Details of the Target

General Information of Target

Target ID LDTP07484
Target Name Repulsive guidance molecule B (RGMB)
Gene Name RGMB
Gene ID 285704
Synonyms
Repulsive guidance molecule B; DRG11-responsive axonal guidance and outgrowth of neurite; DRAGON
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MGLRAAPSSAAAAAAEVEQRRSPGLCPPPLELLLLLLFSLGLLHAGDCQQPAQCRIQKCT
TDFVSLTSHLNSAVDGFDSEFCKALRAYAGCTQRTSKACRGNLVYHSAVLGISDLMSQRN
CSKDGPTSSTNPEVTHDPCNYHSHAGAREHRRGDQNPPSYLFCGLFGDPHLRTFKDNFQT
CKVEGAWPLIDNNYLSVQVTNVPVVPGSSATATNKITIIFKAHHECTDQKVYQAVTDDLP
AAFVDGTTSGGDSDAKSLRIVERESGHYVEMHARYIGTTVFVRQVGRYLTLAIRMPEDLA
MSYEESQDLQLCVNGCPLSERIDDGQGQVSAILGHSLPRTSLVQAWPGYTLETANTQCHE
KMPVKDIYFQSCVFDLLTTGDANFTAAAHSALEDVEALHPRKERWHIFPSSGNGTPRGGS
DLSVSLGLTCLILIVFL
Target Bioclass
Other
Family
Repulsive guidance molecule (RGM) family
Subcellular location
Cell membrane
Function
Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system. Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling. Promotes neuronal adhesion. May inhibit neurite outgrowth.
Uniprot ID
Q6NW40
Ensemble ID
ENST00000513185.3
HGNC ID
HGNC:26896

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C226(1.01)  LDD1492  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0259  AC14 HEK-293T C226(0.98)  LDD1512  [1]
 LDCM0281  AC21 HEK-293T C226(1.05)  LDD1520  [1]
 LDCM0282  AC22 HEK-293T C226(1.01)  LDD1521  [1]
 LDCM0284  AC24 HEK-293T C226(0.97)  LDD1523  [1]
 LDCM0289  AC29 HEK-293T C226(1.03)  LDD1528  [1]
 LDCM0291  AC30 HEK-293T C226(1.03)  LDD1530  [1]
 LDCM0293  AC32 HEK-293T C226(1.05)  LDD1532  [1]
 LDCM0298  AC37 HEK-293T C226(1.20)  LDD1537  [1]
 LDCM0299  AC38 HEK-293T C226(1.18)  LDD1538  [1]
 LDCM0302  AC40 HEK-293T C226(1.06)  LDD1541  [1]
 LDCM0307  AC45 HEK-293T C226(1.10)  LDD1546  [1]
 LDCM0308  AC46 HEK-293T C226(1.05)  LDD1547  [1]
 LDCM0310  AC48 HEK-293T C226(1.08)  LDD1549  [1]
 LDCM0312  AC5 HEK-293T C226(1.01)  LDD1551  [1]
 LDCM0316  AC53 HEK-293T C226(1.18)  LDD1555  [1]
 LDCM0317  AC54 HEK-293T C226(1.11)  LDD1556  [1]
 LDCM0319  AC56 HEK-293T C226(0.95)  LDD1558  [1]
 LDCM0323  AC6 HEK-293T C226(1.11)  LDD1562  [1]
 LDCM0325  AC61 HEK-293T C226(1.12)  LDD1564  [1]
 LDCM0326  AC62 HEK-293T C226(1.02)  LDD1565  [1]
 LDCM0328  AC64 HEK-293T C226(0.90)  LDD1567  [1]
 LDCM0345  AC8 HEK-293T C226(0.91)  LDD1569  [1]
 LDCM0248  AKOS034007472 HEK-293T C226(1.13)  LDD1511  [1]
 LDCM0275  AKOS034007705 HEK-293T C226(0.99)  LDD1514  [1]
 LDCM0367  CL1 HEK-293T C226(1.08)  LDD1571  [1]
 LDCM0368  CL10 HEK-293T C226(0.97)  LDD1572  [1]
 LDCM0370  CL101 HEK-293T C226(1.10)  LDD1574  [1]
 LDCM0374  CL105 HEK-293T C226(1.14)  LDD1578  [1]
 LDCM0378  CL109 HEK-293T C226(1.16)  LDD1582  [1]
 LDCM0383  CL113 HEK-293T C226(1.08)  LDD1587  [1]
 LDCM0387  CL117 HEK-293T C226(1.05)  LDD1591  [1]
 LDCM0390  CL12 HEK-293T C226(1.00)  LDD1594  [1]
 LDCM0392  CL121 HEK-293T C226(1.13)  LDD1596  [1]
 LDCM0396  CL125 HEK-293T C226(0.96)  LDD1600  [1]
 LDCM0400  CL13 HEK-293T C226(1.38)  LDD1604  [1]
 LDCM0409  CL21 HEK-293T C226(1.02)  LDD1613  [1]
 LDCM0410  CL22 HEK-293T C226(1.16)  LDD1614  [1]
 LDCM0412  CL24 HEK-293T C226(1.01)  LDD1616  [1]
 LDCM0413  CL25 HEK-293T C226(0.96)  LDD1617  [1]
 LDCM0422  CL33 HEK-293T C226(1.10)  LDD1626  [1]
 LDCM0423  CL34 HEK-293T C226(1.10)  LDD1627  [1]
 LDCM0425  CL36 HEK-293T C226(1.13)  LDD1629  [1]
 LDCM0426  CL37 HEK-293T C226(1.11)  LDD1630  [1]
 LDCM0435  CL45 HEK-293T C226(1.02)  LDD1639  [1]
 LDCM0436  CL46 HEK-293T C226(1.09)  LDD1640  [1]
 LDCM0438  CL48 HEK-293T C226(1.10)  LDD1642  [1]
 LDCM0439  CL49 HEK-293T C226(1.12)  LDD1643  [1]
 LDCM0448  CL57 HEK-293T C226(1.15)  LDD1651  [1]
 LDCM0449  CL58 HEK-293T C226(1.08)  LDD1652  [1]
 LDCM0452  CL60 HEK-293T C226(1.11)  LDD1655  [1]
 LDCM0453  CL61 HEK-293T C226(1.13)  LDD1656  [1]
 LDCM0461  CL69 HEK-293T C226(1.15)  LDD1664  [1]
 LDCM0463  CL70 HEK-293T C226(1.13)  LDD1666  [1]
 LDCM0465  CL72 HEK-293T C226(1.16)  LDD1668  [1]
 LDCM0466  CL73 HEK-293T C226(1.06)  LDD1669  [1]
 LDCM0475  CL81 HEK-293T C226(1.17)  LDD1678  [1]
 LDCM0476  CL82 HEK-293T C226(1.11)  LDD1679  [1]
 LDCM0478  CL84 HEK-293T C226(0.98)  LDD1681  [1]
 LDCM0479  CL85 HEK-293T C226(1.08)  LDD1682  [1]
 LDCM0484  CL9 HEK-293T C226(0.95)  LDD1687  [1]
 LDCM0488  CL93 HEK-293T C226(1.15)  LDD1691  [1]
 LDCM0489  CL94 HEK-293T C226(1.16)  LDD1692  [1]
 LDCM0491  CL96 HEK-293T C226(1.01)  LDD1694  [1]
 LDCM0492  CL97 HEK-293T C226(1.30)  LDD1695  [1]
 LDCM0022  KB02 HEK-293T C226(1.01)  LDD1492  [1]
 LDCM0023  KB03 HEK-293T C226(1.12)  LDD1497  [1]
 LDCM0024  KB05 HEK-293T C226(1.03)  LDD1502  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402