Details of the Target

General Information of Target

Target ID LDTP07352
Target Name BRD4-interacting chromatin-remodeling complex-associated protein-like (BICRAL)
Gene Name BICRAL
Gene ID 23506
Synonyms
GLTSCR1L; KIAA0240; BRD4-interacting chromatin-remodeling complex-associated protein-like; Glioma tumor suppressor candidate region gene 1 protein-like
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MDDDDDSCLLDLIGDPQALNYFLHGPSNKSSNDDLTNAGYSAANSNSIFANSSNADPKSS
LKGVSNQLGEGPSDGLPLSSSLQFLEDELESSPLPDLTEDQPFDILQKSLQEANITEQTL
AEEAYLDASIGSSQQFAQAQLHPSSSASFTQASNVSNYSGQTLQPIGVTHVPVGASFASN
TVGVQHGFMQHVGISVPSQHLSNSSQISGSGQIQLIGSFGNHPSMMTINNLDGSQIILKG
SGQQAPSNVSGGLLVHRQTPNGNSLFGNSSSSPVAQPVTVPFNSTNFQTSLPVHNIIIQR
GLAPNSNKVPINIQPKPIQMGQQNTYNVNNLGIQQHHVQQGISFASASSPQGSVVGPHMS
VNIVNQQNTRKPVTSQAVSSTGGSIVIHSPMGQPHAPQSQFLIPTSLSVSSNSVHHVQTI
NGQLLQTQPSQLISGQVASEHVMLNRNSSNMLRTNQPYTGPMLNNQNTAVHLVSGQTFAA
SGSPVIANHASPQLVGGQMPLQQASPTVLHLSPGQSSVSQGRPGFATMPSVTSMSGPSRF
PAVSSASTAHPSLGSAVQSGSSGSNFTGDQLTQPNRTPVPVSVSHRLPVSSSKSTSTFSN
TPGTGTQQQFFCQAQKKCLNQTSPISAPKTTDGLRQAQIPGLLSTTLPGQDSGSKVISAS
LGTAQPQQEKVVGSSPGHPAVQVESHSGGQKRPAAKQLTKGAFILQQLQRDQAHTVTPDK
SHFRSLSDAVQRLLSYHVCQGSMPTEEDLRKVDNEFETVATQLLKRTQAMLNKYRCLLLE
DAMRINPSAEMVMIDRMFNQEERASLSRDKRLALVDPEGFQADFCCSFKLDKAAHETQFG
RSDQHGSKASSSLQPPAKAQGRDRAKTGVTEPMNHDQFHLVPNHIVVSAEGNISKKTECL
GRALKFDKVGLVQYQSTSEEKASRREPLKASQCSPGPEGHRKTSSRSDHGTESKLSSILA
DSHLEMTCNNSFQDKSLRNSPKNEVLHTDIMKGSGEPQPDLQLTKSLETTFKNILELKKA
GRQPQSDPTVSGSVELDFPNFSPMASQENCLEKFIPDHSEGVVETDSILEAAVNSILEC
Target Bioclass
Other
Function
Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner.
Uniprot ID
Q6AI39
Ensemble ID
ENST00000314073.10
HGNC ID
HGNC:21111

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C776(7.49)  LDD0209  [1]
IA-alkyne
 Probe Info  		C612(6.52)  LDD1704  [2]
NAIA_4
 Probe Info  		N.A.  LDD2226  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C968(0.82); C899(0.87)  LDD1508  [5]
 LDCM0226  AC11 HEK-293T C968(0.99)  LDD1509  [5]
 LDCM0237  AC12 HEK-293T C968(1.20)  LDD1510  [5]
 LDCM0270  AC15 HEK-293T C933(1.06); C899(1.02)  LDD1513  [5]
 LDCM0277  AC18 HEK-293T C968(1.31); C899(1.06)  LDD1516  [5]
 LDCM0278  AC19 HEK-293T C968(1.15)  LDD1517  [5]
 LDCM0279  AC2 HEK-293T C968(1.10); C899(1.08)  LDD1518  [5]
 LDCM0280  AC20 HEK-293T C968(1.03)  LDD1519  [5]
 LDCM0281  AC21 HEK-293T C899(1.04)  LDD1520  [5]
 LDCM0283  AC23 HEK-293T C933(1.55); C899(0.61)  LDD1522  [5]
 LDCM0286  AC26 HEK-293T C968(1.10); C899(0.65)  LDD1525  [5]
 LDCM0287  AC27 HEK-293T C968(0.95)  LDD1526  [5]
 LDCM0288  AC28 HEK-293T C968(1.07)  LDD1527  [5]
 LDCM0289  AC29 HEK-293T C899(0.94)  LDD1528  [5]
 LDCM0290  AC3 HEK-293T C968(1.11)  LDD1529  [5]
 LDCM0292  AC31 HEK-293T C933(1.00); C899(0.58)  LDD1531  [5]
 LDCM0295  AC34 HEK-293T C968(1.49); C899(1.08)  LDD1534  [5]
 LDCM0296  AC35 HEK-293T C968(1.18)  LDD1535  [5]
 LDCM0297  AC36 HEK-293T C968(1.15)  LDD1536  [5]
 LDCM0298  AC37 HEK-293T C899(1.16)  LDD1537  [5]
 LDCM0300  AC39 HEK-293T C933(1.17); C899(1.24)  LDD1539  [5]
 LDCM0301  AC4 HEK-293T C968(1.09)  LDD1540  [5]
 LDCM0304  AC42 HEK-293T C968(0.92); C899(0.66)  LDD1543  [5]
 LDCM0305  AC43 HEK-293T C968(1.05)  LDD1544  [5]
 LDCM0306  AC44 HEK-293T C968(0.92)  LDD1545  [5]
 LDCM0307  AC45 HEK-293T C899(0.85)  LDD1546  [5]
 LDCM0309  AC47 HEK-293T C933(1.06); C899(0.66)  LDD1548  [5]
 LDCM0312  AC5 HEK-293T C899(0.85)  LDD1551  [5]
 LDCM0313  AC50 HEK-293T C968(1.09); C899(0.76)  LDD1552  [5]
 LDCM0314  AC51 HEK-293T C968(0.87)  LDD1553  [5]
 LDCM0315  AC52 HEK-293T C968(1.09)  LDD1554  [5]
 LDCM0316  AC53 HEK-293T C899(0.82)  LDD1555  [5]
 LDCM0318  AC55 HEK-293T C933(1.12); C899(0.93)  LDD1557  [5]
 LDCM0321  AC58 HEK-293T C968(1.18); C899(0.96)  LDD1560  [5]
 LDCM0322  AC59 HEK-293T C968(0.93)  LDD1561  [5]
 LDCM0324  AC60 HEK-293T C968(1.11)  LDD1563  [5]
 LDCM0325  AC61 HEK-293T C899(0.86)  LDD1564  [5]
 LDCM0327  AC63 HEK-293T C933(0.97); C899(0.90)  LDD1566  [5]
 LDCM0334  AC7 HEK-293T C933(0.95); C899(1.23)  LDD1568  [5]
 LDCM0248  AKOS034007472 HEK-293T C899(0.98)  LDD1511  [5]
 LDCM0367  CL1 HEK-293T C968(0.89)  LDD1571  [5]
 LDCM0369  CL100 HEK-293T C933(0.82); C618(1.02)  LDD1573  [5]
 LDCM0370  CL101 HEK-293T C968(1.18)  LDD1574  [5]
 LDCM0372  CL103 HEK-293T C776(0.94)  LDD1576  [5]
 LDCM0373  CL104 HEK-293T C933(0.92); C618(1.03)  LDD1577  [5]
 LDCM0374  CL105 HEK-293T C968(1.25)  LDD1578  [5]
 LDCM0376  CL107 HEK-293T C776(0.81)  LDD1580  [5]
 LDCM0377  CL108 HEK-293T C933(0.99); C618(1.17)  LDD1581  [5]
 LDCM0378  CL109 HEK-293T C968(0.80)  LDD1582  [5]
 LDCM0379  CL11 HEK-293T C933(1.28); C899(0.93)  LDD1583  [5]
 LDCM0381  CL111 HEK-293T C776(0.91)  LDD1585  [5]
 LDCM0382  CL112 HEK-293T C933(1.30); C618(1.04)  LDD1586  [5]
 LDCM0383  CL113 HEK-293T C968(1.11)  LDD1587  [5]
 LDCM0385  CL115 HEK-293T C776(0.93)  LDD1589  [5]
 LDCM0386  CL116 HEK-293T C933(1.07); C618(1.12)  LDD1590  [5]
 LDCM0387  CL117 HEK-293T C968(0.92)  LDD1591  [5]
 LDCM0389  CL119 HEK-293T C776(0.96)  LDD1593  [5]
 LDCM0391  CL120 HEK-293T C933(1.17); C618(1.14)  LDD1595  [5]
 LDCM0392  CL121 HEK-293T C968(1.25)  LDD1596  [5]
 LDCM0394  CL123 HEK-293T C776(0.83)  LDD1598  [5]
 LDCM0395  CL124 HEK-293T C933(1.28); C618(1.11)  LDD1599  [5]
 LDCM0396  CL125 HEK-293T C968(1.08)  LDD1600  [5]
 LDCM0398  CL127 HEK-293T C776(0.91)  LDD1602  [5]
 LDCM0399  CL128 HEK-293T C933(1.11); C618(1.21)  LDD1603  [5]
 LDCM0400  CL13 HEK-293T C968(1.22)  LDD1604  [5]
 LDCM0402  CL15 HEK-293T C776(0.90)  LDD1606  [5]
 LDCM0403  CL16 HEK-293T C933(1.17); C618(1.13)  LDD1607  [5]
 LDCM0405  CL18 HEK-293T C968(1.13); C899(0.72)  LDD1609  [5]
 LDCM0406  CL19 HEK-293T C968(0.93)  LDD1610  [5]
 LDCM0408  CL20 HEK-293T C968(0.95)  LDD1612  [5]
 LDCM0409  CL21 HEK-293T C899(1.04)  LDD1613  [5]
 LDCM0411  CL23 HEK-293T C933(1.01); C899(0.91)  LDD1615  [5]
 LDCM0413  CL25 HEK-293T C968(0.94)  LDD1617  [5]
 LDCM0415  CL27 HEK-293T C776(1.09)  LDD1619  [5]
 LDCM0416  CL28 HEK-293T C933(1.11); C618(0.90)  LDD1620  [5]
 LDCM0418  CL3 HEK-293T C776(0.97)  LDD1622  [5]
 LDCM0419  CL30 HEK-293T C968(0.98); C899(0.93)  LDD1623  [5]
 LDCM0420  CL31 HEK-293T C968(0.90)  LDD1624  [5]
 LDCM0421  CL32 HEK-293T C968(1.02)  LDD1625  [5]
 LDCM0422  CL33 HEK-293T C899(0.70)  LDD1626  [5]
 LDCM0424  CL35 HEK-293T C933(1.09); C899(0.86)  LDD1628  [5]
 LDCM0426  CL37 HEK-293T C968(1.01)  LDD1630  [5]
 LDCM0428  CL39 HEK-293T C776(0.91)  LDD1632  [5]
 LDCM0429  CL4 HEK-293T C933(1.09); C618(1.20)  LDD1633  [5]
 LDCM0430  CL40 HEK-293T C933(1.05); C618(1.15)  LDD1634  [5]
 LDCM0432  CL42 HEK-293T C968(1.19); C899(0.93)  LDD1636  [5]
 LDCM0433  CL43 HEK-293T C968(0.90)  LDD1637  [5]
 LDCM0434  CL44 HEK-293T C968(0.99)  LDD1638  [5]
 LDCM0435  CL45 HEK-293T C899(0.75)  LDD1639  [5]
 LDCM0437  CL47 HEK-293T C933(1.02); C899(1.00)  LDD1641  [5]
 LDCM0439  CL49 HEK-293T C968(0.87)  LDD1643  [5]
 LDCM0443  CL52 HEK-293T C933(1.08); C618(1.02)  LDD1646  [5]
 LDCM0445  CL54 HEK-293T C968(1.34); C899(1.00)  LDD1648  [5]
 LDCM0446  CL55 HEK-293T C968(0.99)  LDD1649  [5]
 LDCM0447  CL56 HEK-293T C968(0.97)  LDD1650  [5]
 LDCM0448  CL57 HEK-293T C899(0.99)  LDD1651  [5]
 LDCM0450  CL59 HEK-293T C933(1.11); C899(0.77)  LDD1653  [5]
 LDCM0451  CL6 HEK-293T C968(0.85); C899(0.89)  LDD1654  [5]
 LDCM0453  CL61 HEK-293T C968(1.17)  LDD1656  [5]
 LDCM0455  CL63 HEK-293T C776(0.98)  LDD1658  [5]
 LDCM0456  CL64 HEK-293T C933(1.42); C618(1.14)  LDD1659  [5]
 LDCM0458  CL66 HEK-293T C968(1.00); C899(1.51)  LDD1661  [5]
 LDCM0459  CL67 HEK-293T C968(0.78)  LDD1662  [5]
 LDCM0460  CL68 HEK-293T C968(0.89)  LDD1663  [5]
 LDCM0461  CL69 HEK-293T C899(1.00)  LDD1664  [5]
 LDCM0462  CL7 HEK-293T C968(0.93)  LDD1665  [5]
 LDCM0464  CL71 HEK-293T C933(1.30); C899(0.88)  LDD1667  [5]
 LDCM0466  CL73 HEK-293T C968(1.17)  LDD1669  [5]
 LDCM0469  CL76 HEK-293T C933(0.98); C618(0.96)  LDD1672  [5]
 LDCM0471  CL78 HEK-293T C968(1.03); C899(0.67)  LDD1674  [5]
 LDCM0472  CL79 HEK-293T C968(0.78)  LDD1675  [5]
 LDCM0473  CL8 HEK-293T C968(0.86)  LDD1676  [5]
 LDCM0474  CL80 HEK-293T C968(0.89)  LDD1677  [5]
 LDCM0475  CL81 HEK-293T C899(0.79)  LDD1678  [5]
 LDCM0477  CL83 HEK-293T C933(1.09); C899(0.86)  LDD1680  [5]
 LDCM0479  CL85 HEK-293T C968(0.93)  LDD1682  [5]
 LDCM0481  CL87 HEK-293T C776(0.88)  LDD1684  [5]
 LDCM0482  CL88 HEK-293T C933(1.35); C618(1.05)  LDD1685  [5]
 LDCM0484  CL9 HEK-293T C899(1.24)  LDD1687  [5]
 LDCM0485  CL90 HEK-293T C968(1.22); C899(0.79)  LDD1688  [5]
 LDCM0486  CL91 HEK-293T C968(0.84)  LDD1689  [5]
 LDCM0487  CL92 HEK-293T C968(1.08)  LDD1690  [5]
 LDCM0488  CL93 HEK-293T C899(0.78)  LDD1691  [5]
 LDCM0490  CL95 HEK-293T C933(0.93); C899(0.85)  LDD1693  [5]
 LDCM0492  CL97 HEK-293T C968(1.34)  LDD1695  [5]
 LDCM0494  CL99 HEK-293T C776(0.88)  LDD1697  [5]
 LDCM0495  E2913 HEK-293T C776(0.89)  LDD1698  [5]
 LDCM0468  Fragment33 HEK-293T C776(0.95)  LDD1671  [5]
 LDCM0022  KB02 T cell-activated C612(6.52)  LDD1704  [2]
 LDCM0023  KB03 Jurkat C776(7.49)  LDD0209  [1]
 LDCM0024  KB05 OVCAR-4 C776(2.15)  LDD3382  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable E3 ubiquitin-protein ligase DTX2 (DTX2) Deltex family Q86UW9
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (NGLY1) PNGase family Q96IV0
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Exocyst complex component 8 (EXOC8) EXO84 family Q8IYI6
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcriptional regulator QRICH1 (QRICH1) . Q2TAL8
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Phakinin (BFSP2) Intermediate filament family Q13515
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Proline-rich protein 20D (PRR20D) PRR20 family P86480
Rho GDP-dissociation inhibitor 3 (ARHGDIG) Rho GDI family Q99819
Heat shock protein beta-2 (HSPB2) Small heat shock protein (HSP20) family Q16082
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840