Details of the Target

General Information of Target

Target ID LDTP02402
Target Name Zinc finger protein 688 (ZNF688)
Gene Name ZNF688
Gene ID 146542
Synonyms
Zinc finger protein 688
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPPPAPLLAPRPGETRPGCRKPGTVSFADVAVYFSPEEWGCLRPAQRALYRDVMQETYG
HLGALGFPGPKPALISWMEQESEAWSPAAQDPEKGERLGGARRGDVPNRKEEEPEEVPRA
KGPRKAPVKESPEVLVERNPDPAISVAPARAQPPKNAAWDPTTGAQPPAPIPSMDAQAGQ
RRHVCTDCGRRFTYPSLLVSHRRMHSGERPFPCPECGMRFKRKFAVEAHQWIHRSCSGGR
RGRRPGIRAVPRAPVRGDRDPPVLFRHYPDIFEECG
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
P0C7X2
Ensemble ID
ENST00000223459.11
HGNC ID
HGNC:30489

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HSC4 SNV: p.P118L .
JURKAT Deletion: p.R240GfsTer97
SNV: p.P11R		 .
LS180 SNV: p.H229R .
TOV21G SNV: p.Q56H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C20(1.06)  LDD1507  [1]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C20(1.06)  LDD1507  [1]
 LDCM0226  AC11 HEK-293T C20(0.99)  LDD1509  [1]
 LDCM0237  AC12 HEK-293T C20(1.12)  LDD1510  [1]
 LDCM0270  AC15 HEK-293T C20(1.02)  LDD1513  [1]
 LDCM0276  AC17 HEK-293T C20(1.16)  LDD1515  [1]
 LDCM0278  AC19 HEK-293T C20(0.99)  LDD1517  [1]
 LDCM0280  AC20 HEK-293T C20(1.11)  LDD1519  [1]
 LDCM0281  AC21 HEK-293T C20(1.08)  LDD1520  [1]
 LDCM0283  AC23 HEK-293T C20(1.09)  LDD1522  [1]
 LDCM0285  AC25 HEK-293T C20(1.08)  LDD1524  [1]
 LDCM0287  AC27 HEK-293T C20(0.97)  LDD1526  [1]
 LDCM0288  AC28 HEK-293T C20(1.08)  LDD1527  [1]
 LDCM0289  AC29 HEK-293T C20(1.05)  LDD1528  [1]
 LDCM0290  AC3 HEK-293T C20(0.97)  LDD1529  [1]
 LDCM0292  AC31 HEK-293T C20(1.04)  LDD1531  [1]
 LDCM0294  AC33 HEK-293T C20(1.06)  LDD1533  [1]
 LDCM0296  AC35 HEK-293T C20(0.95)  LDD1535  [1]
 LDCM0297  AC36 HEK-293T C20(1.18)  LDD1536  [1]
 LDCM0298  AC37 HEK-293T C20(1.02)  LDD1537  [1]
 LDCM0300  AC39 HEK-293T C20(1.18)  LDD1539  [1]
 LDCM0301  AC4 HEK-293T C20(1.19)  LDD1540  [1]
 LDCM0303  AC41 HEK-293T C20(1.23)  LDD1542  [1]
 LDCM0305  AC43 HEK-293T C20(0.98)  LDD1544  [1]
 LDCM0306  AC44 HEK-293T C20(1.21)  LDD1545  [1]
 LDCM0307  AC45 HEK-293T C20(1.11)  LDD1546  [1]
 LDCM0309  AC47 HEK-293T C20(1.22)  LDD1548  [1]
 LDCM0311  AC49 HEK-293T C20(1.21)  LDD1550  [1]
 LDCM0312  AC5 HEK-293T C20(1.05)  LDD1551  [1]
 LDCM0314  AC51 HEK-293T C20(0.93)  LDD1553  [1]
 LDCM0315  AC52 HEK-293T C20(1.08)  LDD1554  [1]
 LDCM0316  AC53 HEK-293T C20(1.09)  LDD1555  [1]
 LDCM0318  AC55 HEK-293T C20(1.16)  LDD1557  [1]
 LDCM0320  AC57 HEK-293T C20(1.04)  LDD1559  [1]
 LDCM0322  AC59 HEK-293T C20(0.91)  LDD1561  [1]
 LDCM0324  AC60 HEK-293T C20(1.02)  LDD1563  [1]
 LDCM0325  AC61 HEK-293T C20(1.02)  LDD1564  [1]
 LDCM0327  AC63 HEK-293T C20(1.10)  LDD1566  [1]
 LDCM0334  AC7 HEK-293T C20(1.01)  LDD1568  [1]
 LDCM0248  AKOS034007472 HEK-293T C20(1.12)  LDD1511  [1]
 LDCM0356  AKOS034007680 HEK-293T C20(1.19)  LDD1570  [1]
 LDCM0367  CL1 HEK-293T C20(1.04)  LDD1571  [1]
 LDCM0370  CL101 HEK-293T C20(1.24)  LDD1574  [1]
 LDCM0372  CL103 HEK-293T C20(1.01)  LDD1576  [1]
 LDCM0374  CL105 HEK-293T C20(1.02)  LDD1578  [1]
 LDCM0376  CL107 HEK-293T C20(1.13)  LDD1580  [1]
 LDCM0378  CL109 HEK-293T C20(1.18)  LDD1582  [1]
 LDCM0379  CL11 HEK-293T C20(0.80)  LDD1583  [1]
 LDCM0381  CL111 HEK-293T C20(1.09)  LDD1585  [1]
 LDCM0383  CL113 HEK-293T C20(1.02)  LDD1587  [1]
 LDCM0385  CL115 HEK-293T C20(1.29)  LDD1589  [1]
 LDCM0387  CL117 HEK-293T C20(1.15)  LDD1591  [1]
 LDCM0389  CL119 HEK-293T C20(1.10)  LDD1593  [1]
 LDCM0392  CL121 HEK-293T C20(1.22)  LDD1596  [1]
 LDCM0394  CL123 HEK-293T C20(1.16)  LDD1598  [1]
 LDCM0396  CL125 HEK-293T C20(1.18)  LDD1600  [1]
 LDCM0398  CL127 HEK-293T C20(1.02)  LDD1602  [1]
 LDCM0400  CL13 HEK-293T C20(1.24)  LDD1604  [1]
 LDCM0402  CL15 HEK-293T C20(1.03)  LDD1606  [1]
 LDCM0404  CL17 HEK-293T C20(1.24)  LDD1608  [1]
 LDCM0406  CL19 HEK-293T C20(0.94)  LDD1610  [1]
 LDCM0408  CL20 HEK-293T C20(0.99)  LDD1612  [1]
 LDCM0409  CL21 HEK-293T C20(1.06)  LDD1613  [1]
 LDCM0411  CL23 HEK-293T C20(0.92)  LDD1615  [1]
 LDCM0413  CL25 HEK-293T C20(1.21)  LDD1617  [1]
 LDCM0415  CL27 HEK-293T C20(1.11)  LDD1619  [1]
 LDCM0417  CL29 HEK-293T C20(1.07)  LDD1621  [1]
 LDCM0418  CL3 HEK-293T C20(0.93)  LDD1622  [1]
 LDCM0420  CL31 HEK-293T C20(0.97)  LDD1624  [1]
 LDCM0421  CL32 HEK-293T C20(1.07)  LDD1625  [1]
 LDCM0422  CL33 HEK-293T C20(0.92)  LDD1626  [1]
 LDCM0424  CL35 HEK-293T C20(0.88)  LDD1628  [1]
 LDCM0426  CL37 HEK-293T C20(1.17)  LDD1630  [1]
 LDCM0428  CL39 HEK-293T C20(1.16)  LDD1632  [1]
 LDCM0431  CL41 HEK-293T C20(1.09)  LDD1635  [1]
 LDCM0433  CL43 HEK-293T C20(0.94)  LDD1637  [1]
 LDCM0434  CL44 HEK-293T C20(1.07)  LDD1638  [1]
 LDCM0435  CL45 HEK-293T C20(1.06)  LDD1639  [1]
 LDCM0437  CL47 HEK-293T C20(0.84)  LDD1641  [1]
 LDCM0439  CL49 HEK-293T C20(1.22)  LDD1643  [1]
 LDCM0440  CL5 HEK-293T C20(1.01)  LDD1644  [1]
 LDCM0444  CL53 HEK-293T C20(0.99)  LDD1647  [1]
 LDCM0446  CL55 HEK-293T C20(1.00)  LDD1649  [1]
 LDCM0447  CL56 HEK-293T C20(1.13)  LDD1650  [1]
 LDCM0448  CL57 HEK-293T C20(1.03)  LDD1651  [1]
 LDCM0450  CL59 HEK-293T C20(0.94)  LDD1653  [1]
 LDCM0453  CL61 HEK-293T C20(1.22)  LDD1656  [1]
 LDCM0455  CL63 HEK-293T C20(1.04)  LDD1658  [1]
 LDCM0457  CL65 HEK-293T C20(1.13)  LDD1660  [1]
 LDCM0459  CL67 HEK-293T C20(0.93)  LDD1662  [1]
 LDCM0460  CL68 HEK-293T C20(1.06)  LDD1663  [1]
 LDCM0461  CL69 HEK-293T C20(0.99)  LDD1664  [1]
 LDCM0462  CL7 HEK-293T C20(0.90)  LDD1665  [1]
 LDCM0464  CL71 HEK-293T C20(0.93)  LDD1667  [1]
 LDCM0466  CL73 HEK-293T C20(1.25)  LDD1669  [1]
 LDCM0470  CL77 HEK-293T C20(1.17)  LDD1673  [1]
 LDCM0472  CL79 HEK-293T C20(0.89)  LDD1675  [1]
 LDCM0473  CL8 HEK-293T C20(1.08)  LDD1676  [1]
 LDCM0474  CL80 HEK-293T C20(1.00)  LDD1677  [1]
 LDCM0475  CL81 HEK-293T C20(1.03)  LDD1678  [1]
 LDCM0477  CL83 HEK-293T C20(0.95)  LDD1680  [1]
 LDCM0479  CL85 HEK-293T C20(1.23)  LDD1682  [1]
 LDCM0481  CL87 HEK-293T C20(1.32)  LDD1684  [1]
 LDCM0483  CL89 HEK-293T C20(1.27)  LDD1686  [1]
 LDCM0484  CL9 HEK-293T C20(0.87)  LDD1687  [1]
 LDCM0486  CL91 HEK-293T C20(1.18)  LDD1689  [1]
 LDCM0487  CL92 HEK-293T C20(1.18)  LDD1690  [1]
 LDCM0488  CL93 HEK-293T C20(1.05)  LDD1691  [1]
 LDCM0490  CL95 HEK-293T C20(1.10)  LDD1693  [1]
 LDCM0492  CL97 HEK-293T C20(1.02)  LDD1695  [1]
 LDCM0494  CL99 HEK-293T C20(1.35)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C20(1.23)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C20(1.27)  LDD1671  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-directed RNA polymerases I and III subunit RPAC1 (POLR1C) Archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family O15160
Glycerate kinase (GLYCTK) Glycerate kinase type-2 family Q8IVS8
Proteasome subunit beta type-1 (PSMB1) Peptidase T1B family P20618
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (PFKFB1) Phosphoglycerate mutase family P16118
GTP-binding protein GEM (GEM) RGK family P55040
Terminal nucleotidyltransferase 5B (TENT5B) TENT family Q96A09
Probable E3 ubiquitin-protein ligase makorin-3 (MKRN3) . Q13064
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cation channel sperm-associated protein 1 (CATSPER1) Cation channel sperm-associated (TC 1.A.1.19) family Q8NEC5
Sodium channel modifier 1 (SCNM1) . Q9BWG6
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
PHD finger protein 1 (PHF1) Polycomblike family O43189
Other
Click To Hide/Show 18 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclin-dependent kinase 4 inhibitor D (CDKN2D) CDKN2 cyclin-dependent kinase inhibitor family P55273
Cerebellar degeneration-related protein 2-like (CDR2L) CDR2 family Q86X02
Cyclin-C (CCNC) Cyclin family P24863
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
Myozenin-3 (MYOZ3) Myozenin family Q8TDC0
NFU1 iron-sulfur cluster scaffold homolog, mitochondrial (NFU1) NifU family Q9UMS0
Zinc finger protein 330 (ZNF330) NOA36 family Q9Y3S2
PIH1 domain-containing protein 2 (PIH1D2) PIH1 family Q8WWB5
Tektin-4 (TEKT4) Tektin family Q8WW24
Tetratricopeptide repeat protein 19, mitochondrial (TTC19) TTC19 family Q6DKK2
AFG2-interacting ribosome maturation factor (AIRIM) . Q9NX04
Calcium and integrin-binding family member 3 (CIB3) . Q96Q77
Coiled-coil domain-containing protein 102B (CCDC102B) . Q68D86
Cytoplasmic protein NCK2 (NCK2) . O43639
Differentially expressed in FDCP 6 homolog (DEF6) . Q9H4E7
G patch domain and ankyrin repeat-containing protein 1 (GPANK1) . O95872
Heat shock factor 2-binding protein (HSF2BP) . O75031
Rhombotin-1 (LMO1) . P25800

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.