Details of the Target

General Information of Target

Target ID LDTP06157
Target Name Zinc finger protein 268 (ZNF268)
Gene Name ZNF268
Gene ID 10795
Synonyms
Zinc finger protein 268; Zinc finger protein HZF3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATRVRTASIWVPPLQERNSSWDRIRKLQGQESILGQGTPGLQPLPGTPRQKQKSRRIEK
VLEWLFISQEQPKITKSWGPLSFMDVFVDFTWEEWQLLDPAQKCLYRSVMLENYSNLVSL
GYQHTKPDIIFKLEQGEELCMVQAQVPNQTCPNTVWKIDDLMDWHQENKDKLGSTAKSFE
CTTFGKLCLLSTKYLSRQKPHKCGTHGKSLKYIDFTSDYARNNPNGFQVHGKSFFHSKHE
QTVIGIKYCESIESGKTVNKKSQLMCQQMYMGEKPFGCSCCEKAFSSKSYLLVHQQTHAE
EKPYGCNECGKDFSSKSYLIVHQRIHTGEKLHECSECRKTFSFHSQLVIHQRIHTGENPY
ECCECGKVFSRKDQLVSHQKTHSGQKPYVCNECGKAFGLKSQLIIHERIHTGEKPYECNE
CQKAFNTKSNLMVHQRTHTGEKPYVCSDCGKAFTFKSQLIVHQGIHTGVKPYGCIQCGKG
FSLKSQLIVHQRSHTGMKPYVCNECGKAFRSKSYLIIHTRTHTGEKLHECNNCGKAFSFK
SQLIIHQRIHTGENPYECHECGKAFSRKYQLISHQRTHAGEKPYECTDCGKAFGLKSQLI
IHQRTHTGEKPFECSECQKAFNTKSNLIVHQRTHTGEKPYSCNECGKAFTFKSQLIVHKG
VHTGVKPYGCSQCAKTFSLKSQLIVHQRSHTGVKPYGCSECGKAFRSKSYLIIHMRTHTG
EKPHECRECGKSFSFNSQLIVHQRIHTGENPYECSECGKAFNRKDQLISHQRTHAGEKPY
GCSECGKAFSSKSYLIIHMRTHSGEKPYECNECGKAFIWKSLLIVHERTHAGVNPYKCSQ
CEKSFSGKLRLLVHQRMHTREKPYECSECGKAFIRNSQLIVHQRTHSGEKPYGCNECGKT
FSQKSILSAHQRTHTGEKPCKCTECGKAFCWKSQLIMHQRTHVDDKH
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function
[Isoform 1]: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression.; [Isoform 2]: Contributes to cervical carcinogenesis in part through the TNF-alpha-induced NF-kappa-B signaling pathway by interacting with the I-kappa-B-kinase (IKK) core complex.
Uniprot ID
Q14587
Ensemble ID
ENST00000228289.9
HGNC ID
HGNC:13061

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CALU1 SNV: p.S653L .
COLO792 SNV: p.P13S; p.Q771Ter .
HCT116 SNV: p.T216A DBIA    Probe Info 
HCT15 SNV: p.N225S .
HEC1 SNV: p.R727M .
HEC1B SNV: p.R727M .
IPC298 SNV: p.P583L .
LNCaP clone FGC SNV: p.K792R .
MCC26 SNV: p.R576K .
MM1S SNV: p.R940K .
MOLT4 SNV: p.G748R .
SKES1 SNV: p.P695S .
SW837 SNV: p.E644Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C140(1.25); C151(1.25)  LDD0532  [1]
CY4
 Probe Info  		Q570(0.00); Q575(0.00)  LDD0247  [2]
WYneN
 Probe Info  		N.A.  LDD0021  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HCT 116 C140(1.25); C151(1.25)  LDD0532  [1]
 LDCM0226  AC11 HCT 116 C140(1.21); C151(1.21)  LDD0543  [1]
 LDCM0237  AC12 HCT 116 C140(0.99); C151(0.99)  LDD0554  [1]
 LDCM0259  AC14 HCT 116 C140(1.07); C151(1.07)  LDD0576  [1]
 LDCM0263  AC143 HCT 116 C140(1.16); C151(1.16)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C151(0.91); C140(1.15)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C151(1.07); C140(1.22)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C151(0.96); C140(1.17)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C140(1.02); C151(1.06)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C140(0.98); C151(1.04)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C151(0.96); C140(1.16)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C140(1.09); C151(1.09)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C151(0.91); C140(1.01)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C151(1.06); C140(1.14)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C151(0.96); C140(1.46)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C151(0.90); C140(1.34)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C140(1.29); C151(0.89)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C140(1.14); C151(0.95)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C140(1.14); C151(1.03)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C140(1.39); C151(0.86)  LDD2161  [1]
 LDCM0323  AC6 HCT 116 C140(1.00); C151(1.00)  LDD0640  [1]
 LDCM0334  AC7 HCT 116 C140(1.03); C151(1.03)  LDD0651  [1]
 LDCM0345  AC8 HCT 116 C140(0.98); C151(0.98)  LDD0662  [1]
 LDCM0248  AKOS034007472 HCT 116 C140(0.95); C151(0.95)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C140(1.01); C151(1.01)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C140(1.55); C151(1.55)  LDD0592  [1]
 LDCM0370  CL101 HCT 116 C140(1.28); C151(1.28)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C140(0.95); C151(0.95)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C140(1.40); C151(1.40)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C140(1.16); C151(1.16)  LDD0690  [1]
 LDCM0403  CL16 HCT 116 C140(1.09); C151(1.09)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C140(1.29); C151(1.29)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C140(1.09); C151(1.09)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C140(1.14); C151(1.14)  LDD0723  [1]
 LDCM0408  CL20 HCT 116 C140(1.73); C151(1.73)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C140(1.74); C151(1.74)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C140(1.82); C151(1.82)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C140(1.07); C151(1.07)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C140(1.15); C151(1.15)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C140(1.58); C151(1.58)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C140(1.26); C151(1.26)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C140(1.19); C151(1.19)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C140(1.20); C151(1.20)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C140(1.35); C151(1.35)  LDD0734  [1]
 LDCM0419  CL30 HCT 116 C140(1.08); C151(1.08)  LDD0736  [1]
 LDCM0453  CL61 HCT 116 C140(0.95); C151(0.95)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C140(0.94); C151(0.94)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C140(1.29); C151(1.29)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C140(1.86); C151(1.86)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C140(1.17); C151(1.17)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C140(2.13); C151(2.13)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C140(1.41); C151(1.41)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C140(1.57); C151(1.57)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C140(1.13); C151(1.13)  LDD0778  [1]
 LDCM0463  CL70 HCT 116 C140(1.18); C151(1.18)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C140(1.44); C151(1.44)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C140(1.09); C151(1.09)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C140(1.51); C151(1.51)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C140(1.29); C151(1.29)  LDD0784  [1]
 LDCM0468  Fragment33 HCT 116 C140(1.23); C151(1.23)  LDD0785  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764