Details of the Target

General Information of Target

Target ID LDTP02988
Target Name Lymphocyte function-associated antigen 3 (CD58)
Gene Name CD58
Gene ID 965
Synonyms
LFA3; Lymphocyte function-associated antigen 3; Ag3; Surface glycoprotein LFA-3; CD antigen CD58
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVAGSDAGRALGVLSVVCLLHCFGFISCFSQQIYGVVYGNVTFHVPSNVPLKEVLWKKQK
DKVAELENSEFRAFSSFKNRVYLDTVSGSLTIYNLTSSDEDEYEMESPNITDTMKFFLYV
LESLPSPTLTCALTNGSIEVQCMIPEHYNSHRGLIMYSWDCPMEQCKRNSTSIYFKMEND
LPQKIQCTLSNPLFNTTSSIILTTCIPSSGHSRHRYALIPIPLAVITTCIVLYMNGILKC
DRKPDRTNSN
Target Type
Successful
Target Bioclass
Other
Subcellular location
Cell membrane
Function
Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells.
TTD ID
T59122
Uniprot ID
P19256
DrugMap ID
TT5KSBY
Ensemble ID
ENST00000369489.10
HGNC ID
HGNC:1688
ChEMBL ID
CHEMBL3790

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCSW1 SNV: p.Q32K .
GB2 SNV: p.S107L .
LS180 Deletion: p.S30PfsTer12 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K62(1.03); K78(4.55)  LDD0277  [1]
OPA-S-S-alkyne
 Probe Info  		K167(2.06); K62(5.48); K60(6.36); K78(8.22)  LDD3494  [2]
DBIA
 Probe Info  		C161(1.02)  LDD1510  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0237  AC12 HEK-293T C161(1.02)  LDD1510  [3]
 LDCM0280  AC20 HEK-293T C161(0.96)  LDD1519  [3]
 LDCM0281  AC21 HEK-293T C161(1.23)  LDD1520  [3]
 LDCM0284  AC24 HEK-293T C161(1.54)  LDD1523  [3]
 LDCM0288  AC28 HEK-293T C161(0.95)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C161(1.09)  LDD1528  [3]
 LDCM0293  AC32 HEK-293T C161(1.34)  LDD1532  [3]
 LDCM0297  AC36 HEK-293T C161(1.10)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C161(0.90)  LDD1537  [3]
 LDCM0301  AC4 HEK-293T C161(0.95)  LDD1540  [3]
 LDCM0302  AC40 HEK-293T C161(1.39)  LDD1541  [3]
 LDCM0306  AC44 HEK-293T C161(0.92)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C161(0.90)  LDD1546  [3]
 LDCM0310  AC48 HEK-293T C161(1.46)  LDD1549  [3]
 LDCM0312  AC5 HEK-293T C161(1.08)  LDD1551  [3]
 LDCM0315  AC52 HEK-293T C161(0.82)  LDD1554  [3]
 LDCM0316  AC53 HEK-293T C161(0.98)  LDD1555  [3]
 LDCM0319  AC56 HEK-293T C161(1.65)  LDD1558  [3]
 LDCM0324  AC60 HEK-293T C161(1.35)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C161(1.23)  LDD1564  [3]
 LDCM0328  AC64 HEK-293T C161(1.76)  LDD1567  [3]
 LDCM0345  AC8 HEK-293T C161(1.22)  LDD1569  [3]
 LDCM0248  AKOS034007472 HEK-293T C161(1.05)  LDD1511  [3]
 LDCM0275  AKOS034007705 HEK-293T C161(1.29)  LDD1514  [3]
 LDCM0367  CL1 HEK-293T C161(0.83)  LDD1571  [3]
 LDCM0370  CL101 HEK-293T C161(0.80)  LDD1574  [3]
 LDCM0371  CL102 HEK-293T C161(0.86)  LDD1575  [3]
 LDCM0374  CL105 HEK-293T C161(1.00)  LDD1578  [3]
 LDCM0375  CL106 HEK-293T C161(1.08)  LDD1579  [3]
 LDCM0378  CL109 HEK-293T C161(1.06)  LDD1582  [3]
 LDCM0380  CL110 HEK-293T C161(0.92)  LDD1584  [3]
 LDCM0383  CL113 HEK-293T C161(1.22)  LDD1587  [3]
 LDCM0384  CL114 HEK-293T C161(1.09)  LDD1588  [3]
 LDCM0387  CL117 HEK-293T C161(1.04)  LDD1591  [3]
 LDCM0388  CL118 HEK-293T C161(1.34)  LDD1592  [3]
 LDCM0390  CL12 HEK-293T C161(1.51)  LDD1594  [3]
 LDCM0392  CL121 HEK-293T C161(0.82)  LDD1596  [3]
 LDCM0393  CL122 HEK-293T C161(1.21)  LDD1597  [3]
 LDCM0396  CL125 HEK-293T C161(0.81)  LDD1600  [3]
 LDCM0397  CL126 HEK-293T C161(1.25)  LDD1601  [3]
 LDCM0400  CL13 HEK-293T C161(0.76)  LDD1604  [3]
 LDCM0401  CL14 HEK-293T C161(0.98)  LDD1605  [3]
 LDCM0407  CL2 HEK-293T C161(0.83)  LDD1611  [3]
 LDCM0408  CL20 HEK-293T C161(0.69)  LDD1612  [3]
 LDCM0409  CL21 HEK-293T C161(0.82)  LDD1613  [3]
 LDCM0412  CL24 HEK-293T C161(1.24)  LDD1616  [3]
 LDCM0413  CL25 HEK-293T C161(0.80)  LDD1617  [3]
 LDCM0414  CL26 HEK-293T C161(0.84)  LDD1618  [3]
 LDCM0421  CL32 HEK-293T C161(0.70)  LDD1625  [3]
 LDCM0422  CL33 HEK-293T C161(1.00)  LDD1626  [3]
 LDCM0425  CL36 HEK-293T C161(1.38)  LDD1629  [3]
 LDCM0426  CL37 HEK-293T C161(1.05)  LDD1630  [3]
 LDCM0434  CL44 HEK-293T C161(1.03)  LDD1638  [3]
 LDCM0435  CL45 HEK-293T C161(1.21)  LDD1639  [3]
 LDCM0438  CL48 HEK-293T C161(1.19)  LDD1642  [3]
 LDCM0439  CL49 HEK-293T C161(0.89)  LDD1643  [3]
 LDCM0441  CL50 HEK-293T C161(1.13)  LDD1645  [3]
 LDCM0447  CL56 HEK-293T C161(1.08)  LDD1650  [3]
 LDCM0448  CL57 HEK-293T C161(1.42)  LDD1651  [3]
 LDCM0452  CL60 HEK-293T C161(1.44)  LDD1655  [3]
 LDCM0453  CL61 HEK-293T C161(0.86)  LDD1656  [3]
 LDCM0454  CL62 HEK-293T C161(1.15)  LDD1657  [3]
 LDCM0460  CL68 HEK-293T C161(1.11)  LDD1663  [3]
 LDCM0461  CL69 HEK-293T C161(1.10)  LDD1664  [3]
 LDCM0465  CL72 HEK-293T C161(1.50)  LDD1668  [3]
 LDCM0466  CL73 HEK-293T C161(0.77)  LDD1669  [3]
 LDCM0467  CL74 HEK-293T C161(0.90)  LDD1670  [3]
 LDCM0473  CL8 HEK-293T C161(1.17)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C161(1.18)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C161(0.94)  LDD1678  [3]
 LDCM0478  CL84 HEK-293T C161(1.87)  LDD1681  [3]
 LDCM0479  CL85 HEK-293T C161(0.82)  LDD1682  [3]
 LDCM0480  CL86 HEK-293T C161(1.00)  LDD1683  [3]
 LDCM0484  CL9 HEK-293T C161(1.00)  LDD1687  [3]
 LDCM0487  CL92 HEK-293T C161(1.06)  LDD1690  [3]
 LDCM0488  CL93 HEK-293T C161(1.09)  LDD1691  [3]
 LDCM0491  CL96 HEK-293T C161(1.31)  LDD1694  [3]
 LDCM0492  CL97 HEK-293T C161(0.99)  LDD1695  [3]
 LDCM0493  CL98 HEK-293T C161(1.00)  LDD1696  [3]
 LDCM0427  Fragment51 HEK-293T C161(1.04)  LDD1631  [3]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Alefacept . D09ZSO

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060