Details of the Target

General Information of Target

Target ID LDTP06854
Target Name Taperin (TPRN)
Gene Name TPRN
Gene ID 286262
Synonyms
C9orf75; Taperin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAALGRPGSGPRAAVPAWKREILERKRAKLAALGGGAGPGAAEPEQRVLAESLGPLRENP
FMLLEAERRRGGGAAGARLLERYRRVPGVRALRADSVLIIETVPGFPPAPPAPGAAQIRA
AEVLVYGAPPGRVSRLLERFDPPAAPRRRGSPERARPPPPPPPPAPPRPPPAAPSPPAAP
GPRGGGASPGARRSDFLQKTGSNSFTVHPRGLHRGAGARLLSNGHSAPEPRAGPANRLAG
SPPGSGQWKPKVESGDPSLHPPPSPGTPSATPASPPASATPSQRQCVSAATSTNDSFEIR
PAPKPVMETIPLGDLQARALASLRANSRNSFMVIPKSKASGAPPPEGRQSVELPKGDLGP
ASPSQELGSQPVPGGDGAPALGKSPLEVEAQWAVEEGACPRTATALADRAIRWQRPSSPP
PFLPAASEEAEPAEGLRVPGLAKNSREYVRPGLPVTFIDEVDSEEAPQAAKLPYLPHPAR
PLHPARPGCVAELQPRGSNTFTVVPKRKPGTLQDQHFSQANREPRPREAEEEEASCLLGP
TLKKRYPTVHEIEVIGGYLALQKSCLTKAGSSRKKMKISFNDKSLQTTFEYPSESSLEQE
EEVDQQEEEEEEEEEEEEEEEGSGSEEKPFALFLPRATFVSSVRPESSRLPEGSSGLSSY
TPKHSVAFSKWQEQALEQAPREAEPPPVEAMLTPASQNDLSDFRSEPALYF
Target Bioclass
Other
Family
Taperin family
Subcellular location
Cell projection, stereocilium
Uniprot ID
Q4KMQ1
Ensemble ID
ENST00000409012.6
HGNC ID
HGNC:26894

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.I299T .
HCC1395 SNV: p.E428D .
HCC15 SNV: p.E395Ter .
HCT15 SNV: p.Q562Ter .
JURKAT SNV: p.G341R .
KYSE30 SNV: p.E352Ter .
LNCaP clone FGC SNV: p.M307I .
MFE319 SNV: p.E431G .
NCIH1993 SNV: p.S362P; p.P363R .
RPMI8226 SNV: p.S134G .
SKHEP1 SNV: p.S350Y .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C536(1.42)  LDD3320  [1]
AHL-Pu-1
 Probe Info  		C399(3.37)  LDD0171  [2]
IPM
 Probe Info  		C286(1.11); C489(0.90)  LDD1701  [3]
Phosphinate-6
 Probe Info  		C536(0.00); C489(0.00)  LDD0018  [4]
NAIA_5
 Probe Info  		N.A.  LDD2223  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C399(3.37)  LDD0171  [2]
 LDCM0226  AC11 HEK-293T C399(1.14)  LDD1509  [6]
 LDCM0237  AC12 HEK-293T C399(1.12)  LDD1510  [6]
 LDCM0259  AC14 HEK-293T C399(0.80)  LDD1512  [6]
 LDCM0278  AC19 HEK-293T C399(1.15)  LDD1517  [6]
 LDCM0280  AC20 HEK-293T C399(1.06)  LDD1519  [6]
 LDCM0281  AC21 HEK-293T C399(1.19)  LDD1520  [6]
 LDCM0282  AC22 HEK-293T C399(1.21)  LDD1521  [6]
 LDCM0287  AC27 HEK-293T C399(0.82)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C399(1.78)  LDD1527  [6]
 LDCM0289  AC29 HEK-293T C399(0.92)  LDD1528  [6]
 LDCM0290  AC3 HEK-293T C399(1.02)  LDD1529  [6]
 LDCM0291  AC30 HEK-293T C399(0.95)  LDD1530  [6]
 LDCM0296  AC35 HEK-293T C399(1.02)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C399(1.04)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C399(1.05)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C399(0.78)  LDD1538  [6]
 LDCM0301  AC4 HEK-293T C399(1.30)  LDD1540  [6]
 LDCM0305  AC43 HEK-293T C399(1.09)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C399(0.97)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C399(0.93)  LDD1546  [6]
 LDCM0308  AC46 HEK-293T C399(0.87)  LDD1547  [6]
 LDCM0312  AC5 HEK-293T C399(0.95)  LDD1551  [6]
 LDCM0314  AC51 HEK-293T C399(1.02)  LDD1553  [6]
 LDCM0315  AC52 HEK-293T C399(1.11)  LDD1554  [6]
 LDCM0316  AC53 HEK-293T C399(1.04)  LDD1555  [6]
 LDCM0317  AC54 HEK-293T C399(0.98)  LDD1556  [6]
 LDCM0322  AC59 HEK-293T C399(0.94)  LDD1561  [6]
 LDCM0323  AC6 HEK-293T C399(0.69)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C399(1.05)  LDD1563  [6]
 LDCM0325  AC61 HEK-293T C399(1.23)  LDD1564  [6]
 LDCM0326  AC62 HEK-293T C399(1.00)  LDD1565  [6]
 LDCM0248  AKOS034007472 HEK-293T C399(1.34)  LDD1511  [6]
 LDCM0632  CL-Sc Hep-G2 C536(0.64)  LDD2227  [5]
 LDCM0368  CL10 HEK-293T C399(0.78)  LDD1572  [6]
 LDCM0371  CL102 HEK-293T C399(1.08)  LDD1575  [6]
 LDCM0375  CL106 HEK-293T C399(1.03)  LDD1579  [6]
 LDCM0380  CL110 HEK-293T C399(1.50)  LDD1584  [6]
 LDCM0384  CL114 HEK-293T C399(1.21)  LDD1588  [6]
 LDCM0388  CL118 HEK-293T C399(1.11)  LDD1592  [6]
 LDCM0393  CL122 HEK-293T C399(0.98)  LDD1597  [6]
 LDCM0397  CL126 HEK-293T C399(0.98)  LDD1601  [6]
 LDCM0401  CL14 HEK-293T C399(1.30)  LDD1605  [6]
 LDCM0406  CL19 HEK-293T C399(1.14)  LDD1610  [6]
 LDCM0407  CL2 HEK-293T C399(1.19)  LDD1611  [6]
 LDCM0408  CL20 HEK-293T C399(1.29)  LDD1612  [6]
 LDCM0409  CL21 HEK-293T C399(1.32)  LDD1613  [6]
 LDCM0410  CL22 HEK-293T C399(0.94)  LDD1614  [6]
 LDCM0414  CL26 HEK-293T C399(1.19)  LDD1618  [6]
 LDCM0420  CL31 HEK-293T C399(1.11)  LDD1624  [6]
 LDCM0421  CL32 HEK-293T C399(1.21)  LDD1625  [6]
 LDCM0422  CL33 HEK-293T C399(0.81)  LDD1626  [6]
 LDCM0423  CL34 HEK-293T C399(1.02)  LDD1627  [6]
 LDCM0433  CL43 HEK-293T C399(0.95)  LDD1637  [6]
 LDCM0434  CL44 HEK-293T C399(1.25)  LDD1638  [6]
 LDCM0435  CL45 HEK-293T C399(1.11)  LDD1639  [6]
 LDCM0436  CL46 HEK-293T C399(0.84)  LDD1640  [6]
 LDCM0441  CL50 HEK-293T C399(1.04)  LDD1645  [6]
 LDCM0446  CL55 HEK-293T C399(0.94)  LDD1649  [6]
 LDCM0447  CL56 HEK-293T C399(1.33)  LDD1650  [6]
 LDCM0448  CL57 HEK-293T C399(1.43)  LDD1651  [6]
 LDCM0449  CL58 HEK-293T C399(0.89)  LDD1652  [6]
 LDCM0454  CL62 HEK-293T C399(1.53)  LDD1657  [6]
 LDCM0459  CL67 HEK-293T C399(1.25)  LDD1662  [6]
 LDCM0460  CL68 HEK-293T C399(1.09)  LDD1663  [6]
 LDCM0461  CL69 HEK-293T C399(1.03)  LDD1664  [6]
 LDCM0462  CL7 HEK-293T C399(1.04)  LDD1665  [6]
 LDCM0463  CL70 HEK-293T C399(1.18)  LDD1666  [6]
 LDCM0467  CL74 HEK-293T C399(1.16)  LDD1670  [6]
 LDCM0472  CL79 HEK-293T C399(0.96)  LDD1675  [6]
 LDCM0473  CL8 HEK-293T C399(1.29)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C399(0.99)  LDD1677  [6]
 LDCM0475  CL81 HEK-293T C399(0.81)  LDD1678  [6]
 LDCM0476  CL82 HEK-293T C399(1.03)  LDD1679  [6]
 LDCM0480  CL86 HEK-293T C399(1.29)  LDD1683  [6]
 LDCM0484  CL9 HEK-293T C399(1.09)  LDD1687  [6]
 LDCM0486  CL91 HEK-293T C399(0.89)  LDD1689  [6]
 LDCM0487  CL92 HEK-293T C399(1.32)  LDD1690  [6]
 LDCM0488  CL93 HEK-293T C399(1.17)  LDD1691  [6]
 LDCM0489  CL94 HEK-293T C399(0.87)  LDD1692  [6]
 LDCM0493  CL98 HEK-293T C399(0.94)  LDD1696  [6]
 LDCM0634  CY-0357 Hep-G2 C536(0.36)  LDD2228  [5]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C286(1.39)  LDD1702  [3]
 LDCM0427  Fragment51 HEK-293T C399(1.33)  LDD1631  [6]
 LDCM0022  KB02 ECC2 C536(2.41)  LDD2320  [1]
 LDCM0023  KB03 MDA-MB-231 C286(1.11); C489(0.90)  LDD1701  [3]
 LDCM0024  KB05 RVH421 C536(1.42)  LDD3320  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA) PPP phosphatase family P62136
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PPP1CC) PPP phosphatase family P36873
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Chloride intracellular channel protein 1 (CLIC1) Chloride channel CLIC family O00299
Chloride intracellular channel protein 2 (CLIC2) Chloride channel CLIC family O15247
Chloride intracellular channel protein 4 (CLIC4) Chloride channel CLIC family Q9Y696
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Whirlin (WHRN) . Q9P202

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402