Details of the Target

General Information of Target

Target ID LDTP03803
Target Name Gap junction gamma-1 protein (GJC1)
Gene Name GJC1
Gene ID 10052
Synonyms
GJA7; Gap junction gamma-1 protein; Connexin-45; Cx45; Gap junction alpha-7 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC
ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMR
WKQHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQ
LLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTG
LCLLLNIWEMLHLGFGTIRDSLNSKRRELEDPGAYNYPFTWNTPSAPPGYNIAVKPDQIQ
YTELSNAKIAYKQNKANTAQEQQYGSHEENLPADLEALQREIRMAQERLDLAVQAYSHQN
NPHGPREKKAKVGSKAGSNKSTASSKSGDGKTSVWI
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Family
Connexin family, Gamma-type subfamily
Subcellular location
Cell membrane
Function One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
TTD ID
T05828
Uniprot ID
P36383
DrugMap ID
TTEP7OC
Ensemble ID
ENST00000330514.4
HGNC ID
HGNC:4280

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C214(1.38)  LDD3360  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C220(1.08)  LDD1507  [2]
 LDCM0215  AC10 HEK-293T C220(0.73)  LDD1508  [2]
 LDCM0226  AC11 HEK-293T C220(1.04)  LDD1509  [2]
 LDCM0237  AC12 HEK-293T C220(0.93)  LDD1510  [2]
 LDCM0276  AC17 HEK-293T C220(1.02)  LDD1515  [2]
 LDCM0277  AC18 HEK-293T C220(0.91)  LDD1516  [2]
 LDCM0278  AC19 HEK-293T C220(1.12)  LDD1517  [2]
 LDCM0279  AC2 HEK-293T C220(0.68)  LDD1518  [2]
 LDCM0280  AC20 HEK-293T C220(0.87)  LDD1519  [2]
 LDCM0281  AC21 HEK-293T C220(0.93)  LDD1520  [2]
 LDCM0284  AC24 HEK-293T C220(1.04)  LDD1523  [2]
 LDCM0285  AC25 HEK-293T C220(1.01)  LDD1524  [2]
 LDCM0286  AC26 HEK-293T C220(0.76)  LDD1525  [2]
 LDCM0287  AC27 HEK-293T C220(0.95)  LDD1526  [2]
 LDCM0288  AC28 HEK-293T C220(0.76)  LDD1527  [2]
 LDCM0289  AC29 HEK-293T C220(0.93)  LDD1528  [2]
 LDCM0290  AC3 HEK-293T C220(0.98)  LDD1529  [2]
 LDCM0293  AC32 HEK-293T C220(0.98)  LDD1532  [2]
 LDCM0294  AC33 HEK-293T C220(0.86)  LDD1533  [2]
 LDCM0295  AC34 HEK-293T C220(0.68)  LDD1534  [2]
 LDCM0296  AC35 HEK-293T C220(0.92)  LDD1535  [2]
 LDCM0297  AC36 HEK-293T C220(0.82)  LDD1536  [2]
 LDCM0298  AC37 HEK-293T C220(0.96)  LDD1537  [2]
 LDCM0301  AC4 HEK-293T C220(1.00)  LDD1540  [2]
 LDCM0302  AC40 HEK-293T C220(0.88)  LDD1541  [2]
 LDCM0303  AC41 HEK-293T C220(1.05)  LDD1542  [2]
 LDCM0304  AC42 HEK-293T C220(0.89)  LDD1543  [2]
 LDCM0305  AC43 HEK-293T C220(1.05)  LDD1544  [2]
 LDCM0306  AC44 HEK-293T C220(0.75)  LDD1545  [2]
 LDCM0307  AC45 HEK-293T C220(0.99)  LDD1546  [2]
 LDCM0310  AC48 HEK-293T C220(0.92)  LDD1549  [2]
 LDCM0311  AC49 HEK-293T C220(1.17)  LDD1550  [2]
 LDCM0312  AC5 HEK-293T C220(0.99)  LDD1551  [2]
 LDCM0313  AC50 HEK-293T C220(0.64)  LDD1552  [2]
 LDCM0314  AC51 HEK-293T C220(0.94)  LDD1553  [2]
 LDCM0315  AC52 HEK-293T C220(0.79)  LDD1554  [2]
 LDCM0316  AC53 HEK-293T C220(0.99)  LDD1555  [2]
 LDCM0319  AC56 HEK-293T C220(0.86)  LDD1558  [2]
 LDCM0320  AC57 HEK-293T C220(1.09)  LDD1559  [2]
 LDCM0321  AC58 HEK-293T C220(0.70)  LDD1560  [2]
 LDCM0322  AC59 HEK-293T C220(1.05)  LDD1561  [2]
 LDCM0324  AC60 HEK-293T C220(0.98)  LDD1563  [2]
 LDCM0325  AC61 HEK-293T C220(1.09)  LDD1564  [2]
 LDCM0328  AC64 HEK-293T C220(0.89)  LDD1567  [2]
 LDCM0345  AC8 HEK-293T C220(0.94)  LDD1569  [2]
 LDCM0248  AKOS034007472 HEK-293T C220(1.00)  LDD1511  [2]
 LDCM0356  AKOS034007680 HEK-293T C220(1.11)  LDD1570  [2]
 LDCM0275  AKOS034007705 HEK-293T C220(1.04)  LDD1514  [2]
 LDCM0367  CL1 HEK-293T C220(1.20)  LDD1571  [2]
 LDCM0370  CL101 HEK-293T C220(0.77)  LDD1574  [2]
 LDCM0374  CL105 HEK-293T C220(0.73)  LDD1578  [2]
 LDCM0378  CL109 HEK-293T C220(0.91)  LDD1582  [2]
 LDCM0383  CL113 HEK-293T C220(0.69)  LDD1587  [2]
 LDCM0387  CL117 HEK-293T C220(0.99)  LDD1591  [2]
 LDCM0390  CL12 HEK-293T C220(0.83)  LDD1594  [2]
 LDCM0392  CL121 HEK-293T C220(1.02)  LDD1596  [2]
 LDCM0396  CL125 HEK-293T C220(1.11)  LDD1600  [2]
 LDCM0400  CL13 HEK-293T C220(0.86)  LDD1604  [2]
 LDCM0404  CL17 HEK-293T C220(1.60)  LDD1608  [2]
 LDCM0405  CL18 HEK-293T C220(0.78)  LDD1609  [2]
 LDCM0406  CL19 HEK-293T C220(0.89)  LDD1610  [2]
 LDCM0408  CL20 HEK-293T C220(0.94)  LDD1612  [2]
 LDCM0409  CL21 HEK-293T C220(1.51)  LDD1613  [2]
 LDCM0412  CL24 HEK-293T C220(0.77)  LDD1616  [2]
 LDCM0413  CL25 HEK-293T C220(1.63)  LDD1617  [2]
 LDCM0417  CL29 HEK-293T C220(0.80)  LDD1621  [2]
 LDCM0419  CL30 HEK-293T C220(0.58)  LDD1623  [2]
 LDCM0420  CL31 HEK-293T C220(0.85)  LDD1624  [2]
 LDCM0421  CL32 HEK-293T C220(0.76)  LDD1625  [2]
 LDCM0422  CL33 HEK-293T C220(1.82)  LDD1626  [2]
 LDCM0425  CL36 HEK-293T C220(0.73)  LDD1629  [2]
 LDCM0426  CL37 HEK-293T C220(1.49)  LDD1630  [2]
 LDCM0431  CL41 HEK-293T C220(1.02)  LDD1635  [2]
 LDCM0432  CL42 HEK-293T C220(0.71)  LDD1636  [2]
 LDCM0433  CL43 HEK-293T C220(0.95)  LDD1637  [2]
 LDCM0434  CL44 HEK-293T C220(0.83)  LDD1638  [2]
 LDCM0435  CL45 HEK-293T C220(1.14)  LDD1639  [2]
 LDCM0438  CL48 HEK-293T C220(0.84)  LDD1642  [2]
 LDCM0439  CL49 HEK-293T C220(1.16)  LDD1643  [2]
 LDCM0440  CL5 HEK-293T C220(1.10)  LDD1644  [2]
 LDCM0444  CL53 HEK-293T C220(1.42)  LDD1647  [2]
 LDCM0445  CL54 HEK-293T C220(1.54)  LDD1648  [2]
 LDCM0446  CL55 HEK-293T C220(1.03)  LDD1649  [2]
 LDCM0447  CL56 HEK-293T C220(0.80)  LDD1650  [2]
 LDCM0448  CL57 HEK-293T C220(1.19)  LDD1651  [2]
 LDCM0451  CL6 HEK-293T C220(1.60)  LDD1654  [2]
 LDCM0452  CL60 HEK-293T C220(0.77)  LDD1655  [2]
 LDCM0453  CL61 HEK-293T C220(0.80)  LDD1656  [2]
 LDCM0457  CL65 HEK-293T C220(0.89)  LDD1660  [2]
 LDCM0458  CL66 HEK-293T C220(0.68)  LDD1661  [2]
 LDCM0459  CL67 HEK-293T C220(0.86)  LDD1662  [2]
 LDCM0460  CL68 HEK-293T C220(0.75)  LDD1663  [2]
 LDCM0461  CL69 HEK-293T C220(1.09)  LDD1664  [2]
 LDCM0462  CL7 HEK-293T C220(0.88)  LDD1665  [2]
 LDCM0465  CL72 HEK-293T C220(0.87)  LDD1668  [2]
 LDCM0466  CL73 HEK-293T C220(1.07)  LDD1669  [2]
 LDCM0470  CL77 HEK-293T C220(1.51)  LDD1673  [2]
 LDCM0471  CL78 HEK-293T C220(0.69)  LDD1674  [2]
 LDCM0472  CL79 HEK-293T C220(0.87)  LDD1675  [2]
 LDCM0473  CL8 HEK-293T C220(3.00)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C220(0.83)  LDD1677  [2]
 LDCM0475  CL81 HEK-293T C220(0.93)  LDD1678  [2]
 LDCM0478  CL84 HEK-293T C220(0.98)  LDD1681  [2]
 LDCM0479  CL85 HEK-293T C220(1.12)  LDD1682  [2]
 LDCM0483  CL89 HEK-293T C220(1.00)  LDD1686  [2]
 LDCM0484  CL9 HEK-293T C220(1.25)  LDD1687  [2]
 LDCM0485  CL90 HEK-293T C220(2.56)  LDD1688  [2]
 LDCM0486  CL91 HEK-293T C220(1.03)  LDD1689  [2]
 LDCM0487  CL92 HEK-293T C220(1.24)  LDD1690  [2]
 LDCM0488  CL93 HEK-293T C220(1.56)  LDD1691  [2]
 LDCM0491  CL96 HEK-293T C220(1.58)  LDD1694  [2]
 LDCM0492  CL97 HEK-293T C220(1.09)  LDD1695  [2]
 LDCM0022  KB02 A2058 C214(2.34)  LDD2474  [1]
 LDCM0023  KB03 A2058 C214(2.29)  LDD2891  [1]
 LDCM0024  KB05 NCI-H3122 C214(1.38)  LDD3360  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lysoplasmalogenase TMEM86A (TMEM86A) TMEM86 family Q8N2M4

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Octanol Small molecular drug D00VJY

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402