Details of the Target

General Information of Target

Target ID LDTP05184
Target Name U7 snRNA-associated Sm-like protein LSm11 (LSM11)
Gene Name LSM11
Gene ID 134353
Synonyms
U7 snRNA-associated Sm-like protein LSm11
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEERERGARSAGAGSPARPPSPRLDVSSDSFDPLLALYAPRLPPIPYPNAPCFNNVAEYE
SFLRTGVRGGGRGRGRARGAAAGSGVPAAPGPSGRTRRRPDAPAPDPERIQRLRRLMVAK
EEGDGAAGAGRRGPGRSRKAPRNVLTRMPLHEGSPLGELHRCIREGVKVNVHIRTFKGLR
GVCTGFLVAFDKFWNMALTDVDETYRKPVLGKAYERDSSLTLTRLFDRLKLQDSSKKEAD
SKSAVEDSTLSRYSQTSTWKLASVWGRADTGRGSHKRSRSVPSSLQASAREESRSELSGR
TTRTDGSSVGGTFSRATTLSRGQSRKKKRKPKVDYQQVFTRHINQIFIRGENVLLVHLAQ
Target Bioclass
Other
Family
SnRNP Sm proteins family
Subcellular location
Nucleus
Function
Component of the U7 snRNP complex that is involved in the histone 3'-end pre-mRNA processing. Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to the Sm-binding site of U7 snRNA.
Uniprot ID
P83369
Ensemble ID
ENST00000286307.6
HGNC ID
HGNC:30860

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C52(2.15)  LDD0168  [1]
DBIA
 Probe Info  		C52(1.04)  LDD1492  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [4]
IPM
 Probe Info  		N.A.  LDD0147  [5]
m-APA
 Probe Info  		N.A.  LDD0404  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C52(2.15)  LDD0168  [1]
 LDCM0284  AC24 HEK-293T C52(0.99)  LDD1523  [2]
 LDCM0293  AC32 HEK-293T C52(0.94)  LDD1532  [2]
 LDCM0302  AC40 HEK-293T C52(0.87)  LDD1541  [2]
 LDCM0310  AC48 HEK-293T C52(1.05)  LDD1549  [2]
 LDCM0319  AC56 HEK-293T C52(0.89)  LDD1558  [2]
 LDCM0328  AC64 HEK-293T C52(1.18)  LDD1567  [2]
 LDCM0345  AC8 HEK-293T C52(1.18)  LDD1569  [2]
 LDCM0275  AKOS034007705 HEK-293T C52(1.76)  LDD1514  [2]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [6]
 LDCM0630  CCW28-3 231MFP C52(2.56)  LDD2214  [7]
 LDCM0367  CL1 HEK-293T C52(0.62)  LDD1571  [2]
 LDCM0370  CL101 HEK-293T C52(0.88)  LDD1574  [2]
 LDCM0371  CL102 HEK-293T C52(0.86)  LDD1575  [2]
 LDCM0374  CL105 HEK-293T C52(0.59)  LDD1578  [2]
 LDCM0375  CL106 HEK-293T C52(0.79)  LDD1579  [2]
 LDCM0378  CL109 HEK-293T C52(0.83)  LDD1582  [2]
 LDCM0380  CL110 HEK-293T C52(0.70)  LDD1584  [2]
 LDCM0383  CL113 HEK-293T C52(0.64)  LDD1587  [2]
 LDCM0384  CL114 HEK-293T C52(1.03)  LDD1588  [2]
 LDCM0387  CL117 HEK-293T C52(0.90)  LDD1591  [2]
 LDCM0388  CL118 HEK-293T C52(0.97)  LDD1592  [2]
 LDCM0390  CL12 HEK-293T C52(0.76)  LDD1594  [2]
 LDCM0392  CL121 HEK-293T C52(0.61)  LDD1596  [2]
 LDCM0393  CL122 HEK-293T C52(0.94)  LDD1597  [2]
 LDCM0396  CL125 HEK-293T C52(0.87)  LDD1600  [2]
 LDCM0397  CL126 HEK-293T C52(0.93)  LDD1601  [2]
 LDCM0400  CL13 HEK-293T C52(0.92)  LDD1604  [2]
 LDCM0401  CL14 HEK-293T C52(1.08)  LDD1605  [2]
 LDCM0407  CL2 HEK-293T C52(1.03)  LDD1611  [2]
 LDCM0412  CL24 HEK-293T C52(1.19)  LDD1616  [2]
 LDCM0413  CL25 HEK-293T C52(0.59)  LDD1617  [2]
 LDCM0414  CL26 HEK-293T C52(0.90)  LDD1618  [2]
 LDCM0425  CL36 HEK-293T C52(0.97)  LDD1629  [2]
 LDCM0426  CL37 HEK-293T C52(0.83)  LDD1630  [2]
 LDCM0438  CL48 HEK-293T C52(0.96)  LDD1642  [2]
 LDCM0439  CL49 HEK-293T C52(0.69)  LDD1643  [2]
 LDCM0441  CL50 HEK-293T C52(0.87)  LDD1645  [2]
 LDCM0452  CL60 HEK-293T C52(1.09)  LDD1655  [2]
 LDCM0453  CL61 HEK-293T C52(0.74)  LDD1656  [2]
 LDCM0454  CL62 HEK-293T C52(0.96)  LDD1657  [2]
 LDCM0465  CL72 HEK-293T C52(0.88)  LDD1668  [2]
 LDCM0466  CL73 HEK-293T C52(1.09)  LDD1669  [2]
 LDCM0467  CL74 HEK-293T C52(0.95)  LDD1670  [2]
 LDCM0478  CL84 HEK-293T C52(0.83)  LDD1681  [2]
 LDCM0479  CL85 HEK-293T C52(0.99)  LDD1682  [2]
 LDCM0480  CL86 HEK-293T C52(0.83)  LDD1683  [2]
 LDCM0491  CL96 HEK-293T C52(1.41)  LDD1694  [2]
 LDCM0492  CL97 HEK-293T C52(0.70)  LDD1695  [2]
 LDCM0493  CL98 HEK-293T C52(0.87)  LDD1696  [2]
 LDCM0427  Fragment51 HEK-293T C52(1.01)  LDD1631  [2]
 LDCM0022  KB02 HEK-293T C52(1.04)  LDD1492  [2]
 LDCM0023  KB03 HEK-293T C52(1.05)  LDD1497  [2]
 LDCM0024  KB05 HEK-293T C52(1.17)  LDD1502  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ras-related protein Rab-19 (RAB19) Rab family A4D1S5

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
7 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.