Details of the Target

General Information of Target

Target ID LDTP06448
Target Name Disks large homolog 2 (DLG2)
Gene Name DLG2
Gene ID 1740
Synonyms
Disks large homolog 2; Channel-associated protein of synapse-110; Chapsyn-110; Postsynaptic density protein PSD-93
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MFFACYCALRTNVKKYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVL
QSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPH
IGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLY
VRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQ
VGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPP
MENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPAS
PRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPR
KVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASH
EQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLY
VRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKR
RVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPER
GQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYE
VDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNA
IKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQG
DTLEDIYNQCKLVIEEQSGPFIWIPSKEKL
Target Bioclass
Other
Family
MAGUK family
Subcellular location
Cell membrane
Function
Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses.
Uniprot ID
Q15700
Ensemble ID
ENST00000280241.12
HGNC ID
HGNC:2901

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K641(7.29)  LDD0277  [1]
BTD
 Probe Info  		C149(1.29); C708(1.04)  LDD2093  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C149(1.29); C708(1.04)  LDD2093  [2]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C772(0.34)  LDD2096  [2]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C708(0.93)  LDD2097  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C149(1.45)  LDD2099  [2]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C149(0.69)  LDD2101  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C708(0.71)  LDD2109  [2]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C772(0.57)  LDD2116  [2]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C772(0.88)  LDD2118  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C149(1.07)  LDD2123  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C149(0.88)  LDD2125  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C149(1.29)  LDD2127  [2]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C708(0.62)  LDD2133  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C149(1.17)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C149(1.08)  LDD2137  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C149(0.79)  LDD2140  [2]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C708(0.20)  LDD2145  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761