Details of the Target

General Information of Target

Target ID LDTP03432
Target Name Long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADL)
Gene Name ACADL
Gene ID 33
Synonyms
Long-chain specific acyl-CoA dehydrogenase, mitochondrial; LCAD; EC 1.3.8.8
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAARLLRGSLRVLGGHRAPRQLPAARCSHSGGEERLETPSAKKLTDIGIRRIFSPEHDIF
RKSVRKFFQEEVIPHHSEWEKAGEVSREVWEKAGKQGLLGVNIAEHLGGIGGDLYSAAIV
WEEQAYSNCSGPGFSIHSGIVMSYITNHGSEEQIKHFIPQMTAGKCIGAIAMTEPGAGSD
LQGIKTNAKKDGSDWILNGSKVFISNGSLSDVVIVVAVTNHEAPSPAHGISLFLVENGMK
GFIKGRKLHKMGLKAQDTAELFFEDIRLPASALLGEENKGFYYIMKELPQERLLIADVAI
SASEFMFEETRNYVKQRKAFGKTVAHLQTVQHKLAELKTHICVTRAFVDNCLQLHEAKRL
DSATACMAKYWASELQNSVAYDCVQLHGGWGYMWEYPIAKAYVDARVQPIYGGTNEIMKE
LIAREIVFDK
Target Bioclass
Enzyme
Family
Acyl-CoA dehydrogenase family
Subcellular location
Mitochondrion matrix
Function
Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, long-chain specific acyl-CoA dehydrogenase can act on saturated and unsaturated acyl-CoAs with 6 to 24 carbons with a preference for 8 to 18 carbons long primary chains.
Uniprot ID
P28330
Ensemble ID
ENST00000233710.4
HGNC ID
HGNC:88

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C342(1.45)  LDD0080  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C366(0.90)  LDD1509  [3]
 LDCM0237  AC12 HEK-293T C366(1.04)  LDD1510  [3]
 LDCM0259  AC14 HEK-293T C366(0.89)  LDD1512  [3]
 LDCM0270  AC15 HEK-293T C366(0.89); C342(0.96)  LDD1513  [3]
 LDCM0278  AC19 HEK-293T C366(1.11)  LDD1517  [3]
 LDCM0280  AC20 HEK-293T C366(1.06)  LDD1519  [3]
 LDCM0281  AC21 HEK-293T C366(1.08); C342(0.89)  LDD1520  [3]
 LDCM0282  AC22 HEK-293T C366(0.88)  LDD1521  [3]
 LDCM0283  AC23 HEK-293T C366(0.73); C342(0.99)  LDD1522  [3]
 LDCM0287  AC27 HEK-293T C366(1.02)  LDD1526  [3]
 LDCM0288  AC28 HEK-293T C366(0.92)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C366(1.14); C342(0.98)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C366(0.95)  LDD1529  [3]
 LDCM0291  AC30 HEK-293T C366(0.87)  LDD1530  [3]
 LDCM0292  AC31 HEK-293T C366(0.87); C342(0.94)  LDD1531  [3]
 LDCM0296  AC35 HEK-293T C366(0.89)  LDD1535  [3]
 LDCM0297  AC36 HEK-293T C366(0.85)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C366(1.12); C342(0.97)  LDD1537  [3]
 LDCM0299  AC38 HEK-293T C366(1.04)  LDD1538  [3]
 LDCM0300  AC39 HEK-293T C366(0.87); C342(1.05)  LDD1539  [3]
 LDCM0301  AC4 HEK-293T C366(1.10)  LDD1540  [3]
 LDCM0305  AC43 HEK-293T C366(0.86)  LDD1544  [3]
 LDCM0306  AC44 HEK-293T C366(0.74)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C366(0.94); C342(0.95)  LDD1546  [3]
 LDCM0308  AC46 HEK-293T C366(1.00)  LDD1547  [3]
 LDCM0309  AC47 HEK-293T C366(0.93); C342(1.03)  LDD1548  [3]
 LDCM0312  AC5 HEK-293T C366(1.03); C342(0.94)  LDD1551  [3]
 LDCM0314  AC51 HEK-293T C366(0.86)  LDD1553  [3]
 LDCM0315  AC52 HEK-293T C366(0.88)  LDD1554  [3]
 LDCM0316  AC53 HEK-293T C366(0.98); C342(0.94)  LDD1555  [3]
 LDCM0317  AC54 HEK-293T C366(0.99)  LDD1556  [3]
 LDCM0318  AC55 HEK-293T C366(0.90); C342(1.07)  LDD1557  [3]
 LDCM0322  AC59 HEK-293T C366(0.99)  LDD1561  [3]
 LDCM0323  AC6 HEK-293T C366(1.06)  LDD1562  [3]
 LDCM0324  AC60 HEK-293T C366(1.08)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C366(1.13); C342(0.92)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C366(1.14)  LDD1565  [3]
 LDCM0327  AC63 HEK-293T C366(1.01); C342(0.94)  LDD1566  [3]
 LDCM0334  AC7 HEK-293T C366(0.88); C342(0.95)  LDD1568  [3]
 LDCM0248  AKOS034007472 HEK-293T C366(0.94); C342(0.97)  LDD1511  [3]
 LDCM0368  CL10 HEK-293T C366(1.57)  LDD1572  [3]
 LDCM0372  CL103 HEK-293T C366(0.93)  LDD1576  [3]
 LDCM0376  CL107 HEK-293T C366(0.71)  LDD1580  [3]
 LDCM0379  CL11 HEK-293T C366(0.77); C342(1.23)  LDD1583  [3]
 LDCM0381  CL111 HEK-293T C366(1.07)  LDD1585  [3]
 LDCM0385  CL115 HEK-293T C366(0.89)  LDD1589  [3]
 LDCM0389  CL119 HEK-293T C366(0.89)  LDD1593  [3]
 LDCM0394  CL123 HEK-293T C366(1.23)  LDD1598  [3]
 LDCM0398  CL127 HEK-293T C366(1.04)  LDD1602  [3]
 LDCM0402  CL15 HEK-293T C366(0.97)  LDD1606  [3]
 LDCM0406  CL19 HEK-293T C366(0.93)  LDD1610  [3]
 LDCM0408  CL20 HEK-293T C366(0.77)  LDD1612  [3]
 LDCM0409  CL21 HEK-293T C366(0.98); C342(1.09)  LDD1613  [3]
 LDCM0410  CL22 HEK-293T C366(0.89)  LDD1614  [3]
 LDCM0411  CL23 HEK-293T C366(0.76); C342(1.25)  LDD1615  [3]
 LDCM0415  CL27 HEK-293T C366(0.86)  LDD1619  [3]
 LDCM0418  CL3 HEK-293T C366(0.87)  LDD1622  [3]
 LDCM0420  CL31 HEK-293T C366(0.83)  LDD1624  [3]
 LDCM0421  CL32 HEK-293T C366(0.88)  LDD1625  [3]
 LDCM0422  CL33 HEK-293T C366(1.13); C342(1.22)  LDD1626  [3]
 LDCM0423  CL34 HEK-293T C366(0.93)  LDD1627  [3]
 LDCM0424  CL35 HEK-293T C366(0.72); C342(1.10)  LDD1628  [3]
 LDCM0428  CL39 HEK-293T C366(1.04)  LDD1632  [3]
 LDCM0433  CL43 HEK-293T C366(0.91)  LDD1637  [3]
 LDCM0434  CL44 HEK-293T C366(0.94)  LDD1638  [3]
 LDCM0435  CL45 HEK-293T C366(1.14); C342(1.09)  LDD1639  [3]
 LDCM0436  CL46 HEK-293T C366(0.85)  LDD1640  [3]
 LDCM0437  CL47 HEK-293T C366(0.73); C342(1.09)  LDD1641  [3]
 LDCM0446  CL55 HEK-293T C366(0.94)  LDD1649  [3]
 LDCM0447  CL56 HEK-293T C366(0.74)  LDD1650  [3]
 LDCM0448  CL57 HEK-293T C366(1.34); C342(1.06)  LDD1651  [3]
 LDCM0449  CL58 HEK-293T C366(1.09)  LDD1652  [3]
 LDCM0450  CL59 HEK-293T C366(0.91); C342(1.18)  LDD1653  [3]
 LDCM0455  CL63 HEK-293T C366(0.83)  LDD1658  [3]
 LDCM0459  CL67 HEK-293T C366(0.83)  LDD1662  [3]
 LDCM0460  CL68 HEK-293T C366(0.86)  LDD1663  [3]
 LDCM0461  CL69 HEK-293T C366(1.01); C342(1.18)  LDD1664  [3]
 LDCM0462  CL7 HEK-293T C366(0.85)  LDD1665  [3]
 LDCM0463  CL70 HEK-293T C366(0.85)  LDD1666  [3]
 LDCM0464  CL71 HEK-293T C366(0.86); C342(1.13)  LDD1667  [3]
 LDCM0472  CL79 HEK-293T C366(0.82)  LDD1675  [3]
 LDCM0473  CL8 HEK-293T C366(1.49)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C366(0.81)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C366(0.97); C342(0.96)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C366(0.85)  LDD1679  [3]
 LDCM0477  CL83 HEK-293T C366(0.86); C342(1.16)  LDD1680  [3]
 LDCM0481  CL87 HEK-293T C366(1.03)  LDD1684  [3]
 LDCM0484  CL9 HEK-293T C366(0.96); C342(1.06)  LDD1687  [3]
 LDCM0486  CL91 HEK-293T C366(1.01)  LDD1689  [3]
 LDCM0487  CL92 HEK-293T C366(0.86)  LDD1690  [3]
 LDCM0488  CL93 HEK-293T C366(1.02); C342(1.01)  LDD1691  [3]
 LDCM0489  CL94 HEK-293T C366(0.93)  LDD1692  [3]
 LDCM0490  CL95 HEK-293T C366(1.21); C342(1.18)  LDD1693  [3]
 LDCM0494  CL99 HEK-293T C366(0.91)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C366(0.88)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C366(1.00)  LDD1671  [3]
 LDCM0022  KB02 HCT 116 C342(1.45)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C342(1.96)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C342(1.77)  LDD0082  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein-glutamine gamma-glutamyltransferase K (TGM1) Transglutaminase family P22735

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402