Details of the Target

General Information of Target

Target ID LDTP03320
Target Name Laminin subunit alpha-1 (LAMA1)
Gene Name LAMA1
Gene ID 284217
Synonyms
LAMA; Laminin subunit alpha-1; Laminin A chain; Laminin-1 subunit alpha; Laminin-3 subunit alpha; S-laminin subunit alpha; S-LAM alpha
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRGGVLLVLLLCVAAQCRQRGLFPAILNLASNAHISTNATCGEKGPEMFCKLVEHVPGRP
VRNPQCRICDGNSANPRERHPISHAIDGTNNWWQSPSIQNGREYHWVTITLDLRQVFQVA
YVIIKAANAPRPGNWILERSLDGTTFSPWQYYAVSDSECLSRYNITPRRGPPTYRADDEV
ICTSYYSRLVPLEHGEIHTSLINGRPSADDLSPKLLEFTSARYIRLRLQRIRTLNADLMT
LSHREPKELDPIVTRRYYYSIKDISVGGMCICYGHASSCPWDETTKKLQCQCEHNTCGES
CNRCCPGYHQQPWRPGTVSSGNTCEACNCHNKAKDCYYDESVAKQKKSLNTAGQFRGGGV
CINCLQNTMGINCETCIDGYYRPHKVSPYEDEPCRPCNCDPVGSLSSVCIKDDLHSDLHN
GKQPGQCPCKEGYTGEKCDRCQLGYKDYPTCVSCGCNPVGSASDEPCTGPCVCKENVEGK
ACDRCKPGFYNLKEKNPRGCSECFCFGVSDVCSSLSWPVGQVNSMSGWLVTDLISPRKIP
SQQDALGGRHQVSINNTAVMQRLAPKYYWAAPEAYLGNKLTAFGGFLKYTVSYDIPVETV
DSNLMSHADVIIKGNGLTLSTQAEGLSLQPYEEYLNVVRLVPENFQDFHSKRQIDRDQLM
TVLANVTHLLIRANYNSAKMALYRLESVSLDIASSNAIDLVVAADVEHCECPQGYTGTSC
ESCLSGYYRVDGILFGGICQPCECHGHAAECNVHGVCIACAHNTTGVHCEQCLPGFYGEP
SRGTPGDCQPCACPLTIASNNFSPTCHLNDGDEVVCDWCAPGYSGAWCERCADGYYGNPT
VPGESCVPCDCSGNVDPSEAGHCDSVTGECLKCLGNTDGAHCERCADGFYGDAVTAKNCR
ACECHVKGSHSAVCHLETGLCDCKPNVTGQQCDQCLHGYYGLDSGHGCRPCNCSVAGSVS
DGCTDEGQCHCVPGVAGKRCDRCAHGFYAYQDGSCTPCDCPHTQNTCDPETGECVCPPHT
QGVKCEECEDGHWGYDAEVGCQACNCSLVGSTHHRCDVVTGHCQCKSKFGGRACDQCSLG
YRDFPDCVPCDCDLRGTSGDACNLEQGLCGCVEETGACPCKENVFGPQCNECREGTFALR
ADNPLGCSPCFCSGLSHLCSELEDYVRTPVTLGSDQPLLRVVSQSNLRGTTEGVYYQAPD
FLLDAATVRQHIRAEPFYWRLPQQFQGDQLMAYGGKLKYSVAFYSLDGVGTSNFEPQVLI
KGGRIRKQVIYMDAPAPENGVRQEQEVAMRENFWKYFNSVSEKPVTREDFMSVLSDIEYI
LIKASYGQGLQQSRISDISMEVGRKAEKLHPEEEVASLLENCVCPPGTVGFSCQDCAPGY
HRGKLPAGSDRGPRPLVAPCVPCSCNNHSDTCDPNTGKCLNCGDNTAGDHCDVCTSGYYG
KVTGSASDCALCACPHSPPASFSPTCVLEGDHDFRCDACLLGYEGKHCERCSSSYYGNPQ
TPGGSCQKCDCNPHGSVHGDCDRTSGQCVCRLGASGLRCDECEPRHILMETDCVSCDDEC
VGVLLNDLDEIGDAVLSLNLTGIIPVPYGILSNLENTTKYLQESLLKENMQKDLGKIKLE
GVAEETDNLQKKLTRMLASTQKVNRATERIFKESQDLAIAIERLQMSITEIMEKTTLNQT
LDEDFLLPNSTLQNMQQNGTSLLEIMQIRDFTQLHQNATLELKAAEDLLSQIQENYQKPL
EELEVLKEAASHVLSKHNNELKAAEALVREAEAKMQESNHLLLMVNANLREFSDKKLHVQ
EEQNLTSELIVQGRGLIDAAAAQTDAVQDALEHLEDHQDKLLLWSAKIRHHIDDLVMHMS
QRNAVDLVYRAEDHAAEFQRLADVLYSGLENIRNVSLNATSAAYVHYNIQSLIEESEELA
RDAHRTVTETSLLSESLVSNGKAAVQRSSRFLKEGNNLSRKLPGIALELSELRNKTNRFQ
ENAVEITRQTNESLLILRAIPKGIRDKGAKTKELATSASQSAVSTLRDVAGLSQELLNTS
ASLSRVNTTLRETHQLLQDSTMATLLAGRKVKDVEIQANLLFDRLKPLKMLEENLSRNLS
EIKLLISQARKQAASIKVAVSADRDCIRAYQPQISSTNYNTLTLNVKTQEPDNLLFYLGS
STASDFLAVEMRRGRVAFLWDLGSGSTRLEFPDFPIDDNRWHSIHVARFGNIGSLSVKEM
SSNQKSPTKTSKSPGTANVLDVNNSTLMFVGGLGGQIKKSPAVKVTHFKGCLGEAFLNGK
SIGLWNYIEREGKCRGCFGSSQNEDPSFHFDGSGYSVVEKSLPATVTQIIMLFNTFSPNG
LLLYLGSYGTKDFLSIELFRGRVKVMTDLGSGPITLLTDRRYNNGTWYKIAFQRNRKQGV
LAVIDAYNTSNKETKQGETPGASSDLNRLDKDPIYVGGLPRSRVVRRGVTTKSFVGCIKN
LEISRSTFDLLRNSYGVRKGCLLEPIRSVSFLKGGYIELPPKSLSPESEWLVTFATTNSS
GIILAALGGDVEKRGDREEAHVPFFSVMLIGGNIEVHVNPGDGTGLRKALLHAPTGTCSD
GQAHSISLVRNRRIITVQLDENNPVEMKLGTLVESRTINVSNLYVGGIPEGEGTSLLTMR
RSFHGCIKNLIFNLELLDFNSAVGHEQVDLDTCWLSERPKLAPDAEDSKLLPEPRAFPEQ
CVVDAALEYVPGAHQFGLTQNSHFILPFNQSAVRKKLSVELSIRTFASSGLIYYMAHQNQ
ADYAVLQLHGGRLHFMFDLGKGRTKVSHPALLSDGKWHTVKTDYVKRKGFITVDGRESPM
VTVVGDGTMLDVEGLFYLGGLPSQYQARKIGNITHSIPACIGDVTVNSKQLDKDSPVSAF
TVNRCYAVAQEGTYFDGSGYAALVKEGYKVQSDVNITLEFRTSSQNGVLLGISTAKVDAI
GLELVDGKVLFHVNNGAGRITAAYEPKTATVLCDGKWHTLQANKSKHRITLIVDGNAVGA
ESPHTQSTSVDTNNPIYVGGYPAGVKQKCLRSQTSFRGCLRKLALIKSPQVQSFDFSRAF
ELHGVFLHSCPGTES
Target Bioclass
Other
Subcellular location
Secreted, extracellular space, extracellular matrix, basement membrane
Function
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Uniprot ID
P25391
Ensemble ID
ENST00000389658.4
HGNC ID
HGNC:6481
ChEMBL ID
CHEMBL4523594

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		K493(2.08)  LDD0274  [1]
DBIA
 Probe Info  		C2481(4.01)  LDD3419  [2]
BTD
 Probe Info  		C17(0.69)  LDD2128  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]
IPM
 Probe Info  		C2126(0.00); C2271(0.00); C2481(0.00); C2457(0.00)  LDD0147  [5]
TFBX
 Probe Info  		C2457(0.00); C885(0.00); C2271(0.00); C2126(0.00)  LDD0148  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C2271(1.10)  LDD1507  [6]
 LDCM0215  AC10 HEK-293T C2973(1.01); C2481(1.07)  LDD1508  [6]
 LDCM0237  AC12 HEK-293T C2973(0.93)  LDD1510  [6]
 LDCM0259  AC14 HEK-293T C2481(0.87)  LDD1512  [6]
 LDCM0270  AC15 HEK-293T C2481(1.02)  LDD1513  [6]
 LDCM0276  AC17 HEK-293T C2271(1.01)  LDD1515  [6]
 LDCM0277  AC18 HEK-293T C2973(0.96); C2481(1.02)  LDD1516  [6]
 LDCM0279  AC2 HEK-293T C2973(0.98); C2481(1.06)  LDD1518  [6]
 LDCM0280  AC20 HEK-293T C2973(0.88)  LDD1519  [6]
 LDCM0282  AC22 HEK-293T C2481(0.93)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C2481(1.04)  LDD1522  [6]
 LDCM0285  AC25 HEK-293T C2271(1.02)  LDD1524  [6]
 LDCM0286  AC26 HEK-293T C2973(0.98); C2481(0.95)  LDD1525  [6]
 LDCM0288  AC28 HEK-293T C2973(0.98)  LDD1527  [6]
 LDCM0291  AC30 HEK-293T C2481(0.91)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C2481(1.01)  LDD1531  [6]
 LDCM0294  AC33 HEK-293T C2271(1.09)  LDD1533  [6]
 LDCM0295  AC34 HEK-293T C2973(1.03); C2481(1.08)  LDD1534  [6]
 LDCM0297  AC36 HEK-293T C2973(0.96)  LDD1536  [6]
 LDCM0299  AC38 HEK-293T C2481(0.86)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C2481(1.02)  LDD1539  [6]
 LDCM0301  AC4 HEK-293T C2973(0.94)  LDD1540  [6]
 LDCM0303  AC41 HEK-293T C2271(1.07)  LDD1542  [6]
 LDCM0304  AC42 HEK-293T C2973(1.00); C2481(1.12)  LDD1543  [6]
 LDCM0306  AC44 HEK-293T C2973(1.00)  LDD1545  [6]
 LDCM0308  AC46 HEK-293T C2481(1.01)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C2481(1.13)  LDD1548  [6]
 LDCM0311  AC49 HEK-293T C2271(1.18)  LDD1550  [6]
 LDCM0313  AC50 HEK-293T C2973(1.04); C2481(0.98)  LDD1552  [6]
 LDCM0315  AC52 HEK-293T C2973(0.95)  LDD1554  [6]
 LDCM0317  AC54 HEK-293T C2481(1.00)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C2481(1.01)  LDD1557  [6]
 LDCM0320  AC57 HEK-293T C2271(1.13)  LDD1559  [6]
 LDCM0321  AC58 HEK-293T C2973(1.02); C2481(1.03)  LDD1560  [6]
 LDCM0323  AC6 HEK-293T C2481(0.92)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C2973(0.97)  LDD1563  [6]
 LDCM0326  AC62 HEK-293T C2481(1.03)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C2481(1.04)  LDD1566  [6]
 LDCM0334  AC7 HEK-293T C2481(1.05)  LDD1568  [6]
 LDCM0356  AKOS034007680 HEK-293T C2271(1.11)  LDD1570  [6]
 LDCM0367  CL1 HEK-293T C2646(1.08)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C2481(1.10)  LDD1572  [6]
 LDCM0370  CL101 HEK-293T C2646(1.00)  LDD1574  [6]
 LDCM0371  CL102 HEK-293T C2973(0.89)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C2271(0.95)  LDD1576  [6]
 LDCM0374  CL105 HEK-293T C2646(1.00)  LDD1578  [6]
 LDCM0375  CL106 HEK-293T C2973(0.95)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C2271(0.96)  LDD1580  [6]
 LDCM0378  CL109 HEK-293T C2646(1.04)  LDD1582  [6]
 LDCM0379  CL11 HEK-293T C2481(1.21)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C2973(0.87)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C2271(1.00)  LDD1585  [6]
 LDCM0383  CL113 HEK-293T C2646(0.99)  LDD1587  [6]
 LDCM0384  CL114 HEK-293T C2973(1.02)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C2271(1.00)  LDD1589  [6]
 LDCM0387  CL117 HEK-293T C2646(1.07)  LDD1591  [6]
 LDCM0388  CL118 HEK-293T C2973(0.98)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C2271(1.05)  LDD1593  [6]
 LDCM0392  CL121 HEK-293T C2646(0.97)  LDD1596  [6]
 LDCM0393  CL122 HEK-293T C2973(0.95)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C2271(0.96)  LDD1598  [6]
 LDCM0396  CL125 HEK-293T C2646(0.95)  LDD1600  [6]
 LDCM0397  CL126 HEK-293T C2973(0.96)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C2271(0.98)  LDD1602  [6]
 LDCM0400  CL13 HEK-293T C2646(1.06)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C2973(1.10)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C2271(0.99)  LDD1606  [6]
 LDCM0404  CL17 HEK-293T C2271(1.10)  LDD1608  [6]
 LDCM0405  CL18 HEK-293T C2973(1.04); C2481(1.07)  LDD1609  [6]
 LDCM0407  CL2 HEK-293T C2973(0.97)  LDD1611  [6]
 LDCM0408  CL20 HEK-293T C2973(1.39)  LDD1612  [6]
 LDCM0410  CL22 HEK-293T C2481(1.14)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C2481(1.06)  LDD1615  [6]
 LDCM0413  CL25 HEK-293T C2646(0.87)  LDD1617  [6]
 LDCM0414  CL26 HEK-293T C2973(0.96)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C2271(1.08)  LDD1619  [6]
 LDCM0417  CL29 HEK-293T C2271(1.07)  LDD1621  [6]
 LDCM0418  CL3 HEK-293T C2271(1.12)  LDD1622  [6]
 LDCM0419  CL30 HEK-293T C2973(1.07); C2481(1.05)  LDD1623  [6]
 LDCM0421  CL32 HEK-293T C2973(1.00)  LDD1625  [6]
 LDCM0423  CL34 HEK-293T C2481(1.19)  LDD1627  [6]
 LDCM0424  CL35 HEK-293T C2481(1.18)  LDD1628  [6]
 LDCM0426  CL37 HEK-293T C2646(0.86)  LDD1630  [6]
 LDCM0428  CL39 HEK-293T C2271(1.02)  LDD1632  [6]
 LDCM0431  CL41 HEK-293T C2271(0.96)  LDD1635  [6]
 LDCM0432  CL42 HEK-293T C2973(1.06); C2481(1.15)  LDD1636  [6]
 LDCM0434  CL44 HEK-293T C2973(1.22)  LDD1638  [6]
 LDCM0436  CL46 HEK-293T C2481(1.03)  LDD1640  [6]
 LDCM0437  CL47 HEK-293T C2481(1.24)  LDD1641  [6]
 LDCM0439  CL49 HEK-293T C2646(0.94)  LDD1643  [6]
 LDCM0440  CL5 HEK-293T C2271(1.07)  LDD1644  [6]
 LDCM0441  CL50 HEK-293T C2973(0.86)  LDD1645  [6]
 LDCM0444  CL53 HEK-293T C2271(1.03)  LDD1647  [6]
 LDCM0445  CL54 HEK-293T C2973(0.98); C2481(1.50)  LDD1648  [6]
 LDCM0447  CL56 HEK-293T C2973(1.16)  LDD1650  [6]
 LDCM0449  CL58 HEK-293T C2481(1.24)  LDD1652  [6]
 LDCM0450  CL59 HEK-293T C2481(1.29)  LDD1653  [6]
 LDCM0451  CL6 HEK-293T C2973(1.07); C2481(1.30)  LDD1654  [6]
 LDCM0453  CL61 HEK-293T C2646(1.03)  LDD1656  [6]
 LDCM0454  CL62 HEK-293T C2973(0.95)  LDD1657  [6]
 LDCM0455  CL63 HEK-293T C2271(0.98)  LDD1658  [6]
 LDCM0457  CL65 HEK-293T C2271(0.95)  LDD1660  [6]
 LDCM0458  CL66 HEK-293T C2973(0.93); C2481(1.09)  LDD1661  [6]
 LDCM0460  CL68 HEK-293T C2973(1.18)  LDD1663  [6]
 LDCM0463  CL70 HEK-293T C2481(1.11)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C2481(1.08)  LDD1667  [6]
 LDCM0466  CL73 HEK-293T C2646(1.04)  LDD1669  [6]
 LDCM0467  CL74 HEK-293T C2973(0.83)  LDD1670  [6]
 LDCM0470  CL77 HEK-293T C2271(1.03)  LDD1673  [6]
 LDCM0471  CL78 HEK-293T C2973(0.91); C2481(1.08)  LDD1674  [6]
 LDCM0473  CL8 HEK-293T C2973(1.31)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C2973(1.13)  LDD1677  [6]
 LDCM0476  CL82 HEK-293T C2481(1.04)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C2481(1.16)  LDD1680  [6]
 LDCM0479  CL85 HEK-293T C2646(0.84)  LDD1682  [6]
 LDCM0480  CL86 HEK-293T C2973(1.01)  LDD1683  [6]
 LDCM0481  CL87 HEK-293T C2271(1.10)  LDD1684  [6]
 LDCM0483  CL89 HEK-293T C2271(1.10)  LDD1686  [6]
 LDCM0485  CL90 HEK-293T C2973(1.01); C2481(1.67)  LDD1688  [6]
 LDCM0487  CL92 HEK-293T C2973(1.02)  LDD1690  [6]
 LDCM0489  CL94 HEK-293T C2481(1.11)  LDD1692  [6]
 LDCM0490  CL95 HEK-293T C2481(1.48)  LDD1693  [6]
 LDCM0492  CL97 HEK-293T C2646(0.97)  LDD1695  [6]
 LDCM0493  CL98 HEK-293T C2973(1.04)  LDD1696  [6]
 LDCM0494  CL99 HEK-293T C2271(0.95)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C2271(0.94)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C2271(1.03)  LDD1671  [6]
 LDCM0427  Fragment51 HEK-293T C2973(1.05)  LDD1631  [6]
 LDCM0022  KB02 A2058 C485(2.15); C441(1.91); C2271(3.07); C2481(8.76)  LDD2253  [2]
 LDCM0023  KB03 A2058 C485(2.01); C441(2.05); C2481(11.27); C69(2.63)  LDD2670  [2]
 LDCM0024  KB05 SH-4 C2481(4.01)  LDD3419  [2]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C17(0.69)  LDD2128  [3]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Lanoteplase . DB06245

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402