Details of the Target

General Information of Target

Target ID LDTP00374
Target Name Cytoplasmic dynein 1 intermediate chain 1 (DYNC1I1)
Gene Name DYNC1I1
Gene ID 1780
Synonyms
DNCI1; DNCIC1; Cytoplasmic dynein 1 intermediate chain 1; Cytoplasmic dynein intermediate chain 1; Dynein intermediate chain 1, cytosolic; DH IC-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSDKSDLKAELERKKQRLAQIREEKKRKEEERKKKEADMQQKKEPVQDDSDLDRKRRETE
ALLQSIGISPEPPLVQPLHFLTWDTCYFHYLVPTPMSPSSKSVSTPSEAGSQDSGDLGPL
TRTLQWDTDPSVLQLQSDSELGRRLHKLGVSKVTQVDFLPREVVSYSKETQTPLATHQSE
EDEEDEEMVESKVGQDSELENQDKKQEVKEAPPRELTEEEKQQILHSEEFLIFFDRTIRV
IERALAEDSDIFFDYSGRELEEKDGDVQAGANLSFNRQFYDEHWSKHRVVTCMDWSLQYP
ELMVASYNNNEDAPHEPDGVALVWNMKFKKTTPEYVFHCQSSVMSVCFARFHPNLVVGGT
YSGQIVLWDNRSHRRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLITVSTDGKMCSWSL
DMLSTPQESMELVYNKSKPVAVTGMAFPTGDVNNFVVGSEEGTVYTACRHGSKAGIGEVF
EGHQGPVTGINCHMAVGPIDFSHLFVTSSFDWTVKLWTTKHNKPLYSFEDNADYVYDVMW
SPVHPALFACVDGMGRLDLWNLNNDTEVPTASVAIEGASALNRVRWAQAGKEVAVGDSEG
RIWVYDVGELAVPHNDEWTRFARTLVEIRANRADSEEEGTVELSA
Target Bioclass
Other
Family
Dynein intermediate chain family
Subcellular location
Cytoplasm
Function
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores.
Uniprot ID
O14576
Ensemble ID
ENST00000324972.10
HGNC ID
HGNC:2963

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C394(0.81)  LDD1509  [1]
NAIA_5
 Probe Info  		N.A.  LDD2223  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C394(0.81)  LDD1509  [1]
 LDCM0278  AC19 HEK-293T C394(0.84)  LDD1517  [1]
 LDCM0284  AC24 HEK-293T C394(1.00)  LDD1523  [1]
 LDCM0287  AC27 HEK-293T C394(0.96)  LDD1526  [1]
 LDCM0290  AC3 HEK-293T C394(0.90)  LDD1529  [1]
 LDCM0293  AC32 HEK-293T C394(0.96)  LDD1532  [1]
 LDCM0296  AC35 HEK-293T C394(0.94)  LDD1535  [1]
 LDCM0302  AC40 HEK-293T C394(1.19)  LDD1541  [1]
 LDCM0305  AC43 HEK-293T C394(0.97)  LDD1544  [1]
 LDCM0310  AC48 HEK-293T C394(1.12)  LDD1549  [1]
 LDCM0314  AC51 HEK-293T C394(0.90)  LDD1553  [1]
 LDCM0319  AC56 HEK-293T C394(1.09)  LDD1558  [1]
 LDCM0322  AC59 HEK-293T C394(0.92)  LDD1561  [1]
 LDCM0328  AC64 HEK-293T C394(1.15)  LDD1567  [1]
 LDCM0345  AC8 HEK-293T C394(1.10)  LDD1569  [1]
 LDCM0275  AKOS034007705 HEK-293T C394(1.04)  LDD1514  [1]
 LDCM0369  CL100 HEK-293T C394(1.02)  LDD1573  [1]
 LDCM0373  CL104 HEK-293T C394(1.09)  LDD1577  [1]
 LDCM0377  CL108 HEK-293T C394(1.09)  LDD1581  [1]
 LDCM0382  CL112 HEK-293T C394(0.98)  LDD1586  [1]
 LDCM0386  CL116 HEK-293T C394(1.11)  LDD1590  [1]
 LDCM0390  CL12 HEK-293T C394(0.96)  LDD1594  [1]
 LDCM0391  CL120 HEK-293T C394(1.33)  LDD1595  [1]
 LDCM0395  CL124 HEK-293T C394(0.92)  LDD1599  [1]
 LDCM0399  CL128 HEK-293T C394(1.00)  LDD1603  [1]
 LDCM0403  CL16 HEK-293T C394(1.01)  LDD1607  [1]
 LDCM0406  CL19 HEK-293T C394(0.74)  LDD1610  [1]
 LDCM0412  CL24 HEK-293T C394(1.05)  LDD1616  [1]
 LDCM0416  CL28 HEK-293T C394(1.05)  LDD1620  [1]
 LDCM0420  CL31 HEK-293T C394(0.71)  LDD1624  [1]
 LDCM0425  CL36 HEK-293T C394(0.96)  LDD1629  [1]
 LDCM0429  CL4 HEK-293T C394(0.84)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C394(1.10)  LDD1634  [1]
 LDCM0433  CL43 HEK-293T C394(0.69)  LDD1637  [1]
 LDCM0438  CL48 HEK-293T C394(0.88)  LDD1642  [1]
 LDCM0443  CL52 HEK-293T C394(1.22)  LDD1646  [1]
 LDCM0446  CL55 HEK-293T C394(0.74)  LDD1649  [1]
 LDCM0452  CL60 HEK-293T C394(0.93)  LDD1655  [1]
 LDCM0456  CL64 HEK-293T C394(0.99)  LDD1659  [1]
 LDCM0459  CL67 HEK-293T C394(0.75)  LDD1662  [1]
 LDCM0462  CL7 HEK-293T C394(0.68)  LDD1665  [1]
 LDCM0465  CL72 HEK-293T C394(0.99)  LDD1668  [1]
 LDCM0469  CL76 HEK-293T C394(0.94)  LDD1672  [1]
 LDCM0472  CL79 HEK-293T C394(0.77)  LDD1675  [1]
 LDCM0478  CL84 HEK-293T C394(1.07)  LDD1681  [1]
 LDCM0482  CL88 HEK-293T C394(0.92)  LDD1685  [1]
 LDCM0486  CL91 HEK-293T C394(0.65)  LDD1689  [1]
 LDCM0491  CL96 HEK-293T C394(0.82)  LDD1694  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264