Details of the Target

General Information of Target

Target ID LDTP06332
Target Name BOS complex subunit NOMO1 (NOMO1)
Gene Name NOMO1
Gene ID 23420
Synonyms
PM5; BOS complex subunit NOMO1; Nodal modulator 1; pM5 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLVGQGAGPLGPAVVTAAVVLLLSGVGPAHGSEDIVVGCGGFVKSDVEINYSLIEIKLYT
KHGTLKYQTDCAPNNGYFMIPLYDKGDFILKIEPPLGWSFEPTTVELHVDGVSDICTKGG
DINFVFTGFSVNGKVLSKGQPLGPAGVQVSLRNTGTEAKIQSTVTQPGGKFAFFKVLPGD
YEILATHPTWALKEASTTVRVTNSNANAASPLIVAGYNVSGSVRSDGEPMKGVKFLLFSS
LVTKEDVLGCNVSPVPGFQPQDESLVYLCYTVSREDGSFSFYSLPSGGYTVIPFYRGERI
TFDVAPSRLDFTVEHDSLKIEPVFHVMGFSVTGRVLNGPEGDGVPEAVVTLNNQIKVKTK
ADGSFRLENITTGTYTIHAQKEHLYFETVTIKIAPNTPQLADIIATGFSVCGQISIIRFP
DTVKQMNKYKVVLSSQDKDKSLVTVETDAHGSFCFKAKPGTYKVQVMVPEAETRAGLTLK
PQTFPLTVTNRPMMDVAFVQFLASVSGKVSCLDTCGDLLVTLQSLSRQGEKRSLQLSGKV
NAMTFTFDNVLPGKYKISIMHEDWCWKNKSLEVEVLEDDMSAVEFRQTGYMLRCSLSHAI
TLEFYQDGNGRENVGIYNLSKGVNRFCLSKPGVYKVTPRSCHRFEQAFYTYDTSSPSILT
LTAIRHHVLGTITTDKMMDVTVTIKSSIDSEPALVLGPLKSVQELRREQQLAEIEARRQE
REKNGNEEGEERMTKPPVQEMVDELQGPFSYDFSYWARSGEKITVTPSSKELLFYPPSME
AVVSGESCPGKLIEIHGKAGLFLEGQIHPELEGVEIVISEKGASSPLITVFTDDKGAYSV
GPLHSDLEYTVTSQKEGYVLTAVEGTIGDFKAYALAGVSFEIKAEDDQPLPGVLLSLSGG
LFRSNLLTQDNGILTFSNLSPGQYYFKPMMKEFRFEPSSQMIEVQEGQNLKITITGYRTA
YSCYGTVSSLNGEPEQGVAMEAVGQNDCSIYGEDTVTDEEGKFRLRGLLPGCVYHVQLKA
EGNDHIERALPHHRVIEVGNNDIDDVNIIVFRQINQFDLSGNVITSSEYLPTLWVKLYKS
ENLDNPIQTVSLGQSLFFHFPPLLRDGENYVVLLDSTLPRSQYDYILPQVSFTAVGYHKH
ITLIFNPTRKLPEQDIAQGSYIALPLTLLVLLAGYNHDKLIPLLLQLTSRLQGVRALGQA
ASDNSGPEDAKRQAKKQKTRRT
Target Bioclass
Other
Subcellular location
Endoplasmic reticulum membrane
Function
Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions.
Uniprot ID
Q15155
Ensemble ID
ENST00000287667.12
HGNC ID
HGNC:30060

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C-Sul
 Probe Info  		5.09  LDD0066  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
BTD
 Probe Info  		C627(0.52)  LDD2095  [3]
IA-alkyne
 Probe Info  		C627(0.00); C1012(0.00); C788(0.00)  LDD0162  [4]
Acrolein
 Probe Info  		C39(0.00); H796(0.00)  LDD0217  [5]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [5]
Methacrolein
 Probe Info  		N.A.  LDD0218  [5]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		20.00  LDD0476  [6]
FFF probe3
 Probe Info  		20.00  LDD0465  [6]
STS-2
 Probe Info  		N.A.  LDD0139  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C627(0.52)  LDD2095  [3]
 LDCM0108  Chloroacetamide HeLa C1012(0.00); C39(0.00); H796(0.00); H383(0.00)  LDD0222  [5]
 LDCM0107  IAA HeLa H383(0.00); H666(0.00); H315(0.00); C39(0.00)  LDD0221  [5]
 LDCM0109  NEM HeLa H383(0.00); H667(0.00); H315(0.00); H796(0.00)  LDD0223  [5]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C627(0.34)  LDD2104  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C627(0.98)  LDD2107  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C627(1.09)  LDD2119  [3]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C627(0.41)  LDD2120  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C627(1.21)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C627(0.84)  LDD2127  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C627(1.93)  LDD2135  [3]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C627(0.66)  LDD2150  [3]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Theophylline Small molecular drug DB00277

References

1 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
7 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.