Details of the Target

General Information of Target

Target ID LDTP07174
Target Name Protein furry homolog (FRY)
Gene Name FRY
Gene ID 10129
Synonyms
C13orf14; Protein furry homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASQQDSGFFEISIKYLLKSWSNTSPVGNGYIKPPVPPASGTHREKGPPTMLPINVDPDS
KPGEYVLKSLFVNFTTQAERKIRIIMAEPLEKPLTKSLQRGEDPQFDQVISSMSSLSEYC
LPSILRTLFDWYKRQNGIEDESHEYRPRTSNKSKSDEQQRDYLMERRDLAIDFIFSLVLI
EVLKQIPLHPVIDSLIHDVINLAFKHFKYKEGYLGPNTGNMHIVADLYAEVIGVLAQAKF
PAVKKKFMAELKELRHKEQNPYVVQSIISLIMGMKFFRIKMYPVEDFEASLQFMQECAHY
FLEVKDKDIKHALAGLFVEILVPVAAAVKNEVNVPCLRNFVESLYDTTLELSSRKKHSLA
LYPLVTCLLCVSQKQLFLNRWHIFLNNCLSNLKNKDPKMARVALESLYRLLWVYMIRIKC
ESNTATQSRLITIITTLFPKGSRGVVPRDMPLNIFVKIIQFIAQERLDFAMKEIIFDFLC
VGKPAKAFSLNPERMNIGLRAFLVIADSLQQKDGEPPMPVTGAVLPSGNTLRVKKTYLSK
TLTEEEAKMIGMSLYYSQVRKAVDNILRHLDKEVGRCMMLTNVQMLNKEPEDMITGERKP
KIDLFRTCVAAIPRLLPDGMSKLELIDLLARLSIHMDDELRHIAQNSLQGLLVDFSDWRE
DVLFGFTNFLLREVNDMHHTLLDSSLKLLLQLLTQWKLVIQTQGKVYEQANKIRNSELIA
NGSSHRIQSERGPHCSVLHAVEGFALVLLCSFQVATRKLSVLILKEIRALFIALGQPEDD
DRPMIDVMDQLSSSILESFIHVAVSDSATLPLTHNVDLQWLVEWNAVLVNSHYDVKSPSH
VWIFAQSVKDPWVLCLFSFLRQENLPKHCPTALSYAWPYAFTRLQSVMPLVDPNSPINAK
KTSTAGSGDNYVTLWRNYLILCFGVAKPSIMSPGHLRASTPEIMATTPDGTVSYDNKAIG
TPSVGVLLKQLVPLMRLESIEITESLVLGFGRTNSLVFRELVEELHPLMKEALERRPENK
KRRERRDLLRLQLLRIFELLADAGVISDSTNGALERDTLALGALFLEYVDLTRMLLEAEN
DKEVEILKDIRAHFSAMVANLIQCVPVHHRRFLFPQQSLRHHLFILFSQWAGPFSIMFTP
LDRYSDRNHQITRYQYCALKAMSAVLCCGPVFDNVGLSPDGYLYKWLDNILACQDLRVHQ
LGCEVVVLLLELNPDQINLFNWAIDRCYTGSYQLASGCFKAIATVCGSRNYPFDIVTLLN
LVLFKASDTNREIYEISMQLMQILEAKLFVYSKKVAEQRPGSILYGTHGPLPPLYSVSLA
LLSCELARMYPELTLPLFSEVSQRFPTTHPNGRQIMLTYLLPWLHNIELVDSRLLLPGSS
PSSPEDEVKDREGDVTASHGLRGNGWGSPEATSLVLNNLMYMTAKYGDEVPGPEMENAWN
ALANNEKWSNNLRITLQFLISLCGVSSDTVLLPYIKKVAIYLCRNNTIQTMEELLFELQQ
TEPVNPIVQHCDNPPFYRFTASSKASAAASGTTSSSNTVVAGQENFPDAEENKILKESDE
RFSNVIRAHTRLESRYSNSSGGSYDEDKNDPISPYTGWLLTITETKQPQPLPMPCTGGCW
APLVDYLPETITPRGPLHRCNIAVIFMTEMVVDHSVREDWALHLPLLLHAVFLGLDHYRP
EVFEHSKKLLLHLLIALSCNSNFHSIASVLLQTREMGEAKTLTVQPAYQPEYLYTGGFDF
LREDQSSPVPDSGLSSSSTSSSISLGGSSGNLPQMTQEVEDVDTAAETDEKANKLIEFLT
TRAFGPLWCHEDITPKNQNSKSAEQLTNFLRHVVSVFKDSKSGFHLEHQLSEVALQTALA
SSSRHYAGRSFQIFRALKQPLSAHALSDLLSRLVEVIGEHGDEIQGYVMEALLTLEAAVD
NLSDCLKNSDLLTVLSRSSSPDLSSSSKLTASRKSTGQLNMNPGTTSGNTATAERSRHQR
SFSVPKKFGVIDRSSDPPRSATLDRIQACTQQGLSSKTRSSSSLKDSLTDPSHINHPTNL
LATIFWVTVALMESDFEFEYLMALRLLSRLLAHMPLDKAENREKLEKLQAQLKWADFSGL
QQLLLKGFTSLTTTDLTLQLFSLLTPVSKISMVDASHAIGFPLNVLCLLPQLIQHFENPN
QFCKDIAERIAQVCLEEKNPKLSNLAHVMTLYKTHSYTRDCATWVNVVCRYLHEAYADIT
LNMVTYLAELLEKGLPSVQQPLLQVIYSLLSYMDLSVVPVKQFNVEVLKTIEKYVQSVHW
REALNILKLVVSRSASLVLPSYQHSDLSKIEIHRVWTSASKELPGKTLDFHFDISETPII
GRRYDELQNSSGRDGKPRAMAVTRSTSSTSSGSNSNVLVPVSWKRPQYSQKRTKEKLVHV
LSLCGQEVGLSKNPSVIFSSCGDLDLLEHQTSLVSSEDGAREQENMDDTNSEQQFRVFRD
FDFLDVELEDGEGESMDNFNWGVRRRSLDSLDKCDMQILEERQLSGSTPSLNKMHHEDSD
ESSEEEDLTASQILEHSDLIMTLSPSEETNPMELLTTACDSTPAEPHSFNTRMSSFDASL
PDMNNLQISEGSKAEAVREEEDTTVHEDDLSSSINELPAAFECSDSFSLDMTEGEEKGNR
ALDQFTLASFGEGDRGVSPPPSPFFSAILAAFQPAACDDAEEAWRSHINQLMCDSDGSCA
VYTFHVFSSLFKNIQKRFCFLTCDAASYLGDNLRGIGSKFVSSSQMLTSCSECPTLFVDA
ETLLSCGLLDKLKFSVLELQEYLDTYNNRKEATLSWLANCKATFAGGSRDGVITCQPGDS
EEKQLELCQRLYKLHFQLLLLFQSYCKLIGQVHEVSSMPELLNMSRELSDLKKHLKEASA
VIAADPLYSDGAWSEPTFTSTEAAIQSMLECLKNNELGKALRQIRECRSLWPNDIFGSSS
DDEVQTLLNIYFRHQTLGQTGTYALVGSNQSLTEICTKLMELNMEIRDMIRRAQSYRVLT
TFLPDSSVSGTSL
Target Bioclass
Other
Family
Furry protein family
Subcellular location
Cytoplasm
Function
Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.
Uniprot ID
Q5TBA9
Ensemble ID
ENST00000542859.6
HGNC ID
HGNC:20367

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C420(3.63)  LDD3333  [1]
BTD
 Probe Info  		C2976(0.96)  LDD2123  [2]
NAIA_5
 Probe Info  		C1246(20.00)  LDD2227  [3]
CY-1
 Probe Info  		E2266(0.00); E2272(0.00)  LDD0246  [4]
N1
 Probe Info  		N.A.  LDD0245  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0259  AC14 HEK-293T C2800(1.03)  LDD1512  [5]
 LDCM0282  AC22 HEK-293T C2800(1.00)  LDD1521  [5]
 LDCM0284  AC24 HEK-293T C2800(1.00)  LDD1523  [5]
 LDCM0291  AC30 HEK-293T C2800(0.90)  LDD1530  [5]
 LDCM0293  AC32 HEK-293T C2800(1.08)  LDD1532  [5]
 LDCM0299  AC38 HEK-293T C2800(1.08)  LDD1538  [5]
 LDCM0302  AC40 HEK-293T C2800(1.09)  LDD1541  [5]
 LDCM0308  AC46 HEK-293T C2800(1.08)  LDD1547  [5]
 LDCM0310  AC48 HEK-293T C2800(1.04)  LDD1549  [5]
 LDCM0317  AC54 HEK-293T C2800(0.99)  LDD1556  [5]
 LDCM0319  AC56 HEK-293T C2800(1.07)  LDD1558  [5]
 LDCM0323  AC6 HEK-293T C2800(0.87)  LDD1562  [5]
 LDCM0326  AC62 HEK-293T C2800(0.91)  LDD1565  [5]
 LDCM0328  AC64 HEK-293T C2800(1.09)  LDD1567  [5]
 LDCM0345  AC8 HEK-293T C2800(0.99)  LDD1569  [5]
 LDCM0275  AKOS034007705 HEK-293T C2800(1.07)  LDD1514  [5]
 LDCM0632  CL-Sc Hep-G2 C1246(20.00)  LDD2227  [3]
 LDCM0368  CL10 HEK-293T C2800(1.01)  LDD1572  [5]
 LDCM0390  CL12 HEK-293T C2800(0.95)  LDD1594  [5]
 LDCM0410  CL22 HEK-293T C2800(0.98)  LDD1614  [5]
 LDCM0412  CL24 HEK-293T C2800(0.95)  LDD1616  [5]
 LDCM0423  CL34 HEK-293T C2800(1.03)  LDD1627  [5]
 LDCM0425  CL36 HEK-293T C2800(0.94)  LDD1629  [5]
 LDCM0436  CL46 HEK-293T C2800(1.00)  LDD1640  [5]
 LDCM0438  CL48 HEK-293T C2800(0.90)  LDD1642  [5]
 LDCM0449  CL58 HEK-293T C2800(0.98)  LDD1652  [5]
 LDCM0452  CL60 HEK-293T C2800(0.91)  LDD1655  [5]
 LDCM0463  CL70 HEK-293T C2800(0.98)  LDD1666  [5]
 LDCM0465  CL72 HEK-293T C2800(1.01)  LDD1668  [5]
 LDCM0476  CL82 HEK-293T C2800(0.98)  LDD1679  [5]
 LDCM0478  CL84 HEK-293T C2800(1.04)  LDD1681  [5]
 LDCM0489  CL94 HEK-293T C2800(0.91)  LDD1692  [5]
 LDCM0491  CL96 HEK-293T C2800(1.04)  LDD1694  [5]
 LDCM0022  KB02 EoL-1 C2174(1.44)  LDD2324  [1]
 LDCM0023  KB03 EoL-1 C2174(5.12)  LDD2741  [1]
 LDCM0024  KB05 MOLM-13 C420(3.63)  LDD3333  [1]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C2976(0.96)  LDD2123  [2]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402