Details of the Target

General Information of Target

Target ID LDTP00657
Target Name Nucleoporin NUP42 (NUP42)
Gene Name NUP42
Gene ID 11097
Synonyms
CG1; NUPL2; Nucleoporin NUP42; NLP-1; NUP42 homolog; Nucleoporin hCG1; Nucleoporin-42; Nucleoporin-like protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAICQFFLQGRCRFGDRCWNEHPGARGAGGGRQQPQQQPSGNNRRGWNTTSQRYSNVIQP
SSFSKSTPWGGSRDQEKPYFSSFDSGASTNRKEGFGLSENPFASLSPDEQKDEKKLLEGI
VKDMEVWESSGQWMFSVYSPVKKKPNISGFTDISPEELRLEYHNFLTSNNLQSYLNSVQR
LINQWRNRVNELKSLNISTKVALLSDVKDGVNQAAPAFGFGSSQAATFMSPGFPVNNSSS
DNAQNFSFKTNSGFAAASSGSPAGFGSSPAFGAAASTSSGISTSAPAFGFGKPEVTSAAS
FSFKSPAASSFGSPGFSGLPASLATGPVRAPVAPAFGGGSSVAGFGSPGSHSHTAFSKPS
SDTFGNSSISTSLSASSSIIATDNVLFTPRDKLTVEELEQFQSKKFTLGKIPLKPPPLEL
LNV
Target Bioclass
Transporter and channel
Subcellular location
Nucleus, nuclear pore complex
Function
Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm.; (Microbial infection) In case of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelope.
Uniprot ID
O15504
Ensemble ID
ENST00000258742.10
HGNC ID
HGNC:17010

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2780 SNV: p.P314L .
CAL27 SNV: p.Q9K .
DU145 SNV: p.N100I .
HCT15 SNV: p.P417S .
HEC1 SNV: p.L160I .
HUPT4 SNV: p.S139L .
MCC13 SNV: p.P348S .
MELHO SNV: p.A299G .
MEWO SNV: p.A299G .
MFE319 SNV: p.P389L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
IA-alkyne
 Probe Info  		C4(0.54)  LDD2182  [2]
5E-2FA
 Probe Info  		N.A.  LDD2235  [3]
m-APA
 Probe Info  		N.A.  LDD2231  [3]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C094
 Probe Info  		23.26  LDD1785  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos C4(0.76)  LDD2187  [2]
 LDCM0572  Fragment10 Ramos C4(0.43)  LDD2189  [2]
 LDCM0573  Fragment11 Ramos C4(6.37)  LDD2190  [2]
 LDCM0574  Fragment12 Ramos C4(0.51)  LDD2191  [2]
 LDCM0579  Fragment20 Ramos C4(0.44)  LDD2194  [2]
 LDCM0580  Fragment21 Ramos C4(0.70)  LDD2195  [2]
 LDCM0582  Fragment23 Ramos C4(1.00)  LDD2196  [2]
 LDCM0588  Fragment30 Ramos C4(0.46)  LDD2199  [2]
 LDCM0590  Fragment32 Ramos C4(0.40)  LDD2201  [2]
 LDCM0596  Fragment38 Ramos C4(0.75)  LDD2203  [2]
 LDCM0566  Fragment4 Ramos C4(0.63)  LDD2184  [2]
 LDCM0610  Fragment52 Ramos C4(0.66)  LDD2204  [2]
 LDCM0614  Fragment56 Ramos C4(0.69)  LDD2205  [2]
 LDCM0569  Fragment7 Ramos C4(0.61)  LDD2186  [2]
 LDCM0571  Fragment9 Ramos C4(0.53)  LDD2188  [2]
 LDCM0022  KB02 Ramos C4(0.54)  LDD2182  [2]
 LDCM0023  KB03 Ramos C4(1.39)  LDD2183  [2]
 LDCM0024  KB05 Ramos C4(0.66)  LDD2185  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
3 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
4 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587