Details of the Target

General Information of Target

Target ID LDTP07303
Target Name Kazrin (KAZN)
Gene Name KAZN
Gene ID 23254
Synonyms
C1orf196; KAZ; KIAA1026; Kazrin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMEDNKQLALRIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAG
DSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATEL
RVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNY
EQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAEL
AMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTAAIRQSQQTLYHSHPPH
PADRQAVRVSPCHSRQPSVISDASAAEGDRSSTPSDINSPRHRTHSLCNGDSPGPVQKNL
HNPIVQSLEDLEDQKRKKKKEKMGFGSISRVFARGKQRKSLDPGLFDDSDSQCSPTRQSL
SLSEGEEQMDRLQQVELVRTTPMSHWKAGTVQAWLEVVMAMPMYVKACTENVKSGKVLLS
LSDEDLQLGLGVCSSLHRRKLRLAIEDYRDAEAGRSLSKAAELDHHWVAKAWLNDIGLSQ
YSQAFQNHLVDGRMLNSLMKRDLEKHLNVSKKFHQVSILLGIELLYQVNFSREALQERRA
RCETQNIDPVVWTNQRVLKWVRDIDLKEYADNLTNSGVHGAVLVLEPTFNAEAMATALGI
PSGKHILRRHLAEEMSAVFHPANSTGIREAERFGTPPGRASSVTRAGKEENSSGLKYKAG
RLPLGKIGRGFSSKDPDFHDDYGSLQNEDCGDDDPQSRLEQCRLEGYNSLEVTNV
Target Bioclass
Other
Family
Kazrin family
Subcellular location
Cytoplasm; Cytoplasm, cytoskeleton
Function Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known.
Uniprot ID
Q674X7
Ensemble ID
ENST00000361144.9
HGNC ID
HGNC:29173

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO792 SNV: p.F679V .
HEPG2 SNV: p.V319L .
IGR1 SNV: p.D410N .
L428 SNV: p.S676N .
SNGM SNV: p.S542A .
SW756 SNV: p.E81K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C312(2.42)  LDD1702  [1]
DBIA
 Probe Info  		C348(1.24)  LDD1507  [2]
NAIA_5
 Probe Info  		N.A.  LDD2224  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C348(1.24)  LDD1507  [2]
 LDCM0237  AC12 HEK-293T C348(1.12)  LDD1510  [2]
 LDCM0259  AC14 HEK-293T C348(0.94)  LDD1512  [2]
 LDCM0270  AC15 HEK-293T C348(1.07)  LDD1513  [2]
 LDCM0276  AC17 HEK-293T C348(1.25)  LDD1515  [2]
 LDCM0280  AC20 HEK-293T C348(1.02)  LDD1519  [2]
 LDCM0281  AC21 HEK-293T C348(1.18)  LDD1520  [2]
 LDCM0282  AC22 HEK-293T C348(0.96)  LDD1521  [2]
 LDCM0283  AC23 HEK-293T C348(0.92)  LDD1522  [2]
 LDCM0285  AC25 HEK-293T C348(1.10)  LDD1524  [2]
 LDCM0288  AC28 HEK-293T C348(0.98)  LDD1527  [2]
 LDCM0289  AC29 HEK-293T C348(1.12)  LDD1528  [2]
 LDCM0291  AC30 HEK-293T C348(1.04)  LDD1530  [2]
 LDCM0292  AC31 HEK-293T C348(0.95)  LDD1531  [2]
 LDCM0294  AC33 HEK-293T C348(1.47)  LDD1533  [2]
 LDCM0297  AC36 HEK-293T C348(1.23)  LDD1536  [2]
 LDCM0298  AC37 HEK-293T C348(1.07)  LDD1537  [2]
 LDCM0299  AC38 HEK-293T C348(1.14)  LDD1538  [2]
 LDCM0300  AC39 HEK-293T C348(1.18)  LDD1539  [2]
 LDCM0301  AC4 HEK-293T C348(1.03)  LDD1540  [2]
 LDCM0303  AC41 HEK-293T C348(1.30)  LDD1542  [2]
 LDCM0306  AC44 HEK-293T C348(1.13)  LDD1545  [2]
 LDCM0307  AC45 HEK-293T C348(1.03)  LDD1546  [2]
 LDCM0308  AC46 HEK-293T C348(1.05)  LDD1547  [2]
 LDCM0309  AC47 HEK-293T C348(1.16)  LDD1548  [2]
 LDCM0311  AC49 HEK-293T C348(1.32)  LDD1550  [2]
 LDCM0312  AC5 HEK-293T C348(0.98)  LDD1551  [2]
 LDCM0315  AC52 HEK-293T C348(1.10)  LDD1554  [2]
 LDCM0316  AC53 HEK-293T C348(1.16)  LDD1555  [2]
 LDCM0317  AC54 HEK-293T C348(1.20)  LDD1556  [2]
 LDCM0318  AC55 HEK-293T C348(1.13)  LDD1557  [2]
 LDCM0320  AC57 HEK-293T C348(1.40)  LDD1559  [2]
 LDCM0323  AC6 HEK-293T C348(1.13)  LDD1562  [2]
 LDCM0324  AC60 HEK-293T C348(1.09)  LDD1563  [2]
 LDCM0325  AC61 HEK-293T C348(1.11)  LDD1564  [2]
 LDCM0326  AC62 HEK-293T C348(0.98)  LDD1565  [2]
 LDCM0327  AC63 HEK-293T C348(1.02)  LDD1566  [2]
 LDCM0334  AC7 HEK-293T C348(1.06)  LDD1568  [2]
 LDCM0248  AKOS034007472 HEK-293T C348(1.05)  LDD1511  [2]
 LDCM0356  AKOS034007680 HEK-293T C348(1.37)  LDD1570  [2]
 LDCM0368  CL10 HEK-293T C348(0.78)  LDD1572  [2]
 LDCM0379  CL11 HEK-293T C348(0.90)  LDD1583  [2]
 LDCM0404  CL17 HEK-293T C348(1.09)  LDD1608  [2]
 LDCM0408  CL20 HEK-293T C348(1.07)  LDD1612  [2]
 LDCM0409  CL21 HEK-293T C348(0.99)  LDD1613  [2]
 LDCM0410  CL22 HEK-293T C348(1.15)  LDD1614  [2]
 LDCM0411  CL23 HEK-293T C348(1.00)  LDD1615  [2]
 LDCM0417  CL29 HEK-293T C348(1.32)  LDD1621  [2]
 LDCM0421  CL32 HEK-293T C348(0.96)  LDD1625  [2]
 LDCM0422  CL33 HEK-293T C348(1.05)  LDD1626  [2]
 LDCM0423  CL34 HEK-293T C348(0.93)  LDD1627  [2]
 LDCM0424  CL35 HEK-293T C348(0.96)  LDD1628  [2]
 LDCM0431  CL41 HEK-293T C348(0.91)  LDD1635  [2]
 LDCM0434  CL44 HEK-293T C348(1.00)  LDD1638  [2]
 LDCM0435  CL45 HEK-293T C348(0.93)  LDD1639  [2]
 LDCM0436  CL46 HEK-293T C348(1.13)  LDD1640  [2]
 LDCM0437  CL47 HEK-293T C348(0.89)  LDD1641  [2]
 LDCM0440  CL5 HEK-293T C348(1.21)  LDD1644  [2]
 LDCM0444  CL53 HEK-293T C348(1.08)  LDD1647  [2]
 LDCM0447  CL56 HEK-293T C348(0.96)  LDD1650  [2]
 LDCM0448  CL57 HEK-293T C348(1.26)  LDD1651  [2]
 LDCM0449  CL58 HEK-293T C348(1.09)  LDD1652  [2]
 LDCM0450  CL59 HEK-293T C348(0.89)  LDD1653  [2]
 LDCM0457  CL65 HEK-293T C348(1.49)  LDD1660  [2]
 LDCM0460  CL68 HEK-293T C348(0.96)  LDD1663  [2]
 LDCM0461  CL69 HEK-293T C348(0.93)  LDD1664  [2]
 LDCM0463  CL70 HEK-293T C348(0.84)  LDD1666  [2]
 LDCM0464  CL71 HEK-293T C348(0.89)  LDD1667  [2]
 LDCM0470  CL77 HEK-293T C348(1.00)  LDD1673  [2]
 LDCM0473  CL8 HEK-293T C348(0.98)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C348(1.05)  LDD1677  [2]
 LDCM0475  CL81 HEK-293T C348(1.03)  LDD1678  [2]
 LDCM0476  CL82 HEK-293T C348(0.85)  LDD1679  [2]
 LDCM0477  CL83 HEK-293T C348(0.97)  LDD1680  [2]
 LDCM0483  CL89 HEK-293T C348(1.05)  LDD1686  [2]
 LDCM0484  CL9 HEK-293T C348(0.96)  LDD1687  [2]
 LDCM0487  CL92 HEK-293T C348(1.00)  LDD1690  [2]
 LDCM0488  CL93 HEK-293T C348(0.89)  LDD1691  [2]
 LDCM0489  CL94 HEK-293T C348(0.88)  LDD1692  [2]
 LDCM0490  CL95 HEK-293T C348(1.00)  LDD1693  [2]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C312(2.42)  LDD1702  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin carboxyl-terminal hydrolase 2 (USP2) Peptidase C19 family O75604
Proteasome subunit alpha type-1 (PSMA1) Peptidase T1A family P25786
Tensin-4 (TNS4) PTEN phosphatase protein family Q8IZW8
Thioredoxin, mitochondrial (TXN2) Thioredoxin family Q99757
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Leucine zipper putative tumor suppressor 1 (LZTS1) LZTS family Q9Y250
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AT-rich interactive domain-containing protein 5A (ARID5A) . Q03989
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
RNA-binding protein FXR1 (FXR1) FMR1 family P51114
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Clavesin-2 (CLVS2) . Q5SYC1
Hamartin (TSC1) . Q92574

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264