Details of the Target
General Information of Target
Target ID | LDTP00349 | |||||
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Target Name | Phospholipid phosphatase 3 (PLPP3) | |||||
Gene Name | PLPP3 | |||||
Gene ID | 8613 | |||||
Synonyms |
LPP3; PPAP2B; Phospholipid phosphatase 3; EC 3.1.3.-; EC 3.1.3.4; Lipid phosphate phosphohydrolase 3; PAP2-beta; Phosphatidate phosphohydrolase type 2b; Phosphatidic acid phosphatase 2b; PAP-2b; PAP2b; Vascular endothelial growth factor and type I collagen-inducible protein; VCIP
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3D Structure | ||||||
Sequence |
MQNYKYDKAIVPESKNGGSPALNNNPRRSGSKRVLLICLDLFCLFMAGLPFLIIETSTIK
PYHRGFYCNDESIKYPLKTGETINDAVLCAVGIVIAILAIITGEFYRIYYLKKSRSTIQN PYVAALYKQVGCFLFGCAISQSFTDIAKVSIGRLRPHFLSVCNPDFSQINCSEGYIQNYR CRGDDSKVQEARKSFFSGHASFSMYTMLYLVLYLQARFTWRGARLLRPLLQFTLIMMAFY TGLSRVSDHKHHPSDVLAGFAQGALVACCIVFFVSDLFKTKTTLSLPAPAIRKEILSPVD IIDRNNHHNMM |
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Target Bioclass |
Enzyme
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Family |
PA-phosphatase related phosphoesterase family
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Subcellular location |
Cell membrane
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Function |
Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P. Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound. Has both an extracellular and an intracellular phosphatase activity, allowing the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes. Through the dephosphorylation of extracellular sphingosine-1-phosphate and the regulation of its extra- and intracellular availability, plays a role in vascular homeostasis, regulating endothelial cell migration, adhesion, survival, proliferation and the production of pro-inflammatory cytokines. By maintaining the appropriate levels of this lipid in the cerebellum, also ensure its proper development and function. Through its intracellular lipid phosphatase activity may act in early compartments of the secretory pathway, regulating the formation of Golgi to endoplasmic reticulum retrograde transport carriers.; Independently of this phosphatase activity may also function in the Wnt signaling pathway and the stabilization of beta-catenin/CTNNB1, thereby regulating cell proliferation, migration and differentiation in angiogenesis or yet in tumor growth. Also plays a role in integrin-mediated cell-cell adhesion in angiogenesis.
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Uniprot ID | ||||||
Ensemble ID | ||||||
HGNC ID |
Probe(s) Labeling This Target
ABPP Probe
Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
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YN-1 Probe Info |
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100.00 | LDD0444 | [1] | |
OPA-S-S-alkyne Probe Info |
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K187(2.06) | LDD3494 | [2] | |
DBIA Probe Info |
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C68(4.87) | LDD3310 | [3] | |
NAIA_5 Probe Info |
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N.A. | LDD2223 | [4] |
Competitor(s) Related to This Target
Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
---|---|---|---|---|---|
LDCM0214 | AC1 | HEK-293T | C68(1.20) | LDD1507 | [5] |
LDCM0215 | AC10 | HEK-293T | C68(0.95) | LDD1508 | [5] |
LDCM0226 | AC11 | HEK-293T | C68(0.92) | LDD1509 | [5] |
LDCM0259 | AC14 | HEK-293T | C68(0.92) | LDD1512 | [5] |
LDCM0270 | AC15 | HEK-293T | C68(1.06) | LDD1513 | [5] |
LDCM0276 | AC17 | HEK-293T | C68(0.95) | LDD1515 | [5] |
LDCM0277 | AC18 | HEK-293T | C68(1.02) | LDD1516 | [5] |
LDCM0278 | AC19 | HEK-293T | C68(1.07) | LDD1517 | [5] |
LDCM0279 | AC2 | HEK-293T | C68(0.84) | LDD1518 | [5] |
LDCM0281 | AC21 | HEK-293T | C68(1.01) | LDD1520 | [5] |
LDCM0282 | AC22 | HEK-293T | C68(0.97) | LDD1521 | [5] |
LDCM0283 | AC23 | HEK-293T | C68(0.93) | LDD1522 | [5] |
LDCM0285 | AC25 | HEK-293T | C68(1.02) | LDD1524 | [5] |
LDCM0286 | AC26 | HEK-293T | C68(0.86) | LDD1525 | [5] |
LDCM0287 | AC27 | HEK-293T | C68(0.87) | LDD1526 | [5] |
LDCM0289 | AC29 | HEK-293T | C68(1.06) | LDD1528 | [5] |
LDCM0290 | AC3 | HEK-293T | C68(0.96) | LDD1529 | [5] |
LDCM0291 | AC30 | HEK-293T | C68(0.97) | LDD1530 | [5] |
LDCM0292 | AC31 | HEK-293T | C68(0.93) | LDD1531 | [5] |
LDCM0294 | AC33 | HEK-293T | C68(1.04) | LDD1533 | [5] |
LDCM0295 | AC34 | HEK-293T | C68(0.92) | LDD1534 | [5] |
LDCM0296 | AC35 | HEK-293T | C68(0.87) | LDD1535 | [5] |
LDCM0298 | AC37 | HEK-293T | C68(1.15) | LDD1537 | [5] |
LDCM0299 | AC38 | HEK-293T | C68(0.98) | LDD1538 | [5] |
LDCM0300 | AC39 | HEK-293T | C68(0.97) | LDD1539 | [5] |
LDCM0303 | AC41 | HEK-293T | C68(1.09) | LDD1542 | [5] |
LDCM0304 | AC42 | HEK-293T | C68(0.96) | LDD1543 | [5] |
LDCM0305 | AC43 | HEK-293T | C68(1.00) | LDD1544 | [5] |
LDCM0307 | AC45 | HEK-293T | C68(1.00) | LDD1546 | [5] |
LDCM0308 | AC46 | HEK-293T | C68(0.96) | LDD1547 | [5] |
LDCM0309 | AC47 | HEK-293T | C68(0.91) | LDD1548 | [5] |
LDCM0311 | AC49 | HEK-293T | C68(1.25) | LDD1550 | [5] |
LDCM0312 | AC5 | HEK-293T | C68(1.15) | LDD1551 | [5] |
LDCM0313 | AC50 | HEK-293T | C68(0.91) | LDD1552 | [5] |
LDCM0314 | AC51 | HEK-293T | C68(0.81) | LDD1553 | [5] |
LDCM0316 | AC53 | HEK-293T | C68(0.97) | LDD1555 | [5] |
LDCM0317 | AC54 | HEK-293T | C68(0.94) | LDD1556 | [5] |
LDCM0318 | AC55 | HEK-293T | C68(1.03) | LDD1557 | [5] |
LDCM0320 | AC57 | HEK-293T | C68(1.14) | LDD1559 | [5] |
LDCM0321 | AC58 | HEK-293T | C68(0.94) | LDD1560 | [5] |
LDCM0322 | AC59 | HEK-293T | C68(0.89) | LDD1561 | [5] |
LDCM0323 | AC6 | HEK-293T | C68(0.87) | LDD1562 | [5] |
LDCM0325 | AC61 | HEK-293T | C68(1.01) | LDD1564 | [5] |
LDCM0326 | AC62 | HEK-293T | C68(0.89) | LDD1565 | [5] |
LDCM0327 | AC63 | HEK-293T | C68(0.98) | LDD1566 | [5] |
LDCM0334 | AC7 | HEK-293T | C68(0.93) | LDD1568 | [5] |
LDCM0248 | AKOS034007472 | HEK-293T | C68(0.93) | LDD1511 | [5] |
LDCM0356 | AKOS034007680 | HEK-293T | C68(1.09) | LDD1570 | [5] |
LDCM0367 | CL1 | HEK-293T | C68(1.00) | LDD1571 | [5] |
LDCM0368 | CL10 | HEK-293T | C68(1.06) | LDD1572 | [5] |
LDCM0369 | CL100 | HEK-293T | C68(1.10) | LDD1573 | [5] |
LDCM0370 | CL101 | HEK-293T | C68(1.06) | LDD1574 | [5] |
LDCM0372 | CL103 | HEK-293T | C68(1.05) | LDD1576 | [5] |
LDCM0373 | CL104 | HEK-293T | C68(1.05) | LDD1577 | [5] |
LDCM0374 | CL105 | HEK-293T | C68(0.91) | LDD1578 | [5] |
LDCM0376 | CL107 | HEK-293T | C68(1.16) | LDD1580 | [5] |
LDCM0377 | CL108 | HEK-293T | C68(1.01) | LDD1581 | [5] |
LDCM0378 | CL109 | HEK-293T | C68(0.81) | LDD1582 | [5] |
LDCM0379 | CL11 | HEK-293T | C68(1.06) | LDD1583 | [5] |
LDCM0381 | CL111 | HEK-293T | C68(1.02) | LDD1585 | [5] |
LDCM0382 | CL112 | HEK-293T | C68(0.98) | LDD1586 | [5] |
LDCM0383 | CL113 | HEK-293T | C68(1.02) | LDD1587 | [5] |
LDCM0385 | CL115 | HEK-293T | C68(1.07) | LDD1589 | [5] |
LDCM0386 | CL116 | HEK-293T | C68(1.11) | LDD1590 | [5] |
LDCM0387 | CL117 | HEK-293T | C68(0.99) | LDD1591 | [5] |
LDCM0389 | CL119 | HEK-293T | C68(1.04) | LDD1593 | [5] |
LDCM0391 | CL120 | HEK-293T | C68(1.12) | LDD1595 | [5] |
LDCM0392 | CL121 | HEK-293T | C68(0.94) | LDD1596 | [5] |
LDCM0394 | CL123 | HEK-293T | C68(1.19) | LDD1598 | [5] |
LDCM0395 | CL124 | HEK-293T | C68(1.07) | LDD1599 | [5] |
LDCM0396 | CL125 | HEK-293T | C68(1.05) | LDD1600 | [5] |
LDCM0398 | CL127 | HEK-293T | C68(1.20) | LDD1602 | [5] |
LDCM0399 | CL128 | HEK-293T | C68(1.11) | LDD1603 | [5] |
LDCM0400 | CL13 | HEK-293T | C68(1.05) | LDD1604 | [5] |
LDCM0402 | CL15 | HEK-293T | C68(1.16) | LDD1606 | [5] |
LDCM0403 | CL16 | HEK-293T | C68(1.07) | LDD1607 | [5] |
LDCM0404 | CL17 | HEK-293T | C68(1.47) | LDD1608 | [5] |
LDCM0405 | CL18 | HEK-293T | C68(0.92) | LDD1609 | [5] |
LDCM0406 | CL19 | HEK-293T | C68(1.05) | LDD1610 | [5] |
LDCM0409 | CL21 | HEK-293T | C68(1.07) | LDD1613 | [5] |
LDCM0410 | CL22 | HEK-293T | C68(1.01) | LDD1614 | [5] |
LDCM0411 | CL23 | HEK-293T | C68(1.03) | LDD1615 | [5] |
LDCM0413 | CL25 | HEK-293T | C68(0.93) | LDD1617 | [5] |
LDCM0415 | CL27 | HEK-293T | C68(1.15) | LDD1619 | [5] |
LDCM0416 | CL28 | HEK-293T | C68(1.00) | LDD1620 | [5] |
LDCM0417 | CL29 | HEK-293T | C68(1.14) | LDD1621 | [5] |
LDCM0418 | CL3 | HEK-293T | C68(1.10) | LDD1622 | [5] |
LDCM0419 | CL30 | HEK-293T | C68(0.87) | LDD1623 | [5] |
LDCM0420 | CL31 | HEK-293T | C68(1.03) | LDD1624 | [5] |
LDCM0422 | CL33 | HEK-293T | C68(1.44) | LDD1626 | [5] |
LDCM0423 | CL34 | HEK-293T | C68(0.97) | LDD1627 | [5] |
LDCM0424 | CL35 | HEK-293T | C68(1.05) | LDD1628 | [5] |
LDCM0426 | CL37 | HEK-293T | C68(1.12) | LDD1630 | [5] |
LDCM0428 | CL39 | HEK-293T | C68(1.12) | LDD1632 | [5] |
LDCM0429 | CL4 | HEK-293T | C68(1.11) | LDD1633 | [5] |
LDCM0430 | CL40 | HEK-293T | C68(0.91) | LDD1634 | [5] |
LDCM0431 | CL41 | HEK-293T | C68(1.11) | LDD1635 | [5] |
LDCM0432 | CL42 | HEK-293T | C68(0.90) | LDD1636 | [5] |
LDCM0433 | CL43 | HEK-293T | C68(0.93) | LDD1637 | [5] |
LDCM0435 | CL45 | HEK-293T | C68(1.10) | LDD1639 | [5] |
LDCM0436 | CL46 | HEK-293T | C68(1.05) | LDD1640 | [5] |
LDCM0437 | CL47 | HEK-293T | C68(1.12) | LDD1641 | [5] |
LDCM0439 | CL49 | HEK-293T | C68(1.24) | LDD1643 | [5] |
LDCM0440 | CL5 | HEK-293T | C68(1.23) | LDD1644 | [5] |
LDCM0443 | CL52 | HEK-293T | C68(0.98) | LDD1646 | [5] |
LDCM0444 | CL53 | HEK-293T | C68(1.07) | LDD1647 | [5] |
LDCM0445 | CL54 | HEK-293T | C68(0.99) | LDD1648 | [5] |
LDCM0446 | CL55 | HEK-293T | C68(0.93) | LDD1649 | [5] |
LDCM0448 | CL57 | HEK-293T | C68(1.16) | LDD1651 | [5] |
LDCM0449 | CL58 | HEK-293T | C68(0.96) | LDD1652 | [5] |
LDCM0450 | CL59 | HEK-293T | C68(1.07) | LDD1653 | [5] |
LDCM0451 | CL6 | HEK-293T | C68(1.23) | LDD1654 | [5] |
LDCM0453 | CL61 | HEK-293T | C68(1.01) | LDD1656 | [5] |
LDCM0455 | CL63 | HEK-293T | C68(1.07) | LDD1658 | [5] |
LDCM0456 | CL64 | HEK-293T | C68(1.23) | LDD1659 | [5] |
LDCM0457 | CL65 | HEK-293T | C68(1.01) | LDD1660 | [5] |
LDCM0458 | CL66 | HEK-293T | C68(0.97) | LDD1661 | [5] |
LDCM0459 | CL67 | HEK-293T | C68(0.97) | LDD1662 | [5] |
LDCM0461 | CL69 | HEK-293T | C68(1.10) | LDD1664 | [5] |
LDCM0462 | CL7 | HEK-293T | C68(1.09) | LDD1665 | [5] |
LDCM0463 | CL70 | HEK-293T | C68(0.89) | LDD1666 | [5] |
LDCM0464 | CL71 | HEK-293T | C68(1.19) | LDD1667 | [5] |
LDCM0466 | CL73 | HEK-293T | C68(0.96) | LDD1669 | [5] |
LDCM0469 | CL76 | HEK-293T | C68(1.02) | LDD1672 | [5] |
LDCM0470 | CL77 | HEK-293T | C68(1.00) | LDD1673 | [5] |
LDCM0471 | CL78 | HEK-293T | C68(0.93) | LDD1674 | [5] |
LDCM0472 | CL79 | HEK-293T | C68(0.97) | LDD1675 | [5] |
LDCM0475 | CL81 | HEK-293T | C68(1.06) | LDD1678 | [5] |
LDCM0476 | CL82 | HEK-293T | C68(1.02) | LDD1679 | [5] |
LDCM0477 | CL83 | HEK-293T | C68(0.98) | LDD1680 | [5] |
LDCM0479 | CL85 | HEK-293T | C68(1.04) | LDD1682 | [5] |
LDCM0481 | CL87 | HEK-293T | C68(1.26) | LDD1684 | [5] |
LDCM0482 | CL88 | HEK-293T | C68(1.14) | LDD1685 | [5] |
LDCM0483 | CL89 | HEK-293T | C68(1.14) | LDD1686 | [5] |
LDCM0484 | CL9 | HEK-293T | C68(1.12) | LDD1687 | [5] |
LDCM0485 | CL90 | HEK-293T | C68(1.17) | LDD1688 | [5] |
LDCM0486 | CL91 | HEK-293T | C68(1.07) | LDD1689 | [5] |
LDCM0488 | CL93 | HEK-293T | C68(1.06) | LDD1691 | [5] |
LDCM0489 | CL94 | HEK-293T | C68(0.94) | LDD1692 | [5] |
LDCM0490 | CL95 | HEK-293T | C68(1.07) | LDD1693 | [5] |
LDCM0492 | CL97 | HEK-293T | C68(1.03) | LDD1695 | [5] |
LDCM0494 | CL99 | HEK-293T | C68(1.10) | LDD1697 | [5] |
LDCM0495 | E2913 | HEK-293T | C68(1.25) | LDD1698 | [5] |
LDCM0468 | Fragment33 | HEK-293T | C68(1.01) | LDD1671 | [5] |
LDCM0022 | KB02 | BT-549 | C68(1.35) | LDD2279 | [3] |
LDCM0023 | KB03 | BT-549 | C68(1.28) | LDD2696 | [3] |
LDCM0024 | KB05 | COLO792 | C68(4.87) | LDD3310 | [3] |
The Interaction Atlas With This Target
References