Details of the Target

General Information of Target

Target ID LDTP03582
Target Name Homeobox protein Hox-A9 (HOXA9)
Gene Name HOXA9
Gene ID 3205
Synonyms
HOX1G; Homeobox protein Hox-A9; Homeobox protein Hox-1G
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATTGALGNYYVDSFLLGADAADELSVGRYAPGTLGQPPRQAATLAEHPDFSPCSFQSKA
TVFGASWNPVHAAGANAVPAAVYHHHHHHPYVHPQAPVAAAAPDGRYMRSWLEPTPGALS
FAGLPSSRPYGIKPEPLSARRGDCPTLDTHTLSLTDYACGSPPVDREKQPSEGAFSENNA
ENESGGDKPPIDPNNPAANWLHARSTRKKRCPYTKHQTLELEKEFLFNMYLTRDRRYEVA
RLLNLTERQVKIWFQNRRMKMKKINKDRAKDE
Target Bioclass
Transcription factor
Family
Abd-B homeobox family
Subcellular location
Nucleus
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of SELE/E-selectin and VCAM1 on the endothelial cells surface at sites of inflammation. Positively regulates EIF4E-mediated mRNA nuclear export and also increases the translation efficiency of ODC mRNA in the cytoplasm by competing with factors which repress EIF4E activity such as PRH.
Uniprot ID
P31269
Ensemble ID
ENST00000343483.7
HGNC ID
HGNC:5109

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C54(0.96)  LDD1492  [1]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C54(1.01)  LDD1507  [1]
 LDCM0237  AC12 HEK-293T C54(1.03)  LDD1510  [1]
 LDCM0276  AC17 HEK-293T C54(0.93)  LDD1515  [1]
 LDCM0280  AC20 HEK-293T C54(1.08)  LDD1519  [1]
 LDCM0284  AC24 HEK-293T C54(0.92)  LDD1523  [1]
 LDCM0285  AC25 HEK-293T C54(0.90)  LDD1524  [1]
 LDCM0288  AC28 HEK-293T C54(1.02)  LDD1527  [1]
 LDCM0293  AC32 HEK-293T C54(1.03)  LDD1532  [1]
 LDCM0294  AC33 HEK-293T C54(1.05)  LDD1533  [1]
 LDCM0297  AC36 HEK-293T C54(1.02)  LDD1536  [1]
 LDCM0301  AC4 HEK-293T C54(1.19)  LDD1540  [1]
 LDCM0302  AC40 HEK-293T C54(1.08)  LDD1541  [1]
 LDCM0303  AC41 HEK-293T C54(1.00)  LDD1542  [1]
 LDCM0306  AC44 HEK-293T C54(1.01)  LDD1545  [1]
 LDCM0310  AC48 HEK-293T C54(1.00)  LDD1549  [1]
 LDCM0311  AC49 HEK-293T C54(1.10)  LDD1550  [1]
 LDCM0315  AC52 HEK-293T C54(0.96)  LDD1554  [1]
 LDCM0319  AC56 HEK-293T C54(0.98)  LDD1558  [1]
 LDCM0320  AC57 HEK-293T C54(1.08)  LDD1559  [1]
 LDCM0324  AC60 HEK-293T C54(1.01)  LDD1563  [1]
 LDCM0328  AC64 HEK-293T C54(1.05)  LDD1567  [1]
 LDCM0345  AC8 HEK-293T C54(1.06)  LDD1569  [1]
 LDCM0356  AKOS034007680 HEK-293T C54(1.03)  LDD1570  [1]
 LDCM0275  AKOS034007705 HEK-293T C54(1.01)  LDD1514  [1]
 LDCM0367  CL1 HEK-293T C54(1.09)  LDD1571  [1]
 LDCM0370  CL101 HEK-293T C54(1.06)  LDD1574  [1]
 LDCM0374  CL105 HEK-293T C54(0.99)  LDD1578  [1]
 LDCM0378  CL109 HEK-293T C54(1.02)  LDD1582  [1]
 LDCM0383  CL113 HEK-293T C54(1.07)  LDD1587  [1]
 LDCM0387  CL117 HEK-293T C54(1.17)  LDD1591  [1]
 LDCM0390  CL12 HEK-293T C54(1.05)  LDD1594  [1]
 LDCM0392  CL121 HEK-293T C54(1.08)  LDD1596  [1]
 LDCM0396  CL125 HEK-293T C54(1.15)  LDD1600  [1]
 LDCM0400  CL13 HEK-293T C54(1.04)  LDD1604  [1]
 LDCM0404  CL17 HEK-293T C54(1.00)  LDD1608  [1]
 LDCM0408  CL20 HEK-293T C54(1.19)  LDD1612  [1]
 LDCM0412  CL24 HEK-293T C54(1.04)  LDD1616  [1]
 LDCM0413  CL25 HEK-293T C54(1.01)  LDD1617  [1]
 LDCM0417  CL29 HEK-293T C54(0.99)  LDD1621  [1]
 LDCM0421  CL32 HEK-293T C54(1.04)  LDD1625  [1]
 LDCM0425  CL36 HEK-293T C54(0.86)  LDD1629  [1]
 LDCM0426  CL37 HEK-293T C54(0.99)  LDD1630  [1]
 LDCM0431  CL41 HEK-293T C54(0.99)  LDD1635  [1]
 LDCM0434  CL44 HEK-293T C54(1.01)  LDD1638  [1]
 LDCM0438  CL48 HEK-293T C54(0.91)  LDD1642  [1]
 LDCM0439  CL49 HEK-293T C54(0.98)  LDD1643  [1]
 LDCM0440  CL5 HEK-293T C54(0.85)  LDD1644  [1]
 LDCM0444  CL53 HEK-293T C54(1.21)  LDD1647  [1]
 LDCM0447  CL56 HEK-293T C54(0.99)  LDD1650  [1]
 LDCM0452  CL60 HEK-293T C54(0.94)  LDD1655  [1]
 LDCM0453  CL61 HEK-293T C54(1.03)  LDD1656  [1]
 LDCM0457  CL65 HEK-293T C54(0.98)  LDD1660  [1]
 LDCM0460  CL68 HEK-293T C54(0.89)  LDD1663  [1]
 LDCM0465  CL72 HEK-293T C54(0.93)  LDD1668  [1]
 LDCM0466  CL73 HEK-293T C54(1.06)  LDD1669  [1]
 LDCM0470  CL77 HEK-293T C54(1.04)  LDD1673  [1]
 LDCM0473  CL8 HEK-293T C54(1.11)  LDD1676  [1]
 LDCM0474  CL80 HEK-293T C54(1.02)  LDD1677  [1]
 LDCM0478  CL84 HEK-293T C54(0.89)  LDD1681  [1]
 LDCM0479  CL85 HEK-293T C54(1.11)  LDD1682  [1]
 LDCM0483  CL89 HEK-293T C54(1.08)  LDD1686  [1]
 LDCM0487  CL92 HEK-293T C54(1.02)  LDD1690  [1]
 LDCM0491  CL96 HEK-293T C54(0.95)  LDD1694  [1]
 LDCM0492  CL97 HEK-293T C54(1.05)  LDD1695  [1]
 LDCM0022  KB02 HEK-293T C54(0.96)  LDD1492  [1]
 LDCM0023  KB03 HEK-293T C54(0.88)  LDD1497  [1]
 LDCM0024  KB05 HEK-293T C54(0.90)  LDD1502  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein arginine N-methyltransferase 5 (PRMT5) Protein arginine N-methyltransferase family O14744
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin-associated protein 9-3 (KRTAP9-3) KRTAP type 9 family Q9BYQ3
Thyroid receptor-interacting protein 6 (TRIP6) Zyxin/ajuba family Q15654

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004