Details of the Target

General Information of Target

Target ID LDTP00508
Target Name Zinc finger protein 646 (ZNF646)
Gene Name ZNF646
Gene ID 9726
Synonyms
KIAA0296; Zinc finger protein 646
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEDTPPSLSCSDCQRHFPSLPELSRHRELLHPSPNQDSEEADSIPRPYRCQQCGRGYRHP
GSLVNHRRTHETGLFPCTTCGKDFSNPMALKSHMRTHAPEGRRRHRPPRPKEATPHLQGE
TVSTDSWGQRLGSSEGWENQTKHTEETPDCESVPDPRAASGTWEDLPTRQREGLASHPGP
EDGADGWGPSTNSARAPPLPIPASSLLSNLEQYLAESVVNFTGGQEPTQSPPAEEERRYK
CSQCGKTYKHAGSLTNHRQSHTLGIYPCAICFKEFSNLMALKNHSRLHAQYRPYHCPHCP
RVFRLPRELLEHQQSHEGERQEPRWEEKGMPTTNGHTDESSQDQLPSAQMLNGSAELSTS
GELEDSGLEEYRPFRCGDCGRTYRHAGSLINHRKSHQTGVYPCSLCSKQLFNAAALKNHV
RAHHRPRQGVGENGQPSVPPAPLLLAETTHKEEEDPTTTLDHRPYKCSECGRAYRHRGSL
VNHRHSHRTGEYQCSLCPRKYPNLMALRNHVRVHCKAARRSADIGAEGAPSHLKVELPPD
PVEAEAAPHTDQDHVCKHEEEATDITPAADKTAAHICSICGLLFEDAESLERHGLTHGAG
EKENSRTETTMSPPRAFACRDCGKSYRHSGSLINHRQTHQTGDFSCGACAKHFHTMAAMK
NHLRRHSRRRSRRHRKRAGGASGGREAKLLAAESWTRELEDNEGLESPQDPSGESPHGAE
GNLESDGDCLQAESEGDKCGLERDETHFQGDKESGGTGEGLERKDASLLDNLDIPGEEGG
GTHFCDSLTGVDEDQKPATGQPNSSSHSANAVTGWQAGAAHTCSDCGHSFPHATGLLSHR
PCHPPGIYQCSLCPKEFDSLPALRSHFQNHRPGEATSAQPFLCCLCGMIFPGRAGYRLHR
RQAHSSSGMTEGSEEEGEEEGVAEAAPARSPPLQLSEAELLNQLQREVEALDSAGYGHIC
GCCGQTYDDLGSLERHHQSQSSGTTADKAPSPLGVAGDAMEMVVDSVLEDIVNSVSGEGG
DAKSQEGAGTPLGDSLCIQGGESLLEAQPRPFRCNQCGKTYRHGGSLVNHRKIHQTGDFL
CPVCSRCYPNLAAYRNHLRNHPRCKGSEPQVGPIPEAAGSSELQVGPIPEGGSNKPQHMA
EEGPGQAEVEKLQEELKVEPLEEVARVKEEVWEETTVKGEEIEPRLETAEKGCQTEASSE
RPFSCEVCGRSYKHAGSLINHRQSHQTGHFGCQACSKGFSNLMSLKNHRRIHADPRRFRC
SECGKAFRLRKQLASHQRVHMERRGGGGTRKATREDRPFRCGQCGRTYRHAGSLLNHRRS
HETGQYSCPTCPKTYSNRMALKDHQRLHSENRRRRAGRSRRTAVRCALCGRSFPGRGSLE
RHLREHEETEREPANGQGGLDGTAASEANLTGSQGLETQLGGAEPVPHLEDGVPRPGERS
QSPIRAASSEAPEPLSWGAGKAGGWPVGGGLGNHSGGWVPQFLTRSEEPEDSVHRSPCHA
GDCQLNGPTLSHMDSWDNRDNSSQLQPGSHSSCSQCGKTYCQSGSLLNHNTNKTDRHYCL
LCSKEFLNPVATKSHSHNHIDAQTFACPDCGKAFESHQELASHLQAHARGHSQVPAQMEE
ARDPKAGTGEDQVVLPGQGKAQEAPSETPRGPGESVERARGGQAVTSMAAEDKERPFRCT
QCGRSYRHAGSLLNHQKAHTTGLYPCSLCPKLLPNLLSLKNHSRTHTDPKRHCCSICGKA
FRTAARLEGHGRVHAPREGPFTCPHCPRHFRRRISFVQHQQQHQEEWTVAGSGAPVAPVT
GRGDLPLPPPPTPTTPLLDPSPQWPADLSFSL
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
O15015
Ensemble ID
ENST00000300850.5
HGNC ID
HGNC:29004

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1087(1.45)  LDD3316  [1]
Acrolein
 Probe Info  		N.A.  LDD0226  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0259  AC14 HEK-293T C1087(1.02)  LDD1512  [3]
 LDCM0281  AC21 HEK-293T C1087(1.06); C1037(1.25)  LDD1520  [3]
 LDCM0282  AC22 HEK-293T C1087(0.84)  LDD1521  [3]
 LDCM0284  AC24 HEK-293T C1193(0.64)  LDD1523  [3]
 LDCM0289  AC29 HEK-293T C1087(1.20); C1037(0.90)  LDD1528  [3]
 LDCM0291  AC30 HEK-293T C1087(1.05)  LDD1530  [3]
 LDCM0293  AC32 HEK-293T C1193(0.57)  LDD1532  [3]
 LDCM0298  AC37 HEK-293T C1087(1.35); C1037(1.19)  LDD1537  [3]
 LDCM0299  AC38 HEK-293T C1087(0.99)  LDD1538  [3]
 LDCM0302  AC40 HEK-293T C1193(0.55)  LDD1541  [3]
 LDCM0307  AC45 HEK-293T C1087(1.08); C1037(1.41)  LDD1546  [3]
 LDCM0308  AC46 HEK-293T C1087(0.90)  LDD1547  [3]
 LDCM0310  AC48 HEK-293T C1193(0.60)  LDD1549  [3]
 LDCM0312  AC5 HEK-293T C1087(0.95); C1037(1.09)  LDD1551  [3]
 LDCM0316  AC53 HEK-293T C1087(1.06); C1037(1.20)  LDD1555  [3]
 LDCM0317  AC54 HEK-293T C1087(0.89)  LDD1556  [3]
 LDCM0319  AC56 HEK-293T C1193(0.67)  LDD1558  [3]
 LDCM0323  AC6 HEK-293T C1087(1.01)  LDD1562  [3]
 LDCM0325  AC61 HEK-293T C1087(1.11); C1037(1.12)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C1087(1.03)  LDD1565  [3]
 LDCM0328  AC64 HEK-293T C1193(0.87)  LDD1567  [3]
 LDCM0345  AC8 HEK-293T C1193(0.59)  LDD1569  [3]
 LDCM0248  AKOS034007472 HEK-293T C1087(0.93); C1037(0.99)  LDD1511  [3]
 LDCM0275  AKOS034007705 HEK-293T C1193(1.01)  LDD1514  [3]
 LDCM0368  CL10 HEK-293T C1087(1.24)  LDD1572  [3]
 LDCM0390  CL12 HEK-293T C1193(0.66)  LDD1594  [3]
 LDCM0409  CL21 HEK-293T C1087(1.61); C1037(1.28)  LDD1613  [3]
 LDCM0410  CL22 HEK-293T C1087(1.24)  LDD1614  [3]
 LDCM0412  CL24 HEK-293T C1193(0.94)  LDD1616  [3]
 LDCM0422  CL33 HEK-293T C1087(1.30); C1037(1.17)  LDD1626  [3]
 LDCM0423  CL34 HEK-293T C1087(1.29)  LDD1627  [3]
 LDCM0425  CL36 HEK-293T C1193(0.94)  LDD1629  [3]
 LDCM0435  CL45 HEK-293T C1087(1.33); C1037(1.00)  LDD1639  [3]
 LDCM0436  CL46 HEK-293T C1087(1.27)  LDD1640  [3]
 LDCM0438  CL48 HEK-293T C1193(0.99)  LDD1642  [3]
 LDCM0448  CL57 HEK-293T C1087(1.53); C1037(1.19)  LDD1651  [3]
 LDCM0449  CL58 HEK-293T C1087(1.30)  LDD1652  [3]
 LDCM0452  CL60 HEK-293T C1193(0.80)  LDD1655  [3]
 LDCM0461  CL69 HEK-293T C1087(1.31); C1037(0.74)  LDD1664  [3]
 LDCM0463  CL70 HEK-293T C1087(1.23)  LDD1666  [3]
 LDCM0465  CL72 HEK-293T C1193(0.72)  LDD1668  [3]
 LDCM0475  CL81 HEK-293T C1087(1.41); C1037(1.62)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C1087(1.37)  LDD1679  [3]
 LDCM0478  CL84 HEK-293T C1193(0.68)  LDD1681  [3]
 LDCM0484  CL9 HEK-293T C1087(1.49); C1037(1.68)  LDD1687  [3]
 LDCM0488  CL93 HEK-293T C1087(1.45); C1037(1.02)  LDD1691  [3]
 LDCM0489  CL94 HEK-293T C1087(1.26)  LDD1692  [3]
 LDCM0491  CL96 HEK-293T C1193(0.82)  LDD1694  [3]
 LDCM0022  KB02 HEK-293T C150(1.09)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C150(0.98)  LDD1497  [3]
 LDCM0024  KB05 MEL167 C1087(1.45)  LDD3316  [1]
 LDCM0109  NEM HeLa N.A.  LDD0226  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
cGMP-dependent protein kinase 1 (PRKG1) AGC Ser/Thr protein kinase family Q13976
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Paired-like homeodomain transcription factor LEUTX (LEUTX) Paired homeobox family A8MZ59
BRCA2-interacting transcriptional repressor EMSY (EMSY) . Q7Z589

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402