Details of the Target

General Information of Target

Target ID LDTP05083
Target Name Hemoglobin subunit gamma-2 (HBG2)
Gene Name HBG2
Gene ID 3048
Synonyms
Hemoglobin subunit gamma-2; Gamma-2-globin; Hb F Ggamma; Hemoglobin gamma-2 chain; Hemoglobin gamma-G chain
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MGHFTEEDKATITSLWGKVNVEDAGGETLGRLLVVYPWTQRFFDSFGNLSSASAIMGNPK
VKAHGKKVLTSLGDAIKHLDDLKGTFAQLSELHCDKLHVDPENFKLLGNVLVTVLAIHFG
KEFTPEVQASWQKMVTGVASALSSRYH
Target Bioclass
Other
Family
Globin family
Function Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.
Uniprot ID
P69892
Ensemble ID
ENST00000336906.6
HGNC ID
HGNC:4832

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C94(2.72)  LDD3335  [1]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		5.89  LDD0476  [2]
FFF probe3
 Probe Info  		7.56  LDD0465  [2]
DA-2
 Probe Info  		N.A.  LDD0070  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 CMK C94(2.68)  LDD2302  [1]
 LDCM0023  KB03 CMK C94(9.36)  LDD2719  [1]
 LDCM0024  KB05 MONO-MAC-6 C94(2.72)  LDD3335  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hemoglobin subunit alpha (HBA1; HBA2) Globin family P69905
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hemoglobin subunit mu (HBM) Globin family Q6B0K9
Hemoglobin subunit theta-1 (HBQ1) Globin family P09105

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
3 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.