Details of the Target

General Information of Target

Target ID LDTP02900
Target Name Homeobox protein Hox-B4 (HOXB4)
Gene Name HOXB4
Gene ID 3214
Synonyms
HOX2F; Homeobox protein Hox-B4; Homeobox protein Hox-2.6; Homeobox protein Hox-2F
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAMSSFLINSNYVDPKFPPCEEYSQSDYLPSDHSPGYYAGGQRRESSFQPEAGFGRRAAC
TVQRYAACRDPGPPPPPPPPPPPPPPPGLSPRAPAPPPAGALLPEPGQRCEAVSSSPPPP
PCAQNPLHPSPSHSACKEPVVYPWMRKVHVSTVNPNYAGGEPKRSRTAYTRQQVLELEKE
FHYNRYLTRRRRVEIAHALCLSERQIKIWFQNRRMKWKKDHKLPNTKIRSGGAAGSAGGP
PGRPNGGPRAL
Target Bioclass
Transcription factor
Family
Antp homeobox family, Deformed subfamily
Subcellular location
Nucleus
Function Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Uniprot ID
P17483
Ensemble ID
ENST00000332503.6
HGNC ID
HGNC:5115

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.20  LDD0402  [1]
IA-alkyne
 Probe Info  		C60(1.23)  LDD2183  [2]
DBIA
 Probe Info  		C60(0.98)  LDD0531  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C60(0.98)  LDD0531  [3]
 LDCM0259  AC14 HEK-293T C60(1.20)  LDD1512  [5]
 LDCM0263  AC143 HCT 116 C60(1.29)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C60(1.06)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C60(1.33)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C60(1.33)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C60(1.17)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C60(1.32)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C60(1.50)  LDD0586  [3]
 LDCM0270  AC15 HEK-293T C60(0.80)  LDD1513  [5]
 LDCM0271  AC150 HCT 116 C60(1.47)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C60(0.95)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C60(1.21)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C60(1.45)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C60(1.28)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C60(1.38)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C60(1.18)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C60(1.18)  LDD2161  [3]
 LDCM0279  AC2 HCT 116 C60(1.62)  LDD0596  [3]
 LDCM0281  AC21 HEK-293T C60(1.08)  LDD1520  [5]
 LDCM0282  AC22 HEK-293T C60(1.03)  LDD1521  [5]
 LDCM0283  AC23 HEK-293T C60(0.81)  LDD1522  [5]
 LDCM0289  AC29 HEK-293T C60(1.02)  LDD1528  [5]
 LDCM0290  AC3 HCT 116 C60(1.23)  LDD0607  [3]
 LDCM0291  AC30 HEK-293T C60(0.97)  LDD1530  [5]
 LDCM0292  AC31 HEK-293T C60(1.05)  LDD1531  [5]
 LDCM0298  AC37 HEK-293T C60(0.88)  LDD1537  [5]
 LDCM0299  AC38 HEK-293T C60(1.16)  LDD1538  [5]
 LDCM0300  AC39 HEK-293T C60(0.89)  LDD1539  [5]
 LDCM0301  AC4 HCT 116 C60(1.32)  LDD0618  [3]
 LDCM0307  AC45 HEK-293T C60(1.09)  LDD1546  [5]
 LDCM0308  AC46 HEK-293T C60(1.09)  LDD1547  [5]
 LDCM0309  AC47 HEK-293T C60(0.93)  LDD1548  [5]
 LDCM0312  AC5 HCT 116 C60(1.32)  LDD0629  [3]
 LDCM0316  AC53 HEK-293T C60(1.06)  LDD1555  [5]
 LDCM0317  AC54 HEK-293T C60(1.09)  LDD1556  [5]
 LDCM0318  AC55 HEK-293T C60(0.89)  LDD1557  [5]
 LDCM0323  AC6 HEK-293T C60(1.02)  LDD1562  [5]
 LDCM0325  AC61 HEK-293T C60(1.07)  LDD1564  [5]
 LDCM0326  AC62 HEK-293T C60(1.02)  LDD1565  [5]
 LDCM0327  AC63 HEK-293T C60(0.91)  LDD1566  [5]
 LDCM0334  AC7 HEK-293T C60(0.87)  LDD1568  [5]
 LDCM0349  AC83 HCT 116 C60(0.48)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C60(0.45)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C60(0.57)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C60(0.80)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C60(0.64)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C60(0.49)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C60(0.50)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C60(0.72)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C60(0.46)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C60(0.54)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C60(0.58)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C60(0.41)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C60(0.43)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C60(0.75)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C60(0.65)  LDD0681  [3]
 LDCM0248  AKOS034007472 HEK-293T C60(0.95)  LDD1511  [5]
 LDCM0156  Aniline NCI-H1299 13.78  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C60(1.26)  LDD2171  [3]
 LDCM0367  CL1 HCT 116 C60(0.98)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C60(1.11)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C60(1.24)  LDD0686  [3]
 LDCM0379  CL11 HCT 116 C60(1.20)  LDD0696  [3]
 LDCM0390  CL12 HCT 116 C60(1.10)  LDD0707  [3]
 LDCM0400  CL13 HCT 116 C60(0.91)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C60(1.10)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C60(0.94)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C60(1.20)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C60(1.02)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C60(1.22)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C60(0.99)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C60(0.99)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C60(1.10)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C60(0.87)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C60(0.75)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C60(1.12)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C60(0.80)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C60(1.00)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C60(1.16)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C60(0.99)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C60(1.19)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C60(1.09)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C60(0.90)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C60(1.05)  LDD0736  [3]
 LDCM0422  CL33 HEK-293T C60(1.08)  LDD1626  [5]
 LDCM0423  CL34 HEK-293T C60(1.12)  LDD1627  [5]
 LDCM0424  CL35 HEK-293T C60(0.70)  LDD1628  [5]
 LDCM0429  CL4 HCT 116 C60(0.92)  LDD0746  [3]
 LDCM0435  CL45 HEK-293T C60(1.07)  LDD1639  [5]
 LDCM0436  CL46 HEK-293T C60(1.16)  LDD1640  [5]
 LDCM0437  CL47 HEK-293T C60(0.95)  LDD1641  [5]
 LDCM0440  CL5 HCT 116 C60(1.05)  LDD0757  [3]
 LDCM0448  CL57 HEK-293T C60(1.16)  LDD1651  [5]
 LDCM0449  CL58 HEK-293T C60(1.19)  LDD1652  [5]
 LDCM0450  CL59 HEK-293T C60(0.97)  LDD1653  [5]
 LDCM0451  CL6 HCT 116 C60(0.88)  LDD0768  [3]
 LDCM0461  CL69 HEK-293T C60(1.18)  LDD1664  [5]
 LDCM0462  CL7 HCT 116 C60(1.38)  LDD0779  [3]
 LDCM0463  CL70 HEK-293T C60(1.05)  LDD1666  [5]
 LDCM0464  CL71 HEK-293T C60(0.84)  LDD1667  [5]
 LDCM0473  CL8 HCT 116 C60(0.78)  LDD0790  [3]
 LDCM0475  CL81 HEK-293T C60(0.98)  LDD1678  [5]
 LDCM0476  CL82 HEK-293T C60(1.12)  LDD1679  [5]
 LDCM0477  CL83 HEK-293T C60(0.97)  LDD1680  [5]
 LDCM0484  CL9 HCT 116 C60(1.05)  LDD0801  [3]
 LDCM0486  CL91 HCT 116 C60(0.76)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C60(0.92)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C60(0.91)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C60(1.09)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C60(0.77)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C60(1.48)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C60(1.16)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C60(0.88)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C60(1.15)  LDD0811  [3]
 LDCM0625  F8 Ramos C60(1.04)  LDD2187  [2]
 LDCM0586  Fragment28 Ramos C60(0.93)  LDD2198  [2]
 LDCM0569  Fragment7 Ramos C60(0.60)  LDD2186  [2]
 LDCM0022  KB02 DEL C60(2.52)  LDD2315  [6]
 LDCM0023  KB03 Ramos C60(1.23)  LDD2183  [2]
 LDCM0024  KB05 OAW-28 C60(1.44)  LDD3368  [6]
 LDCM0021  THZ1 HCT 116 C60(1.26)  LDD2173  [3]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840