Details of the Target

General Information of Target

Target ID LDTP00811
Target Name Lysine-specific demethylase hairless (HR)
Gene Name HR
Gene ID 55806
Synonyms
Lysine-specific demethylase hairless; EC 1.14.11.65; [histone H3]-dimethyl-L-lysine(9) demethylase hairless
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MESTPSFLKGTPTWEKTAPENGIVRQEPGSPPRDGLHHGPLCLGEPAPFWRGVLSTPDSW
LPPGFPQGPKDMLPLVEGEGPQNGERKVNWLGSKEGLRWKEAMLTHPLAFCGPACPPRCG
PLMPEHSGGHLKSDPVAFRPWHCPFLLETKILERAPFWVPTCLPPYLVSGLPPEHPCDWP
LTPHPWVYSGGQPKVPSAFSLGSKGFYYKDPSIPRLAKEPLAAAEPGLFGLNSGGHLQRA
GEAERPSLHQRDGEMGAGRQQNPCPLFLGQPDTVPWTSWPACPPGLVHTLGNVWAGPGDG
NLGYQLGPPATPRCPSPEPPVTQRGCCSSYPPTKGGGLGPCGKCQEGLEGGASGASEPSE
EVNKASGPRACPPSHHTKLKKTWLTRHSEQFECPRGCPEVEERPVARLRALKRAGSPEVQ
GAMGSPAPKRPPDPFPGTAEQGAGGWQEVRDTSIGNKDVDSGQHDEQKGPQDGQASLQDP
GLQDIPCLALPAKLAQCQSCAQAAGEGGGHACHSQQVRRSPLGGELQQEEDTATNSSSEE
GPGSGPDSRLSTGLAKHLLSGLGDRLCRLLRREREALAWAQREGQGPAVTEDSPGIPRCC
SRCHHGLFNTHWRCPRCSHRLCVACGRVAGTGRAREKAGFQEQSAEECTQEAGHAACSLM
LTQFVSSQALAELSTAMHQVWVKFDIRGHCPCQADARVWAPGDAGQQKESTQKTPPTPQP
SCNGDTHRTKSIKEETPDSAETPAEDRAGRGPLPCPSLCELLASTAVKLCLGHERIHMAF
APVTPALPSDDRITNILDSIIAQVVERKIQEKALGPGLRAGPGLRKGLGLPLSPVRPRLP
PPGALLWLQEPQPCPRRGFHLFQEHWRQGQPVLVSGIQRTLQGNLWGTEALGALGGQVQA
LSPLGPPQPSSLGSTTFWEGFSWPELRPKSDEGSVLLLHRALGDEDTSRVENLAASLPLP
EYCALHGKLNLASYLPPGLALRPLEPQLWAAYGVSPHRGHLGTKNLCVEVADLVSILVHA
DTPLPAWHRAQKDFLSGLDGEGLWSPGSQVSTVWHVFRAQDAQRIRRFLQMVCPAGAGAL
EPGAPGSCYLDAGLRRRLREEWGVSCWTLLQAPGEAVLVPAGAPHQVQGLVSTVSVTQHF
LSPETSALSAQLCHQGPSLPPDCHLLYAQMDWAVFQAVKVAVGTLQEAK
Target Bioclass
Enzyme
Subcellular location
Nucleus
Function
Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle.
Uniprot ID
O43593
Ensemble ID
ENST00000312841.9
HGNC ID
HGNC:5172

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA Deletion: p.G191AfsTer11 .
FTC133 SNV: p.P737H .
G401 SNV: p.N232K .
HCT116 SNV: p.G367A DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER Deletion: p.P842QfsTer60 .
JURKAT SNV: p.E392K .
KELLY SNV: p.E864Ter .
LN18 SNV: p.P394L .
MELJUSO SNV: p.D460H .
MFE319 Deletion: p.P63LfsTer60 .
MOLT4 SNV: p.S200N; p.P308S .
NCIH1703 SNV: p.G1156Ter .
NCIH23 SNV: p.S1036Ter .
REH SNV: p.C341Y; p.E1115K .
SKMEL24 SNV: p.P74S .
SKNSH SNV: p.G190W .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C487(6.06)  LDD2207  [1]
DBIA
 Probe Info  		C690(1.00); C692(1.00)  LDD0533  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0216  AC100 HCT 116 C690(1.00); C692(1.00)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C690(0.90); C692(0.90)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C690(0.90); C692(0.90)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C690(1.43); C692(1.43)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C690(1.29); C692(1.29)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C690(1.16); C692(1.16)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C690(1.28); C692(1.28)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C690(1.20); C692(1.20)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C690(0.94); C692(0.94)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C690(0.87); C692(0.87)  LDD0542  [2]
 LDCM0227  AC110 HCT 116 C690(0.92); C692(0.92)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C690(1.03); C692(1.03)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C690(1.01); C692(1.01)  LDD0546  [2]
 LDCM0263  AC143 HCT 116 C690(1.13); C692(1.13)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C690(1.83); C692(1.83)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C690(1.09); C692(1.09)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C690(1.66); C692(1.66)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C690(1.48); C692(1.48)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C690(2.06); C692(2.06)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C690(1.70); C692(1.70)  LDD0586  [2]
 LDCM0271  AC150 HCT 116 C690(1.14); C692(1.14)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C690(1.09); C692(1.09)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C690(1.27); C692(1.27)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C690(2.49); C692(2.49)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C690(1.47); C692(1.47)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C690(1.33); C692(1.33)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C690(1.27); C692(1.27)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C690(1.31); C692(1.31)  LDD2161  [2]
 LDCM0320  AC57 HCT 116 C690(1.34); C692(1.34)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C690(1.52); C692(1.52)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C690(1.63); C692(1.63)  LDD0639  [2]
 LDCM0324  AC60 HCT 116 C690(1.23); C692(1.23)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C690(1.43); C692(1.43)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C690(1.61); C692(1.61)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C690(1.35); C692(1.35)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C690(1.59); C692(1.59)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C690(1.57); C692(1.57)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C690(1.46); C692(1.46)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C690(1.77); C692(1.77)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C690(1.38); C692(1.38)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C690(1.33); C692(1.33)  LDD0650  [2]
 LDCM0335  AC70 HCT 116 C690(2.70); C692(2.70)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C690(1.35); C692(1.35)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C690(1.35); C692(1.35)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C690(2.01); C692(2.01)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C690(1.87); C692(1.87)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C690(2.29); C692(2.29)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C690(1.35); C692(1.35)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C690(1.53); C692(1.53)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C690(1.30); C692(1.30)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C690(1.34); C692(1.34)  LDD0661  [2]
 LDCM0346  AC80 HCT 116 C690(1.44); C692(1.44)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C690(1.30); C692(1.30)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C690(2.42); C692(2.42)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C690(2.24); C692(2.24)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C690(2.56); C692(2.56)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C690(1.31); C692(1.31)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C690(1.17); C692(1.17)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C690(1.43); C692(1.43)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C690(1.20); C692(1.20)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C690(1.43); C692(1.43)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C690(1.13); C692(1.13)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C690(2.17); C692(2.17)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C690(1.56); C692(1.56)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C690(1.33); C692(1.33)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C690(1.31); C692(1.31)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C690(1.55); C692(1.55)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C690(1.63); C692(1.63)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C690(1.66); C692(1.66)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C690(1.61); C692(1.61)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C690(0.78); C692(0.78)  LDD0683  [2]
 LDCM0367  CL1 HCT 116 C690(1.91); C692(1.91)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C690(3.01); C692(3.01)  LDD0685  [2]
 LDCM0379  CL11 HCT 116 C690(2.17); C692(2.17)  LDD0696  [2]
 LDCM0390  CL12 HCT 116 C690(1.70); C692(1.70)  LDD0707  [2]
 LDCM0396  CL125 HCT 116 C690(1.03); C692(1.03)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C690(1.35); C692(1.35)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C690(1.03); C692(1.03)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C690(1.29); C692(1.29)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C690(1.26); C692(1.26)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C690(2.01); C692(2.01)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C690(2.58); C692(2.58)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C690(1.34); C692(1.34)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C690(2.59); C692(2.59)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C690(1.21); C692(1.21)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C690(1.17); C692(1.17)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C690(0.86); C692(0.86)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C690(1.23); C692(1.23)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C690(5.65); C692(5.65)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C690(2.53); C692(2.53)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C690(1.12); C692(1.12)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C690(1.44); C692(1.44)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C690(2.78); C692(2.78)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C690(1.16); C692(1.16)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C690(1.32); C692(1.32)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C690(1.38); C692(1.38)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C690(1.30); C692(1.30)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C690(1.11); C692(1.11)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C690(1.19); C692(1.19)  LDD0736  [2]
 LDCM0429  CL4 HCT 116 C690(1.35); C692(1.35)  LDD0746  [2]
 LDCM0440  CL5 HCT 116 C690(1.06); C692(1.06)  LDD0757  [2]
 LDCM0451  CL6 HCT 116 C690(1.93); C692(1.93)  LDD0768  [2]
 LDCM0462  CL7 HCT 116 C690(1.31); C692(1.31)  LDD0779  [2]
 LDCM0473  CL8 HCT 116 C690(2.89); C692(2.89)  LDD0790  [2]
 LDCM0484  CL9 HCT 116 C690(1.32); C692(1.32)  LDD0801  [2]
 LDCM0628  OTUB2-COV-1 HEK-293T C487(6.06)  LDD2207  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mitochondrial inner membrane protease ATP23 homolog (ATP23) Peptidase M76 family Q9Y6H3
Retinol-binding protein 3 (RBP3) Peptidase S41A family P10745
Group 10 secretory phospholipase A2 (PLA2G10) Phospholipase A2 family O15496
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Other
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cilia- and flagella-associated protein 68 (CFAP68) CFAP68 family Q9H5F2
Cornifelin (CNFN) Cornifelin family Q9BYD5
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Protein INCA1 (INCA1) INCA family Q0VD86
Keratin-associated protein 3-1 (KRTAP3-1) KRTAP type 3 family Q9BYR8
Keratin-associated protein 3-3 (KRTAP3-3) KRTAP type 3 family Q9BYR6
Keratin-associated protein 11-1 (KRTAP11-1) PMG family Q8IUC1
Keratin-associated protein 13-2 (KRTAP13-2) PMG family Q52LG2
Keratin-associated protein 15-1 (KRTAP15-1) PMG family Q3LI76
Protein sprouty homolog 3 (SPRY3) Sprouty family O43610
Gem-associated protein 4 (GEMIN4) . P57678
Zinc finger MYND domain-containing protein 12 (ZMYND12) . Q9H0C1

References

1 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.