Details of the Target

General Information of Target

Target ID LDTP02349
Target Name SPARC (SPARC)
Gene Name SPARC
Gene ID 6678
Synonyms
ON; SPARC; Basement-membrane protein 40; BM-40; Osteonectin; ON; Secreted protein acidic and rich in cysteine
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRAWIFFLLCLAGRALAAPQQEALPDETEVVEETVAEVTEVSVGANPVQVEVGEFDDGAE
ETEEEVVAENPCQNHHCKHGKVCELDENNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFD
SSCHFFATKCTLEGTKKGHKLHLDYIGPCKYIPPCLDSELTEFPLRMRDWLKNVLVTLYE
RDEDNNLLTEKQKLRVKKIHENEKRLEAGDHPVELLARDFEKNYNMYIFPVHWQFGQLDQ
HPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALDEWAGCFGIKQKDIDKD
LVI
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Family
SPARC family
Subcellular location
Secreted, extracellular space, extracellular matrix, basement membrane
Function
Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
TTD ID
T09439
Uniprot ID
P09486
DrugMap ID
TTBQFM7
Ensemble ID
ENST00000231061.9
HGNC ID
HGNC:11219

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		3.94  LDD0318  [1]
DBIA
 Probe Info  		C149(2.85); C155(1.65)  LDD3310  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C155(1.07); C265(0.80)  LDD1508  [3]
 LDCM0226  AC11 HEK-293T C155(0.94)  LDD1509  [3]
 LDCM0237  AC12 HEK-293T C155(0.98)  LDD1510  [3]
 LDCM0259  AC14 HEK-293T C265(0.90)  LDD1512  [3]
 LDCM0277  AC18 HEK-293T C155(1.08); C265(0.85)  LDD1516  [3]
 LDCM0278  AC19 HEK-293T C155(0.80)  LDD1517  [3]
 LDCM0279  AC2 HEK-293T C155(0.95); C265(0.92)  LDD1518  [3]
 LDCM0280  AC20 HEK-293T C155(1.09)  LDD1519  [3]
 LDCM0281  AC21 HEK-293T C265(0.86); C149(0.94)  LDD1520  [3]
 LDCM0282  AC22 HEK-293T C265(0.97)  LDD1521  [3]
 LDCM0286  AC26 HEK-293T C155(0.98); C265(0.79)  LDD1525  [3]
 LDCM0287  AC27 HEK-293T C155(0.99)  LDD1526  [3]
 LDCM0288  AC28 HEK-293T C155(0.97)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C265(0.98); C149(0.93)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C155(0.92)  LDD1529  [3]
 LDCM0291  AC30 HEK-293T C265(0.98)  LDD1530  [3]
 LDCM0295  AC34 HEK-293T C155(1.05); C265(0.86)  LDD1534  [3]
 LDCM0296  AC35 HEK-293T C155(0.89)  LDD1535  [3]
 LDCM0297  AC36 HEK-293T C155(0.97)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C265(0.92); C149(0.99)  LDD1537  [3]
 LDCM0299  AC38 HEK-293T C265(1.19)  LDD1538  [3]
 LDCM0301  AC4 HEK-293T C155(0.99)  LDD1540  [3]
 LDCM0304  AC42 HEK-293T C155(1.20); C265(1.05)  LDD1543  [3]
 LDCM0305  AC43 HEK-293T C155(0.85)  LDD1544  [3]
 LDCM0306  AC44 HEK-293T C155(1.02)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C265(1.32); C149(0.98)  LDD1546  [3]
 LDCM0308  AC46 HEK-293T C265(1.26)  LDD1547  [3]
 LDCM0312  AC5 HEK-293T C265(0.90); C149(0.94)  LDD1551  [3]
 LDCM0313  AC50 HEK-293T C155(0.97); C265(0.93)  LDD1552  [3]
 LDCM0314  AC51 HEK-293T C155(1.02)  LDD1553  [3]
 LDCM0315  AC52 HEK-293T C155(1.04)  LDD1554  [3]
 LDCM0316  AC53 HEK-293T C265(1.07); C149(0.92)  LDD1555  [3]
 LDCM0317  AC54 HEK-293T C265(1.01)  LDD1556  [3]
 LDCM0321  AC58 HEK-293T C155(1.03); C265(0.79)  LDD1560  [3]
 LDCM0322  AC59 HEK-293T C155(1.12)  LDD1561  [3]
 LDCM0323  AC6 HEK-293T C265(0.85)  LDD1562  [3]
 LDCM0324  AC60 HEK-293T C155(1.07)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C265(0.85); C149(1.06)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C265(0.97)  LDD1565  [3]
 LDCM0248  AKOS034007472 HEK-293T C265(0.95); C149(1.00)  LDD1511  [3]
 LDCM0367  CL1 HEK-293T C155(1.11)  LDD1571  [3]
 LDCM0368  CL10 HEK-293T C265(1.34)  LDD1572  [3]
 LDCM0370  CL101 HEK-293T C155(1.10)  LDD1574  [3]
 LDCM0371  CL102 HEK-293T C130(1.16); C265(0.90)  LDD1575  [3]
 LDCM0374  CL105 HEK-293T C155(0.97)  LDD1578  [3]
 LDCM0375  CL106 HEK-293T C130(1.05); C265(0.68)  LDD1579  [3]
 LDCM0378  CL109 HEK-293T C155(0.98)  LDD1582  [3]
 LDCM0380  CL110 HEK-293T C130(0.94); C265(0.81)  LDD1584  [3]
 LDCM0383  CL113 HEK-293T C155(0.95)  LDD1587  [3]
 LDCM0384  CL114 HEK-293T C130(1.05); C265(1.21)  LDD1588  [3]
 LDCM0387  CL117 HEK-293T C155(0.97)  LDD1591  [3]
 LDCM0388  CL118 HEK-293T C130(1.14); C265(0.82)  LDD1592  [3]
 LDCM0392  CL121 HEK-293T C155(1.02)  LDD1596  [3]
 LDCM0393  CL122 HEK-293T C130(1.14); C265(0.84)  LDD1597  [3]
 LDCM0396  CL125 HEK-293T C155(0.80)  LDD1600  [3]
 LDCM0397  CL126 HEK-293T C130(1.02); C265(0.69)  LDD1601  [3]
 LDCM0400  CL13 HEK-293T C155(0.81)  LDD1604  [3]
 LDCM0401  CL14 HEK-293T C130(1.21); C265(0.80)  LDD1605  [3]
 LDCM0405  CL18 HEK-293T C155(1.15); C265(0.93)  LDD1609  [3]
 LDCM0406  CL19 HEK-293T C155(0.98)  LDD1610  [3]
 LDCM0407  CL2 HEK-293T C130(1.12); C265(0.80)  LDD1611  [3]
 LDCM0408  CL20 HEK-293T C155(1.15)  LDD1612  [3]
 LDCM0409  CL21 HEK-293T C265(0.98); C149(1.14)  LDD1613  [3]
 LDCM0410  CL22 HEK-293T C265(1.33)  LDD1614  [3]
 LDCM0413  CL25 HEK-293T C155(1.18)  LDD1617  [3]
 LDCM0414  CL26 HEK-293T C130(1.18); C265(0.76)  LDD1618  [3]
 LDCM0419  CL30 HEK-293T C155(1.04); C265(0.76)  LDD1623  [3]
 LDCM0420  CL31 HEK-293T C155(0.86)  LDD1624  [3]
 LDCM0421  CL32 HEK-293T C155(1.07)  LDD1625  [3]
 LDCM0422  CL33 HEK-293T C265(1.02); C149(1.06)  LDD1626  [3]
 LDCM0423  CL34 HEK-293T C265(0.93)  LDD1627  [3]
 LDCM0426  CL37 HEK-293T C155(0.78)  LDD1630  [3]
 LDCM0432  CL42 HEK-293T C155(1.09); C265(0.77)  LDD1636  [3]
 LDCM0433  CL43 HEK-293T C155(1.13)  LDD1637  [3]
 LDCM0434  CL44 HEK-293T C155(1.02)  LDD1638  [3]
 LDCM0435  CL45 HEK-293T C265(0.96); C149(1.05)  LDD1639  [3]
 LDCM0436  CL46 HEK-293T C265(0.95)  LDD1640  [3]
 LDCM0439  CL49 HEK-293T C155(1.12)  LDD1643  [3]
 LDCM0441  CL50 HEK-293T C130(1.11); C265(1.15)  LDD1645  [3]
 LDCM0445  CL54 HEK-293T C155(1.02); C265(0.99)  LDD1648  [3]
 LDCM0446  CL55 HEK-293T C155(0.90)  LDD1649  [3]
 LDCM0447  CL56 HEK-293T C155(1.00)  LDD1650  [3]
 LDCM0448  CL57 HEK-293T C265(1.03); C149(1.23)  LDD1651  [3]
 LDCM0449  CL58 HEK-293T C265(1.03)  LDD1652  [3]
 LDCM0451  CL6 HEK-293T C155(1.11); C265(1.03)  LDD1654  [3]
 LDCM0453  CL61 HEK-293T C155(0.88)  LDD1656  [3]
 LDCM0454  CL62 HEK-293T C130(1.09); C265(0.88)  LDD1657  [3]
 LDCM0458  CL66 HEK-293T C155(0.98); C265(1.00)  LDD1661  [3]
 LDCM0459  CL67 HEK-293T C155(1.07)  LDD1662  [3]
 LDCM0460  CL68 HEK-293T C155(1.01)  LDD1663  [3]
 LDCM0461  CL69 HEK-293T C265(1.08); C149(0.99)  LDD1664  [3]
 LDCM0462  CL7 HEK-293T C155(1.02)  LDD1665  [3]
 LDCM0463  CL70 HEK-293T C265(1.26)  LDD1666  [3]
 LDCM0466  CL73 HEK-293T C155(0.96)  LDD1669  [3]
 LDCM0467  CL74 HEK-293T C130(1.22); C265(0.71)  LDD1670  [3]
 LDCM0471  CL78 HEK-293T C155(1.06); C265(1.12)  LDD1674  [3]
 LDCM0472  CL79 HEK-293T C155(1.29)  LDD1675  [3]
 LDCM0473  CL8 HEK-293T C155(1.02)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C155(1.09)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C265(0.96); C149(1.01)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C265(0.95)  LDD1679  [3]
 LDCM0479  CL85 HEK-293T C155(1.08)  LDD1682  [3]
 LDCM0480  CL86 HEK-293T C130(1.17); C265(0.88)  LDD1683  [3]
 LDCM0484  CL9 HEK-293T C265(1.04); C149(0.98)  LDD1687  [3]
 LDCM0485  CL90 HEK-293T C155(0.99); C265(1.18)  LDD1688  [3]
 LDCM0486  CL91 HEK-293T C155(1.01)  LDD1689  [3]
 LDCM0487  CL92 HEK-293T C155(0.99)  LDD1690  [3]
 LDCM0488  CL93 HEK-293T C265(0.98); C149(1.11)  LDD1691  [3]
 LDCM0489  CL94 HEK-293T C265(0.96)  LDD1692  [3]
 LDCM0492  CL97 HEK-293T C155(0.94)  LDD1695  [3]
 LDCM0493  CL98 HEK-293T C130(1.00); C265(0.80)  LDD1696  [3]
 LDCM0427  Fragment51 HEK-293T C130(1.19); C265(0.79)  LDD1631  [3]
 LDCM0022  KB02 HEK-293T C265(0.89)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C265(0.98)  LDD1497  [3]
 LDCM0024  KB05 COLO792 C149(2.85); C155(1.65)  LDD3310  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Myocilin (MYOC) . Q99972

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Calcium Phosphate Small molecular drug DB11348
Calcium Phosphate Dihydrate Small molecular drug DB14481
Calcium Citrate . DB11093

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402