)  LDD1627  [4]
 LDCM0429  CL4 HEK-293T C134(1.02)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C134(1.02)  LDD1634  [4]
 LDCM0432  CL42 HEK-293T C134(1.11)  LDD1636  [4]
 LDCM0433  CL43 HEK-293T C134(1.07)  LDD1637  [4]
 LDCM0435  CL45 HEK-293T C134(1.17)  LDD1639  [4]
 LDCM0436  CL46 HEK-293T C134(1.19)  LDD1640  [4]
 LDCM0441  CL50 HEK-293T C134(1.12)  LDD1645  [4]
 LDCM0443  CL52 HEK-293T C134(1.03)  LDD1646  [4]
 LDCM0445  CL54 HEK-293T C134(1.24)  LDD1648  [4]
 LDCM0446  CL55 HEK-293T C134(1.23)  LDD1649  [4]
 LDCM0448  CL57 HEK-293T C134(1.22)  LDD1651  [4]
 LDCM0449  CL58 HEK-293T C134(1.53)  LDD1652  [4]
 LDCM0451  CL6 HEK-293T C134(1.05)  LDD1654  [4]
 LDCM0454  CL62 HEK-293T C134(1.18)  LDD1657  [4]
 LDCM0456  CL64 HEK-293T C134(0.91)  LDD1659  [4]
 LDCM0458  CL66 HEK-293T C134(1.18)  LDD1661  [4]
 LDCM0459  CL67 HEK-293T C134(1.13)  LDD1662  [4]
 LDCM0461  CL69 HEK-293T C134(1.13)  LDD1664  [4]
 LDCM0462  CL7 HEK-293T C134(1.13)  LDD1665  [4]
 LDCM0463  CL70 HEK-293T C134(1.17)  LDD1666  [4]
 LDCM0467  CL74 HEK-293T C134(1.08)  LDD1670  [4]
 LDCM0469  CL76 HEK-293T C134(1.07)  LDD1672  [4]
 LDCM0471  CL78 HEK-293T C134(1.00)  LDD1674  [4]
 LDCM0472  CL79 HEK-293T C134(1.16)  LDD1675  [4]
 LDCM0475  CL81 HEK-293T C134(1.12)  LDD1678  [4]
 LDCM0476  CL82 HEK-293T C134(1.19)  LDD1679  [4]
 LDCM0480  CL86 HEK-293T C134(1.55)  LDD1683  [4]
 LDCM0482  CL88 HEK-293T C134(1.02)  LDD1685  [4]
 LDCM0484  CL9 HEK-293T C134(1.12)  LDD1687  [4]
 LDCM0485  CL90 HEK-293T C134(1.56)  LDD1688  [4]
 LDCM0486  CL91 HEK-293T C134(1.01)  LDD1689  [4]
 LDCM0488  CL93 HEK-293T C134(1.09)  LDD1691  [4]
 LDCM0489  CL94 HEK-293T C134(1.16)  LDD1692  [4]
 LDCM0493  CL98 HEK-293T C134(1.25)  LDD1696  [4]
 LDCM0427  Fragment51 HEK-293T C134(0.96)  LDD1631  [4]
 LDCM0024  KB05 T cell-activated C134(6.81)  LDD1706  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase TRIM41 (TRIM41) TRIM/RBCC family Q8WV44
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
TBC1 domain family member 1 (TBC1D1) . Q86TI0
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytokine receptor-like factor 3 (CRLF3) Cytokine receptor-like factor 3 family Q8IUI8
Other
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caveolae-associated protein 1 (CAVIN1) CAVIN family Q6NZI2
Centrosomal protein of 19 kDa (CEP19) CEP19 family Q96LK0
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Protein LDOC1 (LDOC1) LDOC1 family O95751
Microfibrillar-associated protein 1 (MFAP1) MFAP1 family P55081
Testis-specific Y-encoded-like protein 2 (TSPYL2) Nucleosome assembly protein (NAP) family Q9H2G4
Calcium and integrin-binding family member 3 (CIB3) . Q96Q77
Caspase recruitment domain-containing protein 10 (CARD10) . Q9BWT7
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Coiled-coil domain-containing protein 125 (CCDC125) . Q86Z20
Emerin (EMD) . P50402
Huntingtin-associated protein 1 (HAP1) . P54257

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402