Details of the Target

General Information of Target

Target ID LDTP03746
Target Name Homeobox protein Hox-D13 (HOXD13)
Gene Name HOXD13
Gene ID 3239
Synonyms
HOX4I; Homeobox protein Hox-D13; Homeobox protein Hox-4I
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSRAGSWDMDGLRADGGGAGGAPASSSSSSVAAAAASGQCRGFLSAPVFAGTHSGRAAAA
AAAAAAAAAAASGFAYPGTSERTGSSSSSSSSAVVAARPEAPPAKECPAPTPAAAAAAPP
SAPALGYGYHFGNGYYSCRMSHGVGLQQNALKSSPHASLGGFPVEKYMDVSGLASSSVPA
NEVPARAKEVSFYQGYTSPYQHVPGYIDMVSTFGSGEPRHEAYISMEGYQSWTLANGWNS
QVYCTKDQPQGSHFWKSSFPGDVALNQPDMCVYRRGRKKRVPYTKLQLKELENEYAINKF
INKDKRRRISAATNLSERQVTIWFQNRRVKDKKIVSKLKDTVS
Target Bioclass
Transcription factor
Family
Abd-B homeobox family
Subcellular location
Nucleus
Function
Sequence-specific transcription factor that binds gene promoters and activates their transcription. Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Uniprot ID
P35453
Ensemble ID
ENST00000392539.4
HGNC ID
HGNC:5136

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C271(2.97)  LDD0171  [1]
DBIA
 Probe Info  		C271(6.57)  LDD0080  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]
SF
 Probe Info  		N.A.  LDD0028  [4]
VSF
 Probe Info  		N.A.  LDD0007  [5]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [6]
AOyne
 Probe Info  		13.60  LDD0443  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C271(2.97)  LDD0171  [1]
 LDCM0214  AC1 HEK-293T C40(1.34)  LDD1507  [8]
 LDCM0215  AC10 HEK-293T C40(1.01)  LDD1508  [8]
 LDCM0276  AC17 HEK-293T C40(1.09)  LDD1515  [8]
 LDCM0277  AC18 HEK-293T C40(1.09)  LDD1516  [8]
 LDCM0279  AC2 HEK-293T C40(0.98)  LDD1518  [8]
 LDCM0284  AC24 HEK-293T C40(0.97); C271(1.00)  LDD1523  [8]
 LDCM0285  AC25 HEK-293T C40(1.22)  LDD1524  [8]
 LDCM0286  AC26 HEK-293T C40(0.93)  LDD1525  [8]
 LDCM0293  AC32 HEK-293T C40(1.12); C271(1.12)  LDD1532  [8]
 LDCM0294  AC33 HEK-293T C40(1.09)  LDD1533  [8]
 LDCM0295  AC34 HEK-293T C40(0.91)  LDD1534  [8]
 LDCM0302  AC40 HEK-293T C40(0.92); C271(1.17)  LDD1541  [8]
 LDCM0303  AC41 HEK-293T C40(1.53)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C40(1.23)  LDD1543  [8]
 LDCM0310  AC48 HEK-293T C40(0.78); C271(1.04)  LDD1549  [8]
 LDCM0311  AC49 HEK-293T C40(1.36)  LDD1550  [8]
 LDCM0313  AC50 HEK-293T C40(1.25)  LDD1552  [8]
 LDCM0319  AC56 HEK-293T C40(1.09); C271(0.87)  LDD1558  [8]
 LDCM0320  AC57 HEK-293T C40(1.10)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C40(0.98)  LDD1560  [8]
 LDCM0328  AC64 HEK-293T C40(1.34); C271(0.97)  LDD1567  [8]
 LDCM0345  AC8 HEK-293T C40(0.83); C271(1.06)  LDD1569  [8]
 LDCM0356  AKOS034007680 HEK-293T C40(1.18)  LDD1570  [8]
 LDCM0275  AKOS034007705 HEK-293T C40(0.99); C271(1.07)  LDD1514  [8]
 LDCM0390  CL12 HEK-293T C40(1.52); C271(0.86)  LDD1594  [8]
 LDCM0404  CL17 HEK-293T C40(1.30)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C40(1.13)  LDD1609  [8]
 LDCM0412  CL24 HEK-293T C40(1.02); C271(1.08)  LDD1616  [8]
 LDCM0417  CL29 HEK-293T C40(0.93)  LDD1621  [8]
 LDCM0419  CL30 HEK-293T C40(0.86)  LDD1623  [8]
 LDCM0425  CL36 HEK-293T C40(1.25); C271(1.20)  LDD1629  [8]
 LDCM0431  CL41 HEK-293T C40(1.67)  LDD1635  [8]
 LDCM0432  CL42 HEK-293T C40(1.05)  LDD1636  [8]
 LDCM0438  CL48 HEK-293T C40(1.46); C271(0.97)  LDD1642  [8]
 LDCM0440  CL5 HEK-293T C40(1.41)  LDD1644  [8]
 LDCM0444  CL53 HEK-293T C40(1.60)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C40(1.33)  LDD1648  [8]
 LDCM0451  CL6 HEK-293T C40(1.35)  LDD1654  [8]
 LDCM0452  CL60 HEK-293T C40(1.44); C271(1.16)  LDD1655  [8]
 LDCM0457  CL65 HEK-293T C40(0.94)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C40(0.94)  LDD1661  [8]
 LDCM0465  CL72 HEK-293T C40(1.06); C271(1.03)  LDD1668  [8]
 LDCM0470  CL77 HEK-293T C40(1.39)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C40(1.12)  LDD1674  [8]
 LDCM0478  CL84 HEK-293T C40(1.01); C271(1.02)  LDD1681  [8]
 LDCM0483  CL89 HEK-293T C40(1.28)  LDD1686  [8]
 LDCM0485  CL90 HEK-293T C40(1.97)  LDD1688  [8]
 LDCM0491  CL96 HEK-293T C40(0.97); C271(1.20)  LDD1694  [8]
 LDCM0022  KB02 HCT 116 C271(6.57)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C271(2.52)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C271(2.71)  LDD0082  [2]

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402