Details of the Target
General Information of Target
| Target ID | LDTP05081 | |||||
|---|---|---|---|---|---|---|
| Target Name | BOS complex subunit NOMO3 (NOMO3) | |||||
| Gene Name | NOMO3 | |||||
| Gene ID | 408050 | |||||
| Synonyms |
BOS complex subunit NOMO3; Nodal modulator 3; pM5 protein 3 |
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| 3D Structure | ||||||
| Sequence |
MLVGQGAGPLGPAVVTAAVVLLLSGVGPAHGSEDIVVGCGGFVKSDVEINYSLIEIKLYT
KHGTLKYQTDCAPNNGYFMIPLYDKGDFILKIEPPLGWSFEPTTVELHVDGVSDICTKGG DINFVFTGFSVNGKVLSKGQPLGPAGVQVSLRNTGTEAKIQSTVTQPGGKFAFFKVLPGD YEILATHPTWALKEASTTVRVTNSNANAASPLIVAGYNVSGSVRSDGEPMKGVKFLLFSS LVTKEDVLGCNVSPVPGFQPQDESLVYLCYTVSREDGSFSFYSLPSGGYTVIPFYRGERI TFDVAPSRLDFTVEHDSLKIEPVFHVMGFSVTGRVLNGPEGDGVPEAVVTLNNQIKVKTK ADGSFRLENITTGTYTIHAQKEHLYFETVTIKIAPNTPQLADIVATGFSVCGQISIIRFP DTVKQMNKYKVVLSSQDKDKSLVTVETDAHGSFCFKANPGTYKVQVMVPEAETRAGLTLK PQTFPLTVTDRPVMDVAFVQFLASVSGKVSCLDTCGDLLVTLQSLSRQGEKRSLQLSGKV NAMTFTFDNVLPGKYKISIMHEDWCWKNKSLEVEVLEDDVSAVEFRQTGYMLRCSLSHAI TLEFYQDGNGRENVGIYNLSKGVNRFCLSKPGVYKVTPRSCHRFEQAFYTYDTSSPSILT LTAIRHHVLGTITTDKMMDVTVTIKSSIDSEPALVLGPLKSVQELRREQQLAEIEARRQE REKNGNEEGEERMTKPPVQEMVDELQGPFSYDFSYWARSGEKITVTPSSKELLFYPPSME AVVSGESCPGKLIEIHGKAGLFLEGQIHPELEGVEIVISEKGASSPLITVFTDDKGAYSV GPLHSDLEYTVTSQKEGYVLTAVEGTIGDFKAYALAGVSFEIKAEDDQPLPGVLLSLSGG LFRSNLLTQDNGILTFSNLSPGQYYFKPMMKEFRFEPSSQMIEVQEGQNLKITITGYRTA YSCYGTVSSLNGEPEQGVAMEAVGQNDCSIYGEDTVTDEEGKFRLRGLLPGCVYHVQLKA EGNDHIERALPHHRVIEVGNNDIDDVNIIVFRQINQFDLSGNVITSSEYLPTLWVKLYKS ENLDNPIQTVSLGQSLFFHFPPLLRDGENYVVLLDSTLPRSQYDYILPQVSFTAVGYHKH ITLIFNPTRKLPEQDIAQGSYIALPLTLLVLLAGYNHDKLIPLLLQLTSRLQGVGALGQA ASDNSGPEDAKRQAKKQKTRRT |
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| Target Bioclass |
Other
|
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| Subcellular location |
Endoplasmic reticulum membrane
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| Function |
Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
STPyne Probe Info |
 |
K170(4.67); K430(7.69); K630(7.18) | LDD0277 | [1] | |
|
ONAyne Probe Info |
 |
K635(10.00) | LDD0275 | [1] | |
|
5E-2FA Probe Info |
 |
H844(0.00); H325(0.00) | LDD2235 | [2] | |
|
m-APA Probe Info |
 |
H325(0.00); H844(0.00) | LDD2231 | [2] | |
|
4-Iodoacetamidophenylacetylene Probe Info |
 |
C788(0.00); C1012(0.00) | LDD0038 | [3] | |
|
IA-alkyne Probe Info |
 |
C627(0.00); C1012(0.00); C71(0.00) | LDD0036 | [3] | |
|
Lodoacetamide azide Probe Info |
 |
N.A. | LDD0037 | [3] | |
|
NAIA_5 Probe Info |
 |
C627(0.00); C1012(0.00); C454(0.00); C71(0.00) | LDD2223 | [4] | |
PAL-AfBPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
FFF probe13 Probe Info |
 |
20.00 | LDD0476 | [5] | |
|
FFF probe3 Probe Info |
 |
20.00 | LDD0465 | [5] | |
|
VE-P Probe Info |
 |
N.A. | LDD0396 | [6] | |
References