Details of the Target

General Information of Target

Target ID LDTP05095
Target Name Glypican-5 (GPC5)
Gene Name GPC5
Gene ID 2262
Synonyms
Glypican-5 [Cleaved into: Secreted glypican-5]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDAQTWPVGFRCLLLLALVGSARSEGVQTCEEVRKLFQWRLLGAVRGLPDSPRAGPDLQV
CISKKPTCCTRKMEERYQIAARQDMQQFLQTSSSTLKFLISRNAAAFQETLETLIKQAEN
YTSILFCSTYRNMALEAAASVQEFFTDVGLYLFGADVNPEEFVNRFFDSLFPLVYNHLIN
PGVTDSSLEYSECIRMARRDVSPFGNIPQRVMGQMGRSLLPSRTFLQALNLGIEVINTTD
YLHFSKECSRALLKMQYCPHCQGLALTKPCMGYCLNVMRGCLAHMAELNPHWHAYIRSLE
ELSDAMHGTYDIGHVLLNFHLLVNDAVLQAHLNGQKLLEQVNRICGRPVRTPTQSPRCSF
DQSKEKHGMKTTTRNSEETLANRRKEFINSLRLYRSFYGGLADQLCANELAAADGLPCWN
GEDIVKSYTQRVVGNGIKAQSGNPEVKVKGIDPVINQIIDKLKHVVQLLQGRSPKPDKWE
LLQLGSGGGMVEQVSGDCDDEDGCGGSGSGEVKRTLKITDWMPDDMNFSDVKQIHQTDTG
STLDTTGAGCAVATESMTFTLISVVMLLPGIW
Target Bioclass
Other
Family
Glypican family
Subcellular location
Secreted, extracellular space; Cell membrane
Function Cell surface proteoglycan that bears heparan sulfate.
Uniprot ID
P78333
Ensemble ID
ENST00000377067.9
HGNC ID
HGNC:4453

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K385(2.80)  LDD3494  [1]
DBIA
 Probe Info  		C358(1.18)  LDD1492  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C358(1.22)  LDD1507  [2]
 LDCM0259  AC14 HEK-293T C358(1.10)  LDD1512  [2]
 LDCM0276  AC17 HEK-293T C358(1.07)  LDD1515  [2]
 LDCM0281  AC21 HEK-293T C358(1.18)  LDD1520  [2]
 LDCM0282  AC22 HEK-293T C358(0.90)  LDD1521  [2]
 LDCM0284  AC24 HEK-293T C358(1.00)  LDD1523  [2]
 LDCM0285  AC25 HEK-293T C358(1.05)  LDD1524  [2]
 LDCM0289  AC29 HEK-293T C358(1.54)  LDD1528  [2]
 LDCM0291  AC30 HEK-293T C358(1.21)  LDD1530  [2]
 LDCM0293  AC32 HEK-293T C358(0.93)  LDD1532  [2]
 LDCM0294  AC33 HEK-293T C358(1.23)  LDD1533  [2]
 LDCM0298  AC37 HEK-293T C358(1.29)  LDD1537  [2]
 LDCM0299  AC38 HEK-293T C358(0.95)  LDD1538  [2]
 LDCM0302  AC40 HEK-293T C358(1.03)  LDD1541  [2]
 LDCM0303  AC41 HEK-293T C358(1.24)  LDD1542  [2]
 LDCM0307  AC45 HEK-293T C358(1.48)  LDD1546  [2]
 LDCM0308  AC46 HEK-293T C358(1.82)  LDD1547  [2]
 LDCM0310  AC48 HEK-293T C358(1.02)  LDD1549  [2]
 LDCM0311  AC49 HEK-293T C358(1.06)  LDD1550  [2]
 LDCM0312  AC5 HEK-293T C358(0.97)  LDD1551  [2]
 LDCM0316  AC53 HEK-293T C358(1.00)  LDD1555  [2]
 LDCM0317  AC54 HEK-293T C358(1.76)  LDD1556  [2]
 LDCM0319  AC56 HEK-293T C358(0.97)  LDD1558  [2]
 LDCM0320  AC57 HEK-293T C358(1.12)  LDD1559  [2]
 LDCM0323  AC6 HEK-293T C358(1.19)  LDD1562  [2]
 LDCM0325  AC61 HEK-293T C358(1.06)  LDD1564  [2]
 LDCM0326  AC62 HEK-293T C358(1.12)  LDD1565  [2]
 LDCM0328  AC64 HEK-293T C358(1.15)  LDD1567  [2]
 LDCM0345  AC8 HEK-293T C358(1.09)  LDD1569  [2]
 LDCM0248  AKOS034007472 HEK-293T C358(1.31)  LDD1511  [2]
 LDCM0356  AKOS034007680 HEK-293T C358(1.13)  LDD1570  [2]
 LDCM0275  AKOS034007705 HEK-293T C358(1.06)  LDD1514  [2]
 LDCM0367  CL1 HEK-293T C358(1.18)  LDD1571  [2]
 LDCM0368  CL10 HEK-293T C358(2.27)  LDD1572  [2]
 LDCM0370  CL101 HEK-293T C358(0.94)  LDD1574  [2]
 LDCM0374  CL105 HEK-293T C358(1.01)  LDD1578  [2]
 LDCM0378  CL109 HEK-293T C358(1.07)  LDD1582  [2]
 LDCM0383  CL113 HEK-293T C358(0.99)  LDD1587  [2]
 LDCM0387  CL117 HEK-293T C358(1.03)  LDD1591  [2]
 LDCM0390  CL12 HEK-293T C358(1.16)  LDD1594  [2]
 LDCM0392  CL121 HEK-293T C358(1.07)  LDD1596  [2]
 LDCM0396  CL125 HEK-293T C358(0.96)  LDD1600  [2]
 LDCM0400  CL13 HEK-293T C358(1.32)  LDD1604  [2]
 LDCM0404  CL17 HEK-293T C358(1.28)  LDD1608  [2]
 LDCM0409  CL21 HEK-293T C358(1.39)  LDD1613  [2]
 LDCM0410  CL22 HEK-293T C358(1.30)  LDD1614  [2]
 LDCM0412  CL24 HEK-293T C358(0.88)  LDD1616  [2]
 LDCM0413  CL25 HEK-293T C358(1.04)  LDD1617  [2]
 LDCM0417  CL29 HEK-293T C358(1.12)  LDD1621  [2]
 LDCM0422  CL33 HEK-293T C358(1.16)  LDD1626  [2]
 LDCM0423  CL34 HEK-293T C358(1.26)  LDD1627  [2]
 LDCM0425  CL36 HEK-293T C358(1.15)  LDD1629  [2]
 LDCM0426  CL37 HEK-293T C358(0.98)  LDD1630  [2]
 LDCM0431  CL41 HEK-293T C358(1.16)  LDD1635  [2]
 LDCM0435  CL45 HEK-293T C358(1.65)  LDD1639  [2]
 LDCM0436  CL46 HEK-293T C358(1.96)  LDD1640  [2]
 LDCM0438  CL48 HEK-293T C358(0.85)  LDD1642  [2]
 LDCM0439  CL49 HEK-293T C358(1.00)  LDD1643  [2]
 LDCM0440  CL5 HEK-293T C358(1.09)  LDD1644  [2]
 LDCM0444  CL53 HEK-293T C358(1.12)  LDD1647  [2]
 LDCM0448  CL57 HEK-293T C358(1.44)  LDD1651  [2]
 LDCM0449  CL58 HEK-293T C358(1.27)  LDD1652  [2]
 LDCM0452  CL60 HEK-293T C358(1.06)  LDD1655  [2]
 LDCM0453  CL61 HEK-293T C358(0.95)  LDD1656  [2]
 LDCM0457  CL65 HEK-293T C358(1.15)  LDD1660  [2]
 LDCM0461  CL69 HEK-293T C358(1.43)  LDD1664  [2]
 LDCM0463  CL70 HEK-293T C358(1.27)  LDD1666  [2]
 LDCM0465  CL72 HEK-293T C358(1.02)  LDD1668  [2]
 LDCM0466  CL73 HEK-293T C358(0.83)  LDD1669  [2]
 LDCM0470  CL77 HEK-293T C358(1.17)  LDD1673  [2]
 LDCM0475  CL81 HEK-293T C358(1.65)  LDD1678  [2]
 LDCM0476  CL82 HEK-293T C358(1.14)  LDD1679  [2]
 LDCM0478  CL84 HEK-293T C358(1.04)  LDD1681  [2]
 LDCM0479  CL85 HEK-293T C358(0.84)  LDD1682  [2]
 LDCM0483  CL89 HEK-293T C358(1.09)  LDD1686  [2]
 LDCM0484  CL9 HEK-293T C358(1.29)  LDD1687  [2]
 LDCM0488  CL93 HEK-293T C358(1.41)  LDD1691  [2]
 LDCM0489  CL94 HEK-293T C358(1.20)  LDD1692  [2]
 LDCM0491  CL96 HEK-293T C358(1.15)  LDD1694  [2]
 LDCM0492  CL97 HEK-293T C358(0.99)  LDD1695  [2]
 LDCM0022  KB02 HEK-293T C358(1.18)  LDD1492  [2]
 LDCM0023  KB03 HEK-293T C358(0.92)  LDD1497  [2]
 LDCM0024  KB05 HEK-293T C358(0.92)  LDD1502  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable G-protein coupled receptor 179 (GPR179) G-protein coupled receptor 3 family Q6PRD1
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM117B (FAM117B) . Q6P1L5
RING1 and YY1-binding protein (RYBP) . Q8N488

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019