Details of the Target

General Information of Target

Target ID LDTP07475
Target Name Serine/threonine-protein phosphatase 4 regulatory subunit 4 (PPP4R4)
Gene Name PPP4R4
Gene ID 57718
Synonyms
KIAA1622; PP4R4; Serine/threonine-protein phosphatase 4 regulatory subunit 4
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MHPPPPAAAMDFSQNSLFGYMEDLQELTIIERPVRRSLKTPEEIERLTVDEDLSDIERAV
YLLSAGQDVQGTSVIANLPFLMRQNPTETLRRVLPKVREALHVAGVEMQLTAAMSFLTIL
QDESVSIHAYTHSFLQVILLHLEHRDTGVSNAWLETLLSVIEVLPKETLRHEILNPLVSK
AQLSQTVQSRLVSCKILGKLTNKFDAHTIKREILPLVKSLCQDVEYEVRSCMCRQLENIA
QGIGTELTKSVVLPELIELSRDEGSSVRLAAFETLVNLLDIFDTDDRSQTILPLVKSFCE
KSFKADESILISLSFHLGKLCHGLYGIFTPDQHLRFLEFYKKLCTLGLQQENGHNENQIP
PQILEQEKKYISVRKNCAYNFPAMIVFVDPKNFHMELYSTFFCLCHDPEVPVRYTIAICF
YEVSKLLNSGVYLIHKELITLLQDESLEVLDALIDHLPEILELMSTGGESSVQENKLSSL
PDLIPALTAAEQRAAASLKWRTHEKLLQKYACLPHVISSDQIYYRFLQRMFTIMMTNNVL
PVQKAASRTLCIFLRYNRKQEQRHEVIQKLIEQLGQGKSYWNRLRFLDTCEFIIEIFSKS
FFCKYFFLPAIELTHDPVANVRMKLCYLLPKVKSTLKIPADKHLLQQLEMCVRKLLCQEK
DKDVLAIVKRTVLELDRMEMSMDAFQKKFYEKDLLDQEKEREELLLLEMEQLEKEKQQND
GRPMSDKMFEKKRRDTKTPTQSLPKNIPISVPGPSSVTPSTSKEIKKSKLIRSQSFNNQA
FHAKYGNLEKCASKSSTTGYTTSVSGLGKTSVLSLADDSFRTRNASSVPSSFSPNTPLPS
TSRGTGNSVDPKSSGSKDTQPRKATLKSRKSNP
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Putative regulatory subunit of serine/threonine-protein phosphatase 4.
Uniprot ID
Q6NUP7
Ensemble ID
ENST00000304338.8
HGNC ID
HGNC:23788

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ABC1 SNV: p.N746K .
DEL Deletion: p.P6del
SNV: p.P4Q		 .
HCT116 Deletion: p.L81Ter .
IGR1 SNV: p.G577E .
IPC298 SNV: p.P330L .
JURKAT SNV: p.R234W .
KPL1 SNV: p.D283Y .
MCF7 SNV: p.D283Y .
MEWO SNV: p.Q576R .
MONOMAC6 SNV: p.G71E .
NCIH1155 SNV: p.L334F .
RKO SNV: p.V516A .
SUIT2 Deletion: p.C403KfsTer19 .
SW1116 SNV: p.Q241K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C551(0.97)  LDD1512  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0259  AC14 HEK-293T C551(0.97)  LDD1512  [1]
 LDCM0282  AC22 HEK-293T C551(0.74)  LDD1521  [1]
 LDCM0284  AC24 HEK-293T C626(1.16)  LDD1523  [1]
 LDCM0291  AC30 HEK-293T C551(0.76)  LDD1530  [1]
 LDCM0293  AC32 HEK-293T C626(1.03)  LDD1532  [1]
 LDCM0299  AC38 HEK-293T C551(1.52)  LDD1538  [1]
 LDCM0302  AC40 HEK-293T C626(0.88)  LDD1541  [1]
 LDCM0308  AC46 HEK-293T C551(0.99)  LDD1547  [1]
 LDCM0310  AC48 HEK-293T C626(1.05)  LDD1549  [1]
 LDCM0317  AC54 HEK-293T C551(0.96)  LDD1556  [1]
 LDCM0319  AC56 HEK-293T C626(1.07)  LDD1558  [1]
 LDCM0323  AC6 HEK-293T C551(1.21)  LDD1562  [1]
 LDCM0326  AC62 HEK-293T C551(0.92)  LDD1565  [1]
 LDCM0328  AC64 HEK-293T C626(1.08)  LDD1567  [1]
 LDCM0345  AC8 HEK-293T C626(1.05)  LDD1569  [1]
 LDCM0275  AKOS034007705 HEK-293T C626(1.21)  LDD1514  [1]
 LDCM0368  CL10 HEK-293T C551(1.17)  LDD1572  [1]
 LDCM0390  CL12 HEK-293T C626(1.14)  LDD1594  [1]
 LDCM0410  CL22 HEK-293T C551(1.48)  LDD1614  [1]
 LDCM0412  CL24 HEK-293T C626(1.30)  LDD1616  [1]
 LDCM0423  CL34 HEK-293T C551(0.91)  LDD1627  [1]
 LDCM0425  CL36 HEK-293T C626(0.86)  LDD1629  [1]
 LDCM0436  CL46 HEK-293T C551(1.29)  LDD1640  [1]
 LDCM0438  CL48 HEK-293T C626(0.96)  LDD1642  [1]
 LDCM0449  CL58 HEK-293T C551(0.84)  LDD1652  [1]
 LDCM0452  CL60 HEK-293T C626(1.15)  LDD1655  [1]
 LDCM0463  CL70 HEK-293T C551(1.08)  LDD1666  [1]
 LDCM0465  CL72 HEK-293T C626(0.91)  LDD1668  [1]
 LDCM0476  CL82 HEK-293T C551(0.98)  LDD1679  [1]
 LDCM0478  CL84 HEK-293T C626(1.11)  LDD1681  [1]
 LDCM0489  CL94 HEK-293T C551(0.65)  LDD1692  [1]
 LDCM0491  CL96 HEK-293T C626(1.27)  LDD1694  [1]
 LDCM0022  KB02 COLO792 C551(1.70)  LDD2476  [2]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840