Details of the Target

General Information of Target

Target ID LDTP04772
Target Name Splicing regulator RBM11 (RBM11)
Gene Name RBM11
Gene ID 54033
Synonyms
Splicing regulator RBM11; RNA-binding motif protein 11
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFPAQEEADRTVFVGNLEARVREEILYELFLQAGPLTKVTICKDREGKPKSFGFVCFKHP
ESVSYAIALLNGIRLYGRPINVQYRFGSSRSSEPANQSFESCVKINSHNYRNEEMLVGRS
SFPMQYFPINNTSLPQEYFLFQKMQWHVYNPVLQLPYYEMTAPLPNSASVSSSLNHVPDL
EAGPSSYKWTHQQPSDSDLYQMTAPLPNSASVSSSLNHVPDLEAGPSSYKWTHQQPSDSD
LYQMNKRKRQKQTSDSDSSTDNNRGNECSQKFRKSKKKKRY
Target Bioclass
Other
Subcellular location
Nucleus, nucleoplasm
Function
Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5' splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1.
Uniprot ID
P57052
Ensemble ID
ENST00000400577.4
HGNC ID
HGNC:9897

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.Y84H .
HGC27 Deletion: p.I105KfsTer8 DBIA    Probe Info 
HS936T SNV: p.Q142Ter .
MEWO SNV: p.P151L; p.P165S .
NCIH358 SNV: p.L31H DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C56(2.24)  LDD3342  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C56(1.02)  LDD1507  [2]
 LDCM0215  AC10 HEK-293T C102(1.45)  LDD1508  [2]
 LDCM0226  AC11 HEK-293T C56(0.94); C102(1.06)  LDD1509  [2]
 LDCM0237  AC12 HEK-293T C102(1.19)  LDD1510  [2]
 LDCM0270  AC15 HEK-293T C56(0.98)  LDD1513  [2]
 LDCM0276  AC17 HEK-293T C56(1.10)  LDD1515  [2]
 LDCM0277  AC18 HEK-293T C102(1.33)  LDD1516  [2]
 LDCM0278  AC19 HEK-293T C56(0.90); C102(1.10)  LDD1517  [2]
 LDCM0279  AC2 HEK-293T C102(1.81)  LDD1518  [2]
 LDCM0280  AC20 HEK-293T C102(1.19)  LDD1519  [2]
 LDCM0281  AC21 HEK-293T C56(0.90)  LDD1520  [2]
 LDCM0283  AC23 HEK-293T C56(0.99)  LDD1522  [2]
 LDCM0285  AC25 HEK-293T C56(0.97)  LDD1524  [2]
 LDCM0286  AC26 HEK-293T C102(2.02)  LDD1525  [2]
 LDCM0287  AC27 HEK-293T C56(0.92); C102(0.92)  LDD1526  [2]
 LDCM0288  AC28 HEK-293T C102(1.14)  LDD1527  [2]
 LDCM0289  AC29 HEK-293T C56(0.92)  LDD1528  [2]
 LDCM0290  AC3 HEK-293T C56(0.89); C102(0.91)  LDD1529  [2]
 LDCM0292  AC31 HEK-293T C56(0.96)  LDD1531  [2]
 LDCM0294  AC33 HEK-293T C56(1.07)  LDD1533  [2]
 LDCM0295  AC34 HEK-293T C102(1.37)  LDD1534  [2]
 LDCM0296  AC35 HEK-293T C56(0.92); C102(0.86)  LDD1535  [2]
 LDCM0297  AC36 HEK-293T C102(1.16)  LDD1536  [2]
 LDCM0298  AC37 HEK-293T C56(1.04)  LDD1537  [2]
 LDCM0300  AC39 HEK-293T C56(0.99)  LDD1539  [2]
 LDCM0301  AC4 HEK-293T C102(0.98)  LDD1540  [2]
 LDCM0303  AC41 HEK-293T C56(0.98)  LDD1542  [2]
 LDCM0304  AC42 HEK-293T C102(1.50)  LDD1543  [2]
 LDCM0305  AC43 HEK-293T C56(0.95); C102(1.03)  LDD1544  [2]
 LDCM0306  AC44 HEK-293T C102(1.15)  LDD1545  [2]
 LDCM0307  AC45 HEK-293T C56(0.92)  LDD1546  [2]
 LDCM0309  AC47 HEK-293T C56(1.03)  LDD1548  [2]
 LDCM0311  AC49 HEK-293T C56(1.19)  LDD1550  [2]
 LDCM0312  AC5 HEK-293T C56(1.05)  LDD1551  [2]
 LDCM0313  AC50 HEK-293T C102(1.73)  LDD1552  [2]
 LDCM0314  AC51 HEK-293T C56(0.90); C102(0.94)  LDD1553  [2]
 LDCM0315  AC52 HEK-293T C102(1.05)  LDD1554  [2]
 LDCM0316  AC53 HEK-293T C56(1.06)  LDD1555  [2]
 LDCM0318  AC55 HEK-293T C56(1.03)  LDD1557  [2]
 LDCM0320  AC57 HEK-293T C56(0.96)  LDD1559  [2]
 LDCM0321  AC58 HEK-293T C102(1.66)  LDD1560  [2]
 LDCM0322  AC59 HEK-293T C56(1.00); C102(0.94)  LDD1561  [2]
 LDCM0324  AC60 HEK-293T C102(1.15)  LDD1563  [2]
 LDCM0325  AC61 HEK-293T C56(1.04)  LDD1564  [2]
 LDCM0327  AC63 HEK-293T C56(1.03)  LDD1566  [2]
 LDCM0334  AC7 HEK-293T C56(1.04)  LDD1568  [2]
 LDCM0248  AKOS034007472 HEK-293T C56(0.93)  LDD1511  [2]
 LDCM0356  AKOS034007680 HEK-293T C56(1.06)  LDD1570  [2]
 LDCM0369  CL100 HEK-293T C56(0.79)  LDD1573  [2]
 LDCM0371  CL102 HEK-293T C56(0.90)  LDD1575  [2]
 LDCM0372  CL103 HEK-293T C56(0.85)  LDD1576  [2]
 LDCM0373  CL104 HEK-293T C56(0.87)  LDD1577  [2]
 LDCM0375  CL106 HEK-293T C56(1.01)  LDD1579  [2]
 LDCM0376  CL107 HEK-293T C56(0.86)  LDD1580  [2]
 LDCM0377  CL108 HEK-293T C56(0.90)  LDD1581  [2]
 LDCM0379  CL11 HEK-293T C56(1.07)  LDD1583  [2]
 LDCM0380  CL110 HEK-293T C56(0.88)  LDD1584  [2]
 LDCM0381  CL111 HEK-293T C56(0.91)  LDD1585  [2]
 LDCM0382  CL112 HEK-293T C56(0.91)  LDD1586  [2]
 LDCM0384  CL114 HEK-293T C56(0.84)  LDD1588  [2]
 LDCM0385  CL115 HEK-293T C56(0.75)  LDD1589  [2]
 LDCM0386  CL116 HEK-293T C56(0.92)  LDD1590  [2]
 LDCM0388  CL118 HEK-293T C56(0.81)  LDD1592  [2]
 LDCM0389  CL119 HEK-293T C56(0.82)  LDD1593  [2]
 LDCM0391  CL120 HEK-293T C56(0.89)  LDD1595  [2]
 LDCM0393  CL122 HEK-293T C56(0.87)  LDD1597  [2]
 LDCM0394  CL123 HEK-293T C56(0.75)  LDD1598  [2]
 LDCM0395  CL124 HEK-293T C56(0.95)  LDD1599  [2]
 LDCM0397  CL126 HEK-293T C56(0.84)  LDD1601  [2]
 LDCM0398  CL127 HEK-293T C56(0.92)  LDD1602  [2]
 LDCM0399  CL128 HEK-293T C56(0.91)  LDD1603  [2]
 LDCM0401  CL14 HEK-293T C56(0.98)  LDD1605  [2]
 LDCM0402  CL15 HEK-293T C56(0.73)  LDD1606  [2]
 LDCM0403  CL16 HEK-293T C56(0.84)  LDD1607  [2]
 LDCM0404  CL17 HEK-293T C56(0.98)  LDD1608  [2]
 LDCM0405  CL18 HEK-293T C102(1.13)  LDD1609  [2]
 LDCM0406  CL19 HEK-293T C56(0.99); C102(0.90)  LDD1610  [2]
 LDCM0407  CL2 HEK-293T C56(0.97)  LDD1611  [2]
 LDCM0408  CL20 HEK-293T C102(1.10)  LDD1612  [2]
 LDCM0409  CL21 HEK-293T C56(0.90)  LDD1613  [2]
 LDCM0411  CL23 HEK-293T C56(0.89)  LDD1615  [2]
 LDCM0414  CL26 HEK-293T C56(0.99)  LDD1618  [2]
 LDCM0415  CL27 HEK-293T C56(0.75)  LDD1619  [2]
 LDCM0416  CL28 HEK-293T C56(0.93)  LDD1620  [2]
 LDCM0417  CL29 HEK-293T C56(1.34)  LDD1621  [2]
 LDCM0418  CL3 HEK-293T C56(0.91)  LDD1622  [2]
 LDCM0419  CL30 HEK-293T C102(1.23)  LDD1623  [2]
 LDCM0420  CL31 HEK-293T C56(0.98); C102(1.08)  LDD1624  [2]
 LDCM0421  CL32 HEK-293T C102(1.24)  LDD1625  [2]
 LDCM0422  CL33 HEK-293T C56(0.87)  LDD1626  [2]
 LDCM0424  CL35 HEK-293T C56(1.01)  LDD1628  [2]
 LDCM0428  CL39 HEK-293T C56(0.72)  LDD1632  [2]
 LDCM0429  CL4 HEK-293T C56(0.89)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C56(1.02)  LDD1634  [2]
 LDCM0431  CL41 HEK-293T C56(0.98)  LDD1635  [2]
 LDCM0432  CL42 HEK-293T C102(1.06)  LDD1636  [2]
 LDCM0433  CL43 HEK-293T C56(1.17); C102(0.97)  LDD1637  [2]
 LDCM0434  CL44 HEK-293T C102(1.16)  LDD1638  [2]
 LDCM0435  CL45 HEK-293T C56(0.89)  LDD1639  [2]
 LDCM0437  CL47 HEK-293T C56(1.08)  LDD1641  [2]
 LDCM0440  CL5 HEK-293T C56(1.11)  LDD1644  [2]
 LDCM0441  CL50 HEK-293T C56(0.98)  LDD1645  [2]
 LDCM0443  CL52 HEK-293T C56(0.96)  LDD1646  [2]
 LDCM0444  CL53 HEK-293T C56(0.99)  LDD1647  [2]
 LDCM0445  CL54 HEK-293T C102(1.82)  LDD1648  [2]
 LDCM0446  CL55 HEK-293T C56(0.98); C102(0.93)  LDD1649  [2]
 LDCM0447  CL56 HEK-293T C102(1.27)  LDD1650  [2]
 LDCM0448  CL57 HEK-293T C56(1.04)  LDD1651  [2]
 LDCM0450  CL59 HEK-293T C56(1.03)  LDD1653  [2]
 LDCM0451  CL6 HEK-293T C102(1.51)  LDD1654  [2]
 LDCM0454  CL62 HEK-293T C56(0.98)  LDD1657  [2]
 LDCM0455  CL63 HEK-293T C56(0.74)  LDD1658  [2]
 LDCM0456  CL64 HEK-293T C56(0.87)  LDD1659  [2]
 LDCM0457  CL65 HEK-293T C56(1.05)  LDD1660  [2]
 LDCM0458  CL66 HEK-293T C102(1.05)  LDD1661  [2]
 LDCM0459  CL67 HEK-293T C56(0.97); C102(0.85)  LDD1662  [2]
 LDCM0460  CL68 HEK-293T C102(1.16)  LDD1663  [2]
 LDCM0461  CL69 HEK-293T C56(1.00)  LDD1664  [2]
 LDCM0462  CL7 HEK-293T C56(1.02); C102(0.88)  LDD1665  [2]
 LDCM0464  CL71 HEK-293T C56(0.94)  LDD1667  [2]
 LDCM0467  CL74 HEK-293T C56(0.94)  LDD1670  [2]
 LDCM0469  CL76 HEK-293T C56(0.99)  LDD1672  [2]
 LDCM0470  CL77 HEK-293T C56(1.01)  LDD1673  [2]
 LDCM0471  CL78 HEK-293T C102(1.38)  LDD1674  [2]
 LDCM0472  CL79 HEK-293T C56(0.97); C102(1.02)  LDD1675  [2]
 LDCM0473  CL8 HEK-293T C102(1.06)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C102(1.15)  LDD1677  [2]
 LDCM0475  CL81 HEK-293T C56(0.95)  LDD1678  [2]
 LDCM0477  CL83 HEK-293T C56(1.05)  LDD1680  [2]
 LDCM0480  CL86 HEK-293T C56(0.98)  LDD1683  [2]
 LDCM0481  CL87 HEK-293T C56(0.68)  LDD1684  [2]
 LDCM0482  CL88 HEK-293T C56(0.88)  LDD1685  [2]
 LDCM0483  CL89 HEK-293T C56(1.10)  LDD1686  [2]
 LDCM0484  CL9 HEK-293T C56(1.05)  LDD1687  [2]
 LDCM0485  CL90 HEK-293T C102(1.20)  LDD1688  [2]
 LDCM0486  CL91 HEK-293T C56(1.06); C102(0.99)  LDD1689  [2]
 LDCM0487  CL92 HEK-293T C102(1.27)  LDD1690  [2]
 LDCM0488  CL93 HEK-293T C56(0.98)  LDD1691  [2]
 LDCM0490  CL95 HEK-293T C56(0.83)  LDD1693  [2]
 LDCM0493  CL98 HEK-293T C56(0.90)  LDD1696  [2]
 LDCM0494  CL99 HEK-293T C56(0.83)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C56(0.76)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C56(0.74)  LDD1671  [2]
 LDCM0427  Fragment51 HEK-293T C56(0.89)  LDD1631  [2]
 LDCM0022  KB02 HEK-293T C56(0.92); C102(0.98)  LDD1492  [2]
 LDCM0023  KB03 HEK-293T C56(0.86); C102(1.11)  LDD1497  [2]
 LDCM0024  KB05 NCI-H1155 C56(2.24)  LDD3342  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
S-adenosylmethionine synthase isoform type-2 (MAT2A) AdoMet synthase family P31153
NADH dehydrogenase flavoprotein 2, mitochondrial (NDUFV2) Complex I 24 kDa subunit family P19404
Probable ATP-dependent RNA helicase DDX6 (DDX6) DEAD box helicase family P26196
Probable E3 ubiquitin-protein ligase DTX2 (DTX2) Deltex family Q86UW9
MYG1 exonuclease (MYG1) MYG1 family Q9HB07
Nitric oxide synthase 3 (NOS3) NOS family P29474
Serine protease HTRA2, mitochondrial (HTRA2) Peptidase S1C family O43464
E3 SUMO-protein ligase PIAS4 (PIAS4) PIAS family Q8N2W9
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
Alpha-synuclein (SNCA) Synuclein family P37840
Sodium channel modifier 1 (SCNM1) . Q9BWG6
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein GLIS2 (GLIS2) GLI C2H2-type zinc-finger protein family Q9BZE0
Zinc finger protein 414 (ZNF414) Krueppel C2H2-type zinc-finger protein family Q96IQ9
Zinc finger protein 774 (ZNF774) Krueppel C2H2-type zinc-finger protein family Q6NX45
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Atos homolog protein B (ATOSB) ATOS family Q7L5A3
Peripherin (PRPH) Intermediate filament family P41219
Large ribosomal subunit protein mL64 (GADD45GIP1) Mitochondrion-specific ribosomal protein mL64 family Q8TAE8
U1 small nuclear ribonucleoprotein A (SNRPA) RRM U1 A/B'' family P09012
Zinc finger MYND domain-containing protein 10 (ZMYND10) ZMYND10 family O75800
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
GA-binding protein subunit beta-1 (GABPB1) . Q06547
KH domain-containing RNA-binding protein QKI (QKI) . Q96PU8

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402