Details of the Target

General Information of Target

Target ID LDTP00685
Target Name Small G protein signaling modulator 2 (SGSM2)
Gene Name SGSM2
Gene ID 9905
Synonyms
KIAA0397; RUTBC1; Small G protein signaling modulator 2; RUN and TBC1 domain-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGSAEDAVKEKLLWNVKKEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAA
GFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAP
ALSPQALKHVWVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCA
LEYTKLKTADHYWTDPSADELVQRHRIRGPPTRQDSPAKRPALGIRKRHSSGSASEDRLA
ACARECVESLHQNSRTRLLYGKNHVLVQPKEDMEAVPGYLSLHQSAESLTLKWTPNQLMN
GTLGDSELEKSVYWDYALVVPFSQVVCIHCHQQKSGGTLVLVSQDGIQRPPLHFPQGGHL
LSFLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSVDMEEMGTGRATDYVFRI
IYPGHRHEHNAGDMIEMQGFGPSLPAWHLEPLCSQGSSCLSCSSSSSPHATPSHCSCIPD
RLPLRLLCESMKRQIVSRAFYGWLAHCRHLSTVRTHLSALVHHSVIPPDRPPGASAGLTK
DVWSKYQKDKKNYKELELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVA
ARYQQVLAEWKACEVVVRQREREAHPATRTKFSSGSSIDSHVQRLIHRDSTISNDVFISV
DDLEPPEPQDPEDSRPKPEQEAGPGTPGTAVVEQQHSVEFDSPDSGLPSSRNYSVASGIQ
SSLDEGQSVGFEEEDGGGEEGSSGPGPAAHTLREPQDPSQEKPQAGELEAGEELAAVCAA
AYTIELLDTVALNLHRIDKDVQRCDRNYWYFTPPNLERLRDVMCSYVWEHLDVGYVQGMC
DLLAPLLVTLDNDQLAYSCFSHLMKRMSQNFPNGGAMDTHFANMRSLIQILDSELFELMH
QNGDYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYRE
IIRDNNMDFTDIIKFFNERAEHHDAQEILRIARDLVHKVQMLIENK
Target Bioclass
Other
Family
RUTBC family
Subcellular location
Cytoplasm
Function
Possesses GTPase activator activity towards RAB32, RAB33B and RAB38. Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation.
Uniprot ID
O43147
Ensemble ID
ENST00000268989.8
HGNC ID
HGNC:29026

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C488(1.00)  LDD1507  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C488(1.00)  LDD1507  [1]
 LDCM0226  AC11 HEK-293T C488(1.06)  LDD1509  [1]
 LDCM0237  AC12 HEK-293T C488(0.86)  LDD1510  [1]
 LDCM0259  AC14 HEK-293T C488(0.95)  LDD1512  [1]
 LDCM0270  AC15 HEK-293T C488(1.11)  LDD1513  [1]
 LDCM0276  AC17 HEK-293T C488(1.09)  LDD1515  [1]
 LDCM0278  AC19 HEK-293T C488(1.80)  LDD1517  [1]
 LDCM0280  AC20 HEK-293T C488(0.94)  LDD1519  [1]
 LDCM0282  AC22 HEK-293T C488(0.86)  LDD1521  [1]
 LDCM0283  AC23 HEK-293T C488(1.05)  LDD1522  [1]
 LDCM0285  AC25 HEK-293T C488(0.85)  LDD1524  [1]
 LDCM0287  AC27 HEK-293T C488(1.03)  LDD1526  [1]
 LDCM0288  AC28 HEK-293T C488(1.01)  LDD1527  [1]
 LDCM0290  AC3 HEK-293T C488(1.06)  LDD1529  [1]
 LDCM0291  AC30 HEK-293T C488(0.88)  LDD1530  [1]
 LDCM0292  AC31 HEK-293T C488(1.14)  LDD1531  [1]
 LDCM0294  AC33 HEK-293T C488(1.02)  LDD1533  [1]
 LDCM0296  AC35 HEK-293T C488(0.98)  LDD1535  [1]
 LDCM0297  AC36 HEK-293T C488(0.99)  LDD1536  [1]
 LDCM0299  AC38 HEK-293T C488(0.88)  LDD1538  [1]
 LDCM0300  AC39 HEK-293T C488(1.23)  LDD1539  [1]
 LDCM0301  AC4 HEK-293T C488(0.88)  LDD1540  [1]
 LDCM0303  AC41 HEK-293T C488(1.10)  LDD1542  [1]
 LDCM0305  AC43 HEK-293T C488(0.99)  LDD1544  [1]
 LDCM0306  AC44 HEK-293T C488(0.88)  LDD1545  [1]
 LDCM0308  AC46 HEK-293T C488(0.97)  LDD1547  [1]
 LDCM0309  AC47 HEK-293T C488(1.17)  LDD1548  [1]
 LDCM0311  AC49 HEK-293T C488(1.03)  LDD1550  [1]
 LDCM0314  AC51 HEK-293T C488(1.09)  LDD1553  [1]
 LDCM0315  AC52 HEK-293T C488(0.95)  LDD1554  [1]
 LDCM0317  AC54 HEK-293T C488(0.88)  LDD1556  [1]
 LDCM0318  AC55 HEK-293T C488(1.13)  LDD1557  [1]
 LDCM0320  AC57 HEK-293T C488(0.97)  LDD1559  [1]
 LDCM0322  AC59 HEK-293T C488(1.24)  LDD1561  [1]
 LDCM0323  AC6 HEK-293T C488(0.86)  LDD1562  [1]
 LDCM0324  AC60 HEK-293T C488(0.93)  LDD1563  [1]
 LDCM0326  AC62 HEK-293T C488(0.93)  LDD1565  [1]
 LDCM0327  AC63 HEK-293T C488(1.21)  LDD1566  [1]
 LDCM0334  AC7 HEK-293T C488(1.07)  LDD1568  [1]
 LDCM0356  AKOS034007680 HEK-293T C488(1.13)  LDD1570  [1]
 LDCM0367  CL1 HEK-293T C488(1.00)  LDD1571  [1]
 LDCM0368  CL10 HEK-293T C488(1.14)  LDD1572  [1]
 LDCM0370  CL101 HEK-293T C488(1.00)  LDD1574  [1]
 LDCM0372  CL103 HEK-293T C488(0.86)  LDD1576  [1]
 LDCM0374  CL105 HEK-293T C488(0.98)  LDD1578  [1]
 LDCM0376  CL107 HEK-293T C488(0.93)  LDD1580  [1]
 LDCM0378  CL109 HEK-293T C488(0.92)  LDD1582  [1]
 LDCM0379  CL11 HEK-293T C488(1.31)  LDD1583  [1]
 LDCM0381  CL111 HEK-293T C488(1.19)  LDD1585  [1]
 LDCM0383  CL113 HEK-293T C488(1.01)  LDD1587  [1]
 LDCM0385  CL115 HEK-293T C488(0.99)  LDD1589  [1]
 LDCM0387  CL117 HEK-293T C488(1.00)  LDD1591  [1]
 LDCM0389  CL119 HEK-293T C488(0.97)  LDD1593  [1]
 LDCM0392  CL121 HEK-293T C488(0.99)  LDD1596  [1]
 LDCM0394  CL123 HEK-293T C488(1.16)  LDD1598  [1]
 LDCM0396  CL125 HEK-293T C488(0.97)  LDD1600  [1]
 LDCM0398  CL127 HEK-293T C488(1.12)  LDD1602  [1]
 LDCM0400  CL13 HEK-293T C488(0.93)  LDD1604  [1]
 LDCM0402  CL15 HEK-293T C488(1.05)  LDD1606  [1]
 LDCM0404  CL17 HEK-293T C488(1.12)  LDD1608  [1]
 LDCM0406  CL19 HEK-293T C488(1.12)  LDD1610  [1]
 LDCM0408  CL20 HEK-293T C488(1.07)  LDD1612  [1]
 LDCM0410  CL22 HEK-293T C488(0.99)  LDD1614  [1]
 LDCM0411  CL23 HEK-293T C488(1.11)  LDD1615  [1]
 LDCM0413  CL25 HEK-293T C488(0.89)  LDD1617  [1]
 LDCM0415  CL27 HEK-293T C488(0.77)  LDD1619  [1]
 LDCM0417  CL29 HEK-293T C488(0.93)  LDD1621  [1]
 LDCM0418  CL3 HEK-293T C488(1.14)  LDD1622  [1]
 LDCM0420  CL31 HEK-293T C488(1.11)  LDD1624  [1]
 LDCM0421  CL32 HEK-293T C488(0.91)  LDD1625  [1]
 LDCM0423  CL34 HEK-293T C488(1.14)  LDD1627  [1]
 LDCM0424  CL35 HEK-293T C488(1.18)  LDD1628  [1]
 LDCM0426  CL37 HEK-293T C488(0.84)  LDD1630  [1]
 LDCM0428  CL39 HEK-293T C488(0.93)  LDD1632  [1]
 LDCM0431  CL41 HEK-293T C488(1.27)  LDD1635  [1]
 LDCM0433  CL43 HEK-293T C488(1.11)  LDD1637  [1]
 LDCM0434  CL44 HEK-293T C488(1.02)  LDD1638  [1]
 LDCM0436  CL46 HEK-293T C488(1.22)  LDD1640  [1]
 LDCM0437  CL47 HEK-293T C488(1.17)  LDD1641  [1]
 LDCM0439  CL49 HEK-293T C488(1.02)  LDD1643  [1]
 LDCM0440  CL5 HEK-293T C488(1.06)  LDD1644  [1]
 LDCM0444  CL53 HEK-293T C488(1.27)  LDD1647  [1]
 LDCM0446  CL55 HEK-293T C488(1.15)  LDD1649  [1]
 LDCM0447  CL56 HEK-293T C488(1.04)  LDD1650  [1]
 LDCM0449  CL58 HEK-293T C488(1.23)  LDD1652  [1]
 LDCM0450  CL59 HEK-293T C488(1.28)  LDD1653  [1]
 LDCM0453  CL61 HEK-293T C488(1.07)  LDD1656  [1]
 LDCM0455  CL63 HEK-293T C488(1.26)  LDD1658  [1]
 LDCM0457  CL65 HEK-293T C488(0.97)  LDD1660  [1]
 LDCM0459  CL67 HEK-293T C488(1.26)  LDD1662  [1]
 LDCM0460  CL68 HEK-293T C488(1.07)  LDD1663  [1]
 LDCM0462  CL7 HEK-293T C488(1.10)  LDD1665  [1]
 LDCM0463  CL70 HEK-293T C488(0.98)  LDD1666  [1]
 LDCM0464  CL71 HEK-293T C488(1.25)  LDD1667  [1]
 LDCM0466  CL73 HEK-293T C488(1.30)  LDD1669  [1]
 LDCM0470  CL77 HEK-293T C488(1.21)  LDD1673  [1]
 LDCM0472  CL79 HEK-293T C488(1.27)  LDD1675  [1]
 LDCM0473  CL8 HEK-293T C488(1.25)  LDD1676  [1]
 LDCM0474  CL80 HEK-293T C488(0.86)  LDD1677  [1]
 LDCM0476  CL82 HEK-293T C488(1.16)  LDD1679  [1]
 LDCM0477  CL83 HEK-293T C488(1.41)  LDD1680  [1]
 LDCM0479  CL85 HEK-293T C488(0.88)  LDD1682  [1]
 LDCM0481  CL87 HEK-293T C488(0.88)  LDD1684  [1]
 LDCM0483  CL89 HEK-293T C488(1.04)  LDD1686  [1]
 LDCM0486  CL91 HEK-293T C488(1.04)  LDD1689  [1]
 LDCM0487  CL92 HEK-293T C488(0.96)  LDD1690  [1]
 LDCM0489  CL94 HEK-293T C488(1.23)  LDD1692  [1]
 LDCM0490  CL95 HEK-293T C488(1.54)  LDD1693  [1]
 LDCM0492  CL97 HEK-293T C488(1.00)  LDD1695  [1]
 LDCM0494  CL99 HEK-293T C488(1.05)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C488(1.06)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C488(1.04)  LDD1671  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402