Details of the Target

General Information of Target

Target ID LDTP00963
Target Name HMG box-containing protein 1 (HBP1)
Gene Name HBP1
Gene ID 26959
Synonyms
HMG box-containing protein 1; HMG box transcription factor 1; High mobility group box transcription factor 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVWEVKTNQMPNAVQKLLLVMDKRASGMNDSLELLQCNENLPSSPGYNSCDEHMELDDLP
ELQAVQSDPTQSGMYQLSSDVSHQEYPRSSWNQNTSDIPETTYRENEVDWLTELANIATS
PQSPLMQCSFYNRSSPVHIIATSKSLHSYARPPPVSSSSKSEPAFPHHHWKEETPVRHER
ANSESESGIFCMSSLSDDDDLGWCNSWPSTVWHCFLKGTRLCFHKGSNKEWQDVEDFARA
EGCDNEEDLQMGIHKGYGSDGLKLLSHEESVSFGESVLKLTFDPGTVEDGLLTVECKLDH
PFYVKNKGWSSFYPSLTVVQHGIPCCEVHIGDVCLPPGHPDAINFDDSGVFDTFKSYDFT
PMDSSAVYVLSSMARQRRASLSCGGPGGQDFARSGFSKNCGSPGSSQLSSNSLYAKAVKN
HSSGTVSATSPNKCKRPMNAFMLFAKKYRVEYTQMYPGKDNRAISVILGDRWKKMKNEER
RMYTLEAKALAEEQKRLNPDCWKRKRTNSGSQQH
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function
Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.
Uniprot ID
O60381
Ensemble ID
ENST00000222574.9
HGNC ID
HGNC:23200

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CHL1 Insertion: p.A374_R375insPP .
NCIH358 SNV: p.L292R .
OZ SNV: p.E327D .
SW1271 SNV: p.Q454R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C501(2.20)  LDD3325  [1]
IA-alkyne
 Probe Info  		C383(5.37); C400(7.03)  LDD1705  [2]
NAIA_5
 Probe Info  		N.A.  LDD2224  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0270  AC15 HEK-293T C383(0.99)  LDD1513  [4]
 LDCM0283  AC23 HEK-293T C383(0.95)  LDD1522  [4]
 LDCM0284  AC24 HEK-293T C383(1.07)  LDD1523  [4]
 LDCM0292  AC31 HEK-293T C383(0.88)  LDD1531  [4]
 LDCM0293  AC32 HEK-293T C383(1.04)  LDD1532  [4]
 LDCM0300  AC39 HEK-293T C383(0.94)  LDD1539  [4]
 LDCM0302  AC40 HEK-293T C383(0.95)  LDD1541  [4]
 LDCM0309  AC47 HEK-293T C383(1.08)  LDD1548  [4]
 LDCM0310  AC48 HEK-293T C383(0.95)  LDD1549  [4]
 LDCM0318  AC55 HEK-293T C383(0.99)  LDD1557  [4]
 LDCM0319  AC56 HEK-293T C383(1.12)  LDD1558  [4]
 LDCM0327  AC63 HEK-293T C383(1.12)  LDD1566  [4]
 LDCM0328  AC64 HEK-293T C383(1.01)  LDD1567  [4]
 LDCM0334  AC7 HEK-293T C383(1.11)  LDD1568  [4]
 LDCM0345  AC8 HEK-293T C383(1.04)  LDD1569  [4]
 LDCM0275  AKOS034007705 HEK-293T C383(1.06)  LDD1514  [4]
 LDCM0371  CL102 HEK-293T C383(0.96)  LDD1575  [4]
 LDCM0375  CL106 HEK-293T C383(1.12)  LDD1579  [4]
 LDCM0379  CL11 HEK-293T C383(1.12)  LDD1583  [4]
 LDCM0380  CL110 HEK-293T C383(0.89)  LDD1584  [4]
 LDCM0384  CL114 HEK-293T C383(0.94)  LDD1588  [4]
 LDCM0388  CL118 HEK-293T C383(1.01)  LDD1592  [4]
 LDCM0390  CL12 HEK-293T C383(1.13)  LDD1594  [4]
 LDCM0393  CL122 HEK-293T C383(0.95)  LDD1597  [4]
 LDCM0397  CL126 HEK-293T C383(0.95)  LDD1601  [4]
 LDCM0401  CL14 HEK-293T C383(1.04)  LDD1605  [4]
 LDCM0407  CL2 HEK-293T C383(0.88)  LDD1611  [4]
 LDCM0411  CL23 HEK-293T C383(1.13)  LDD1615  [4]
 LDCM0412  CL24 HEK-293T C383(1.07)  LDD1616  [4]
 LDCM0414  CL26 HEK-293T C383(0.86)  LDD1618  [4]
 LDCM0424  CL35 HEK-293T C383(1.02)  LDD1628  [4]
 LDCM0425  CL36 HEK-293T C383(1.03)  LDD1629  [4]
 LDCM0437  CL47 HEK-293T C383(1.06)  LDD1641  [4]
 LDCM0438  CL48 HEK-293T C383(0.93)  LDD1642  [4]
 LDCM0441  CL50 HEK-293T C383(1.08)  LDD1645  [4]
 LDCM0450  CL59 HEK-293T C383(1.09)  LDD1653  [4]
 LDCM0452  CL60 HEK-293T C383(1.06)  LDD1655  [4]
 LDCM0454  CL62 HEK-293T C383(0.89)  LDD1657  [4]
 LDCM0464  CL71 HEK-293T C383(1.12)  LDD1667  [4]
 LDCM0465  CL72 HEK-293T C383(1.16)  LDD1668  [4]
 LDCM0467  CL74 HEK-293T C383(1.04)  LDD1670  [4]
 LDCM0477  CL83 HEK-293T C383(1.05)  LDD1680  [4]
 LDCM0478  CL84 HEK-293T C383(1.07)  LDD1681  [4]
 LDCM0480  CL86 HEK-293T C383(0.94)  LDD1683  [4]
 LDCM0490  CL95 HEK-293T C383(1.21)  LDD1693  [4]
 LDCM0491  CL96 HEK-293T C383(0.99)  LDD1694  [4]
 LDCM0493  CL98 HEK-293T C383(0.77)  LDD1696  [4]
 LDCM0427  Fragment51 HEK-293T C383(0.96)  LDD1631  [4]
 LDCM0022  KB02 UACC257 C501(2.14)  LDD2491  [1]
 LDCM0023  KB03 UACC257 C501(2.02)  LDD2908  [1]
 LDCM0024  KB05 UACC257 C501(2.20)  LDD3325  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Retinoblastoma-associated protein (RB1) Retinoblastoma protein (RB) family P06400

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402