Details of the Target

General Information of Target

Target ID LDTP01626
Target Name Chromobox protein homolog 6 (CBX6)
Gene Name CBX6
Gene ID 23466
Synonyms
Chromobox protein homolog 6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MELSAVGERVFAAESIIKRRIRKGRIEYLVKWKGWAIKYSTWEPEENILDSRLIAAFEQK
ERERELYGPKKRGPKPKTFLLKARAQAEALRISDVHFSVKPSASASSPKLHSSAAVHRLK
KDIRRCHRMSRRPLPRPDPQGGSPGLRPPISPFSETVRIINRKVKPREPKRNRIILNLKV
IDKGAGGGGAGQGAGALARPKVPSRNRVIGKSKKFSESVLRTQIRHMKFGAFALYKPPPA
PLVAPSPGKAEASAPGPGLLLAAPAAPYDARSSGSSGCPSPTPQSSDPDDTPPKLLPETV
SPSAPSWREPEVLDLSLPPESAATSKRAPPEVTAAAGPAPPTAPEPAGASSEPEAGDWRP
EMSPCSNVVVTDVTSNLLTVTIKEFCNPEDFEKVAAGVAGAAGGGGSIGASK
Target Bioclass
Other
Subcellular location
Nucleus
Function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin. Recruitment to chromatin might occur in an H3K27me3-independent fashion. May have a PRC1-independent function in embryonic stem cells.
Uniprot ID
O95503
Ensemble ID
ENST00000407418.8
HGNC ID
HGNC:1556
ChEMBL ID
CHEMBL3779762

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C386(0.99)  LDD1512  [1]
IPM
 Probe Info  		N.A.  LDD2156  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0259  AC14 HEK-293T C386(0.99)  LDD1512  [1]
 LDCM0282  AC22 HEK-293T C386(0.90)  LDD1521  [1]
 LDCM0284  AC24 HEK-293T C386(0.82)  LDD1523  [1]
 LDCM0291  AC30 HEK-293T C386(1.00)  LDD1530  [1]
 LDCM0293  AC32 HEK-293T C386(0.99)  LDD1532  [1]
 LDCM0299  AC38 HEK-293T C386(1.04)  LDD1538  [1]
 LDCM0302  AC40 HEK-293T C386(1.05)  LDD1541  [1]
 LDCM0308  AC46 HEK-293T C386(1.20)  LDD1547  [1]
 LDCM0310  AC48 HEK-293T C386(0.92)  LDD1549  [1]
 LDCM0317  AC54 HEK-293T C386(0.98)  LDD1556  [1]
 LDCM0319  AC56 HEK-293T C386(0.79)  LDD1558  [1]
 LDCM0323  AC6 HEK-293T C386(1.04)  LDD1562  [1]
 LDCM0326  AC62 HEK-293T C386(0.97)  LDD1565  [1]
 LDCM0328  AC64 HEK-293T C386(0.80)  LDD1567  [1]
 LDCM0345  AC8 HEK-293T C386(0.87)  LDD1569  [1]
 LDCM0275  AKOS034007705 HEK-293T C386(0.79)  LDD1514  [1]
 LDCM0368  CL10 HEK-293T C386(1.33)  LDD1572  [1]
 LDCM0371  CL102 HEK-293T C386(0.99)  LDD1575  [1]
 LDCM0372  CL103 HEK-293T C386(1.08)  LDD1576  [1]
 LDCM0375  CL106 HEK-293T C386(1.23)  LDD1579  [1]
 LDCM0376  CL107 HEK-293T C386(1.22)  LDD1580  [1]
 LDCM0380  CL110 HEK-293T C386(1.29)  LDD1584  [1]
 LDCM0381  CL111 HEK-293T C386(1.02)  LDD1585  [1]
 LDCM0384  CL114 HEK-293T C386(1.04)  LDD1588  [1]
 LDCM0385  CL115 HEK-293T C386(1.05)  LDD1589  [1]
 LDCM0388  CL118 HEK-293T C386(1.02)  LDD1592  [1]
 LDCM0389  CL119 HEK-293T C386(1.15)  LDD1593  [1]
 LDCM0390  CL12 HEK-293T C386(1.03)  LDD1594  [1]
 LDCM0393  CL122 HEK-293T C386(1.09)  LDD1597  [1]
 LDCM0394  CL123 HEK-293T C386(1.05)  LDD1598  [1]
 LDCM0397  CL126 HEK-293T C386(0.99)  LDD1601  [1]
 LDCM0398  CL127 HEK-293T C386(1.11)  LDD1602  [1]
 LDCM0401  CL14 HEK-293T C386(0.91)  LDD1605  [1]
 LDCM0402  CL15 HEK-293T C386(1.36)  LDD1606  [1]
 LDCM0407  CL2 HEK-293T C386(1.15)  LDD1611  [1]
 LDCM0410  CL22 HEK-293T C386(1.09)  LDD1614  [1]
 LDCM0412  CL24 HEK-293T C386(0.99)  LDD1616  [1]
 LDCM0414  CL26 HEK-293T C386(0.96)  LDD1618  [1]
 LDCM0415  CL27 HEK-293T C386(1.06)  LDD1619  [1]
 LDCM0418  CL3 HEK-293T C386(1.09)  LDD1622  [1]
 LDCM0423  CL34 HEK-293T C386(1.09)  LDD1627  [1]
 LDCM0425  CL36 HEK-293T C386(0.81)  LDD1629  [1]
 LDCM0428  CL39 HEK-293T C386(1.00)  LDD1632  [1]
 LDCM0436  CL46 HEK-293T C386(1.22)  LDD1640  [1]
 LDCM0438  CL48 HEK-293T C386(0.82)  LDD1642  [1]
 LDCM0441  CL50 HEK-293T C386(0.98)  LDD1645  [1]
 LDCM0449  CL58 HEK-293T C386(1.46)  LDD1652  [1]
 LDCM0452  CL60 HEK-293T C386(1.07)  LDD1655  [1]
 LDCM0454  CL62 HEK-293T C386(1.01)  LDD1657  [1]
 LDCM0455  CL63 HEK-293T C386(1.13)  LDD1658  [1]
 LDCM0463  CL70 HEK-293T C386(1.14)  LDD1666  [1]
 LDCM0465  CL72 HEK-293T C386(0.93)  LDD1668  [1]
 LDCM0467  CL74 HEK-293T C386(1.10)  LDD1670  [1]
 LDCM0476  CL82 HEK-293T C386(1.16)  LDD1679  [1]
 LDCM0478  CL84 HEK-293T C386(1.34)  LDD1681  [1]
 LDCM0480  CL86 HEK-293T C386(1.05)  LDD1683  [1]
 LDCM0481  CL87 HEK-293T C386(0.91)  LDD1684  [1]
 LDCM0489  CL94 HEK-293T C386(1.08)  LDD1692  [1]
 LDCM0491  CL96 HEK-293T C386(0.95)  LDD1694  [1]
 LDCM0493  CL98 HEK-293T C386(0.91)  LDD1696  [1]
 LDCM0494  CL99 HEK-293T C386(0.99)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C386(1.08)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C386(1.41)  LDD1671  [1]
 LDCM0427  Fragment51 HEK-293T C386(1.06)  LDD1631  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Helicase MOV-10 (MOV10) DNA2/NAM7 helicase family Q9HCE1
E3 ubiquitin-protein ligase RING1 (RING1) . Q06587
E3 ubiquitin-protein ligase RING2 (RNF2) . Q99496
Polycomb complex protein BMI-1 (BMI1) . P35226
Polycomb group RING finger protein 2 (PCGF2) . P35227
Polycomb group RING finger protein 3 (PCGF3) . Q3KNV8
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019