General Information of Target

Target ID LDTP00349
Target Name Phospholipid phosphatase 3 (PLPP3)
Gene Name PLPP3
Gene ID 8613
Synonyms
LPP3; PPAP2B; Phospholipid phosphatase 3; EC 3.1.3.-; EC 3.1.3.4; Lipid phosphate phosphohydrolase 3; PAP2-beta; Phosphatidate phosphohydrolase type 2b; Phosphatidic acid phosphatase 2b; PAP-2b; PAP2b; Vascular endothelial growth factor and type I collagen-inducible protein; VCIP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQNYKYDKAIVPESKNGGSPALNNNPRRSGSKRVLLICLDLFCLFMAGLPFLIIETSTIK
PYHRGFYCNDESIKYPLKTGETINDAVLCAVGIVIAILAIITGEFYRIYYLKKSRSTIQN
PYVAALYKQVGCFLFGCAISQSFTDIAKVSIGRLRPHFLSVCNPDFSQINCSEGYIQNYR
CRGDDSKVQEARKSFFSGHASFSMYTMLYLVLYLQARFTWRGARLLRPLLQFTLIMMAFY
TGLSRVSDHKHHPSDVLAGFAQGALVACCIVFFVSDLFKTKTTLSLPAPAIRKEILSPVD
IIDRNNHHNMM
Target Bioclass
Enzyme
Family
PA-phosphatase related phosphoesterase family
Subcellular location
Cell membrane
Function
Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P. Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound. Has both an extracellular and an intracellular phosphatase activity, allowing the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes. Through the dephosphorylation of extracellular sphingosine-1-phosphate and the regulation of its extra- and intracellular availability, plays a role in vascular homeostasis, regulating endothelial cell migration, adhesion, survival, proliferation and the production of pro-inflammatory cytokines. By maintaining the appropriate levels of this lipid in the cerebellum, also ensure its proper development and function. Through its intracellular lipid phosphatase activity may act in early compartments of the secretory pathway, regulating the formation of Golgi to endoplasmic reticulum retrograde transport carriers.; Independently of this phosphatase activity may also function in the Wnt signaling pathway and the stabilization of beta-catenin/CTNNB1, thereby regulating cell proliferation, migration and differentiation in angiogenesis or yet in tumor growth. Also plays a role in integrin-mediated cell-cell adhesion in angiogenesis.
Uniprot ID
O14495
Ensemble ID
ENST00000371250.4
HGNC ID
HGNC:9229

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info 
100.00  LDD0444  [1]
OPA-S-S-alkyne
 Probe Info 
K187(2.06)  LDD3494  [2]
DBIA
 Probe Info 
C68(4.87)  LDD3310  [3]
NAIA_5
 Probe Info 
N.A.  LDD2223  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C68(1.20)  LDD1507  [5]
 LDCM0215  AC10 HEK-293T C68(0.95)  LDD1508  [5]
 LDCM0226  AC11 HEK-293T C68(0.92)  LDD1509  [5]
 LDCM0259  AC14 HEK-293T C68(0.92)  LDD1512  [5]
 LDCM0270  AC15 HEK-293T C68(1.06)  LDD1513  [5]
 LDCM0276  AC17 HEK-293T C68(0.95)  LDD1515  [5]
 LDCM0277  AC18 HEK-293T C68(1.02)  LDD1516  [5]
 LDCM0278  AC19 HEK-293T C68(1.07)  LDD1517  [5]
 LDCM0279  AC2 HEK-293T C68(0.84)  LDD1518  [5]
 LDCM0281  AC21 HEK-293T C68(1.01)  LDD1520  [5]
 LDCM0282  AC22 HEK-293T C68(0.97)  LDD1521  [5]
 LDCM0283  AC23 HEK-293T C68(0.93)  LDD1522  [5]
 LDCM0285  AC25 HEK-293T C68(1.02)  LDD1524  [5]
 LDCM0286  AC26 HEK-293T C68(0.86)  LDD1525  [5]
 LDCM0287  AC27 HEK-293T C68(0.87)  LDD1526  [5]
 LDCM0289  AC29 HEK-293T C68(1.06)  LDD1528  [5]
 LDCM0290  AC3 HEK-293T C68(0.96)  LDD1529  [5]
 LDCM0291  AC30 HEK-293T C68(0.97)  LDD1530  [5]
 LDCM0292  AC31 HEK-293T C68(0.93)  LDD1531  [5]
 LDCM0294  AC33 HEK-293T C68(1.04)  LDD1533  [5]
 LDCM0295  AC34 HEK-293T C68(0.92)  LDD1534  [5]
 LDCM0296  AC35 HEK-293T C68(0.87)  LDD1535  [5]
 LDCM0298  AC37 HEK-293T C68(1.15)  LDD1537  [5]
 LDCM0299  AC38 HEK-293T C68(0.98)  LDD1538  [5]
 LDCM0300  AC39 HEK-293T C68(0.97)  LDD1539  [5]
 LDCM0303  AC41 HEK-293T C68(1.09)  LDD1542  [5]
 LDCM0304  AC42 HEK-293T C68(0.96)  LDD1543  [5]
 LDCM0305  AC43 HEK-293T C68(1.00)  LDD1544  [5]
 LDCM0307  AC45 HEK-293T C68(1.00)  LDD1546  [5]
 LDCM0308  AC46 HEK-293T C68(0.96)  LDD1547  [5]
 LDCM0309  AC47 HEK-293T C68(0.91)  LDD1548  [5]
 LDCM0311  AC49 HEK-293T C68(1.25)  LDD1550  [5]
 LDCM0312  AC5 HEK-293T C68(1.15)  LDD1551  [5]
 LDCM0313  AC50 HEK-293T C68(0.91)  LDD1552  [5]
 LDCM0314  AC51 HEK-293T C68(0.81)  LDD1553  [5]
 LDCM0316  AC53 HEK-293T C68(0.97)  LDD1555  [5]
 LDCM0317  AC54 HEK-293T C68(0.94)  LDD1556  [5]
 LDCM0318  AC55 HEK-293T C68(1.03)  LDD1557  [5]
 LDCM0320  AC57 HEK-293T C68(1.14)  LDD1559  [5]
 LDCM0321  AC58 HEK-293T C68(0.94)  LDD1560  [5]
 LDCM0322  AC59 HEK-293T C68(0.89)  LDD1561  [5]
 LDCM0323  AC6 HEK-293T C68(0.87)  LDD1562  [5]
 LDCM0325  AC61 HEK-293T C68(1.01)  LDD1564  [5]
 LDCM0326  AC62 HEK-293T C68(0.89)  LDD1565  [5]
 LDCM0327  AC63 HEK-293T C68(0.98)  LDD1566  [5]
 LDCM0334  AC7 HEK-293T C68(0.93)  LDD1568  [5]
 LDCM0248  AKOS034007472 HEK-293T C68(0.93)  LDD1511  [5]
 LDCM0356  AKOS034007680 HEK-293T C68(1.09)  LDD1570  [5]
 LDCM0367  CL1 HEK-293T C68(1.00)  LDD1571  [5]
 LDCM0368  CL10 HEK-293T C68(1.06)  LDD1572  [5]
 LDCM0369  CL100 HEK-293T C68(1.10)  LDD1573  [5]
 LDCM0370  CL101 HEK-293T C68(1.06)  LDD1574  [5]
 LDCM0372  CL103 HEK-293T C68(1.05)  LDD1576  [5]
 LDCM0373  CL104 HEK-293T C68(1.05)  LDD1577  [5]
 LDCM0374  CL105 HEK-293T C68(0.91)  LDD1578  [5]
 LDCM0376  CL107 HEK-293T C68(1.16)  LDD1580  [5]
 LDCM0377  CL108 HEK-293T C68(1.01)  LDD1581  [5]
 LDCM0378  CL109 HEK-293T C68(0.81)  LDD1582  [5]
 LDCM0379  CL11 HEK-293T C68(1.06)  LDD1583  [5]
 LDCM0381  CL111 HEK-293T C68(1.02)  LDD1585  [5]
 LDCM0382  CL112 HEK-293T C68(0.98)  LDD1586  [5]
 LDCM0383  CL113 HEK-293T C68(1.02)  LDD1587  [5]
 LDCM0385  CL115 HEK-293T C68(1.07)  LDD1589  [5]
 LDCM0386  CL116 HEK-293T C68(1.11)  LDD1590  [5]
 LDCM0387  CL117 HEK-293T C68(0.99)  LDD1591  [5]
 LDCM0389  CL119 HEK-293T C68(1.04)  LDD1593  [5]
 LDCM0391  CL120 HEK-293T C68(1.12)  LDD1595  [5]
 LDCM0392  CL121 HEK-293T C68(0.94)  LDD1596  [5]
 LDCM0394  CL123 HEK-293T C68(1.19)  LDD1598  [5]
 LDCM0395  CL124 HEK-293T C68(1.07)  LDD1599  [5]
 LDCM0396  CL125 HEK-293T C68(1.05)  LDD1600  [5]
 LDCM0398  CL127 HEK-293T C68(1.20)  LDD1602  [5]
 LDCM0399  CL128 HEK-293T C68(1.11)  LDD1603  [5]
 LDCM0400  CL13 HEK-293T C68(1.05)  LDD1604  [5]
 LDCM0402  CL15 HEK-293T C68(1.16)  LDD1606  [5]
 LDCM0403  CL16 HEK-293T C68(1.07)  LDD1607  [5]
 LDCM0404  CL17 HEK-293T C68(1.47)  LDD1608  [5]
 LDCM0405  CL18 HEK-293T C68(0.92)  LDD1609  [5]
 LDCM0406  CL19 HEK-293T C68(1.05)  LDD1610  [5]
 LDCM0409  CL21 HEK-293T C68(1.07)  LDD1613  [5]
 LDCM0410  CL22 HEK-293T C68(1.01)  LDD1614  [5]
 LDCM0411  CL23 HEK-293T C68(1.03)  LDD1615  [5]
 LDCM0413  CL25 HEK-293T C68(0.93)  LDD1617  [5]
 LDCM0415  CL27 HEK-293T C68(1.15)  LDD1619  [5]
 LDCM0416  CL28 HEK-293T C68(1.00)  LDD1620  [5]
 LDCM0417  CL29 HEK-293T C68(1.14)  LDD1621  [5]
 LDCM0418  CL3 HEK-293T C68(1.10)  LDD1622  [5]
 LDCM0419  CL30 HEK-293T C68(0.87)  LDD1623  [5]
 LDCM0420  CL31 HEK-293T C68(1.03)  LDD1624  [5]
 LDCM0422  CL33 HEK-293T C68(1.44)  LDD1626  [5]
 LDCM0423  CL34 HEK-293T C68(0.97)  LDD1627  [5]
 LDCM0424  CL35 HEK-293T C68(1.05)  LDD1628  [5]
 LDCM0426  CL37 HEK-293T C68(1.12)  LDD1630  [5]
 LDCM0428  CL39 HEK-293T C68(1.12)  LDD1632  [5]
 LDCM0429  CL4 HEK-293T C68(1.11)  LDD1633  [5]
 LDCM0430  CL40 HEK-293T C68(0.91)  LDD1634  [5]
 LDCM0431  CL41 HEK-293T C68(1.11)  LDD1635  [5]
 LDCM0432  CL42 HEK-293T C68(0.90)  LDD1636  [5]
 LDCM0433  CL43 HEK-293T C68(0.93)  LDD1637  [5]
 LDCM0435  CL45 HEK-293T C68(1.10)  LDD1639  [5]
 LDCM0436  CL46 HEK-293T C68(1.05)  LDD1640  [5]
 LDCM0437  CL47 HEK-293T C68(1.12)  LDD1641  [5]
 LDCM0439  CL49 HEK-293T C68(1.24)  LDD1643  [5]
 LDCM0440  CL5 HEK-293T C68(1.23)  LDD1644  [5]
 LDCM0443  CL52 HEK-293T C68(0.98)  LDD1646  [5]
 LDCM0444  CL53 HEK-293T C68(1.07)  LDD1647  [5]
 LDCM0445  CL54 HEK-293T C68(0.99)  LDD1648  [5]
 LDCM0446  CL55 HEK-293T C68(0.93)  LDD1649  [5]
 LDCM0448  CL57 HEK-293T C68(1.16)  LDD1651  [5]
 LDCM0449  CL58 HEK-293T C68(0.96)  LDD1652  [5]
 LDCM0450  CL59 HEK-293T C68(1.07)  LDD1653  [5]
 LDCM0451  CL6 HEK-293T C68(1.23)  LDD1654  [5]
 LDCM0453  CL61 HEK-293T C68(1.01)  LDD1656  [5]
 LDCM0455  CL63 HEK-293T C68(1.07)  LDD1658  [5]
 LDCM0456  CL64 HEK-293T C68(1.23)  LDD1659  [5]
 LDCM0457  CL65 HEK-293T C68(1.01)  LDD1660  [5]
 LDCM0458  CL66 HEK-293T C68(0.97)  LDD1661  [5]
 LDCM0459  CL67 HEK-293T C68(0.97)  LDD1662  [5]
 LDCM0461  CL69 HEK-293T C68(1.10)  LDD1664  [5]
 LDCM0462  CL7 HEK-293T C68(1.09)  LDD1665  [5]
 LDCM0463  CL70 HEK-293T C68(0.89)  LDD1666  [5]
 LDCM0464  CL71 HEK-293T C68(1.19)  LDD1667  [5]
 LDCM0466  CL73 HEK-293T C68(0.96)  LDD1669  [5]
 LDCM0469  CL76 HEK-293T C68(1.02)  LDD1672  [5]
 LDCM0470  CL77 HEK-293T C68(1.00)  LDD1673  [5]
 LDCM0471  CL78 HEK-293T C68(0.93)  LDD1674  [5]
 LDCM0472  CL79 HEK-293T C68(0.97)  LDD1675  [5]
 LDCM0475  CL81 HEK-293T C68(1.06)  LDD1678  [5]
 LDCM0476  CL82 HEK-293T C68(1.02)  LDD1679  [5]
 LDCM0477  CL83 HEK-293T C68(0.98)  LDD1680  [5]
 LDCM0479  CL85 HEK-293T C68(1.04)  LDD1682  [5]
 LDCM0481  CL87 HEK-293T C68(1.26)  LDD1684  [5]
 LDCM0482  CL88 HEK-293T C68(1.14)  LDD1685  [5]
 LDCM0483  CL89 HEK-293T C68(1.14)  LDD1686  [5]
 LDCM0484  CL9 HEK-293T C68(1.12)  LDD1687  [5]
 LDCM0485  CL90 HEK-293T C68(1.17)  LDD1688  [5]
 LDCM0486  CL91 HEK-293T C68(1.07)  LDD1689  [5]
 LDCM0488  CL93 HEK-293T C68(1.06)  LDD1691  [5]
 LDCM0489  CL94 HEK-293T C68(0.94)  LDD1692  [5]
 LDCM0490  CL95 HEK-293T C68(1.07)  LDD1693  [5]
 LDCM0492  CL97 HEK-293T C68(1.03)  LDD1695  [5]
 LDCM0494  CL99 HEK-293T C68(1.10)  LDD1697  [5]
 LDCM0495  E2913 HEK-293T C68(1.25)  LDD1698  [5]
 LDCM0468  Fragment33 HEK-293T C68(1.01)  LDD1671  [5]
 LDCM0022  KB02 BT-549 C68(1.35)  LDD2279  [3]
 LDCM0023  KB03 BT-549 C68(1.28)  LDD2696  [3]
 LDCM0024  KB05 COLO792 C68(4.87)  LDD3310  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Catenin delta-1 (CTNND1) Beta-catenin family O60716

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402