Details of the Target

General Information of Target

Target ID LDTP06937
Target Name Protein sidekick-2 (SDK2)
Gene Name SDK2
Gene ID 54549
Synonyms
KIAA1514; Protein sidekick-2
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MWGLLIWTLLALHQIRAARAQDDVSPYFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKW
LHNNRELTKFSLEYRYMITSLDRTHAGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEK
HQSVSHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGR
YYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVAN
ARPLIKLHIIWKKDGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGA
YLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQR
NDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVV
LACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNS
RGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGT
ESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATL
STVERRAINLTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVKGLVPARS
YQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQN
GILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSS
KVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEV
TMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGH
LSFSEILDTSLKVSWQEPGEKNGILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTA
LTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQFRPGYDGK
TSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTS
PPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSR
SDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPS
SGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRS
AQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLI
WQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTR
KGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTR
ELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAA
PDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNP
GATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGE
AVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFL
AENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSV
NVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFR
IRAKTFTYGPEIEANVTTGPGEGAPGPPGVPIIVRYSSAIAIHWSSGDPGKGPITRYVIE
ARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSVPA
QKANPFYEEWWFLVVIALVGLIFILLLVFVLIIRGQSKKYAKKTDSGNSAKSGALGHSEM
MSLDESSFPALELNNRRLSVKNSFCRKNGLYTRSPPRPSPGSLHYSDEDVTKYNDLIPAE
SSSLTEKPSEISDSQGSDSEYEVDSNHQKAHSFVNHYISDPTYYNSWRRQQKGISRAQAY
SYTESDSGEPDHTTVTNSTSTQQGSLFRPKASRTPTPQNPPNPPSQQSTLYRPPSSLAPG
SRAPIAGFSSFV
Target Bioclass
Immunoglobulin
Family
Sidekick family
Subcellular location
Cell membrane
Function
Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types: the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions.
Uniprot ID
Q58EX2
Ensemble ID
ENST00000392650.8
HGNC ID
HGNC:19308

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
769P SNV: p.Q1188Ter .
CAL78 SNV: p.A1180S .
CCK81 Deletion: p.R2017GfsTer28
SNV: p.A607V		 .
COLO800 SNV: p.T1506P .
DU145 SNV: p.G369C .
HCT116 Deletion: p.R2017GfsTer28 .
HS936T SNV: p.E1124K .
Ishikawa (Heraklio) 02 ER Deletion: p.T997PfsTer13 .
JURKAT SNV: p.L538M .
KU1919 SNV: p.G438E .
LU65 SNV: p.A185D .
MCC13 SNV: p.S125F .
MELJUSO SNV: p.K1591E .
MEWO SNV: p.K252R .
NCIH1793 SNV: p.R570L; p.L600I .
NCIH1993 SNV: p.E688Ter .
PANC0403 SNV: p.P736S .
PF382 SNV: p.P2015S .
REH Deletion: p.S1083VfsTer66 DBIA    Probe Info 
RKO SNV: p.V24E .
RPMI8226 SNV: p.T602S .
SNGM SNV: p.G789Ter; p.T956M; p.Y1906C .
SUPT1 Deletion: p.P1613RfsTer30 .
TE11 SNV: p.H1513Q .
TE4 SNV: p.V1028M .
TGBC1TKB SNV: p.R585G .
TOV21G SNV: p.S426Ter; p.Q512K; p.G1019W .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y1138(13.45)  LDD3495  [1]
DBIA
 Probe Info  		C666(2.51); C1764(1.93)  LDD3376  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C330(0.94)  LDD1507  [5]
 LDCM0215  AC10 HEK-293T C731(0.94)  LDD1508  [5]
 LDCM0237  AC12 HEK-293T C1764(0.97)  LDD1510  [5]
 LDCM0259  AC14 HEK-293T C731(1.06)  LDD1512  [5]
 LDCM0276  AC17 HEK-293T C330(0.95)  LDD1515  [5]
 LDCM0277  AC18 HEK-293T C731(1.00)  LDD1516  [5]
 LDCM0279  AC2 HEK-293T C731(1.01)  LDD1518  [5]
 LDCM0280  AC20 HEK-293T C1764(0.91)  LDD1519  [5]
 LDCM0281  AC21 HEK-293T C1764(0.97)  LDD1520  [5]
 LDCM0282  AC22 HEK-293T C731(0.91)  LDD1521  [5]
 LDCM0285  AC25 HEK-293T C330(0.90)  LDD1524  [5]
 LDCM0286  AC26 HEK-293T C731(0.94)  LDD1525  [5]
 LDCM0288  AC28 HEK-293T C1764(1.01)  LDD1527  [5]
 LDCM0289  AC29 HEK-293T C1764(1.06)  LDD1528  [5]
 LDCM0291  AC30 HEK-293T C731(0.87)  LDD1530  [5]
 LDCM0294  AC33 HEK-293T C330(1.05)  LDD1533  [5]
 LDCM0295  AC34 HEK-293T C731(0.99)  LDD1534  [5]
 LDCM0297  AC36 HEK-293T C1764(1.03)  LDD1536  [5]
 LDCM0298  AC37 HEK-293T C1764(1.09)  LDD1537  [5]
 LDCM0299  AC38 HEK-293T C731(1.06)  LDD1538  [5]
 LDCM0301  AC4 HEK-293T C1764(1.01)  LDD1540  [5]
 LDCM0303  AC41 HEK-293T C330(1.04)  LDD1542  [5]
 LDCM0304  AC42 HEK-293T C731(1.00)  LDD1543  [5]
 LDCM0306  AC44 HEK-293T C1764(1.00)  LDD1545  [5]
 LDCM0307  AC45 HEK-293T C1764(1.04)  LDD1546  [5]
 LDCM0308  AC46 HEK-293T C731(0.98)  LDD1547  [5]
 LDCM0311  AC49 HEK-293T C330(1.11)  LDD1550  [5]
 LDCM0312  AC5 HEK-293T C1764(1.08)  LDD1551  [5]
 LDCM0313  AC50 HEK-293T C731(1.06)  LDD1552  [5]
 LDCM0315  AC52 HEK-293T C1764(0.90)  LDD1554  [5]
 LDCM0316  AC53 HEK-293T C1764(1.07)  LDD1555  [5]
 LDCM0317  AC54 HEK-293T C731(0.89)  LDD1556  [5]
 LDCM0320  AC57 HEK-293T C330(1.04)  LDD1559  [5]
 LDCM0321  AC58 HEK-293T C731(1.01)  LDD1560  [5]
 LDCM0323  AC6 HEK-293T C731(0.89)  LDD1562  [5]
 LDCM0324  AC60 HEK-293T C1764(0.97)  LDD1563  [5]
 LDCM0325  AC61 HEK-293T C1764(1.08)  LDD1564  [5]
 LDCM0326  AC62 HEK-293T C731(0.96)  LDD1565  [5]
 LDCM0248  AKOS034007472 HEK-293T C1764(1.11)  LDD1511  [5]
 LDCM0356  AKOS034007680 HEK-293T C330(0.94)  LDD1570  [5]
 LDCM0367  CL1 HEK-293T C731(1.29)  LDD1571  [5]
 LDCM0368  CL10 HEK-293T C731(0.97)  LDD1572  [5]
 LDCM0369  CL100 HEK-293T C873(0.75)  LDD1573  [5]
 LDCM0370  CL101 HEK-293T C731(1.18)  LDD1574  [5]
 LDCM0371  CL102 HEK-293T C48(0.99)  LDD1575  [5]
 LDCM0372  CL103 HEK-293T C1764(1.00)  LDD1576  [5]
 LDCM0373  CL104 HEK-293T C873(0.97)  LDD1577  [5]
 LDCM0374  CL105 HEK-293T C731(1.07)  LDD1578  [5]
 LDCM0375  CL106 HEK-293T C48(0.94)  LDD1579  [5]
 LDCM0376  CL107 HEK-293T C1764(0.96)  LDD1580  [5]
 LDCM0377  CL108 HEK-293T C873(1.04)  LDD1581  [5]
 LDCM0378  CL109 HEK-293T C731(1.04)  LDD1582  [5]
 LDCM0380  CL110 HEK-293T C48(0.94)  LDD1584  [5]
 LDCM0381  CL111 HEK-293T C1764(1.02)  LDD1585  [5]
 LDCM0382  CL112 HEK-293T C873(0.90)  LDD1586  [5]
 LDCM0383  CL113 HEK-293T C731(1.11)  LDD1587  [5]
 LDCM0384  CL114 HEK-293T C48(1.00)  LDD1588  [5]
 LDCM0385  CL115 HEK-293T C1764(1.03)  LDD1589  [5]
 LDCM0386  CL116 HEK-293T C873(1.06)  LDD1590  [5]
 LDCM0387  CL117 HEK-293T C731(1.20)  LDD1591  [5]
 LDCM0388  CL118 HEK-293T C48(1.03)  LDD1592  [5]
 LDCM0389  CL119 HEK-293T C1764(1.19)  LDD1593  [5]
 LDCM0391  CL120 HEK-293T C873(0.95)  LDD1595  [5]
 LDCM0392  CL121 HEK-293T C731(0.99)  LDD1596  [5]
 LDCM0393  CL122 HEK-293T C48(0.98)  LDD1597  [5]
 LDCM0394  CL123 HEK-293T C1764(1.08)  LDD1598  [5]
 LDCM0395  CL124 HEK-293T C873(0.79)  LDD1599  [5]
 LDCM0396  CL125 HEK-293T C731(0.95)  LDD1600  [5]
 LDCM0397  CL126 HEK-293T C48(0.98)  LDD1601  [5]
 LDCM0398  CL127 HEK-293T C1764(1.20)  LDD1602  [5]
 LDCM0399  CL128 HEK-293T C873(0.83)  LDD1603  [5]
 LDCM0400  CL13 HEK-293T C731(1.04)  LDD1604  [5]
 LDCM0401  CL14 HEK-293T C48(0.76)  LDD1605  [5]
 LDCM0402  CL15 HEK-293T C1764(1.15)  LDD1606  [5]
 LDCM0403  CL16 HEK-293T C873(0.99)  LDD1607  [5]
 LDCM0404  CL17 HEK-293T C330(0.87)  LDD1608  [5]
 LDCM0405  CL18 HEK-293T C731(0.96)  LDD1609  [5]
 LDCM0407  CL2 HEK-293T C48(0.80)  LDD1611  [5]
 LDCM0408  CL20 HEK-293T C1764(0.99)  LDD1612  [5]
 LDCM0409  CL21 HEK-293T C1764(1.17)  LDD1613  [5]
 LDCM0410  CL22 HEK-293T C731(0.89)  LDD1614  [5]
 LDCM0413  CL25 HEK-293T C731(1.24)  LDD1617  [5]
 LDCM0414  CL26 HEK-293T C48(0.79)  LDD1618  [5]
 LDCM0415  CL27 HEK-293T C1764(1.01)  LDD1619  [5]
 LDCM0416  CL28 HEK-293T C873(0.86)  LDD1620  [5]
 LDCM0417  CL29 HEK-293T C330(1.09)  LDD1621  [5]
 LDCM0418  CL3 HEK-293T C1764(1.08)  LDD1622  [5]
 LDCM0419  CL30 HEK-293T C731(0.97)  LDD1623  [5]
 LDCM0421  CL32 HEK-293T C1764(1.07)  LDD1625  [5]
 LDCM0422  CL33 HEK-293T C1764(1.07)  LDD1626  [5]
 LDCM0423  CL34 HEK-293T C731(0.92)  LDD1627  [5]
 LDCM0426  CL37 HEK-293T C731(1.10)  LDD1630  [5]
 LDCM0428  CL39 HEK-293T C1764(1.04)  LDD1632  [5]
 LDCM0429  CL4 HEK-293T C873(1.19)  LDD1633  [5]
 LDCM0430  CL40 HEK-293T C873(1.10)  LDD1634  [5]
 LDCM0431  CL41 HEK-293T C330(0.98)  LDD1635  [5]
 LDCM0432  CL42 HEK-293T C731(0.90)  LDD1636  [5]
 LDCM0434  CL44 HEK-293T C1764(1.01)  LDD1638  [5]
 LDCM0435  CL45 HEK-293T C1764(0.92)  LDD1639  [5]
 LDCM0436  CL46 HEK-293T C731(0.88)  LDD1640  [5]
 LDCM0439  CL49 HEK-293T C731(1.20)  LDD1643  [5]
 LDCM0440  CL5 HEK-293T C330(1.01)  LDD1644  [5]
 LDCM0441  CL50 HEK-293T C48(0.78)  LDD1645  [5]
 LDCM0443  CL52 HEK-293T C873(1.02)  LDD1646  [5]
 LDCM0444  CL53 HEK-293T C330(0.90)  LDD1647  [5]
 LDCM0445  CL54 HEK-293T C731(0.88)  LDD1648  [5]
 LDCM0447  CL56 HEK-293T C1764(0.73)  LDD1650  [5]
 LDCM0448  CL57 HEK-293T C1764(1.05)  LDD1651  [5]
 LDCM0449  CL58 HEK-293T C731(0.87)  LDD1652  [5]
 LDCM0451  CL6 HEK-293T C731(0.92)  LDD1654  [5]
 LDCM0453  CL61 HEK-293T C731(1.08)  LDD1656  [5]
 LDCM0454  CL62 HEK-293T C48(0.99)  LDD1657  [5]
 LDCM0455  CL63 HEK-293T C1764(1.19)  LDD1658  [5]
 LDCM0456  CL64 HEK-293T C873(0.82)  LDD1659  [5]
 LDCM0457  CL65 HEK-293T C330(0.93)  LDD1660  [5]
 LDCM0458  CL66 HEK-293T C731(1.04)  LDD1661  [5]
 LDCM0460  CL68 HEK-293T C1764(1.11)  LDD1663  [5]
 LDCM0461  CL69 HEK-293T C1764(1.08)  LDD1664  [5]
 LDCM0463  CL70 HEK-293T C731(0.94)  LDD1666  [5]
 LDCM0466  CL73 HEK-293T C731(1.08)  LDD1669  [5]
 LDCM0467  CL74 HEK-293T C48(1.14)  LDD1670  [5]
 LDCM0469  CL76 HEK-293T C873(0.94)  LDD1672  [5]
 LDCM0470  CL77 HEK-293T C330(0.85)  LDD1673  [5]
 LDCM0471  CL78 HEK-293T C731(0.99)  LDD1674  [5]
 LDCM0473  CL8 HEK-293T C1764(0.93)  LDD1676  [5]
 LDCM0474  CL80 HEK-293T C1764(1.06)  LDD1677  [5]
 LDCM0475  CL81 HEK-293T C1764(1.10)  LDD1678  [5]
 LDCM0476  CL82 HEK-293T C731(0.90)  LDD1679  [5]
 LDCM0479  CL85 HEK-293T C731(1.15)  LDD1682  [5]
 LDCM0480  CL86 HEK-293T C48(0.88)  LDD1683  [5]
 LDCM0481  CL87 HEK-293T C1764(1.10)  LDD1684  [5]
 LDCM0482  CL88 HEK-293T C873(0.93)  LDD1685  [5]
 LDCM0483  CL89 HEK-293T C330(1.00)  LDD1686  [5]
 LDCM0484  CL9 HEK-293T C1764(1.05)  LDD1687  [5]
 LDCM0485  CL90 HEK-293T C731(1.10)  LDD1688  [5]
 LDCM0487  CL92 HEK-293T C1764(0.95)  LDD1690  [5]
 LDCM0488  CL93 HEK-293T C1764(1.06)  LDD1691  [5]
 LDCM0489  CL94 HEK-293T C731(0.97)  LDD1692  [5]
 LDCM0492  CL97 HEK-293T C731(1.02)  LDD1695  [5]
 LDCM0493  CL98 HEK-293T C48(1.01)  LDD1696  [5]
 LDCM0494  CL99 HEK-293T C1764(1.03)  LDD1697  [5]
 LDCM0495  E2913 HEK-293T C1764(1.07)  LDD1698  [5]
 LDCM0468  Fragment33 HEK-293T C1764(1.25)  LDD1671  [5]
 LDCM0427  Fragment51 HEK-293T C48(0.95)  LDD1631  [5]
 LDCM0022  KB02 697 C666(2.06)  LDD2245  [2]
 LDCM0023  KB03 697 C666(2.03)  LDD2662  [2]
 LDCM0024  KB05 ONS-76 C666(2.51); C1764(1.93)  LDD3376  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vimentin-type intermediate filament-associated coiled-coil protein (VMAC) . Q2NL98

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402