Details of the Target

General Information of Target

Target ID LDTP02224
Target Name L-lactate dehydrogenase C chain (LDHC)
Gene Name LDHC
Gene ID 3948
Synonyms
LDH3; LDHX; L-lactate dehydrogenase C chain; LDH-C; EC 1.1.1.27; Cancer/testis antigen 32; CT32; LDH testis subunit; LDH-X
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSTVKEQLIEKLIEDDENSQCKITIVGTGAVGMACAISILLKDLADELALVDVALDKLKG
EMMDLQHGSLFFSTSKITSGKDYSVSANSRIVIVTAGARQQEGETRLALVQRNVAIMKSI
IPAIVHYSPDCKILVVSNPVDILTYIVWKISGLPVTRVIGSGCNLDSARFRYLIGEKLGV
HPTSCHGWIIGEHGDSSVPLWSGVNVAGVALKTLDPKLGTDSDKEHWKNIHKQVIQSAYE
IIKLKGYTSWAIGLSVMDLVGSILKNLRRVHPVSTMVKGLYGIKEELFLSIPCVLGRNGV
SDVVKINLNSEEEALFKKSAETLWNIQKDLIF
Target Bioclass
Enzyme
Family
LDH/MDH superfamily, LDH family
Subcellular location
Cytoplasm
Function Possible role in sperm motility.
Uniprot ID
P07864
Ensemble ID
ENST00000280704.8
HGNC ID
HGNC:6544

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C163(4.33)  LDD0169  [1]
DBIA
 Probe Info  		C293(0.98)  LDD1507  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]
Acrolein
 Probe Info  		N.A.  LDD0217  [4]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [4]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [4]
Methacrolein
 Probe Info  		N.A.  LDD0218  [4]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0136  [5]
STS-2
 Probe Info  		N.A.  LDD0139  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C163(4.33)  LDD0169  [1]
 LDCM0214  AC1 HEK-293T C293(0.98)  LDD1507  [2]
 LDCM0215  AC10 HEK-293T C293(1.17)  LDD1508  [2]
 LDCM0276  AC17 HEK-293T C293(0.92)  LDD1515  [2]
 LDCM0277  AC18 HEK-293T C293(0.90)  LDD1516  [2]
 LDCM0279  AC2 HEK-293T C293(1.11)  LDD1518  [2]
 LDCM0281  AC21 HEK-293T C293(1.14)  LDD1520  [2]
 LDCM0284  AC24 HEK-293T C293(0.90)  LDD1523  [2]
 LDCM0285  AC25 HEK-293T C293(1.01)  LDD1524  [2]
 LDCM0286  AC26 HEK-293T C293(1.14)  LDD1525  [2]
 LDCM0289  AC29 HEK-293T C293(0.98)  LDD1528  [2]
 LDCM0293  AC32 HEK-293T C293(1.00)  LDD1532  [2]
 LDCM0294  AC33 HEK-293T C293(1.02)  LDD1533  [2]
 LDCM0295  AC34 HEK-293T C293(1.20)  LDD1534  [2]
 LDCM0298  AC37 HEK-293T C293(1.04)  LDD1537  [2]
 LDCM0302  AC40 HEK-293T C293(1.19)  LDD1541  [2]
 LDCM0303  AC41 HEK-293T C293(0.95)  LDD1542  [2]
 LDCM0304  AC42 HEK-293T C293(1.07)  LDD1543  [2]
 LDCM0307  AC45 HEK-293T C293(1.06)  LDD1546  [2]
 LDCM0310  AC48 HEK-293T C293(1.08)  LDD1549  [2]
 LDCM0311  AC49 HEK-293T C293(1.15)  LDD1550  [2]
 LDCM0312  AC5 HEK-293T C293(0.86)  LDD1551  [2]
 LDCM0313  AC50 HEK-293T C293(1.00)  LDD1552  [2]
 LDCM0316  AC53 HEK-293T C293(1.13)  LDD1555  [2]
 LDCM0319  AC56 HEK-293T C293(0.93)  LDD1558  [2]
 LDCM0320  AC57 HEK-293T C293(1.09)  LDD1559  [2]
 LDCM0321  AC58 HEK-293T C293(1.09)  LDD1560  [2]
 LDCM0325  AC61 HEK-293T C293(1.17)  LDD1564  [2]
 LDCM0328  AC64 HEK-293T C293(1.29)  LDD1567  [2]
 LDCM0345  AC8 HEK-293T C293(1.17)  LDD1569  [2]
 LDCM0248  AKOS034007472 HEK-293T C293(0.98)  LDD1511  [2]
 LDCM0356  AKOS034007680 HEK-293T C293(1.25)  LDD1570  [2]
 LDCM0275  AKOS034007705 HEK-293T C293(1.29)  LDD1514  [2]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0372  CL103 HEK-293T C293(1.20)  LDD1576  [2]
 LDCM0376  CL107 HEK-293T C293(0.96)  LDD1580  [2]
 LDCM0381  CL111 HEK-293T C293(1.09)  LDD1585  [2]
 LDCM0385  CL115 HEK-293T C293(1.16)  LDD1589  [2]
 LDCM0389  CL119 HEK-293T C293(1.06)  LDD1593  [2]
 LDCM0390  CL12 HEK-293T C293(1.38)  LDD1594  [2]
 LDCM0394  CL123 HEK-293T C293(1.29)  LDD1598  [2]
 LDCM0398  CL127 HEK-293T C293(1.31)  LDD1602  [2]
 LDCM0402  CL15 HEK-293T C293(1.51)  LDD1606  [2]
 LDCM0404  CL17 HEK-293T C293(1.07)  LDD1608  [2]
 LDCM0405  CL18 HEK-293T C293(1.25)  LDD1609  [2]
 LDCM0409  CL21 HEK-293T C293(1.32)  LDD1613  [2]
 LDCM0412  CL24 HEK-293T C293(1.45)  LDD1616  [2]
 LDCM0415  CL27 HEK-293T C293(1.12)  LDD1619  [2]
 LDCM0417  CL29 HEK-293T C293(1.17)  LDD1621  [2]
 LDCM0418  CL3 HEK-293T C293(1.36)  LDD1622  [2]
 LDCM0419  CL30 HEK-293T C293(0.98)  LDD1623  [2]
 LDCM0422  CL33 HEK-293T C293(1.48)  LDD1626  [2]
 LDCM0425  CL36 HEK-293T C293(1.20)  LDD1629  [2]
 LDCM0428  CL39 HEK-293T C293(0.97)  LDD1632  [2]
 LDCM0431  CL41 HEK-293T C293(1.10)  LDD1635  [2]
 LDCM0432  CL42 HEK-293T C293(0.94)  LDD1636  [2]
 LDCM0435  CL45 HEK-293T C293(0.85)  LDD1639  [2]
 LDCM0438  CL48 HEK-293T C293(1.53)  LDD1642  [2]
 LDCM0440  CL5 HEK-293T C293(1.04)  LDD1644  [2]
 LDCM0444  CL53 HEK-293T C293(1.02)  LDD1647  [2]
 LDCM0445  CL54 HEK-293T C293(1.77)  LDD1648  [2]
 LDCM0448  CL57 HEK-293T C293(1.11)  LDD1651  [2]
 LDCM0451  CL6 HEK-293T C293(0.90)  LDD1654  [2]
 LDCM0452  CL60 HEK-293T C293(1.34)  LDD1655  [2]
 LDCM0455  CL63 HEK-293T C293(1.06)  LDD1658  [2]
 LDCM0457  CL65 HEK-293T C293(0.98)  LDD1660  [2]
 LDCM0458  CL66 HEK-293T C293(1.14)  LDD1661  [2]
 LDCM0461  CL69 HEK-293T C293(1.41)  LDD1664  [2]
 LDCM0465  CL72 HEK-293T C293(1.43)  LDD1668  [2]
 LDCM0470  CL77 HEK-293T C293(1.18)  LDD1673  [2]
 LDCM0471  CL78 HEK-293T C293(1.01)  LDD1674  [2]
 LDCM0475  CL81 HEK-293T C293(1.11)  LDD1678  [2]
 LDCM0478  CL84 HEK-293T C293(1.31)  LDD1681  [2]
 LDCM0481  CL87 HEK-293T C293(1.15)  LDD1684  [2]
 LDCM0483  CL89 HEK-293T C293(0.97)  LDD1686  [2]
 LDCM0484  CL9 HEK-293T C293(1.25)  LDD1687  [2]
 LDCM0485  CL90 HEK-293T C293(2.28)  LDD1688  [2]
 LDCM0488  CL93 HEK-293T C293(1.39)  LDD1691  [2]
 LDCM0491  CL96 HEK-293T C293(1.11)  LDD1694  [2]
 LDCM0494  CL99 HEK-293T C293(1.05)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C293(1.14)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C293(1.21)  LDD1671  [2]
 LDCM0107  IAA HeLa N.A.  LDD0221  [4]
 LDCM0109  NEM HeLa N.A.  LDD0223  [4]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nadh Small molecular drug DB00157

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.