Details of the Target

General Information of Target

Target ID LDTP06984
Target Name DDB1- and CUL4-associated factor 17 (DCAF17)
Gene Name DCAF17
Gene ID 80067
Synonyms
C2orf37; DDB1- and CUL4-associated factor 17
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MGPTRKPNVCSRLSRRALGCFSRDAGVVQRTNLGILRALVCQESTKFKNVWTTHSRSPIA
YERGRIYFDNYRRCVSSVASEPRKLYEMPKCSKSEKIEDALLWECPVGDILPNSSDYKSS
LIALTAHNWLLRISATTGKILEKIYLAPYCKFRYLSWDTPQEVIAVKSAQNRGSAVARQA
GIQQHVLLYLAVFRVLPFSLVGILEINKKIFGNVTDATLSHGILIVMYSSGLVRLYSFQT
IAEQFMQQKLDLGCACRWGGTTGTVGEAPFGIPCNIKITDMPPLLFEVSSLENAFQIGGH
PWHYIVTPNKKKQKGVFHICALKDNSLAKNGIQEMDCCSLESDWIYFHPDASGRIIHVGP
NQVKVLKLTEIENNSSQHQISEDFVILANRENHKNENVLTVTASGRVVKKSFNLLDDDPE
QETFKIVDYEDELDLLSVVAVTQIDAEGKAHLDFHCNEYGTLLKSIPLVESWDVTYSHEV
YFDRDLVLHIEQKPNRVFSCYVYQMICDTGEEEETINRSC
Target Bioclass
Other
Subcellular location
Membrane
Function May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Uniprot ID
Q5H9S7
Ensemble ID
ENST00000375255.8
HGNC ID
HGNC:25784

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DANG SNV: p.S437F .
HEC1 SNV: p.S375R; p.R390S .
HT3 SNV: p.L285F .
ICC137 SNV: p.E382K .
IGR1 SNV: p.P360L .
RCC10RGB SNV: p.L219V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C20(22.33)  LDD0209  [1]
IA-alkyne
 Probe Info  		C20(9.36)  LDD1704  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C20(1.11); C456(1.15)  LDD1508  [3]
 LDCM0226  AC11 HEK-293T C20(0.91)  LDD1509  [3]
 LDCM0277  AC18 HEK-293T C20(1.20); C456(1.24)  LDD1516  [3]
 LDCM0278  AC19 HEK-293T C20(0.91)  LDD1517  [3]
 LDCM0279  AC2 HEK-293T C20(0.98); C456(1.07)  LDD1518  [3]
 LDCM0281  AC21 HEK-293T C20(1.09)  LDD1520  [3]
 LDCM0284  AC24 HEK-293T C20(0.91)  LDD1523  [3]
 LDCM0286  AC26 HEK-293T C20(1.04); C456(1.12)  LDD1525  [3]
 LDCM0287  AC27 HEK-293T C20(0.96)  LDD1526  [3]
 LDCM0289  AC29 HEK-293T C20(1.03)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C20(1.09)  LDD1529  [3]
 LDCM0293  AC32 HEK-293T C20(0.94)  LDD1532  [3]
 LDCM0295  AC34 HEK-293T C20(1.08); C456(1.24)  LDD1534  [3]
 LDCM0296  AC35 HEK-293T C20(0.99)  LDD1535  [3]
 LDCM0298  AC37 HEK-293T C20(0.95)  LDD1537  [3]
 LDCM0302  AC40 HEK-293T C20(0.95)  LDD1541  [3]
 LDCM0304  AC42 HEK-293T C20(0.97); C456(1.20)  LDD1543  [3]
 LDCM0305  AC43 HEK-293T C20(0.91)  LDD1544  [3]
 LDCM0307  AC45 HEK-293T C20(1.03)  LDD1546  [3]
 LDCM0310  AC48 HEK-293T C20(0.89)  LDD1549  [3]
 LDCM0312  AC5 HEK-293T C20(1.03)  LDD1551  [3]
 LDCM0313  AC50 HEK-293T C20(0.96); C456(1.35)  LDD1552  [3]
 LDCM0314  AC51 HEK-293T C20(1.02)  LDD1553  [3]
 LDCM0316  AC53 HEK-293T C20(1.06)  LDD1555  [3]
 LDCM0319  AC56 HEK-293T C20(1.02)  LDD1558  [3]
 LDCM0321  AC58 HEK-293T C20(1.05); C456(1.18)  LDD1560  [3]
 LDCM0322  AC59 HEK-293T C20(0.90)  LDD1561  [3]
 LDCM0325  AC61 HEK-293T C20(1.00)  LDD1564  [3]
 LDCM0328  AC64 HEK-293T C20(1.07)  LDD1567  [3]
 LDCM0345  AC8 HEK-293T C20(0.90)  LDD1569  [3]
 LDCM0248  AKOS034007472 HEK-293T C20(1.05)  LDD1511  [3]
 LDCM0275  AKOS034007705 HEK-293T C20(1.06)  LDD1514  [3]
 LDCM0369  CL100 HEK-293T C20(1.07)  LDD1573  [3]
 LDCM0372  CL103 HEK-293T C20(1.18)  LDD1576  [3]
 LDCM0373  CL104 HEK-293T C20(1.07)  LDD1577  [3]
 LDCM0376  CL107 HEK-293T C20(0.92)  LDD1580  [3]
 LDCM0377  CL108 HEK-293T C20(1.04)  LDD1581  [3]
 LDCM0381  CL111 HEK-293T C20(1.06)  LDD1585  [3]
 LDCM0382  CL112 HEK-293T C20(1.15)  LDD1586  [3]
 LDCM0385  CL115 HEK-293T C20(1.03)  LDD1589  [3]
 LDCM0386  CL116 HEK-293T C20(1.00)  LDD1590  [3]
 LDCM0389  CL119 HEK-293T C20(1.04)  LDD1593  [3]
 LDCM0390  CL12 HEK-293T C20(0.90)  LDD1594  [3]
 LDCM0391  CL120 HEK-293T C20(1.19)  LDD1595  [3]
 LDCM0394  CL123 HEK-293T C20(1.05)  LDD1598  [3]
 LDCM0395  CL124 HEK-293T C20(0.96)  LDD1599  [3]
 LDCM0398  CL127 HEK-293T C20(1.04)  LDD1602  [3]
 LDCM0399  CL128 HEK-293T C20(1.09)  LDD1603  [3]
 LDCM0402  CL15 HEK-293T C20(1.37)  LDD1606  [3]
 LDCM0403  CL16 HEK-293T C20(1.13)  LDD1607  [3]
 LDCM0405  CL18 HEK-293T C20(0.82); C456(1.26)  LDD1609  [3]
 LDCM0406  CL19 HEK-293T C20(1.03)  LDD1610  [3]
 LDCM0409  CL21 HEK-293T C20(2.49)  LDD1613  [3]
 LDCM0412  CL24 HEK-293T C20(0.94)  LDD1616  [3]
 LDCM0415  CL27 HEK-293T C20(1.12)  LDD1619  [3]
 LDCM0416  CL28 HEK-293T C20(1.02)  LDD1620  [3]
 LDCM0418  CL3 HEK-293T C20(1.30)  LDD1622  [3]
 LDCM0419  CL30 HEK-293T C20(0.98); C456(1.07)  LDD1623  [3]
 LDCM0420  CL31 HEK-293T C20(1.12)  LDD1624  [3]
 LDCM0422  CL33 HEK-293T C20(1.11)  LDD1626  [3]
 LDCM0425  CL36 HEK-293T C20(0.79)  LDD1629  [3]
 LDCM0428  CL39 HEK-293T C20(1.30)  LDD1632  [3]
 LDCM0429  CL4 HEK-293T C20(1.37)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C20(0.98)  LDD1634  [3]
 LDCM0432  CL42 HEK-293T C20(0.86); C456(1.05)  LDD1636  [3]
 LDCM0433  CL43 HEK-293T C20(0.85)  LDD1637  [3]
 LDCM0435  CL45 HEK-293T C20(1.21)  LDD1639  [3]
 LDCM0438  CL48 HEK-293T C20(0.74)  LDD1642  [3]
 LDCM0443  CL52 HEK-293T C20(1.22)  LDD1646  [3]
 LDCM0445  CL54 HEK-293T C20(0.83); C456(1.69)  LDD1648  [3]
 LDCM0446  CL55 HEK-293T C20(0.98)  LDD1649  [3]
 LDCM0448  CL57 HEK-293T C20(1.44)  LDD1651  [3]
 LDCM0451  CL6 HEK-293T C20(1.56); C456(1.27)  LDD1654  [3]
 LDCM0452  CL60 HEK-293T C20(0.91)  LDD1655  [3]
 LDCM0455  CL63 HEK-293T C20(1.06)  LDD1658  [3]
 LDCM0456  CL64 HEK-293T C20(1.04)  LDD1659  [3]
 LDCM0458  CL66 HEK-293T C20(1.23); C456(1.47)  LDD1661  [3]
 LDCM0459  CL67 HEK-293T C20(0.83)  LDD1662  [3]
 LDCM0461  CL69 HEK-293T C20(1.20)  LDD1664  [3]
 LDCM0462  CL7 HEK-293T C20(0.90)  LDD1665  [3]
 LDCM0465  CL72 HEK-293T C20(0.83)  LDD1668  [3]
 LDCM0469  CL76 HEK-293T C20(0.94)  LDD1672  [3]
 LDCM0471  CL78 HEK-293T C20(0.96); C456(1.14)  LDD1674  [3]
 LDCM0472  CL79 HEK-293T C20(0.91)  LDD1675  [3]
 LDCM0475  CL81 HEK-293T C20(1.12)  LDD1678  [3]
 LDCM0478  CL84 HEK-293T C20(1.21)  LDD1681  [3]
 LDCM0481  CL87 HEK-293T C20(1.43)  LDD1684  [3]
 LDCM0482  CL88 HEK-293T C20(1.00)  LDD1685  [3]
 LDCM0484  CL9 HEK-293T C20(1.28)  LDD1687  [3]
 LDCM0485  CL90 HEK-293T C20(0.96); C456(1.69)  LDD1688  [3]
 LDCM0486  CL91 HEK-293T C20(0.99)  LDD1689  [3]
 LDCM0488  CL93 HEK-293T C20(1.11)  LDD1691  [3]
 LDCM0491  CL96 HEK-293T C20(0.99)  LDD1694  [3]
 LDCM0494  CL99 HEK-293T C20(1.23)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C20(1.36)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C20(1.11)  LDD1671  [3]
 LDCM0022  KB02 T cell-activated C20(9.36)  LDD1704  [2]
 LDCM0023  KB03 Jurkat C20(22.33)  LDD0209  [1]

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402